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Molly Przeworski

TitlePROFESSOR
InstitutionUniversity of Chicago
DepartmentHuman Genetics
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wu FL, Strand AI, Cox LA, Ober C, Wall JD, Moorjani P, Przeworski M. A comparison of humans and baboons suggests germline mutation rates do not track cell divisions. PLoS Biol. 2020 08; 18(8):e3000838. PMID: 32804933.
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    2. Fuller ZL, Mocellin VJL, Morris LA, Cantin N, Shepherd J, Sarre L, Peng J, Liao Y, Pickrell J, Andolfatto P, Matz M, Bay LK, Przeworski M. Population genetics of the coral Acropora millepora: Toward genomic prediction of bleaching. Science. 2020 07 17; 369(6501). PMID: 32675347.
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    3. Mostafavi H, Harpak A, Agarwal I, Conley D, Pritchard JK, Przeworski M. Variable prediction accuracy of polygenic scores within an ancestry group. Elife. 2020 Jan 30; 9. PMID: 31999256.
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    4. Young AI, Benonisdottir S, Przeworski M, Kong A. Deconstructing the sources of genotype-phenotype associations in humans. Science. 2019 09 27; 365(6460):1396-1400. PMID: 31604265.
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    5. Sasani TA, Pedersen BS, Gao Z, Baird L, Przeworski M, Jorde LB, Quinlan AR. Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation. Elife. 2019 09 24; 8. PMID: 31549960.
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    6. Agarwal I, Przeworski M. Signatures of replication timing, recombination, and sex in the spectrum of rare variants on the human X chromosome and autosomes. Proc Natl Acad Sci U S A. 2019 09 03; 116(36):17916-17924. PMID: 31427530.
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    7. Gao Z, Moorjani P, Sasani TA, Pedersen BS, Quinlan AR, Jorde LB, Amster G, Przeworski M. Overlooked roles of DNA damage and maternal age in generating human germline mutations. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9491-9500. PMID: 31019089.
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    8. Fuller ZL, Berg JJ, Mostafavi H, Sella G, Przeworski M. Measuring intolerance to mutation in human genetics. Nat Genet. 2019 05; 51(5):772-776. PMID: 30962618.
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    9. Amorim CEG, Gao Z, Baker Z, Diesel JF, Simons YB, Haque IS, Pickrell J, Przeworski M. Correction: The population genetics of human disease: The case of recessive, lethal mutations. PLoS Genet. 2018 07; 14(7):e1007499. PMID: 29965964.
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    10. Schumer M, Xu C, Powell DL, Durvasula A, Skov L, Holland C, Blazier JC, Sankararaman S, Andolfatto P, Rosenthal GG, Przeworski M. Natural selection interacts with recombination to shape the evolution of hybrid genomes. Science. 2018 May 11; 360(6389):656-660. PMID: 29674434.
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    11. Amorim CEG, Gao Z, Baker Z, Diesel JF, Simons YB, Haque IS, Pickrell J, Przeworski M. The population genetics of human disease: The case of recessive, lethal mutations. PLoS Genet. 2017 Sep; 13(9):e1006915. PMID: 28957316.
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    12. Mostafavi H, Berisa T, Day FR, Perry JRB, Przeworski M, Pickrell JK. Identifying genetic variants that affect viability in large cohorts. PLoS Biol. 2017 Sep; 15(9):e2002458. PMID: 28873088.
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    13. Chen C, Qi H, Shen Y, Pickrell J, Przeworski M. Contrasting Determinants of Mutation Rates in Germline and Soma. Genetics. 2017 09; 207(1):255-267. PMID: 28733365.
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    14. Baker Z, Schumer M, Haba Y, Bashkirova L, Holland C, Rosenthal GG, Przeworski M. Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates. Elife. 2017 06 06; 6. PMID: 28590247.
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    15. Moorjani P, Gao Z, Przeworski M. Human Germline Mutation and the Erratic Evolutionary Clock. PLoS Biol. 2016 Oct; 14(10):e2000744. PMID: 27760127.
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    16. Moorjani P, Amorim CE, Arndt PF, Przeworski M. Variation in the molecular clock of primates. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):10607-12. PMID: 27601674.
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    17. Moorjani P, Sankararaman S, Fu Q, Przeworski M, Patterson N, Reich D. A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years. Proc Natl Acad Sci U S A. 2016 May 17; 113(20):5652-7. PMID: 27140627.
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    18. Gao Z, Wyman MJ, Sella G, Przeworski M. Interpreting the Dependence of Mutation Rates on Age and Time. PLoS Biol. 2016 Jan; 14(1):e1002355. PMID: 26761240.
