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Benjamin Glick

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMolecular Genetics and Cell Biology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Our goal is to understand the processes that generate compartments of the secretory pathway, including ER exit sites (ERES; also known as transitional ER or tER sites) and the cisternae of the Golgi apparatus. Self-organization models provide the conceptual framework. Specifically, we postulate that ERES are generated together with early Golgi cisternae by an integrated self-organization pathway, and that early cisternae progressively mature into late cisternae.

    For exploring these ideas, our main experimental system is a pair of budding yeasts. In Saccharomyces cerevisiae, Golgi cisternae are dispersed throughout the cytoplasm and the ER contains multiple small ERES, whereas in Pichia pastoris, ordered Golgi stacks are located next to large, stable ERES. These two yeasts have complementary advantages for testing specific hypotheses about the secretory pathway. We use a combination of genetics, molecular biology, 4D confocal microscopy, and electron tomography. This work is revealing evolutionarily conserved principles of cellular organization.

    A second project in the lab involves optimizing fluorescent proteins, including the red fluorescent protein DsRed. Wild-type DsRed matures very slowly. We overcame this problem by using directed evolution to create the first rapidly maturing DsRed variants, one of which is marketed commercially as DsRed-Express. More recent work yielded a noncytotoxic variant called DsRed-Express2, as well as a far-red variant called E2-Crimson. These engineering efforts inspired a basic research project in which we clarified the pathway of DsRed chromophore formation. Current efforts are focused on creating improved monomeric green and red fluorescent proteins.
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    Collapse Biography 
    Collapse education and training
    Amherst College, Amherst, MABA05/1983Neuroscience / Mathematics
    Stanford University, Stanford, CAPhD09/1988Biochemistry
    Biozentrum, University of Basel, Basel, Switzerland(postdoc)12/1994Cell Biology

    Collapse Research 
    Collapse research activities and funding
    R01GM137004     (GLICK, BENJAMIN S)Apr 1, 2020 - Mar 31, 2024
    NIH
    Role of the AP-1 Adaptor in Intra-Golgi Recycling
    Role: Principal Investigator

    R01GM104010     (GLICK, BENJAMIN S)Sep 15, 2013 - Jun 30, 2021
    NIH
    Dissecting the functions of yeast COPI
    Role: Principal Investigator

    S10OD016220     (GLICK, BENJAMIN S.)Jun 15, 2013 - Jun 14, 2014
    NIH
    Electron Microscope for a Multi-User Core Facility
    Role: Principal Investigator

    R01EB008087     (GLICK, BENJAMIN S.)Sep 15, 2007 - May 31, 2011
    NIH
    Optimizing and Analyzing Fluorescent Proteins
    Role: Principal Investigator

    R13GM080747     (GLICK, BENJAMIN S.)Jun 25, 2007 - May 31, 2008
    NIH
    2007 Molecular Membrane Biology GRC
    Role: Principal Investigator

    R01EB001566     (GLICK, BENJAMIN S.)Feb 1, 2003 - Jan 31, 2006
    NIH
    Optimizing DsRed
    Role: Principal Investigator

    R01GM061156     (GLICK, BENJAMIN S.)Jul 1, 2000 - Jun 30, 2013
    NIH
    The Transitional ER-Golgi System in Budding Yeasts
    Role: Principal Investigator

    T32GM007183     (GLICK, BENJAMIN S)Jul 1, 1975 - Jun 30, 2022
    NIH
    Molecular and Cellular Biology Training
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Valbuena FM, Krahn AH, Tokamov SA, Greene AC, Fehon RG, Glick BS. Yellow and oxidation-resistant derivatives of a monomeric superfolder GFP. bioRxiv. 2024 Jan 26. PMID: 38328041; PMCID: PMC10849726.
      Citations:    
    2. Glick BS, Zurzolo C. Editorial overview: Membranes in perpetual motion. Curr Opin Cell Biol. 2022 Oct; 78:102128. PMID: 36103730.
      Citations:    Fields:    
    3. Casler JC, Johnson N, Krahn AH, Pantazopoulou A, Day KJ, Glick BS. Clathrin adaptors mediate two sequential pathways of intra-Golgi recycling. J Cell Biol. 2022 01 03; 221(1). PMID: 34739034; PMCID: PMC8576872.
      Citations: 7     Fields:    Translation:AnimalsCells
    4. Govind AP, Jeyifous O, Russell TA, Yi Z, Weigel AV, Ramaprasad A, Newell L, Ramos W, Valbuena FM, Casler JC, Yan JZ, Glick BS, Swanson GT, Lippincott-Schwartz J, Green WN. Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome. Elife. 2021 09 21; 10. PMID: 34545811; PMCID: PMC8494481.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    5. Glick BS. TRAPP structures reveal the big picture. EMBO J. 2021 06 15; 40(12):e108537. PMID: 34018213; PMCID: PMC8204900.
      Citations:    Fields:    Translation:AnimalsCells
    6. Grimm JB, Xie L, Casler JC, Patel R, Tkachuk AN, Falco N, Choi H, Lippincott-Schwartz J, Brown TA, Glick BS, Liu Z, Lavis LD. A General Method to Improve Fluorophores Using Deuterated Auxochromes. JACS Au. 2021 May 24; 1(5):690-696. PMID: 34056637; PMCID: PMC8154212.
