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Candace Cham

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InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhao Y, Zhou R, Xie B, Liu CY, Kalski M, Cham CM, Jiang Z, Koval J, Weber CR, Rubin DT, Sogin M, Crosson S, Chen M, Huang J, Fiebig A, Dalal S, Chang EB, Basu A, Pott S. Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients. Nat Commun. 2025 Jan 21; 16(1):904. PMID: 39837850; PMCID: PMC11751449.
      Citations:    Fields:    Translation:HumansCells
    2. Zhao Y, Zhou R, Xie B, Liu CY, Kalski M, Cham CM, Koval J, Weber CR, Rubin DT, Sogin M, Crosson S, Huang J, Fiebig A, Dalal S, Chang EB, Basu A, Pott S, Zhao Y, Zhou R, Xie B, Liu CY, Kalski M, Cham CM, Jiang Z, Koval J, Weber CR, Rubin DT, Sogin M, Crosson S, Chen M, Huang J, Fiebig A, Dalal S, Chang EB, Basu A, Pott S, Zhao Y, Zhou R, Xie B, Liu CY, Kalski M, Cham CM, Jiang Z, Koval J, Weber CR, Rubin DT, Sogin M, Crosson S, Chen M, Huang J, Fiebig A, Dalal S, Chang EB, Basu A, Pott S. Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients. medRxiv. 2025 Jan 09. PMID: 38014192; PMCID: PMC10680893.
      Citations:    
    3. Zhao Y, Zhou R, Mu Z, Carbonetto P, Zhong X, Xie B, Luo K, Cham CM, Koval J, He X, Dahl AW, Liu X, Chang EB, Basu A, Pott S. Cell-type-resolved chromatin accessibility in the human intestine identifies complex regulatory programs and clarifies genetic associations in Crohn's disease. medRxiv. 2024 Dec 11. PMID: 39711713; PMCID: PMC11661348.
      Citations:    
    4. Kennedy MS, Freiburger A, Cooper M, Beilsmith K, St George ML, Kalski M, Cham C, Guzzetta A, Ng SC, Chan FK, Rubin D, Henry CS, Bergelson J, Chang EB. Diet outperforms microbial transplant to drive microbiome recovery post-antibiotics. bioRxiv. 2024 Aug 01. PMID: 39211181; PMCID: PMC11361181.
      Citations:    
    5. Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG, Silva JF, Zaborina O, Alverdy JC, Herzog H, Witchley J, Noble SM, Leone VA, Chang EB. Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism. Science. 2023 08 04; 381(6657):502-508. PMID: 37535745; PMCID: PMC10876062.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    6. Arvans D, Chang C, Alshaikh A, Tesar C, Babnigg G, Wolfgeher D, Kron S, Antonopoulos D, Bashir M, Cham C, Musch M, Chang E, Joachimiak A, Hassan H. Sel1-like proteins and peptides are the major Oxalobacter formigenes-derived factors stimulating oxalate transport by human intestinal epithelial cells. Am J Physiol Cell Physiol. 2023 07 01; 325(1):C344-C361. PMID: 37125773; PMCID: PMC10393326.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    7. Frazier K, Kambal A, Zale EA, Pierre JF, Hubert N, Miyoshi S, Miyoshi J, Ringus DL, Harris D, Yang K, Carroll K, Hermanson JB, Chlystek JS, Overmyer KA, Cham CM, Musch MW, Coon JJ, Chang EB, Leone VA. High-fat diet disrupts REG3? and gut microbial rhythms promoting metabolic dysfunction. Cell Host Microbe. 2022 06 08; 30(6):809-823.e6. PMID: 35439436; PMCID: PMC9281554.
      Citations: 33     Fields:    
    8. Liu CY, Cham CM, Chang EB. Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier. Transl Res. 2021 10; 236:35-51. PMID: 34126257; PMCID: PMC8380699.
      Citations: 21     Fields:    Translation:HumansCells
    9. Miyoshi J, Miyoshi S, Cham C, Lee STM, Sakatani A, Yang K, Shan Y, Kennedy M, Kiefl E, Yousef M, Crosson S, Sogin M, Antonopoulos DA, Eren AM, Leone V, Chang EB, Delmont TO. Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10-/- Mice. Gastroenterology. 2021 09; 161(3):940-952.e15. PMID: 34111469; PMCID: PMC8577987.
      Citations: 15     Fields:    Translation:AnimalsCells
    10. Watterson WJ, Tanyeri M, Watson AR, Cham CM, Shan Y, Chang EB, Eren AM, Tay S. Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes. Elife. 2020 06 17; 9. PMID: 32553109; PMCID: PMC7351490.
      Citations: 58     Fields:    Translation:Cells
    11. Zhong X, Yu J, Frazier K, Weng X, Li Y, Cham CM, Dolan K, Zhu X, Hubert N, Tao Y, Lin F, Martinez-Guryn K, Huang Y, Wang T, Liu J, He C, Chang EB, Leone V. Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation. Cell Rep. 2018 11 13; 25(7):1816-1828.e4. PMID: 30428350; PMCID: PMC6532766.
