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Cathryn R. Nagler

TitleProfessor
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
Email
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    The Nagler Lab studies the mechanisms governing tolerance to dietary antigens. They were one of the first to identify a link between resident intestinal bacteria and the regulation of mucosal immunity. During the last fifteen years, their work has focused on examining how commensal bacteria regulate susceptibility to allergic responses to food. They have proposed that the striking generational increase in food allergies can be explained, in part, by alterations in the composition and function of the commensal microbiome.

    In support of this hypothesis, Nagler Lab described a role for a particular population of mucosa-associated commensal bacteria in protection from allergic sensitization in mice. Initial translational studies showed that the composition of the fecal microbiota is altered in infants with cow’s milk allergy. To understand how the microbiota regulates allergic disease in humans they have colonized germ free mice with human bacteria from the feces of healthy or cow’s milk allergic (CMA) infants.

    The group discovered that mice colonized with CMA infants’ microbiota exhibited an anaphylactic response to the cow’s milk allergen b-lactoglobulin, while mice colonized with healthy infants’ microbiota were protected against an allergic response. They defined a microbiota signature that distinguishes the CMA and healthy populations in both the human donors and the colonized mice. Analysis of gene expression in ileal intestinal epithelial cells of colonized mice identified a significant correlation between the genes associated with allergy protection and taxa from the Lachnospiraceae family, supporting a causal role for specific bacterial species in protection against food allergy.

    These robust, pre-clinical, gnotobiotic models are an ideal system to identify key host-microbial interactions that contribute to allergic sensitization to food. With support from the Polsky Center for Entrepreneurship and Innovation, Nagler Lab has created a start-up company, ClostraBio, to develop novel microbiome-modulating therapeutics to prevent or treat food allergy.
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    Collapse Biography 
    Collapse education and training
    Massachusetts Institute of Technology, Cambridge, MAPostdoctoral Fellowship07/1990Immunology
    NYU Grossman School of Medicine, New York, NYPh.D.09/1986Immunology
    Barnard College (Columbia University), New York, NYBA05/1979Biology
    Collapse awards and honors
    2017Distinguished Faculty Award for Leadership in Program Innovation, University of Chicago
    2018Tech Top 50 Women, Crain's Chicago Business
    2019Notable Women in Health Care, Crain's Chicago Business
    2019Louis M. Mendelson Award Lectureship, American Academy of Allergy, Asthma and Immunology
    2019Siegel Lectureship, UCLA
    2020Distinguished Fellow, American Association of Immunologists

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Campbell E, Hesser LA, Berni Canani R, Carucci L, Paparo L, Patry RT, Nagler CR. A Lipopolysaccharide-Enriched Cow's Milk Allergy Microbiome Promotes a TLR4-Dependent Proinflammatory Intestinal Immune Response. J Immunol. 2024 Feb 15; 212(4):702-714. PMID: 38169331; PMCID: PMC10872367.
      Citations:    Fields:    Translation:HumansAnimals
    2. Nagler CR. Inhibition of Immunological Suppression. J Immunol. 2023 11 01; 211(9):1255-1256. PMID: 37987807.
      Citations:    Fields:    
    3. Kemter AM, Patry RT, Arnold J, Hesser LA, Campbell E, Ionescu E, Mimee M, Wang S, Nagler CR. Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food. Cell Rep. 2023 10 31; 42(10):113153. PMID: 37742185; PMCID: PMC10697505.
      Citations:    Fields:    Translation:AnimalsCells
    4. Zhang Y, Hardy LC, Kapita CM, Hall JA, Arbeeva L, Campbell E, Urban JF, Belkaid Y, Nagler CR, Iweala OI. Intestinal Helminth Infection Impairs Oral and Parenteral Vaccine Efficacy. J Immunol. 2023 08 01; 211(3):389-402. PMID: 37272847; PMCID: PMC10524302.
      Citations:    Fields:    Translation:AnimalsCells
    5. Wang R, Cao S, Bashir MEH, Hesser LA, Su Y, Hong SMC, Thompson A, Culleen E, Sabados M, Dylla NP, Campbell E, Bao R, Nonnecke EB, Bevins CL, Wilson DS, Hubbell JA, Nagler CR. Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles. Nat Biomed Eng. 2023 Jan; 7(1):38-55. PMID: 36550307; PMCID: PMC9870785.
