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Phoebe Rice

TitleProfessor
InstitutionUniversity of Chicago
DepartmentBiochemistry and Molecular Biology
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    Collapse Overview 
    Collapse overview
    How do mobile genetic elements jump? We use biochemistry, structural biology, and microbiology to get mechanistic answers. Projects include the SCCmec element of MRSA and the paradigmatic Mu transposase.

    Collapse Biography 
    Collapse education and training
    NIH / NIDDK, Bethesda, MDpost-doctoral1997Transposition Biochemistry
    Yale University, New Haven, CTPhD1992Molecular Biophysics & Biochemistry
    Brandeis University, Waltham, MABA1986Biochemistry
    Collapse awards and honors
    2015Distinguished Educator in the Basic Sciences, University of Chicago, Biological Sciences Division
    1987NSF fellowship
    1982 - 1986Gannett Newspaper Carrier Scholarship

    Collapse Research 
    Collapse research activities and funding
    T32GM152395     (SCHWARTZ, NANCY B)Feb 1, 2024 - Jan 31, 2029
    NIH
    The University of Chicago Initiative for Maximizing Student Development (IMSD)
    Role: Co-Principal Investigator
    R35GM149586     (RICE, PHOEBE A)Aug 1, 2023 - Jul 31, 2028
    NIH
    Machinery of the Microbial Mobilome
    Role: Principal Investigator
    K12GM146658     (SCHWARTZ, NANCY B)Aug 15, 2022 - Jul 31, 2027
    NIH
    IRACDA at the University of Chicago
    Role: Co-Principal Investigator
    T32GM144292     (MUNRO, EDWIN MARSHALL)Jul 1, 2022 - Jun 30, 2027
    NIH
    Molecular and Cellular Biology Training Program
    Role: Co-Principal Investigator
    R01GM121655     (RICE, PHOEBE A)Sep 1, 2017 - Apr 30, 2021
    NIH
    Lifestyle of the SCCmec element and mechanisms of self-loading helicases
    Role: Principal Investigator
    R21AI117593     (RICE, PHOEBE A)Feb 1, 2015 - Jan 31, 2018
    NIH
    Unexpected parallels between SaPI replication initiators and conserved SCC ORFs
    Role: Principal Investigator
    R01GM101989     (RICE, PHOEBE A)Mar 1, 2013 - Feb 28, 2018
    NIH
    Structural understanding of Mu transposition
    Role: Principal Investigator
    R21AI087559     (RICE, PHOEBE A)Jun 1, 2010 - May 31, 2013
    NIH
    Systems for studying the mobility of the SCCmec element in MRSA
    Role: Principal Investigator
    R01GM086826     (RICE, PHOEBE A)Mar 1, 2009 - Dec 31, 2013
    NIH
    Mechanisms and regulation of serine resolvases
    Role: Principal Investigator
    R56GM066011     (RICE, PHOEBE A)Aug 15, 2002 - Jul 31, 2009
    NIH
    Structural Biology of a Serine DNA Recombinase
    Role: Principal Investigator
    R01GM066011     (RICE, PHOEBE A)Aug 15, 2002 - Jul 31, 2007
    NIH
    Understanding DNA specificity in the IHF/HU family
    Role: Principal Investigator
    R01GM058827     (RICE, PHOEBE A)Feb 1, 1999 - Apr 30, 2010
    NIH
    Structure and Biochemistry of Recombinase-DNA Complexes
    Role: Principal Investigator
    T32GM007183     (GLICK, BENJAMIN S)Jul 1, 1975 - Jun 30, 2022
    NIH
    Molecular and Cellular Biology Training
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Alsaleh A, Holland A, Shin H, Reyes TP, Baksh A, Taiwo-Aiyerin OT, Pigli Y, Rice PA, Olorunniji FJ. Large serine integrases utilise scavenged phage proteins as directionality cofactors. Nucleic Acids Res. 2025 Jan 24; 53(3). PMID: 39907112; PMCID: PMC11795197.
      Citations:    Fields:    
    2. Shin H, Pigli Y, Reyes TP, Fuller JR, Olorunniji FJ, Rice PA, Peña Reyes T, Shin H, Pigli Y, Reyes TP, Fuller JR, Olorunniji FJ, Rice PA. Structural basis of directionality control in large serine integrases. bioRxiv. 2025 Jan 13. PMID: 39803483; PMCID: PMC11722253.