      Citations: 41     
    7. Dieterich IA, Cui Y, Braun MM, Lawton AJ, Robinson NH, Peotter JL, Yu Q, Casler JC, Glick BS, Audhya A, Denu JM, Li L, Puglielli L. Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway. Sci Rep. 2021 01 21; 11(1):2013. PMID: 33479349; PMCID: PMC7820588.
      Citations: 12     Fields:    Translation:HumansCells
    8. Casler JC, Zajac AL, Valbuena FM, Sparvoli D, Jeyifous O, Turkewitz AP, Horne-Badovinac S, Green WN, Glick BS. ESCargo: a regulatable fluorescent secretory cargo for diverse model organisms. Mol Biol Cell. 2020 12 15; 31(26):2892-2903. PMID: 33112725; PMCID: PMC7927198.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    9. Barrero JJ, Pagazartaundua A, Glick BS, Valero F, Ferrer P. Bioreactor-scale cell performance and protein production can be substantially increased by using a secretion signal that drives co-translational translocation in Pichia pastoris. N Biotechnol. 2021 Jan 25; 60:85-95. PMID: 33045421; PMCID: PMC7680431.
      Citations: 5     Fields:    Translation:Animals
    10. Casler JC, Glick BS. A microscopy-based kinetic analysis of yeast vacuolar protein sorting. Elife. 2020 06 25; 9. PMID: 32584255; PMCID: PMC7338053.
      Citations: 19     Fields:    Translation:AnimalsCells
    11. Valbuena FM, Fitzgerald I, Strack RL, Andruska N, Smith L, Glick BS. A photostable monomeric superfolder green fluorescent protein. Traffic. 2020 08; 21(8):534-544. PMID: 32415747; PMCID: PMC7508230.
      Citations: 9     Fields:    Translation:Cells
    12. Roy Chowdhury S, Bhattacharjee C, Casler JC, Jain BK, Glick BS, Bhattacharyya D. ER arrival sites associate with ER exit sites to create bidirectional transport portals. J Cell Biol. 2020 04 06; 219(4). PMID: 32328626; PMCID: PMC7147096.
      Citations: 5     Fields:    Translation:AnimalsCells
    13. Pantazopoulou A, Glick BS. A Kinetic View of Membrane Traffic Pathways Can Transcend the Classical View of Golgi Compartments. Front Cell Dev Biol. 2019; 7:153. PMID: 31448274; PMCID: PMC6691344.
      Citations: 26     
    14. Johnson N, Glick BS. 4D Microscopy of Yeast. J Vis Exp. 2019 04 28; (146). PMID: 31081807; PMCID: PMC7296613.
      Citations: 5     Fields:    Translation:AnimalsCells
    15. Casler JC, Papanikou E, Barrero JJ, Glick BS. Maturation-driven transport and AP-1-dependent recycling of a secretory cargo in the Golgi. J Cell Biol. 2019 05 06; 218(5):1582-1601. PMID: 30858194; PMCID: PMC6504904.
      Citations: 33     Fields:    Translation:AnimalsCells
    16. Casler JC, Glick BS. Visualizing Secretory Cargo Transport in Budding Yeast. Curr Protoc Cell Biol. 2019 06; 83(1):e80. PMID: 30414385; PMCID: PMC6506369.
      Citations: 7     Fields:    Translation:AnimalsCells
    17. Casler JC, Glick BS, Barrero JJ, Valero F, Ferrer P. An improved secretion signal enhances the secretion of model proteins from Pichia pastoris. Microb Cell Fact. 2018 Oct 12; 17(1):161. PMID: 30314480; PMCID: PMC6182871.
      Citations: 35     Fields:    Translation:AnimalsCells
    18. Day KJ, Casler JC, Glick BS. Budding Yeast Has a Minimal Endomembrane System. Dev Cell. 2018 01 08; 44(1):56-72.e4. PMID: 29316441; PMCID: PMC5765772.
      Citations: 77     Fields:    Translation:AnimalsCells
    19. Day KJ, Chandler T, Bindokas VP, Ferrier NJ, Glick BS, La Rivière PJ. Improved deconvolution of very weak confocal signals. F1000Res. 2017; 6:787. PMID: 28868135; PMCID: PMC5553083.
      Citations: 5     Fields:    
    20. Glick BS. New insights into protein secretion: TANGO1 runs rings around the COPII coat. J Cell Biol. 2017 04 03; 216(4):859-861. PMID: 28292851; PMCID: PMC5379958.
      Citations: 2     Fields:    Translation:AnimalsCells
    21. Barrero JJ, Papanikou E, Casler JC, Day KJ, Glick BS. An improved reversibly dimerizing mutant of the FK506-binding protein FKBP. Cell Logist. 2016 Jul-Sep; 6(3):e1204848. PMID: 27738551; PMCID: PMC5058350.
      Citations: 11     
    22. Sturmberger L, Chappell T, Geier M, Krainer F, Day KJ, Vide U, Trstenjak S, Schiefer A, Richardson T, Soriaga L, Darnhofer B, Birner-Gruenberger R, Glick BS, Tolstorukov I, Cregg J, Madden K, Glieder A. Refined Pichia pastoris reference genome sequence. J Biotechnol. 2016 Oct 10; 235:121-31. PMID: 27084056; PMCID: PMC5089815.