      Citations: 10     Fields:    Translation:Animals
    6. Hwang DW, Nagler CR, Ciaccio CE. New and emerging concepts and therapies for the treatment of food allergy. Immunother Adv. 2022; 2(1):ltac006. PMID: 35434724; PMCID: PMC9007422.
      Citations: 2     
    7. Cao S, Nagler CR. Interpreting success or failure of peanut oral immunotherapy. J Clin Invest. 2022 01 18; 132(2). PMID: 35040441; PMCID: PMC8759774.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    8. Brusilovsky M, Bao R, Rochman M, Kemter AM, Nagler CR, Rothenberg ME. Host-Microbiota Interactions in the Esophagus During Homeostasis and Allergic Inflammation. Gastroenterology. 2022 02; 162(2):521-534.e8. PMID: 34627858; PMCID: PMC9185752.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    9. Nagler CR. Modern World Influences on the Microbiome and Their Consequences for Immune-Mediated Disease. J Immunol. 2021 10 01; 207(7):1695-1696. PMID: 34544809.
      Citations: 3     Fields:    Translation:HumansAnimals
    10. Brough HA, Lanser BJ, Sindher SB, Teng JMC, Leung DYM, Venter C, Chan SM, Santos AF, Bahnson HT, Guttman-Yassky E, Gupta RS, Lack G, Ciaccio CE, Sampath V, Nadeau KC, Nagler CR. Early intervention and prevention of allergic diseases. Allergy. 2022 02; 77(2):416-441. PMID: 34255344.
      Citations: 14     Fields:    Translation:Humans
    11. Campbell E, Nagler CR. Fe, fi, fo, fum, I smell the diet of a healthy human. Cell. 2021 08 05; 184(16):4107-4109. PMID: 34358465.
      Citations: 2     Fields:    Translation:Humans
    12. Hesser LA, Nagler CR. A wild approach to obesity prevention. Nat Metab. 2021 08; 3(8):1038-1039. PMID: 34417592.
      Citations:    Fields:    
    13. Mimee M, Nagler CR. Engineered yeast tune down gut inflammation. Nat Med. 2021 Jul; 27(7):1150-1151. PMID: 34183835.
      Citations: 3     Fields:    Translation:Animals
    14. Patry RT, Nagler CR. Publisher Correction: Fiber-poor Western diets fuel inflammation. Nat Immunol. 2021 Jun; 22(6):795. PMID: 33903768.
      Citations:    Fields:    
    15. Patry RT, Nagler CR. Publisher Correction: Fiber-poor Western diets fuel inflammation. Nat Immunol. 2021 Apr; 22(4):530. PMID: 33664519.
      Citations:    Fields:    
    16. Patry RT, Nagler CR. Fiber-poor Western diets fuel inflammation. Nat Immunol. 2021 03; 22(3):266-268. PMID: 33574618.
      Citations: 2     Fields:    Translation:Humans
    17. Bao R, Hesser LA, He Z, Zhou X, Nadeau KC, Nagler CR. Fecal microbiome and metabolome differ in healthy and food-allergic twins. J Clin Invest. 2021 01 19; 131(2). PMID: 33463536; PMCID: PMC7810484.
      Citations: 36     Fields:    Translation:HumansCellsCTClinical Trials
    18. Campbell E, Hesser LA, Nagler CR. B cells and the microbiota: a missing connection in food allergy. Mucosal Immunol. 2021 01; 14(1):4-13. PMID: 33106585.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    19. Nagler CR. Drugging the microbiome. J Exp Med. 2020 04 06; 217(4). PMID: 32150223; PMCID: PMC7144529.
      Citations: 3     Fields:    Translation:Humans
    20. Wesemann DR, Nagler CR. Origins of peanut allergy-causing antibodies. Science. 2020 03 06; 367(6482):1072-1073. PMID: 32139528; PMCID: PMC8063504.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    21. Bunker JJ, Drees C, Watson AR, Plunkett CH, Nagler CR, Schneewind O, Eren AM, Bendelac A. B cell superantigens in the human intestinal microbiota. Sci Transl Med. 2019 08 28; 11(507). PMID: 31462512; PMCID: PMC6758550.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    22. Iweala OI, Nagler CR. The Microbiome and Food Allergy. Annu Rev Immunol. 2019 04 26; 37:377-403. PMID: 31026410; PMCID: PMC10445337.