      Citations:    
    3. MacDonald AI, Baksh A, Holland A, Shin H, Rice PA, Stark WM, Olorunniji FJ. Variable orthogonality of serine integrase interactions within the ?C31 family. Sci Rep. 2024 11 01; 14(1):26280. PMID: 39487291; PMCID: PMC11530663.
      Citations:    Fields:    Translation:Cells
    4. Wang S, Siddique R, Hall MC, Rice PA, Chang L. Structure of TnsABCD transpososome reveals mechanisms of targeted DNA transposition. Cell. 2024 Nov 27; 187(24):6865-6881.e16. PMID: 39383864; PMCID: PMC11606762.
      Citations: 1     Fields:    Translation:Cells
    5. Nhu NTQ, Lin H, Pigli Y, Sia JK, Kuhn P, Snitkin ES, Young V, Kamboj M, Pamer EG, Rice PA, Shen A, Dong Q. Flagellar switch inverted repeat impacts flagellar invertibility and varies Clostridioides difficile RT027/MLST1 virulence. bioRxiv. 2024 Sep 24. PMID: 39386689; PMCID: PMC11463649.
      Citations:    
    6. Hossain AA, Pigli YZ, Baca CF, Heissel S, Thomas A, Libis VK, Burian J, Chappie JS, Brady SF, Rice PA, Marraffini LA. DNA glycosylases provide antiviral defence in prokaryotes. Nature. 2024 May; 629(8011):410-416. PMID: 38632404; PMCID: PMC11078745.
      Citations: 2     Fields:    Translation:CellsPHPublic Health
    7. MacDonald AI, Baksh A, Holland A, Shin H, Rice PA, Stark WM, Olorunniji FJ. Variable orthogonality of RDF - large serine integrase interactions within the ?C31 family. bioRxiv. 2024 Apr 03. PMID: 38617232; PMCID: PMC11014563.
      Citations:    
    8. Fogarty EC, Schechter MS, Lolans K, Sheahan ML, Veseli I, Moore RM, Kiefl E, Moody T, Rice PA, Yu MK, Mimee M, Chang EB, Ruscheweyh HJ, Sunagawa S, Mclellan SL, Willis AD, Comstock LE, Eren AM. A cryptic plasmid is among the most numerous genetic elements in the human gut. Cell. 2024 Feb 29; 187(5):1206-1222.e16. PMID: 38428395; PMCID: PMC10973873.
      Citations: 8     Fields:    Translation:HumansCells
    9. Lewicka A, Roman C, Jones S, Disare M, Rice PA, Piccirilli JA. Crystal structure of a cap-independent translation enhancer RNA. Nucleic Acids Res. 2023 09 08; 51(16):8891-8907. PMID: 37548413; PMCID: PMC10484670.
      Citations: 2     Fields:    Translation:Cells
    10. Kennedy MS, Zhang M, DeLeon O, Bissell J, Trigodet F, Lolans K, Temelkova S, Carroll KT, Fiebig A, Deutschbauer A, Sidebottom AM, Lake J, Henry C, Rice PA, Bergelson J, Chang EB. Dynamic genetic adaptation of Bacteroides thetaiotaomicron during murine gut colonization. Cell Rep. 2023 08 29; 42(8):113009. PMID: 37598339; PMCID: PMC10528517.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    11. Fogarty EC, Schechter MS, Lolans K, Sheahan ML, Veseli I, Moore R, Kiefl E, Moody T, Rice PA, Yu MK, Mimee M, Chang EB, Mclellan SL, Willis AD, Comstock LE, Eren AM. A highly conserved and globally prevalent cryptic plasmid is among the most numerous mobile genetic elements in the human gut. bioRxiv. 2023 Mar 25. PMID: 36993556; PMCID: PMC10055365.
      Citations:    
    12. Rice PA. Mobile genetic element-encoded putative DNA primases composed of A-family polymerase-SSB pairs. Front Mol Biosci. 2023; 10:1113960. PMID: 37006622; PMCID: PMC10061031.
      Citations:    
    13. Montaño SP, Rowland SJ, Fuller JR, Burke ME, MacDonald AI, Boocock MR, Stark WM, Rice PA. Structural basis for topological regulation of Tn3 resolvase. Nucleic Acids Res. 2023 02 22; 51(3):1001-1018. PMID: 36100255; PMCID: PMC9943657.
      Citations: 1     Fields:    Translation:Cells
    14. Barabas O, Rice PA. First full views of a CRISPR-guided system for gene insertion. Nature. 2023 01; 613(7945):634-635. PMID: 36631579.