      Citations: 39     Fields:    Translation:AnimalsCells
    23. Yu AYH, Omairi-Nasser A, Austin J, Glick BS, Yip CK, Liu X, Mao K, Klionsky DJ. The Atg17-Atg31-Atg29 Complex Coordinates with Atg11 to Recruit the Vam7 SNARE and Mediate Autophagosome-Vacuole Fusion. Curr Biol. 2016 Jan 25; 26(2):150-160. PMID: 26774783; PMCID: PMC4729596.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    24. Day KJ, Papanikou E, Glick BS. 4D Confocal Imaging of Yeast Organelles. Methods Mol Biol. 2016; 1496:1-11. PMID: 27631997; PMCID: PMC5086802.
      Citations: 8     Fields:    Translation:AnimalsCells
    25. Papanikou E, Day KJ, Austin J, Glick BS. COPI selectively drives maturation of the early Golgi. Elife. 2015 Dec 28; 4. PMID: 26709839; PMCID: PMC4758959.
      Citations: 42     Fields:    Translation:AnimalsCells
    26. Glick BS, Haucke V. Gottfried Schatz (1936-2015)-mitochondrial pioneer and ambassador for science. EMBO J. 2015 Nov 12; 34(22):2725-6. PMID: 26503916; PMCID: PMC4682643.
      Citations:    Fields:    Translation:Cells
    27. Adames NR, Wilson ML, Fang G, Lux MW, Glick BS, Peccoud J. GenoLIB: a database of biological parts derived from a library of common plasmid features. Nucleic Acids Res. 2015 May 26; 43(10):4823-32. PMID: 25925571; PMCID: PMC4446419.
      Citations: 9     Fields:    
    28. Fitzgerald I, Glick BS. Secretion of a foreign protein from budding yeasts is enhanced by cotranslational translocation and by suppression of vacuolar targeting. Microb Cell Fact. 2014 Aug 28; 13(1):125. PMID: 25164324; PMCID: PMC4176846.
      Citations: 39     Fields:    Translation:AnimalsCells
    29. Papanikou E, Glick BS. Golgi compartmentation and identity. Curr Opin Cell Biol. 2014 Aug; 29:74-81. PMID: 24840895; PMCID: PMC4130901.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    30. Glick BS. Integrated self-organization of transitional ER and early Golgi compartments. Bioessays. 2014 Feb; 36(2):129-33. PMID: 24242672; PMCID: PMC4041211.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    31. Bhave M, Papanikou E, Iyer P, Pandya K, Jain BK, Ganguly A, Sharma C, Pawar K, Austin J, Day KJ, Rossanese OW, Glick BS, Bhattacharyya D. Golgi enlargement in Arf-depleted yeast cells is due to altered dynamics of cisternal maturation. J Cell Sci. 2014 Jan 01; 127(Pt 1):250-7. PMID: 24190882; PMCID: PMC3874789.
      Citations: 30     Fields:    Translation:AnimalsCells
    32. Bharucha N, Liu Y, Papanikou E, McMahon C, Esaki M, Jeffrey PD, Hughson FM, Glick BS. Sec16 influences transitional ER sites by regulating rather than organizing COPII. Mol Biol Cell. 2013 Nov; 24(21):3406-19. PMID: 24006484; PMCID: PMC3814151.
      Citations: 37     Fields:    Translation:AnimalsCells
    33. Day KJ, Staehelin LA, Glick BS. A three-stage model of Golgi structure and function. Histochem Cell Biol. 2013 Sep; 140(3):239-49. PMID: 23881164; PMCID: PMC3779436.
      Citations: 38     Fields:    Translation:AnimalsCells
    34. Montegna EA, Bhave M, Liu Y, Bhattacharyya D, Glick BS. Sec12 binds to Sec16 at transitional ER sites. PLoS One. 2012; 7(2):e31156. PMID: 22347445; PMCID: PMC3275590.
      Citations: 28     Fields:    Translation:AnimalsCells
    35. Glick BS, Luini A. Models for Golgi traffic: a critical assessment. Cold Spring Harb Perspect Biol. 2011 Nov 01; 3(11):a005215. PMID: 21875986; PMCID: PMC3220355.
      Citations: 113     Fields:    Translation:Cells
    36. Schuldiner M, Glick B. Organelle structure and biogenesis. Mol Biol Cell. 2011 Mar 15; 22(6):723. PMID: 21406586; PMCID: PMC3057695.
      Citations:    Fields:    Translation:Cells
    37. Strack RL, Keenan RJ, Glick BS. Noncytotoxic DsRed derivatives for whole-cell labeling. Methods Mol Biol. 2011; 699:355-70. PMID: 21116992; PMCID: PMC3932555.
      Citations: 9     Fields:    Translation:HumansCells
    38. Strack RL, Strongin DE, Mets L, Glick BS, Keenan RJ. Chromophore formation in DsRed occurs by a branched pathway. J Am Chem Soc. 2010 Jun 23; 132(24):8496-505. PMID: 20509651; PMCID: PMC2891888.
      Citations: 29     Fields:    Translation:Cells
    39. Levi SK, Bhattacharyya D, Strack RL, Austin JR, Glick BS. The yeast GRASP Grh1 colocalizes with COPII and is dispensable for organizing the secretory pathway. Traffic. 2010 Sep; 11(9):1168-79. PMID: 20573068; PMCID: PMC2919637.