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    19. Morton ER, Lynch J, Froment A, Lafosse S, Heyer E, Przeworski M, Blekhman R, Ségurel L. Variation in Rural African Gut Microbiota Is Strongly Correlated with Colonization by Entamoeba and Subsistence. PLoS Genet. 2015 Nov; 11(11):e1005658. PMID: 26619199.
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    20. Singhal S, Leffler EM, Sannareddy K, Turner I, Venn O, Hooper DM, Strand AI, Li Q, Raney B, Balakrishnan CN, Griffith SC, McVean G, Przeworski M. Stable recombination hotspots in birds. Science. 2015 11 20; 350(6263):928-32. PMID: 26586757.
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    21. Meyer WK, Venkat A, Kermany AR, van de Geijn B, Zhang S, Przeworski M. Evolutionary history inferred from the de novo assembly of a nonmodel organism, the blue-eyed black lemur. Mol Ecol. 2015 Sep; 24(17):4392-405. PMID: 26198179.
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    22. Williams AL, Genovese G, Dyer T, Altemose N, Truax K, Jun G, Patterson N, Myers SR, Curran JE, Duggirala R, Blangero J, Reich D, Przeworski M. Non-crossover gene conversions show strong GC bias and unexpected clustering in humans. Elife. 2015 Mar 25; 4. PMID: 25806687.
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    23. Gao Z, Waggoner D, Stephens M, Ober C, Przeworski M. An estimate of the average number of recessive lethal mutations carried by humans. Genetics. 2015 Apr; 199(4):1243-54. PMID: 25697177.
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    24. Gao Z, Przeworski M, Sella G. Footprints of ancient-balanced polymorphisms in genetic variation data from closely related species. Evolution. 2015 Feb; 69(2):431-46. PMID: 25403856.
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    25. Ségurel L, Wyman MJ, Przeworski M. Determinants of mutation rate variation in the human germline. Annu Rev Genomics Hum Genet. 2014; 15:47-70. PMID: 25000986.
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    26. Kermany AR, Segurel L, Oliver TR, Przeworski M. TroX: a new method to learn about the genesis of aneuploidy from trisomic products of conception. Bioinformatics. 2014 Jul 15; 30(14):2035-42. PMID: 24659032.
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    27. Quach H, Wilson D, Laval G, Patin E, Manry J, Guibert J, Barreiro LB, Nerrienet E, Verschoor E, Gessain A, Przeworski M, Quintana-Murci L. Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations. Hum Mol Genet. 2013 Dec 01; 22(23):4829-40. PMID: 23851028.
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    28. Ségurel L, Gao Z, Przeworski M. Ancestry runs deeper than blood: the evolutionary history of ABO points to cryptic variation of functional importance. Bioessays. 2013 Oct; 35(10):862-7. PMID: 23836453.
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    29. Meyer WK, Zhang S, Hayakawa S, Imai H, Przeworski M. The convergent evolution of blue iris pigmentation in primates took distinct molecular paths. Am J Phys Anthropol. 2013 Jul; 151(3):398-407. PMID: 23640739.
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    30. Leffler EM, Gao Z, Pfeifer S, Ségurel L, Auton A, Venn O, Bowden R, Bontrop R, Wall JD, Sella G, Donnelly P, McVean G, Przeworski M. Multiple instances of ancient balancing selection shared between humans and chimpanzees. Science. 2013 Mar 29; 339(6127):1578-82. PMID: 23413192.
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    31. Ségurel L, Thompson EE, Flutre T, Lovstad J, Venkat A, Margulis SW, Moyse J, Ross S, Gamble K, Sella G, Ober C, Przeworski M. The ABO blood group is a trans-species polymorphism in primates. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18493-8. PMID: 23091028.
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    32. Leffler EM, Bullaughey K, Matute DR, Meyer WK, Ségurel L, Venkat A, Andolfatto P, Przeworski M. Revisiting an old riddle: what determines genetic diversity levels within species? PLoS Biol. 2012; 10(9):e1001388. PMID: 22984349.
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    33. Auton A, Fledel-Alon A, Pfeifer S, Venn O, Ségurel L, Street T, Leffler EM, Bowden R, Aneas I, Broxholme J, Humburg P, Iqbal Z, Lunter G, Maller J, Hernandez RD, Melton C, Venkat A, Nobrega MA, Bontrop R, Myers S, Donnelly P, Przeworski M, McVean G. A fine-scale chimpanzee genetic map from population sequencing. Science. 2012 Apr 13; 336(6078):193-8. PMID: 22422862.
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    34. Meyer WK, Arbeithuber B, Ober C, Ebner T, Tiemann-Boege I, Hudson RR, Przeworski M. Evaluating the evidence for transmission distortion in human pedigrees. Genetics. 2012 May; 191(1):215-32. PMID: 22377632.