      Citations:    Fields:    Translation:Cells
    15. Bebel A, Walsh MA, Mir-Sanchis I, Rice PA. A novel DNA primase-helicase pair encoded by SCCmec elements. Elife. 2020 09 18; 9. PMID: 32945259; PMCID: PMC7581432.
      Citations: 5     Fields:    Translation:Cells
    16. Rowland SJ, Boocock MR, Burke ME, Rice PA, Stark WM. The protein-protein interactions required for assembly of the Tn3 resolution synapse. Mol Microbiol. 2020 12; 114(6):952-965. PMID: 33405333.
      Citations: 1     Fields:    Translation:Cells
    17. Rice PA, Craig NL, Dyda F. Comment on "RNA-guided DNA insertion with CRISPR-associated transposases". Science. 2020 06 05; 368(6495). PMID: 32499410.
      Citations: 16     Fields:    Translation:Cells
    18. Cao Y, Qiu T, Kathayat RS, Azizi SA, Thorne AK, Ahn D, Fukata Y, Fukata M, Rice PA, Dickinson BC. ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5. Nat Chem Biol. 2019 12; 15(12):1232-1240. PMID: 31740833; PMCID: PMC6871660.
      Citations: 48     Fields:    Translation:HumansCells
    19. Rice PA. Structure of the P element transpososome reveals new twists on the DD(E/D) theme. Nat Struct Mol Biol. 2019 11; 26(11):989-990. PMID: 31659331.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    20. Lepore R, Kryshtafovych A, Alahuhta M, Bomble YJ, Bufton JC, Bullock AN, Caba C, Cao H, Davies OR, Desfosses A, Dunne M, Fidelis K, Goulding CW, Gurusaran M, Harding CJ, Hayes CS, Joachimiak A, Leiman PG, Loppnau P, Lovering AL, Lunin VV, Michalska K, Mir-Sanchis I, Mitra AK, Moult J, Phillips GN, Pinkas DM, Rice PA, Tong Y, Topf M, Walton JD, Schwede T, Veraszto HA, Gutsche I, Hartmann MD. Target highlights in CASP13: Experimental target structures through the eyes of their authors. Proteins. 2019 12; 87(12):1037-1057. PMID: 31442339; PMCID: PMC6851490.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    21. Koirala D, Shao Y, Koldobskaya Y, Fuller JR, Watkins AM, Shelke SA, Pilipenko EV, Das R, Rice PA, Piccirilli JA. A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites. Nat Commun. 2019 08 09; 10(1):3629. PMID: 31399592; PMCID: PMC6689051.
      Citations: 10     Fields:    Translation:Cells
    22. Zhou H, Sathyamoorthy B, Stelling A, Xu Y, Xue Y, Pigli YZ, Case DA, Rice PA, Al-Hashimi HM. Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA. Biochemistry. 2019 04 16; 58(15):1963-1974. PMID: 30950607; PMCID: PMC8091065.
      Citations: 10     Fields:    Translation:Cells
    23. Connolly M, Arra A, Zvoda V, Steinbach PJ, Rice PA, Ansari A. Static Kinks or Flexible Hinges: Multiple Conformations of Bent DNA Bound to Integration Host Factor Revealed by Fluorescence Lifetime Measurements. J Phys Chem B. 2018 12 13; 122(49):11519-11534. PMID: 30336035; PMCID: PMC8562321.
      Citations: 6     Fields:    Translation:Cells
    24. Dyda F, Rice PA. A new twist on V(D)J recombination. Nat Struct Mol Biol. 2018 08; 25(8):648-649. PMID: 30061601; PMCID: PMC7292638.
      Citations: 1     Fields:    Translation:Cells
    25. Mir-Sanchis I, Pigli YZ, Rice PA. Crystal Structure of an Unusual Single-Stranded DNA-Binding Protein Encoded by Staphylococcal Cassette Chromosome Elements. Structure. 2018 08 07; 26(8):1144-1150.e3. PMID: 30017563; PMCID: PMC6084467.
      Citations: 5     Fields:    Translation:Cells
    26. Trejo CS, Rock RS, Stark WM, Boocock MR, Rice PA. Snapshots of a molecular swivel in action. Nucleic Acids Res. 2018 06 01; 46(10):5286-5296. PMID: 29315406; PMCID: PMC6007550.