      Citations: 40     Fields:    Translation:AnimalsCells
    40. Bhattacharyya D, Hammond AT, Glick BS. High-quality immunofluorescence of cultured cells. Methods Mol Biol. 2010; 619:403-10. PMID: 20419424; PMCID: PMC2893412.
      Citations: 14     Fields:    Translation:Animals
    41. Glick BS, Linstedt AD, Lippincott-Schwartz J, Luini A, Malhotra V, Marsh BJ, Nakano A, Pfeffer SR, Rabouille C, Rothman JE, Warren G, Wieland FT, Emr S. Journeys through the Golgi--taking stock in a new era. J Cell Biol. 2009 Nov 16; 187(4):449-53. PMID: 19948493; PMCID: PMC2779233.
      Citations: 82     Fields:    Translation:AnimalsCells
    42. Papanikou E, Glick BS. The yeast Golgi apparatus: insights and mysteries. FEBS Lett. 2009 Dec 03; 583(23):3746-51. PMID: 19879270; PMCID: PMC2788027.
      Citations: 39     Fields:    Translation:AnimalsCells
    43. Strack RL, Hein B, Bhattacharyya D, Hell SW, Keenan RJ, Glick BS. A rapidly maturing far-red derivative of DsRed-Express2 for whole-cell labeling. Biochemistry. 2009 Sep 08; 48(35):8279-81. PMID: 19658435; PMCID: PMC2861903.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    44. Attali R, Warwar N, Israel A, Gurt I, McNally E, Puckelwartz M, Glick B, Nevo Y, Ben-Neriah Z, Melki J. Mutation of SYNE-1, encoding an essential component of the nuclear lamina, is responsible for autosomal recessive arthrogryposis. Hum Mol Genet. 2009 Sep 15; 18(18):3462-9. PMID: 19542096.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    45. Strack RL, Bhattacharyya D, Glick BS, Keenan RJ. Noncytotoxic orange and red/green derivatives of DsRed-Express2 for whole-cell labeling. BMC Biotechnol. 2009 Apr 03; 9:32. PMID: 19344508; PMCID: PMC2678115.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    46. Glick BS, Nakano A. Membrane traffic within the Golgi apparatus. Annu Rev Cell Dev Biol. 2009; 25:113-32. PMID: 19575639; PMCID: PMC2877624.
      Citations: 147     Fields:    Translation:AnimalsCells
    47. Strack RL, Strongin DE, Bhattacharyya D, Tao W, Berman A, Broxmeyer HE, Keenan RJ, Glick BS. A noncytotoxic DsRed variant for whole-cell labeling. Nat Methods. 2008 Nov; 5(11):955-7. PMID: 18953349; PMCID: PMC4107390.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    48. Losev E, Papanikou E, Rossanese OW, Glick BS. Cdc1p is an endoplasmic reticulum-localized putative lipid phosphatase that affects Golgi inheritance and actin polarization by activating Ca2+ signaling. Mol Cell Biol. 2008 May; 28(10):3336-43. PMID: 18332110; PMCID: PMC2423168.
      Citations: 8     Fields:    Translation:AnimalsCells
    49. Strongin DE, Bevis B, Khuong N, Downing ME, Strack RL, Sundaram K, Glick BS, Keenan RJ. Structural rearrangements near the chromophore influence the maturation speed and brightness of DsRed variants. Protein Eng Des Sel. 2007 Nov; 20(11):525-34. PMID: 17962222.
      Citations: 19     Fields:    Translation:Cells
    50. Levi SK, Glick BS. GRASPing unconventional secretion. Cell. 2007 Aug 10; 130(3):407-9. PMID: 17693251.
      Citations: 12     Fields:    Translation:AnimalsCells
    51. Glick BS. Let there be order. Nat Cell Biol. 2007 Feb; 9(2):130-2. PMID: 17268474.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    52. Schroder LA, Glick BS, Dunn WA. Identification of pexophagy genes by restriction enzyme-mediated integration. Methods Mol Biol. 2007; 389:203-18. PMID: 17951645.
      Citations: 8     Fields:    Translation:Animals
    53. Glick BS. Fluorescence microscopy and thin-section electron microscopy. Methods Mol Biol. 2007; 389:251-60. PMID: 17951648.
      Citations: 1     Fields:    Translation:Animals
    54. Bhattacharyya D, Glick BS. Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization. Mol Biol Cell. 2007 Mar; 18(3):839-49. PMID: 17192411; PMCID: PMC1805085.
      Citations: 81     Fields:    Translation:HumansCells
    55. Stokes WA, Glick BS. MICA: desktop software for comprehensive searching of DNA databases. BMC Bioinformatics. 2006 Oct 03; 7:427. PMID: 17018144; PMCID: PMC1618866.
      Citations: 4     Fields:    Translation:Cells
    56. Esaki M, Liu Y, Glick BS. The budding yeast Pichia pastoris has a novel Sec23p homolog. FEBS Lett. 2006 Oct 02; 580(22):5215-21. PMID: 16962585.
      Citations: 5     Fields:    Translation:AnimalsCells
    57. Losev E, Reinke CA, Jellen J, Strongin DE, Bevis BJ, Glick BS. Golgi maturation visualized in living yeast. Nature. 2006 Jun 22; 441(7096):1002-6. PMID: 16699524.