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    35. Ségurel L, Leffler EM, Przeworski M. The case of the fickle fingers: how the PRDM9 zinc finger protein specifies meiotic recombination hotspots in humans. PLoS Biol. 2011 Dec; 9(12):e1001211. PMID: 22162947.
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    36. Wilson DJ, Hernandez RD, Andolfatto P, Przeworski M. A population genetics-phylogenetics approach to inferring natural selection in coding sequences. PLoS Genet. 2011 Dec; 7(12):e1002395. PMID: 22144911.
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    37. Fledel-Alon A, Leffler EM, Guan Y, Stephens M, Coop G, Przeworski M. Variation in human recombination rates and its genetic determinants. PLoS One. 2011; 6(6):e20321. PMID: 21698098.
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    38. Hernandez RD, Kelley JL, Elyashiv E, Melton SC, Auton A, McVean G. Classic selective sweeps were rare in recent human evolution. Science. 2011 Feb 18; 331(6019):920-4. PMID: 21330547.
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    39. Przeworski M. Genome-sequencing anniversary. The golden age of human population genetics. Science. 2011 Feb 04; 331(6017):547. PMID: 21292966.
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    40. Elyashiv E, Bullaughey K, Sattath S, Rinott Y, Przeworski M, Sella G. Shifts in the intensity of purifying selection: an analysis of genome-wide polymorphism data from two closely related yeast species. Genome Res. 2010 Nov; 20(11):1558-73. PMID: 20817943.
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    41. Baudat F, Buard J, Grey C, Fledel-Alon A, Ober C, Przeworski M, Coop G, de Massy B. PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Science. 2010 Feb 12; 327(5967):836-40. PMID: 20044539.
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    42. Fledel-Alon A, Wilson DJ, Broman K, Wen X, Ober C, Coop G, Przeworski M. Broad-scale recombination patterns underlying proper disjunction in humans. PLoS Genet. 2009 Sep; 5(9):e1000658. PMID: 19763175.
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    43. Sella G, Petrov DA, Przeworski M, Andolfatto P. Pervasive natural selection in the Drosophila genome? PLoS Genet. 2009 Jun; 5(6):e1000495. PMID: 19503600.
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    44. Becquet C, Przeworski M. Learning about modes of speciation by computational approaches. Evolution. 2009 Oct; 63(10):2547-62. PMID: 19228187.
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    45. Blekhman R, Man O, Herrmann L, Boyko AR, Indap A, Kosiol C, Bustamante CD, Teshima KM, Przeworski M. Natural selection on genes that underlie human disease susceptibility. Curr Biol. 2008 Jun 24; 18(12):883-9. PMID: 18571414.
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    46. Coop G, Bullaughey K, Luca F, Przeworski M. The timing of selection at the human FOXP2 gene. Mol Biol Evol. 2008 Jul; 25(7):1257-9. PMID: 18413354.
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    47. Coop G, Wen X, Ober C, Pritchard JK, Przeworski M. High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans. Science. 2008 Mar 07; 319(5868):1395-8. PMID: 18239090.
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    48. Bullaughey K, Przeworski M, Coop G. No effect of recombination on the efficacy of natural selection in primates. Genome Res. 2008 Apr; 18(4):544-54. PMID: 18199888.
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    49. Becquet C, Przeworski M. A new approach to estimate parameters of speciation models with application to apes. Genome Res. 2007 Oct; 17(10):1505-19. PMID: 17712021.
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    50. Becquet C, Patterson N, Stone AC, Przeworski M, Reich D. Genetic structure of chimpanzee populations. PLoS Genet. 2007 Apr 20; 3(4):e66. PMID: 17447846.
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    51. Clark VJ, Ptak SE, Tiemann I, Qian Y, Coop G, Stone AC, Przeworski M, Arnheim N, Di Rienzo A. Combining sperm typing and linkage disequilibrium analyses reveals differences in selective pressures or recombination rates across human populations. Genetics. 2007 Feb; 175(2):795-804. PMID: 17151245.
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    52. Coop G, Przeworski M. An evolutionary view of human recombination. Nat Rev Genet. 2007 Jan; 8(1):23-34. PMID: 17146469.
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    53. Teshima KM, Coop G, Przeworski M. How reliable are empirical genomic scans for selective sweeps? Genome Res. 2006 Jun; 16(6):702-12. PMID: 16687733.
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    54. Przeworski M, Coop G, Wall JD. The signature of positive selection on standing genetic variation. Evolution. 2005 Nov; 59(11):2312-23. PMID: 16396172.
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    55. Przeworski M. Genetics. Motivating hotspots. Science. 2005 Oct 14; 310(5746):247-8. PMID: 16224010.