      Citations: 2     Fields:    Translation:Cells
    27. Rasila TS, Pulkkinen E, Kiljunen S, Haapa-Paananen S, Pajunen MI, Salminen A, Paulin L, Vihinen M, Rice PA, Savilahti H. Mu transpososome activity-profiling yields hyperactive MuA variants for highly efficient genetic and genome engineering. Nucleic Acids Res. 2018 05 18; 46(9):4649-4661. PMID: 29294068; PMCID: PMC5961161.
      Citations: 3     Fields:    Translation:AnimalsCells
    28. Velmurugu Y, Vivas P, Connolly M, Kuznetsov SV, Rice PA, Ansari A. Two-step interrogation then recognition of DNA binding site by Integration Host Factor: an architectural DNA-bending protein. Nucleic Acids Res. 2018 02 28; 46(4):1741-1755. PMID: 29267885; PMCID: PMC5829579.
      Citations: 9     Fields:    Translation:Cells
    29. Lang A, Thomas Beatty J, Rice PA. Guest editorial: Mobile genetic elements and horizontal gene transfer in prokaryotes. Curr Opin Microbiol. 2017 08; 38:v-vii. PMID: 29173837.
      Citations: 5     Fields:    Translation:Cells
    30. Rice PA, Toussaint A. Transposable phages, DNA reorganization and transfer. Curr Opin Microbiol. 2017 Aug; 38:88-94. PMID: 28551392.
      Citations: 22     Fields:    Translation:Cells
    31. Fuller JR, Rice PA. Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal. Elife. 2017 02 13; 6. PMID: 28177285; PMCID: PMC5357137.
      Citations: 12     Fields:    Translation:Cells
    32. Mir-Sanchis I, Roman CA, Misiura A, Pigli YZ, Boyle-Vavra S, Rice PA. Staphylococcal SCCmec elements encode an active MCM-like helicase and thus may be replicative. Nat Struct Mol Biol. 2016 Oct; 23(10):891-898. PMID: 27571176; PMCID: PMC5052118.
      Citations: 21     Fields:    Translation:HumansCells
    33. Arkhipova IR, Rice PA. Mobile genetic elements: in silico, in vitro, in vivo. Mol Ecol. 2016 Mar; 25(5):1027-31. PMID: 26822117; PMCID: PMC4769670.
      Citations: 1     Fields:    Translation:Cells
    34. Suslov NB, DasGupta S, Huang H, Fuller JR, Lilley DM, Rice PA, Piccirilli JA. Crystal structure of the Varkud satellite ribozyme. Nat Chem Biol. 2015 Nov; 11(11):840-6. PMID: 26414446; PMCID: PMC4618023.
      Citations: 59     Fields:    Translation:AnimalsCells
    35. Rice PA. Serine Resolvases. Microbiol Spectr. 2015 Apr; 3(2):MDNA3-0045-2014. PMID: 26104713; PMCID: PMC5659196.
      Citations: 19     Fields:    Translation:Cells
    36. Ling L, Sauer RT, Rice PA, Baker TA, Montaño SP. Deciphering the Roles of Multicomponent Recognition Signals by the AAA+ Unfoldase ClpX. J Mol Biol. 2015 Sep 11; 427(18):2966-82. PMID: 25797169; PMCID: PMC4569521.
      Citations: 8     Fields:    Translation:Cells
    37. Huang H, Suslov NB, Li NS, Shelke SA, Evans ME, Koldobskaya Y, Rice PA, Piccirilli JA. A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore. Nat Chem Biol. 2014 Aug; 10(8):686-91. PMID: 24952597; PMCID: PMC4104137.
      Citations: 144     Fields:    Translation:AnimalsCells
    38. Boocock MR, Rice PA. A proposed mechanism for IS607-family serine transposases. Mob DNA. 2013 Nov 06; 4(1):24. PMID: 24195768; PMCID: PMC4058570.
      Citations: 18     
    39. Vivas P, Velmurugu Y, Kuznetsov SV, Rice PA, Ansari A. Global analysis of ion dependence unveils hidden steps in DNA binding and bending by integration host factor. J Chem Phys. 2013 Sep 28; 139(12):121927. PMID: 24089739.
      Citations: 6     Fields:    Translation:Cells
    40. Keenholtz RA, Mouw KW, Boocock MR, Li NS, Piccirilli JA, Rice PA. Arginine as a general acid catalyst in serine recombinase-mediated DNA cleavage. J Biol Chem. 2013 Oct 04; 288(40):29206-14. PMID: 23970547; PMCID: PMC3790019.