      Citations: 182     Fields:    Translation:AnimalsCells
    58. Hara M, Dizon RF, Glick BS, Lee CS, Kaestner KH, Piston DW, Bindokas VP. Imaging pancreatic beta-cells in the intact pancreas. Am J Physiol Endocrinol Metab. 2006 May; 290(5):E1041-7. PMID: 16368785.
      Citations: 36     Fields:    Translation:AnimalsCells
    59. Glick BS, Barth AL, Genové G. Brighter reporter genes from multimerized fluorescent proteins. Biotechniques. 2005 Dec; 39(6):814, 816, 818 passim. PMID: 16382897.
      Citations: 18     Fields:    Translation:Cells
    60. Connerly PL, Esaki M, Montegna EA, Strongin DE, Levi S, Soderholm J, Glick BS. Sec16 is a determinant of transitional ER organization. Curr Biol. 2005 Aug 23; 15(16):1439-47. PMID: 16111939.
      Citations: 80     Fields:    Translation:AnimalsCells
    61. Reinke CA, Kozik P, Glick BS. Golgi inheritance in small buds of Saccharomyces cerevisiae is linked to endoplasmic reticulum inheritance. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18018-23. PMID: 15596717; PMCID: PMC539800.
      Citations: 25     Fields:    Translation:AnimalsCells
    62. Soderholm J, Bhattacharyya D, Strongin D, Markovitz V, Connerly PL, Reinke CA, Glick BS. The transitional ER localization mechanism of Pichia pastoris Sec12. Dev Cell. 2004 May; 6(5):649-59. PMID: 15130490.
      Citations: 18     Fields:    Translation:AnimalsCells
    63. Bonifacino JS, Glick BS. The mechanisms of vesicle budding and fusion. Cell. 2004 Jan 23; 116(2):153-66. PMID: 14744428.
      Citations: 712     Fields:    Translation:HumansAnimalsCells
    64. Rua D, Holzen T, Glick BS, Kron SJ, Bishop DK. Monitoring changes in the subcellular location of proteins in S. cerevisiae. Methods Mol Biol. 2004; 241:299-311. PMID: 14970663.
      Citations: 1     Fields:    Translation:AnimalsCells
    65. Mogelsvang S, Gomez-Ospina N, Soderholm J, Glick BS, Staehelin LA. Tomographic evidence for continuous turnover of Golgi cisternae in Pichia pastoris. Mol Biol Cell. 2003 Jun; 14(6):2277-91. PMID: 12808029; PMCID: PMC260745.
      Citations: 52     Fields:    Translation:AnimalsCells
    66. Bevis BJ, Hammond AT, Reinke CA, Glick BS, Bevis BJ, Hammond AT, Reinke CA, Glick BS. De novo formation of transitional ER sites and Golgi structures in Pichia pastoris. Nat Cell Biol. 2002 Oct; 4(10):750-6. PMID: 12360285.
      Citations: 98     Fields:    Translation:AnimalsCells
    67. Glick BS. Can the Golgi form de novo? Nat Rev Mol Cell Biol. 2002 08; 3(8):615-9. PMID: 12154372.
      Citations: 20     Fields:    Translation:AnimalsCells
    68. Mukaiyama H, Oku M, Baba M, Samizo T, Hammond AT, Glick BS, Kato N, Sakai Y. Paz2 and 13 other PAZ gene products regulate vacuolar engulfment of peroxisomes during micropexophagy. Genes Cells. 2002 Jan; 7(1):75-90. PMID: 11856375.
      Citations: 48     Fields:    Translation:AnimalsCells
    69. Bevis BJ, Glick BS. Rapidly maturing variants of the Discosoma red fluorescent protein (DsRed). Nat Biotechnol. 2002 Jan; 20(1):83-7. PMID: 11753367.
      Citations: 196     Fields:    Translation:AnimalsCells
    70. van Dijk R, Faber KN, Hammond AT, Glick BS, Veenhuis M, Kiel JA. Tagging Hansenula polymorpha genes by random integration of linear DNA fragments (RALF). Mol Genet Genomics. 2001 Dec; 266(4):646-56. PMID: 11810237.
      Citations: 11     Fields:    Translation:AnimalsCells
    71. Rossanese OW, Glick BS. Deconstructing Golgi inheritance. Traffic. 2001 Sep; 2(9):589-96. PMID: 11555412.
      Citations: 10     Fields:    Translation:AnimalsCells
    72. Soderholm J, Bevis BJ, Glick BS, Soderholm J, Bevis BJ, Glick BS. Vector for pop-in/pop-out gene replacement in Pichia pastoris. Biotechniques. 2001 Aug; 31(2):306-10, 312. PMID: 11515366.
      Citations: 8     Fields:    Translation:Animals
    73. Glick BS. ER export: more than one way out. Curr Biol. 2001 May 01; 11(9):R361-3. PMID: 11369248.
      Citations: 4     Fields:    Translation:Cells
    74. Rossanese OW, Reinke CA, Bevis BJ, Hammond AT, Sears IB, O'Connor J, Glick BS. A role for actin, Cdc1p, and Myo2p in the inheritance of late Golgi elements in Saccharomyces cerevisiae. J Cell Biol. 2001 Apr 02; 153(1):47-62. PMID: 11285273; PMCID: PMC2185536.