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    56. Teshima KM, Przeworski M. Directional positive selection on an allele of arbitrary dominance. Genetics. 2006 Jan; 172(1):713-8. PMID: 16219788.
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    57. Römpler H, Schulz A, Pitra C, Coop G, Przeworski M, Pääbo S, Schöneberg T. The rise and fall of the chemoattractant receptor GPR33. J Biol Chem. 2005 Sep 02; 280(35):31068-75. PMID: 15987686.
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    58. Ptak SE, Hinds DA, Koehler K, Nickel B, Patil N, Ballinger DG, Przeworski M, Frazer KA, Pääbo S. Fine-scale recombination patterns differ between chimpanzees and humans. Nat Genet. 2005 Apr; 37(4):429-34. PMID: 15723063.
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    59. Ptak SE, Roeder AD, Stephens M, Gilad Y, Pääbo S, Przeworski M. Absence of the TAP2 human recombination hotspot in chimpanzees. PLoS Biol. 2004 Jun; 2(6):e155. PMID: 15208713.
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    60. Ptak SE, Voelpel K, Przeworski M. Insights into recombination from patterns of linkage disequilibrium in humans. Genetics. 2004 May; 167(1):387-97. PMID: 15166163.
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    61. Fischer A, Wiebe V, Pääbo S, Przeworski M. Evidence for a complex demographic history of chimpanzees. Mol Biol Evol. 2004 May; 21(5):799-808. PMID: 14963091.
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    62. Gilad Y, Wiebe V, Przeworski M, Lancet D, Pääbo S. Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates. PLoS Biol. 2004 Jan; 2(1):E5. PMID: 14737185.
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    63. Przeworski M. Estimating the time since the fixation of a beneficial allele. Genetics. 2003 Aug; 164(4):1667-76. PMID: 12930770.
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    64. Hellmann I, Ebersberger I, Ptak SE, Pääbo S, Przeworski M. A neutral explanation for the correlation of diversity with recombination rates in humans. Am J Hum Genet. 2003 Jun; 72(6):1527-35. PMID: 12740762.
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    65. Ptak SE, Przeworski M. Evidence for population growth in humans is confounded by fine-scale population structure. Trends Genet. 2002 Nov; 18(11):559-63. PMID: 12414185.
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    66. Wall JD, Andolfatto P, Przeworski M. Testing models of selection and demography in Drosophila simulans. Genetics. 2002 Sep; 162(1):203-16. PMID: 12242234.
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    67. Enard W, Przeworski M, Fisher SE, Lai CS, Wiebe V, Kitano T, Monaco AP, Pääbo S. Molecular evolution of FOXP2, a gene involved in speech and language. Nature. 2002 Aug 22; 418(6900):869-72. PMID: 12192408.
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    68. Przeworski M. The signature of positive selection at randomly chosen loci. Genetics. 2002 Mar; 160(3):1179-89. PMID: 11901132.
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    69. Gilad Y, Rosenberg S, Przeworski M, Lancet D, Skorecki K. Evidence for positive selection and population structure at the human MAO-A gene. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):862-7. PMID: 11805333.
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    70. Pritchard JK, Przeworski M. Linkage disequilibrium in humans: models and data. Am J Hum Genet. 2001 Jul; 69(1):1-14. PMID: 11410837.
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    71. Andolfatto P, Przeworski M. Regions of lower crossing over harbor more rare variants in African populations of Drosophila melanogaster. Genetics. 2001 Jun; 158(2):657-65. PMID: 11404330.
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    72. Przeworski M, Wall JD. Why is there so little intragenic linkage disequilibrium in humans? Genet Res. 2001 Apr; 77(2):143-51. PMID: 11355570.
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    73. Przeworski M, Wall JD, Andolfatto P. Recombination and the frequency spectrum in Drosophila melanogaster and Drosophila simulans. Mol Biol Evol. 2001 Mar; 18(3):291-8. PMID: 11230530.
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    74. Andolfatto P, Przeworski M. A genome-wide departure from the standard neutral model in natural populations of Drosophila. Genetics. 2000 Sep; 156(1):257-68. PMID: 10978290.
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    75. Wall JD, Przeworski M. When did the human population size start increasing? Genetics. 2000 Aug; 155(4):1865-74. PMID: 10924481.
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    76. Przeworski M, Hudson RR, Di Rienzo A. Adjusting the focus on human variation. Trends Genet. 2000 Jul; 16(7):296-302. PMID: 10858659.
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    77. Przeworski M, Charlesworth B, Wall JD. Genealogies and weak purifying selection. Mol Biol Evol. 1999 Feb; 16(2):246-52. PMID: 10084898.
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