      Citations: 133     Fields:    Translation:HumansAnimalsCells
    12. Martinez-Guryn K, Hubert N, Frazier K, Urlass S, Musch MW, Ojeda P, Pierre JF, Miyoshi J, Sontag TJ, Cham CM, Reardon CA, Leone V, Chang EB. Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids. Cell Host Microbe. 2018 04 11; 23(4):458-469.e5. PMID: 29649441; PMCID: PMC5912695.
      Citations: 266     Fields:    Translation:Animals
    13. Beck MW, Kathayat RS, Cham CM, Chang EB, Dickinson BC. Correction: Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues. Chem Sci. 2017 11 01; 8(11):7879. PMID: 30123473; PMCID: PMC6063153.
      Citations:    
    14. Beck MW, Kathayat RS, Cham CM, Chang EB, Dickinson BC. Michael addition-based probes for ratiometric fluorescence imaging of protein S-depalmitoylases in live cells and tissues. Chem Sci. 2017 Nov 01; 8(11):7588-7592. PMID: 29568422; PMCID: PMC5848818.
      Citations: 15     
    15. Pierre JF, Neuman JC, Brill AL, Brar HK, Thompson MF, Cadena MT, Connors KM, Busch RA, Heneghan AF, Cham CM, Jones EK, Kibbe CR, Davis DB, Groblewski GE, Kudsk KA, Kimple ME. The gastrin-releasing peptide analog bombesin preserves exocrine and endocrine pancreas morphology and function during parenteral nutrition. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15; 309(6):G431-42. PMID: 26185331; PMCID: PMC4572409.
      Citations: 4     Fields:    Translation:Animals
    16. Leone V, Gibbons SM, Martinez K, Hutchison AL, Huang EY, Cham CM, Pierre JF, Heneghan AF, Nadimpalli A, Hubert N, Zale E, Wang Y, Huang Y, Theriault B, Dinner AR, Musch MW, Kudsk KA, Prendergast BJ, Gilbert JA, Chang EB. Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. Cell Host Microbe. 2015 May 13; 17(5):681-9. PMID: 25891358; PMCID: PMC4433408.
      Citations: 363     Fields:    Translation:Animals
    17. Zhu X, Messer JS, Wang Y, Lin F, Cham CM, Chang J, Billiar TR, Lotze MT, Boone DL, Chang EB. Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest. 2015 Mar 02; 125(3):1098-110. PMID: 25642769; PMCID: PMC4362239.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    18. Leone VA, Cham CM, Chang EB. Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases? Curr Opin Immunol. 2014 Dec; 31:16-23. PMID: 25214301; PMCID: PMC4253729.
      Citations: 12     Fields:    Translation:HumansAnimals
    19. Cham CM, Ko K, Niewold TB. Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus. Clin Dev Immunol. 2012; 2012:780436. PMID: 23251221; PMCID: PMC3509422.
      Citations: 29     Fields:    Translation:HumansAnimals
    20. Freitag TL, Cham C, Sung HH, Beilhack GF, Patel SD, Bronson RT, Schuppan D, Durinovic-Belló I, Sønderstrup G. Human risk allele HLA-DRB1*0405 predisposes class II transgenic Ab0 NOD mice to autoimmune pancreatitis. Gastroenterology. 2010 Jul; 139(1):281-91. PMID: 20303356; PMCID: PMC2902648.
      Citations: 11     Fields:    
    21. Cham CM, Driessens G, O'Keefe JP, Gajewski TF. Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells. Eur J Immunol. 2008 Sep; 38(9):2438-50. PMID: 18792400; PMCID: PMC3008428.
      Citations: 220     Fields:    
    22. Cham CM, Gajewski TF. Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells. J Immunol. 2005 Apr 15; 174(8):4670-7. PMID: 15814691.
      Citations: 186     Fields:    Translation:AnimalsCells
    23. Cham CM, Gajewski TF. Metabolic mechanisms of tumor resistance to T cell effector function. Immunol Res. 2005; 31(2):107-18. PMID: 15778509.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    24. Cham CM, Xu H, O'Keefe JP, Rivas FV, Zagouras P, Gajewski TF. Gene array and protein expression profiles suggest post-transcriptional regulation during CD8+ T cell differentiation. J Biol Chem. 2003 May 09; 278(19):17044-52. PMID: 12582156.
      Citations: 6     Fields:    Translation:AnimalsCells
    25. Wan YY, Leon RP, Marks R, Cham CM, Schaack J, Gajewski TF, DeGregori J. Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13784-9. PMID: 11095726; PMCID: PMC17653.
      Citations: 32     Fields:    
    26. Hamilton RL, Wong JS, Cham CM, Nielsen LB, Young SG. Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency. J Lipid Res. 1998 Aug; 39(8):1543-57. PMID: 9717714.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    27. McCormick SP, Ng JK, Cham CM, Taylor S, Marcovina SM, Segrest JP, Hammer RE, Young SG. Transgenic mice expressing human ApoB95 and ApoB97. Evidence that sequences within the carboxyl-terminal portion of human apoB100 are important for the assembly of lipoprotein. J Biol Chem. 1997 Sep 19; 272(38):23616-22. PMID: 9295301.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    28. Young SG, Cham CM, Pitas RE, Burri BJ, Connolly A, Flynn L, Pappu AS, Wong JS, Hamilton RL, Farese RV. A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine. J Clin Invest. 1995 Dec; 96(6):2932-46. PMID: 8675665; PMCID: PMC186005.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
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