      Citations: 55     Fields:    Translation:HumansAnimals
    23. Kemter AM, Nagler CR. Influences on allergic mechanisms through gut, lung, and skin microbiome exposures. J Clin Invest. 2019 02 25; 129(4):1483-1492. PMID: 30830878; PMCID: PMC6436857.
      Citations: 27     Fields:    Translation:HumansAnimals
    24. Feehley T, Plunkett CH, Bao R, Choi Hong SM, Culleen E, Belda-Ferre P, Campbell E, Aitoro R, Nocerino R, Paparo L, Andrade J, Antonopoulos DA, Berni Canani R, Nagler CR. Healthy infants harbor intestinal bacteria that protect against food allergy. Nat Med. 2019 03; 25(3):448-453. PMID: 30643289; PMCID: PMC6408964.
      Citations: 161     Fields:    Translation:HumansAnimalsCells
    25. Seo GY, Lee JM, Jang YS, Kang SG, Yoon SI, Ko HJ, Lee GS, Park SR, Nagler CR, Kim PH. Mechanism underlying the suppressor activity of retinoic acid on IL4-induced IgE synthesis and its physiological implication. Cell Immunol. 2017 Dec; 322:49-55. PMID: 29042055; PMCID: PMC5733712.
      Citations: 10     Fields:    Translation:AnimalsCells
    26. Kim YG, Sakamoto K, Seo SU, Pickard JM, Gillilland MG, Pudlo NA, Hoostal M, Li X, Wang TD, Feehley T, Stefka AT, Schmidt TM, Martens EC, Fukuda S, Inohara N, Nagler CR, Núñez G. Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens. Science. 2017 04 21; 356(6335):315-319. PMID: 28428425; PMCID: PMC6082366.
      Citations: 120     Fields:    Translation:AnimalsCells
    27. Aitoro R, Simeoli R, Amoroso A, Paparo L, Nocerino R, Pirozzi C, di Costanzo M, Meli R, De Caro C, Picariello G, Mamone G, Calignano A, Nagler CR, Berni Canani R. Extensively hydrolyzed casein formula alone or with L. rhamnosus GG reduces ß-lactoglobulin sensitization in mice. Pediatr Allergy Immunol. 2017 05; 28(3):230-237. PMID: 27992668.
      Citations: 12     Fields:    Translation:AnimalsCells
    28. Plunkett CH, Nagler CR. The Influence of the Microbiome on Allergic Sensitization to Food. J Immunol. 2017 01 15; 198(2):581-589. PMID: 28069753; PMCID: PMC5228404.
      Citations: 36     Fields:    Translation:Humans
    29. Wroblewska JA, Zhang Y, Tang H, Guo X, Nagler C, Fu YX. Cutting Edge: Lymphotoxin Signaling Is Essential for Clearance of Salmonella from the Gut Lumen and Generation of Anti-Salmonella Protective Immunity. J Immunol. 2017 01 01; 198(1):55-60. PMID: 27913631; PMCID: PMC5173428.
      Citations: 4     Fields:    Translation:AnimalsCells
    30. Nutsch K, Chai JN, Ai TL, Russler-Germain E, Feehley T, Nagler CR, Hsieh CS. Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery. Cell Rep. 2016 09 27; 17(1):206-220. PMID: 27681432; PMCID: PMC5051580.
      Citations: 69     Fields:    Translation:AnimalsCells
    31. Lei YM, Chen L, Wang Y, Stefka AT, Molinero LL, Theriault B, Aquino-Michaels K, Sivan AS, Nagler CR, Gajewski TF, Chong AS, Bartman C, Alegre ML. The composition of the microbiota modulates allograft rejection. J Clin Invest. 2016 07 01; 126(7):2736-44. PMID: 27322054; PMCID: PMC4922695.
      Citations: 42     Fields:    Translation:AnimalsCells
    32. Feehley T, Belda-Ferre P, Nagler CR. What's LPS Got to Do with It? A Role for Gut LPS Variants in Driving Autoimmune and Allergic Disease. Cell Host Microbe. 2016 May 11; 19(5):572-4. PMID: 27173923.