      Citations: 14     Fields:    Translation:Cells
    41. Misiura A, Pigli YZ, Boyle-Vavra S, Daum RS, Boocock MR, Rice PA. Roles of two large serine recombinases in mobilizing the methicillin-resistance cassette SCCmec. Mol Microbiol. 2013 Jun; 88(6):1218-29. PMID: 23651464; PMCID: PMC3714108.
      Citations: 26     Fields:    Translation:Cells
    42. Pigli YZ, Rice PA, Montaño SP. The µ transpososome structure sheds light on DDE recombinase evolution. Nature. 2012 Nov 15; 491(7424):413-7. PMID: 23135398; PMCID: PMC3536463.
      Citations: 87     Fields:    Translation:Cells
    43. Vivas P, Velmurugu Y, Kuznetsov SV, Rice PA, Ansari A. Mapping the transition state for DNA bending by IHF. J Mol Biol. 2012 May 18; 418(5):300-15. PMID: 22370561.
      Citations: 11     Fields:    Translation:Cells
    44. Haddadian EJ, Gong H, Jha AK, Yang X, Debartolo J, Hinshaw JR, Rice PA, Sosnick TR, Freed KF. Automated real-space refinement of protein structures using a realistic backbone move set. Biophys J. 2011 Aug 17; 101(4):899-909. PMID: 21843481; PMCID: PMC3175057.
      Citations: 16     Fields:    Translation:Cells
    45. Flott S, Kwon Y, Pigli YZ, Rice PA, Sung P, Jackson SP. Regulation of Rad51 function by phosphorylation. EMBO Rep. 2011 Jul 08; 12(8):833-9. PMID: 21738226; PMCID: PMC3147262.
      Citations: 34     Fields:    Translation:AnimalsCells
    46. Keenholtz RA, Rowland SJ, Boocock MR, Stark WM, Rice PA. Structural basis for catalytic activation of a serine recombinase. Structure. 2011 Jun 08; 19(6):799-809. PMID: 21645851; PMCID: PMC3238390.
      Citations: 22     Fields:    Translation:Cells
    47. Rice PA, Montaño SP. Moving DNA around: DNA transposition and retroviral integration. Curr Opin Struct Biol. 2011 Jun; 21(3):370-8. PMID: 21439812; PMCID: PMC3112294.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    48. Mouw KW, Steiner AM, Ghirlando R, Li NS, Rowland SJ, Boocock MR, Stark WM, Piccirilli JA, Rice PA. Sin resolvase catalytic activity and oligomerization state are tightly coupled. J Mol Biol. 2010 Nov 19; 404(1):16-33. PMID: 20868695; PMCID: PMC2976518.
      Citations: 10     Fields:    Translation:Cells
    49. Chaconas G, Craig N, Curcio MJ, Deininger P, Feschotte C, Levin H, Rice PA, Voytas DF. Meeting report for mobile DNA 2010. Mob DNA. 2010 Aug 24; 1(1):20. PMID: 20735816; PMCID: PMC2936281.
      Citations:    
    50. Zhang AP, Pigli YZ, Rice PA. Structure of the LexA-DNA complex and implications for SOS box measurement. Nature. 2010 Aug 12; 466(7308):883-6. PMID: 20703307; PMCID: PMC2921665.
      Citations: 56     Fields:    Translation:Cells
    51. Rice PA, Mouw KW, Boocock MR, Rowland SJ, Stark WM, Montaño SP. Orchestrating serine resolvases. Biochem Soc Trans. 2010 Apr; 38(2):384-7. PMID: 20298188; PMCID: PMC3775659.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    52. Poor CB, Chen PR, Duguid E, Rice PA, He C. Crystal structures of the reduced, sulfenic acid, and mixed disulfide forms of SarZ, a redox active global regulator in Staphylococcus aureus. J Biol Chem. 2009 Aug 28; 284(35):23517-24. PMID: 19586910; PMCID: PMC2749125.
      Citations: 47     Fields:    Translation:Cells
    53. Rowland SJ, Boocock MR, McPherson AL, Mouw KW, Rice PA, Stark WM. Regulatory mutations in Sin recombinase support a structure-based model of the synaptosome. Mol Microbiol. 2009 Oct; 74(2):282-98. PMID: 19508283; PMCID: PMC2764113.
