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Cathryn R. Nagler

TitlePROFESSOR
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    We study microbial regulation of allergic responses to food.


    Collapse Biography 
    Collapse education and training
    Massachusetts Institute of Technology, Cambridge, MAPostdoctoral Fellowship07/1990Immunology
    New York University Sackler Institute of Biomedical Science, New York, NYPh.D.12/1986Immunology
    Barnard College (Columbia University), New York, NYBA05/1979Biology

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Bunker JJ, Drees C, Watson AR, Plunkett CH, Nagler CR, Schneewind O, Eren AM, Bendelac A. B cell superantigens in the human intestinal microbiota. Sci Transl Med. 2019 Aug 28; 11(507). PMID: 31462512.
      View in: PubMed
    2. Iweala OI, Nagler CR. The Microbiome and Food Allergy. Annu Rev Immunol. 2019 Apr 26; 37:377-403. PMID: 31026410.
      View in: PubMed
    3. Kemter AM, Nagler CR. Influences on allergic mechanisms through gut, lung, and skin microbiome exposures. J Clin Invest. 2019 Feb 25; 130:1483-1492. PMID: 30830878.
      View in: PubMed
    4. Feehley T, Plunkett CH, Bao R, Choi Hong SM, Culleen E, Belda-Ferre P, Campbell E, Aitoro R, Nocerino R, Paparo L, Andrade J, Antonopoulos DA, Berni Canani R, Nagler CR. Healthy infants harbor intestinal bacteria that protect against food allergy. Nat Med. 2019 03; 25(3):448-453. PMID: 30643289.
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    5. Seo GY, Lee JM, Jang YS, Kang SG, Yoon SI, Ko HJ, Lee GS, Park SR, Nagler CR, Kim PH. Mechanism underlying the suppressor activity of retinoic acid on IL4-induced IgE synthesis and its physiological implication. Cell Immunol. 2017 Dec; 322:49-55. PMID: 29042055.
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    6. Kim YG, Sakamoto K, Seo SU, Pickard JM, Gillilland MG, Pudlo NA, Hoostal M, Li X, Wang TD, Feehley T, Stefka AT, Schmidt TM, Martens EC, Fukuda S, Inohara N, Nagler CR, Núñez G. Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens. Science. 2017 04 21; 356(6335):315-319. PMID: 28428425.
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    7. Aitoro R, Simeoli R, Amoroso A, Paparo L, Nocerino R, Pirozzi C, di Costanzo M, Meli R, De Caro C, Picariello G, Mamone G, Calignano A, Nagler CR, Berni Canani R. Extensively hydrolyzed casein formula alone or with L. rhamnosus GG reduces ß-lactoglobulin sensitization in mice. Pediatr Allergy Immunol. 2017 05; 28(3):230-237. PMID: 27992668.
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    8. Plunkett CH, Nagler CR. The Influence of the Microbiome on Allergic Sensitization to Food. J Immunol. 2017 01 15; 198(2):581-589. PMID: 28069753.
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    9. Wroblewska JA, Zhang Y, Tang H, Guo X, Nagler C, Fu YX. Cutting Edge: Lymphotoxin Signaling Is Essential for Clearance of Salmonella from the Gut Lumen and Generation of Anti-Salmonella Protective Immunity. J Immunol. 2017 01 01; 198(1):55-60. PMID: 27913631.
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    10. Nutsch K, Chai JN, Ai TL, Russler-Germain E, Feehley T, Nagler CR, Hsieh CS. Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery. Cell Rep. 2016 09 27; 17(1):206-220. PMID: 27681432.
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    11. Lei YM, Chen L, Wang Y, Stefka AT, Molinero LL, Theriault B, Aquino-Michaels K, Sivan AS, Nagler CR, Gajewski TF, Chong AS, Bartman C, Alegre ML. The composition of the microbiota modulates allograft rejection. J Clin Invest. 2016 07 01; 126(7):2736-44. PMID: 27322054.
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    12. Feehley T, Belda-Ferre P, Nagler CR. What's LPS Got to Do with It? A Role for Gut LPS Variants in Driving Autoimmune and Allergic Disease. Cell Host Microbe. 2016 May 11; 19(5):572-4. PMID: 27173923.
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    13. Wesemann DR, Nagler CR. The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease. Immunity. 2016 Apr 19; 44(4):728-38. PMID: 27096316.
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    14. Berni Canani R, Sangwan N, Stefka AT, Nocerino R, Paparo L, Aitoro R, Calignano A, Khan AA, Gilbert JA, Nagler CR. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants. ISME J. 2016 Mar; 10(3):742-50. PMID: 26394008.
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    15. Berni Canani R, Gilbert JA, Nagler CR. The role of the commensal microbiota in the regulation of tolerance to dietary allergens. Curr Opin Allergy Clin Immunol. 2015 Jun; 15(3):243-9. PMID: 25827065.
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    16. Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015 Apr 09; 161(2):264-76. PMID: 25860609.
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    17. Lax S, Nagler CR, Gilbert JA. Our interface with the built environment: immunity and the indoor microbiota. Trends Immunol. 2015 Mar; 36(3):121-3. PMID: 25754179.
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    18. Feehley T, Nagler CR. Cellular and molecular pathways through which commensal bacteria modulate sensitization to dietary antigens. Curr Opin Immunol. 2014 Dec; 31:79-86. PMID: 25458998.