      Citations: 8     Fields:    Translation:HumansCells
    33. Wesemann DR, Nagler CR. The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease. Immunity. 2016 Apr 19; 44(4):728-38. PMID: 27096316; PMCID: PMC4869964.
      Citations: 57     Fields:    Translation:HumansCells
    34. Berni Canani R, Sangwan N, Stefka AT, Nocerino R, Paparo L, Aitoro R, Calignano A, Khan AA, Gilbert JA, Nagler CR. Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants. ISME J. 2016 Mar; 10(3):742-50. PMID: 26394008; PMCID: PMC4817673.
      Citations: 195     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    35. Berni Canani R, Gilbert JA, Nagler CR. The role of the commensal microbiota in the regulation of tolerance to dietary allergens. Curr Opin Allergy Clin Immunol. 2015 Jun; 15(3):243-9. PMID: 25827065; PMCID: PMC4498960.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    36. Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015 Apr 09; 161(2):264-76. PMID: 25860609; PMCID: PMC4393509.
      Citations: 1209     Fields:    Translation:HumansAnimalsCells
    37. Lax S, Nagler CR, Gilbert JA. Our interface with the built environment: immunity and the indoor microbiota. Trends Immunol. 2015 Mar; 36(3):121-3. PMID: 25754179; PMCID: PMC4666509.
      Citations: 27     Fields:    Translation:Humans
    38. Feehley T, Nagler CR. Cellular and molecular pathways through which commensal bacteria modulate sensitization to dietary antigens. Curr Opin Immunol. 2014 Dec; 31:79-86. PMID: 25458998; PMCID: PMC4255329.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    39. Feehley T, Nagler CR. Health: The weighty costs of non-caloric sweeteners. Nature. 2014 Oct 09; 514(7521):176-7. PMID: 25231865; PMCID: PMC4449731.
      Citations: 8     Fields:    Translation:HumansAnimals
    40. Stefka AT, Feehley T, Tripathi P, Qiu J, McCoy K, Mazmanian SK, Tjota MY, Seo GY, Cao S, Theriault BR, Antonopoulos DA, Zhou L, Chang EB, Fu YX, Nagler CR. Commensal bacteria protect against food allergen sensitization. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13145-50. PMID: 25157157; PMCID: PMC4246970.
      Citations: 336     Fields:    Translation:AnimalsCellsPHPublic Health
    41. Cao AT, Yao S, Stefka AT, Liu Z, Qin H, Liu H, Evans-Marin HL, Elson CO, Nagler CR, Cong Y. TLR4 regulates IFN-? and IL-17 production by both thymic and induced Foxp3+ Tregs during intestinal inflammation. J Leukoc Biol. 2014 Nov; 96(5):895-905. PMID: 25015957; PMCID: PMC4197555.
      Citations: 23     Fields:    Translation:AnimalsCells
    42. Cao S, Feehley TJ, Nagler CR. The role of commensal bacteria in the regulation of sensitization to food allergens. FEBS Lett. 2014 Nov 17; 588(22):4258-66. PMID: 24791655; PMCID: PMC4216641.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    43. Nagler CR. Introduction to Special Issue on Food Allergy. Semin Immunopathol. 2012 Sep; 34(5):615-6. PMID: 22945458.
      Citations:    Fields:    Translation:HumansAnimalsCells
    44. Feehley T, Stefka AT, Cao S, Nagler CR. Microbial regulation of allergic responses to food. Semin Immunopathol. 2012 Sep; 34(5):671-88. PMID: 22941410; PMCID: PMC3874145.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    45. Upadhyay V, Poroyko V, Kim TJ, Devkota S, Fu S, Liu D, Tumanov AV, Koroleva EP, Deng L, Nagler C, Chang EB, Tang H, Fu YX. Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nat Immunol. 2012 Oct; 13(10):947-53. PMID: 22922363; PMCID: PMC3718316.
      Citations: 68     Fields:    Translation:AnimalsCells
    46. Nagatani K, Wang S, Llado V, Lau CW, Li Z, Mizoguchi A, Nagler CR, Shibata Y, Reinecker HC, Mora JR, Mizoguchi E. Chitin microparticles for the control of intestinal inflammation. Inflamm Bowel Dis. 2012 Sep; 18(9):1698-710. PMID: 22241684; PMCID: PMC3586600.