      Citations: 19     Fields:    Translation:Cells
    54. Grigorescu AA, Vissers JH, Ristic D, Pigli YZ, Lynch TW, Wyman C, Rice PA. Inter-subunit interactions that coordinate Rad51's activities. Nucleic Acids Res. 2009 Feb; 37(2):557-67. PMID: 19066203; PMCID: PMC2632893.
      Citations: 7     Fields:    Translation:Cells
    55. Peng X, Pigli YZ, Rice PA, Greenberg MM. Protein binding has a large effect on radical mediated DNA damage. J Am Chem Soc. 2008 Oct 01; 130(39):12890-1. PMID: 18778053; PMCID: PMC2829750.
      Citations: 8     Fields:    Translation:Cells
    56. Mouw KW, Rowland SJ, Gajjar MM, Boocock MR, Stark WM, Rice PA. Architecture of a serine recombinase-DNA regulatory complex. Mol Cell. 2008 Apr 25; 30(2):145-55. PMID: 18439894; PMCID: PMC2428073.
      Citations: 31     Fields:    Translation:Cells
    57. Yang CG, Yi C, Duguid EM, Sullivan CT, Jian X, Rice PA, He C. Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature. 2008 Apr 24; 452(7190):961-5. PMID: 18432238; PMCID: PMC2587245.
      Citations: 130     Fields:    Translation:HumansCells
    58. Whiteson KL, Rice PA. Binding and catalytic contributions to site recognition by flp recombinase. J Biol Chem. 2008 Apr 25; 283(17):11414-23. PMID: 18276592; PMCID: PMC2431069.
      Citations: 7     Fields:    Translation:AnimalsCells
    59. Mizuuchi M, Rice PA, Wardle SJ, Haniford DB, Mizuuchi K. Control of transposase activity within a transpososome by the configuration of the flanking DNA segment of the transposon. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14622-7. PMID: 17785414; PMCID: PMC1964541.
      Citations: 6     Fields:    Translation:Cells
    60. Whiteson KL, Chen Y, Chopra N, Raymond AC, Rice PA. Identification of a potential general acid/base in the reversible phosphoryl transfer reactions catalyzed by tyrosine recombinases: Flp H305. Chem Biol. 2007 Feb; 14(2):121-9. PMID: 17317566; PMCID: PMC1857323.
      Citations: 15     Fields:    Translation:Cells
    61. Mouw KW, Rice PA. Shaping the Borrelia burgdorferi genome: crystal structure and binding properties of the DNA-bending protein Hbb. Mol Microbiol. 2007 Mar; 63(5):1319-30. PMID: 17244195.
      Citations: 36     Fields:    Translation:Cells
    62. Khrapunov S, Brenowitz M, Rice PA, Catalano CE. Binding then bending: a mechanism for wrapping DNA. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19217-8. PMID: 17159146; PMCID: PMC1748206.
      Citations: 10     Fields:    Translation:Cells
    63. Swinger KK, Rice PA. Structure-based analysis of HU-DNA binding. J Mol Biol. 2007 Jan 26; 365(4):1005-16. PMID: 17097674; PMCID: PMC1945228.
      Citations: 50     Fields:    Translation:Cells
    64. Lu CP, Sandoval H, Brandt VL, Rice PA, Roth DB. Amino acid residues in Rag1 crucial for DNA hairpin formation. Nat Struct Mol Biol. 2006 Nov; 13(11):1010-5. PMID: 17028591.
      Citations: 23     Fields:    Translation:AnimalsCells
    65. Chen PR, Bae T, Williams WA, Duguid EM, Rice PA, Schneewind O, He C. An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. Nat Chem Biol. 2006 Nov; 2(11):591-5. PMID: 16980961.
      Citations: 107     Fields:    Translation:Cells
    66. Grindley ND, Whiteson KL, Rice PA. Mechanisms of site-specific recombination. Annu Rev Biochem. 2006; 75:567-605. PMID: 16756503.
      Citations: 330     Fields:    Translation:AnimalsCells
    67. Rice PA. Resolving integral questions in site-specific recombination. Nat Struct Mol Biol. 2005 Aug; 12(8):641-3. PMID: 16077726.
      Citations: 5     Fields:    
    68. Duguid EM, Rice PA, He C. The structure of the human AGT protein bound to DNA and its implications for damage detection. J Mol Biol. 2005 Jul 22; 350(4):657-66. PMID: 15964013.