      Citations: 103     Fields:    Translation:AnimalsCells
    75. Matouschek A, Glick BS. Barreling through the outer membrane. Nat Struct Biol. 2001 Apr; 8(4):284-6. PMID: 11276240.
      Citations: 6     Fields:    Translation:AnimalsCells
    76. Hammond AT, Glick BS, Hammond AT, Glick BS. Raising the speed limits for 4D fluorescence microscopy. Traffic. 2000 Dec; 1(12):935-40. PMID: 11208083.
      Citations: 17     Fields:    
    77. Hammond AT, Glick BS. Dynamics of transitional endoplasmic reticulum sites in vertebrate cells. Mol Biol Cell. 2000 Sep; 11(9):3013-30. PMID: 10982397; PMCID: PMC14972.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    78. Payne WE, Kaiser CA, Bevis BJ, Soderholm J, Fu D, Sears IB, Glick BS. Isolation of Pichia pastoris genes involved in ER-to-Golgi transport. Yeast. 2000 Aug; 16(11):979-93. PMID: 10923020.
      Citations: 11     Fields:    Translation:AnimalsCells
    79. Glick BS. Organization of the Golgi apparatus. Curr Opin Cell Biol. 2000 Aug; 12(4):450-6. PMID: 10873826.
      Citations: 26     Fields:    Translation:AnimalsCells
    80. Rossanese OW, Soderholm J, Bevis BJ, Sears IB, O'Connor J, Williamson EK, Glick BS. Golgi structure correlates with transitional endoplasmic reticulum organization in Pichia pastoris and Saccharomyces cerevisiae. J Cell Biol. 1999 Apr 05; 145(1):69-81. PMID: 10189369; PMCID: PMC2148216.
      Citations: 118     Fields:    Translation:AnimalsCells
    81. Glick BS, Malhotra V. The curious status of the Golgi apparatus. Cell. 1998 Dec 23; 95(7):883-9. PMID: 9875843.
      Citations: 67     Fields:    Translation:AnimalsCells
    82. Tieaho V, Prescianotto-Baschong C, Aust T, Blondel MO, Guillaud P, Devilliers G, Rossanese OW, Glick BS, Riezman H, Haguenauer-Tsapis R, Séron K, Keränen S. A yeast t-SNARE involved in endocytosis. Mol Biol Cell. 1998 Oct; 9(10):2873-89. PMID: 9763449; PMCID: PMC25562.
      Citations: 43     Fields:    Translation:AnimalsCells
    83. Sears IB, O'Connor J, Rossanese OW, Glick BS. A versatile set of vectors for constitutive and regulated gene expression in Pichia pastoris. Yeast. 1998 Jun 15; 14(8):783-90. PMID: 9675822.
      Citations: 43     Fields:    Translation:AnimalsCells
    84. Chauwin JF, Oster G, Glick BS. Strong precursor-pore interactions constrain models for mitochondrial protein import. Biophys J. 1998 Apr; 74(4):1732-43. PMID: 9545036; PMCID: PMC1299518.
      Citations: 14     Fields:    Translation:AnimalsCells
    85. Matouschek A, Azem A, Ratliff K, Glick BS, Schmid K, Schatz G. Active unfolding of precursor proteins during mitochondrial protein import. EMBO J. 1997 Nov 17; 16(22):6727-36. PMID: 9362487; PMCID: PMC1170277.
      Citations: 50     Fields:    Translation:AnimalsCells
    86. Glick BS, Elston T, Oster G. A cisternal maturation mechanism can explain the asymmetry of the Golgi stack. FEBS Lett. 1997 Sep 08; 414(2):177-81. PMID: 9315681.
      Citations: 55     Fields:    Translation:AnimalsCells
    87. Azem A, Schatz G, Glick BS, Horst M. What is the driving force for protein import into mitochondria? Biochim Biophys Acta. 1997 Jan 16; 1318(1-2):71-8. PMID: 9030256.
      Citations: 10     Fields:    Translation:AnimalsCells
    88. Tokatlidis K, Junne T, Moes S, Schatz G, Glick BS, Kronidou N. Translocation arrest of an intramitochondrial sorting signal next to Tim11 at the inner-membrane import site. Nature. 1996 Dec 12; 384(6609):585-8. PMID: 8955275.
      Citations: 13     Fields:    Translation:AnimalsCells
    89. Glick BS. Cell biology: alternatives to baker's yeast. Curr Biol. 1996 Dec 01; 6(12):1570-2. PMID: 8994815.
      Citations: 8     Fields:    Translation:AnimalsCells
    90. Glick BS, Von Heijne G. Saccharomyces cerevisiae mitochondria lack a bacterial-type sec machinery. Protein Sci. 1996 Dec; 5(12):2651-2. PMID: 8976575; PMCID: PMC2143305.
      Citations: 22     Fields:    Translation:AnimalsCells
    91. Horst M, Oppliger W, Feifel B, Schatz G, Glick BS. The mitochondrial protein import motor: dissociation of mitochondrial hsp70 from its membrane anchor requires ATP binding rather than ATP hydrolysis. Protein Sci. 1996 Apr; 5(4):759-67. PMID: 8845766; PMCID: PMC2143374.
      Citations: 20     Fields:    Translation:AnimalsCells
    92. Rospert S, Looser R, Dubaquie Y, Matouschek A, Glick BS, Schatz G. Hsp60-independent protein folding in the matrix of yeast mitochondria. EMBO J. 1996 Feb 15; 15(4):764-74. PMID: 8631298; PMCID: PMC450275.