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    19. Feehley T, Nagler CR. Health: The weighty costs of non-caloric sweeteners. Nature. 2014 Oct 09; 514(7521):176-7. PMID: 25231865.
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    20. Stefka AT, Feehley T, Tripathi P, Qiu J, McCoy K, Mazmanian SK, Tjota MY, Seo GY, Cao S, Theriault BR, Antonopoulos DA, Zhou L, Chang EB, Fu YX, Nagler CR. Commensal bacteria protect against food allergen sensitization. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13145-50. PMID: 25157157.
      View in: PubMed
    21. Cao AT, Yao S, Stefka AT, Liu Z, Qin H, Liu H, Evans-Marin HL, Elson CO, Nagler CR, Cong Y. TLR4 regulates IFN-? and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation. J Leukoc Biol. 2014 Nov; 96(5):895-905. PMID: 25015957.
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    22. Cao S, Feehley TJ, Nagler CR. The role of commensal bacteria in the regulation of sensitization to food allergens. FEBS Lett. 2014 Nov 17; 588(22):4258-66. PMID: 24791655.
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    23. Nagler CR. Introduction to Special Issue on Food Allergy. Semin Immunopathol. 2012 Sep; 34(5):615-6. PMID: 22945458.
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    24. Feehley T, Stefka AT, Cao S, Nagler CR. Microbial regulation of allergic responses to food. Semin Immunopathol. 2012 Sep; 34(5):671-88. PMID: 22941410.
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    25. Upadhyay V, Poroyko V, Kim TJ, Devkota S, Fu S, Liu D, Tumanov AV, Koroleva EP, Deng L, Nagler C, Chang EB, Tang H, Fu YX. Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nat Immunol. 2012 Oct; 13(10):947-53. PMID: 22922363.
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    26. Nagatani K, Wang S, Llado V, Lau CW, Li Z, Mizoguchi A, Nagler CR, Shibata Y, Reinecker HC, Mora JR, Mizoguchi E. Chitin microparticles for the control of intestinal inflammation. Inflamm Bowel Dis. 2012 Sep; 18(9):1698-710. PMID: 22241684.
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    27. Nagler C, Wroblewska J. TL we meet again. Nat Immunol. 2011 Oct 19; 12(11):1027-8. PMID: 22012434.
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    28. Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, Mora JR. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. J Immunol. 2011 Jul 01; 187(1):141-50. PMID: 21646294.
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    29. Wang Y, Devkota S, Musch MW, Jabri B, Nagler C, Antonopoulos DA, Chervonsky A, Chang EB. Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon. PLoS One. 2010 Oct 22; 5(10):e13607. PMID: 21042588.
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    30. McBee ME, Zeng Y, Parry N, Nagler CR, Tannenbaum SR, Schauer DB. Multivariate modeling identifies neutrophil- and Th17-related factors as differential serum biomarkers of chronic murine colitis. PLoS One. 2010 Oct 19; 5(10):e13277. PMID: 20976045.
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    31. Matharu KS, Mizoguchi E, Cotoner CA, Nguyen DD, Mingle B, Iweala OI, McBee ME, Stefka AT, Prioult G, Haigis KM, Bhan AK, Snapper SB, Murakami H, Schauer DB, Reinecker HC, Mizoguchi A, Nagler CR. Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice. Gastroenterology. 2009 Oct; 137(4):1380-90.e1-3. PMID: 19596011.
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    32. Iweala OI, Smith DW, Matharu KS, Sada-Ovalle I, Nguyen DD, Dekruyff RH, Umetsu DT, Behar SM, Nagler CR. Vaccine-induced antibody isotypes are skewed by impaired CD4 T cell and invariant NKT cell effector responses in MyD88-deficient mice. J Immunol. 2009 Aug 15; 183(4):2252-60. PMID: 19620295.
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    33. Harris JB, Podolsky MJ, Bhuiyan TR, Chowdhury F, Khan AI, Larocque RC, Logvinenko T, Kendall J, Faruque AS, Nagler CR, Ryan ET, Qadri F, Calderwood SB. Immunologic responses to Vibrio cholerae in patients co-infected with intestinal parasites in Bangladesh. PLoS Negl Trop Dis. 2009; 3(3):e403. PMID: 19333369.
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    34. Nguyen DD, Maillard MH, Cotta-de-Almeida V, Mizoguchi E, Klein C, Fuss I, Nagler C, Mizoguchi A, Bhan AK, Snapper SB. Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein. Gastroenterology. 2007 Oct; 133(4):1188-97. PMID: 17764675.
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    35. Urban JF, Steenhard NR, Solano-Aguilar GI, Dawson HD, Iweala OI, Nagler CR, Noland GS, Kumar N, Anthony RM, Shea-Donohue T, Weinstock J, Gause WC. Infection with parasitic nematodes confounds vaccination efficacy. Vet Parasitol. 2007 Aug 19; 148(1):14-20. PMID: 17587500.
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    36. Maillard MH, Cotta-de-Almeida V, Takeshima F, Nguyen DD, Michetti P, Nagler C, Bhan AK, Snapper SB. The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells. J Exp Med. 2007 Feb 19; 204(2):381-91. PMID: 17296786.
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    37. Iweala OI, Nagler CR. Immune privilege in the gut: the establishment and maintenance of non-responsiveness to dietary antigens and commensal flora. Immunol Rev. 2006 Oct; 213:82-100. PMID: 16972898.
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