      Citations: 50     Fields:    Translation:HumansCells
    69. Rice PA. Visualizing Mu transposition: assembling the puzzle pieces. Genes Dev. 2005 Apr 01; 19(7):773-5. PMID: 15805467.
      Citations: 4     Fields:    Translation:Cells
    70. Conway AB, Lynch TW, Zhang Y, Fortin GS, Fung CW, Symington LS, Rice PA. Crystal structure of a Rad51 filament. Nat Struct Mol Biol. 2004 Aug; 11(8):791-6. PMID: 15235592.
      Citations: 159     Fields:    Translation:AnimalsCells
    71. Swinger KK, Rice PA. IHF and HU: flexible architects of bent DNA. Curr Opin Struct Biol. 2004 Feb; 14(1):28-35. PMID: 15102446.
      Citations: 195     Fields:    Translation:Cells
    72. Swinger KK, Lemberg KM, Zhang Y, Rice PA. Flexible DNA bending in HU-DNA cocrystal structures. EMBO J. 2003 Jul 15; 22(14):3749-60. PMID: 12853489; PMCID: PMC165621.
      Citations: 125     Fields:    Translation:Cells
    73. Lynch TW, Read EK, Mattis AN, Gardner JF, Rice PA. Integration host factor: putting a twist on protein-DNA recognition. J Mol Biol. 2003 Jul 11; 330(3):493-502. PMID: 12842466.
      Citations: 35     Fields:    Translation:Cells
    74. Chen Y, Rice PA. The role of the conserved Trp330 in Flp-mediated recombination. Functional and structural analysis. J Biol Chem. 2003 Jul 04; 278(27):24800-7. PMID: 12716882.
      Citations: 19     Fields:    Translation:Cells
    75. Conway AB, Chen Y, Rice PA. Structural plasticity of the Flp-Holliday junction complex. J Mol Biol. 2003 Feb 14; 326(2):425-34. PMID: 12559911.
      Citations: 25     Fields:    Translation:Cells
    76. Chen Y, Rice PA. New insight into site-specific recombination from Flp recombinase-DNA structures. Annu Rev Biophys Biomol Struct. 2003; 32:135-59. PMID: 12598365.
      Citations: 35     Fields:    Translation:Cells
    77. Drum CL, Shen Y, Rice PA, Bohm A, Tang WJ. Crystallization and preliminary X-ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin. Acta Crystallogr D Biol Crystallogr. 2001 Dec; 57(Pt 12):1881-4. PMID: 11717504.
      Citations: 11     Fields:    Translation:Cells
    78. Rice PA, Baker TA. Comparative architecture of transposase and integrase complexes. Nat Struct Biol. 2001 May; 8(5):302-7. PMID: 11774877.
      Citations: 18     Fields:    Translation:Cells
    79. Chen Y, Narendra U, Iype LE, Cox MM, Rice PA. Crystal structure of a Flp recombinase-Holliday junction complex: assembly of an active oligomer by helix swapping. Mol Cell. 2000 Oct; 6(4):885-97. PMID: 11090626.
      Citations: 86     Fields:    Translation:Cells
    80. Rice PA. Holding damaged DNA together. Nat Struct Biol. 1999 Sep; 6(9):805-6. PMID: 10467087.
      Citations: 12     Fields:    Translation:HumansCells
    81. Ram S, Mackinnon FG, Gulati S, McQuillen DP, Vogel U, Frosch M, Elkins C, Guttormsen HK, Wetzler LM, Oppermann M, Pangburn MK, Rice PA. The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis. Mol Immunol. 1999 Sep-Oct; 36(13-14):915-28. PMID: 10698346.
      Citations: 53     Fields:    Translation:HumansCells
    82. Gulati S, McQuillen DP, Ram S, Rice PA, Reinhold VN, Mühlecker W. An essential saccharide binding domain for the mAb 2C7 established for Neisseria gonorrhoeae LOS by ES-MS and MSn. Glycobiology. 1999 Feb; 9(2):157-71. PMID: 9949193.
      Citations: 10     Fields:    Translation:Cells
    83. McQuillen DP, Gulati S, Ram S, Turner AK, Jani DB, Heeren TC, Rice PA. Complement processing and immunoglobulin binding to Neisseria gonorrhoeae determined in vitro simulates in vivo effects. J Infect Dis. 1999 Jan; 179(1):124-35. PMID: 9841831.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    84. Rice PA. Making DNA do a U-turn: IHF and related proteins. Curr Opin Struct Biol. 1997 Feb; 7(1):86-93. PMID: 9032059.