      Citations: 21     Fields:    Translation:AnimalsCells
    93. Rospert S, Schmid K, Glick BS, Schatz G, Matouschek A. Cyclophilin catalyzes protein folding in yeast mitochondria. Proc Natl Acad Sci U S A. 1995 Jul 03; 92(14):6319-23. PMID: 7603990; PMCID: PMC41509.
      Citations: 62     Fields:    Translation:AnimalsCells
    94. Linstedt AD, Foguet M, Renz M, Seelig HP, Glick BS, Hauri HP. A C-terminally-anchored Golgi protein is inserted into the endoplasmic reticulum and then transported to the Golgi apparatus. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):5102-5. PMID: 7761455; PMCID: PMC41856.
      Citations: 42     Fields:    Translation:HumansCells
    95. Lithgow T, Glick BS, Schatz G. The protein import receptor of mitochondria. Trends Biochem Sci. 1995 Mar; 20(3):98-101. PMID: 7709435.
      Citations: 46     Fields:    Translation:AnimalsCells
    96. Glick BS. Can Hsp70 proteins act as force-generating motors? Cell. 1995 Jan 13; 80(1):11-4. PMID: 7813006.
      Citations: 75     Fields:    Translation:Cells
    97. Glick BS, Pon LA. Isolation of highly purified mitochondria from Saccharomyces cerevisiae. Methods Enzymol. 1995; 260:213-23. PMID: 8592446.
      Citations: 129     Fields:    Translation:AnimalsCells
    98. Glick BS. Pathways and energetics of mitochondrial protein import in Saccharomyces cerevisiae. Methods Enzymol. 1995; 260:224-31. PMID: 8592447.
      Citations: 18     Fields:    Translation:AnimalsCells
    99. Kronidou NG, Oppliger W, Bolliger L, Hannavy K, Glick BS, Schatz G, Horst M. Dynamic interaction between Isp45 and mitochondrial hsp70 in the protein import system of the yeast mitochondrial inner membrane. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12818-22. PMID: 7809127; PMCID: PMC45531.
      Citations: 55     Fields:    Translation:AnimalsCells
    100. Rospert S, Schatz G, Glick BS, Müller S. Fusion proteins containing the cytochrome b2 presequence are sorted to the mitochondrial intermembrane space independently of hsp60. J Biol Chem. 1994 Jun 24; 269(25):17279-88. PMID: 7911803.
      Citations: 7     Fields:    Translation:AnimalsCells
    101. Bolliger L, Deloche O, Glick BS, Georgopoulos C, Kronidou N, Horst M, Morishima N, Schatz G, Jenö P. A mitochondrial homolog of bacterial GrpE interacts with mitochondrial hsp70 and is essential for viability. EMBO J. 1994 Apr 15; 13(8):1998-2006. PMID: 8168496; PMCID: PMC395042.
      Citations: 48     Fields:    Translation:AnimalsCells
    102. Wachter C, Schatz G, Glick BS. Protein import into mitochondria: the requirement for external ATP is precursor-specific whereas intramitochondrial ATP is universally needed for translocation into the matrix. Mol Biol Cell. 1994 Apr; 5(4):465-74. PMID: 7914441; PMCID: PMC301055.
      Citations: 40     Fields:    Translation:AnimalsCells
    103. Rospert S, Junne T, Glick BS, Schatz G. Cloning and disruption of the gene encoding yeast mitochondrial chaperonin 10, the homolog of E. coli groES. FEBS Lett. 1993 Dec 13; 335(3):358-60. PMID: 7903252.
      Citations: 18     Fields:    Translation:AnimalsCells
    104. Rospert S, Glick BS, Schatz G, Todd MJ, Lorimer GH, Viitanen PV, Jenö P. Identification and functional analysis of chaperonin 10, the groES homolog from yeast mitochondria. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):10967-71. PMID: 7902576; PMCID: PMC47902.
      Citations: 22     Fields:    Translation:AnimalsCells
    105. Glick BS, Wachter C, Reid GA, Schatz G. Import of cytochrome b2 to the mitochondrial intermembrane space: the tightly folded heme-binding domain makes import dependent upon matrix ATP. Protein Sci. 1993 Nov; 2(11):1901-17. PMID: 8268801; PMCID: PMC2142280.
      Citations: 41     Fields:    Translation:AnimalsCells
    106. Wachter C, Schatz G, Glick BS. Role of ATP in the intramitochondrial sorting of cytochrome c1 and the adenine nucleotide translocator. EMBO J. 1992 Dec; 11(13):4787-94. PMID: 1334457; PMCID: PMC556954.
      Citations: 23     Fields:    Translation:AnimalsCells
    107. Beasley EM, Schatz G, Glick BS. Protein sorting in mitochondria. Trends Biochem Sci. 1992 Nov; 17(11):453-9. PMID: 1455515.
      Citations: 39     Fields:    Translation:Cells
    108. Glick BS, Wachter C, Schatz G. The energetics of protein import into mitochondria. Biochim Biophys Acta. 1992 Jul 17; 1101(2):249-51. PMID: 1633190.