      Citations: 24     Fields:    Translation:AnimalsCells
    47. Nagler C, Wroblewska J. TL we meet again. Nat Immunol. 2011 Oct 19; 12(11):1027-8. PMID: 22012434.
      Citations:    Fields:    Translation:AnimalsCells
    48. Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, Mora JR. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. J Immunol. 2011 Jul 01; 187(1):141-50. PMID: 21646294; PMCID: PMC3119749.
      Citations: 39     Fields:    Translation:AnimalsCells
    49. Wang Y, Devkota S, Musch MW, Jabri B, Nagler C, Antonopoulos DA, Chervonsky A, Chang EB. Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon. PLoS One. 2010 Oct 22; 5(10):e13607. PMID: 21042588; PMCID: PMC2962643.
      Citations: 64     Fields:    Translation:Animals
    50. McBee ME, Zeng Y, Parry N, Nagler CR, Tannenbaum SR, Schauer DB. Multivariate modeling identifies neutrophil- and Th17-related factors as differential serum biomarkers of chronic murine colitis. PLoS One. 2010 Oct 19; 5(10):e13277. PMID: 20976045; PMCID: PMC2957404.
      Citations: 9     Fields:    Translation:AnimalsCells
    51. Matharu KS, Mizoguchi E, Cotoner CA, Nguyen DD, Mingle B, Iweala OI, McBee ME, Stefka AT, Prioult G, Haigis KM, Bhan AK, Snapper SB, Murakami H, Schauer DB, Reinecker HC, Mizoguchi A, Nagler CR. Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice. Gastroenterology. 2009 Oct; 137(4):1380-90.e1-3. PMID: 19596011; PMCID: PMC2757440.
      Citations: 39     Fields:    Translation:AnimalsCells
    52. Iweala OI, Smith DW, Matharu KS, Sada-Ovalle I, Nguyen DD, Dekruyff RH, Umetsu DT, Behar SM, Nagler CR. Vaccine-induced antibody isotypes are skewed by impaired CD4 T cell and invariant NKT cell effector responses in MyD88-deficient mice. J Immunol. 2009 Aug 15; 183(4):2252-60. PMID: 19620295; PMCID: PMC4454352.
      Citations: 9     Fields:    Translation:AnimalsCells
    53. Harris JB, Podolsky MJ, Bhuiyan TR, Chowdhury F, Khan AI, Larocque RC, Logvinenko T, Kendall J, Faruque AS, Nagler CR, Ryan ET, Qadri F, Calderwood SB. Immunologic responses to Vibrio cholerae in patients co-infected with intestinal parasites in Bangladesh. PLoS Negl Trop Dis. 2009; 3(3):e403. PMID: 19333369; PMCID: PMC2657204.
      Citations: 39     Fields:    Translation:HumansCells
    54. Nguyen DD, Maillard MH, Cotta-de-Almeida V, Mizoguchi E, Klein C, Fuss I, Nagler C, Mizoguchi A, Bhan AK, Snapper SB. Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein. Gastroenterology. 2007 Oct; 133(4):1188-97. PMID: 17764675; PMCID: PMC2048975.
      Citations: 38     Fields:    Translation:AnimalsCells
    55. Urban JF, Steenhard NR, Solano-Aguilar GI, Dawson HD, Iweala OI, Nagler CR, Noland GS, Kumar N, Anthony RM, Shea-Donohue T, Weinstock J, Gause WC. Infection with parasitic nematodes confounds vaccination efficacy. Vet Parasitol. 2007 Aug 19; 148(1):14-20. PMID: 17587500; PMCID: PMC1959410.
      Citations: 41     Fields:    Translation:Animals
    56. Maillard MH, Cotta-de-Almeida V, Takeshima F, Nguyen DD, Michetti P, Nagler C, Bhan AK, Snapper SB. The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells. J Exp Med. 2007 Feb 19; 204(2):381-91. PMID: 17296786; PMCID: PMC2118715.
      Citations: 86     Fields:    Translation:AnimalsCells
    57. Iweala OI, Nagler CR. Immune privilege in the gut: the establishment and maintenance of non-responsiveness to dietary antigens and commensal flora. Immunol Rev. 2006 Oct; 213:82-100. PMID: 16972898.
      Citations: 36     Fields:    Translation:HumansAnimals
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