      Citations: 2     Fields:    Translation:Cells
    109. Glick BS, Brandt A, Cunningham K, Hallberg RL, Schatz G, Müller S. Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism. Cell. 1992 May 29; 69(5):809-22. PMID: 1350514.
      Citations: 137     Fields:    Translation:AnimalsCells
    110. Glick B, Wachter C, Schatz G. Protein import into mitochondria: two systems acting in tandem? Trends Cell Biol. 1991 Oct; 1(4):99-103. PMID: 14731796.
      Citations: 24     Fields:    
    111. Glick B, Schatz G. Import of proteins into mitochondria. Annu Rev Genet. 1991; 25:21-44. PMID: 1812807.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    112. Glick BS. Protein import into isolated yeast mitochondria. Methods Cell Biol. 1991; 34:389-99. PMID: 1943812.
      Citations: 16     Fields:    Translation:AnimalsCells
    113. Glick B, Geli V. Mitochondrial protein import. J Bioenerg Biomembr. 1990 Dec; 22(6):725-51. PMID: 2092036.
      Citations: 2     Fields:    Translation:AnimalsCells
    114. Pfanner N, Glick BS, Arden SR, Rothman JE. Fatty acylation promotes fusion of transport vesicles with Golgi cisternae. J Cell Biol. 1990 Apr; 110(4):955-61. PMID: 2324202; PMCID: PMC2116082.
      Citations: 43     Fields:    Translation:Cells
    115. Pfanner N, Orci L, Glick BS, Amherdt M, Arden SR, Malhotra V, Rothman JE. Fatty acyl-coenzyme A is required for budding of transport vesicles from Golgi cisternae. Cell. 1989 Oct 06; 59(1):95-102. PMID: 2790961.
      Citations: 58     Fields:    Translation:AnimalsCells
    116. Beckers CJ, Block MR, Glick BS, Rothman JE, Balch WE. Vesicular transport between the endoplasmic reticulum and the Golgi stack requires the NEM-sensitive fusion protein. Nature. 1989 Jun 01; 339(6223):397-8. PMID: 2542798.
      Citations: 93     Fields:    Translation:AnimalsCells
    117. Glick BS, Malhotra V, Weidman PJ, Serafini T, Orci L, Rothman JE, Melançon P. A role for GTP-binding proteins in vesicular transport through the Golgi complex. Soc Gen Physiol Ser. 1989; 44:175-88. PMID: 2506649.
      Citations: 2     Fields:    Translation:AnimalsCells
    118. Block MR, Glick BS, Wilcox CA, Wieland FT, Rothman JE. Purification of an N-ethylmaleimide-sensitive protein catalyzing vesicular transport. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):7852-6. PMID: 3186695; PMCID: PMC282295.
      Citations: 186     Fields:    Translation:AnimalsCells
    119. Malhotra V, Orci L, Glick BS, Block MR, Rothman JE. Role of an N-ethylmaleimide-sensitive transport component in promoting fusion of transport vesicles with cisternae of the Golgi stack. Cell. 1988 Jul 15; 54(2):221-7. PMID: 3390865.
      Citations: 136     Fields:    Translation:AnimalsCells
    120. Glick BS, Malhotra V, Weidman PJ, Serafini T, Gleason ML, Orci L, Rothman JE, Melançon P. Involvement of GTP-binding "G" proteins in transport through the Golgi stack. Cell. 1987 Dec 24; 51(6):1053-62. PMID: 2826014.
      Citations: 153     Fields:    Translation:AnimalsCells
    121. Glick BS, Rothman JE. Possible role for fatty acyl-coenzyme A in intracellular protein transport. Nature. 1987 Mar 19-25; 326(6110):309-12. PMID: 3821906.
      Citations: 90     Fields:    Translation:AnimalsCells
    122. Orci L, Glick BS, Rothman JE. A new type of coated vesicular carrier that appears not to contain clathrin: its possible role in protein transport within the Golgi stack. Cell. 1986 Jul 18; 46(2):171-84. PMID: 2872969.
      Citations: 139     Fields:    Translation:AnimalsCells
    123. Pfeffer SR, Burczak JD, Glick BS, Rothman JE, Pâquet MR. Components responsible for transport between successive Golgi cisternae are highly conserved in evolution. J Biol Chem. 1986 Apr 05; 261(10):4367-70. PMID: 3007452.
      Citations: 4     Fields:    Translation:AnimalsCells
    124. Dunphy WG, Pfeffer SR, Clary DO, Wattenberg BW, Glick BS, Rothman JE. Yeast and mammals utilize similar cytosolic components to drive protein transport through the Golgi complex. Proc Natl Acad Sci U S A. 1986 Mar; 83(6):1622-6. PMID: 3513182; PMCID: PMC323135.
      Citations: 18     Fields:    Translation:AnimalsCells
    125. George DL, Scott AF, Trusko S, Glick B, Ford E, Dorney DJ. Structure and expression of amplified cKi-ras gene sequences in Y1 mouse adrenal tumor cells. EMBO J. 1985 May; 4(5):1199-203. PMID: 4006913; PMCID: PMC554324.
      Citations: 21     Fields:    Translation:AnimalsCells
    126. Balch WE, Glick BS, Rothman JE. Sequential intermediates in the pathway of intercompartmental transport in a cell-free system. Cell. 1984 Dec; 39(3 Pt 2):525-36. PMID: 6096009.
      Citations: 69     Fields:    Translation:AnimalsCells
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