      Citations: 34     Fields:    Translation:Cells
    85. Rice PA, Yang S, Mizuuchi K, Nash HA. Crystal structure of an IHF-DNA complex: a protein-induced DNA U-turn. Cell. 1996 Dec 27; 87(7):1295-306. PMID: 8980235.
      Citations: 310     Fields:    Translation:Cells
    86. Rice P, Craigie R, Davies DR. Retroviral integrases and their cousins. Curr Opin Struct Biol. 1996 Feb; 6(1):76-83. PMID: 8696976.
      Citations: 53     Fields:    Translation:Cells
    87. Savilahti H, Rice PA, Mizuuchi K. The phage Mu transpososome core: DNA requirements for assembly and function. EMBO J. 1995 Oct 02; 14(19):4893-903. PMID: 7588618; PMCID: PMC394587.
      Citations: 75     Fields:    Translation:Cells
    88. Rice P, Mizuuchi K. Structure of the bacteriophage Mu transposase core: a common structural motif for DNA transposition and retroviral integration. Cell. 1995 Jul 28; 82(2):209-20. PMID: 7628012.
      Citations: 78     Fields:    Translation:Cells
    89. Wang J, Smerdon SJ, Kohlstaedt LA, Rice PA, Friedman JM, Steitz TA, Jäger J. Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7242-6. PMID: 7518928; PMCID: PMC44375.
      Citations: 70     Fields:    Translation:Cells
    90. Rice PA, Steitz TA. Refinement of gamma delta resolvase reveals a strikingly flexible molecule. Structure. 1994 May 15; 2(5):371-84. PMID: 8081753.
      Citations: 16     Fields:    Translation:Cells
    91. Smerdon SJ, Wang J, Kohlstaedt LA, Chirino AJ, Friedman JM, Rice PA, Steitz TA, Jäger J. Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3911-5. PMID: 7513427; PMCID: PMC43692.
      Citations: 85     Fields:    Translation:Cells
    92. Rice PA, Steitz TA. Model for a DNA-mediated synaptic complex suggested by crystal packing of gamma delta resolvase subunits. EMBO J. 1994 Apr 01; 13(7):1514-24. PMID: 8156989; PMCID: PMC394980.
      Citations: 18     Fields:    Translation:Cells
    93. Hughes RE, Rice PA, Steitz TA, Grindley ND. Protein-protein interactions directing resolvase site-specific recombination: a structure-function analysis. EMBO J. 1993 Apr; 12(4):1447-58. PMID: 8385604; PMCID: PMC413356.
      Citations: 15     Fields:    Translation:Cells
    94. Steitz TA, Smerdon S, Wang J, Kohlstaedt LA, Friedman JM, Beese LS, Rice PA, Jäger J. Two DNA polymerases: HIV reverse transcriptase and the Klenow fragment of Escherichia coli DNA polymerase I. Cold Spring Harb Symp Quant Biol. 1993; 58:495-504. PMID: 7525146.
      Citations: 7     Fields:    Translation:Cells
    95. Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA. Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science. 1992 Jun 26; 256(5065):1783-90. PMID: 1377403.
      Citations: 619     Fields:    Translation:Cells
    96. Hughes RE, Hatfull GF, Rice P, Steitz TA, Grindley ND. Cooperativity mutants of the gamma delta resolvase identify an essential interdimer interaction. Cell. 1990 Dec 21; 63(6):1331-8. PMID: 2175679.
      Citations: 29     Fields:    Translation:Cells
    97. Sanderson MR, Freemont PS, Rice PA, Goldman A, Hatfull GF, Grindley ND, Steitz TA. The crystal structure of the catalytic domain of the site-specific recombination enzyme gamma delta resolvase at 2.7 A resolution. Cell. 1990 Dec 21; 63(6):1323-9. PMID: 2175678.
      Citations: 37     Fields:    Translation:Cells
    98. Rice PA, Goldman A, Steitz TA. A helix-turn-strand structural motif common in alpha-beta proteins. Proteins. 1990; 8(4):334-40. PMID: 1708883.
      Citations: 7     Fields:    Translation:Cells
    99. Rice PA, Steitz TA. Ribosomal protein L7/L12 has a helix-turn-helix motif similar to that found in DNA-binding regulatory proteins. Nucleic Acids Res. 1989 May 25; 17(10):3757-62. PMID: 2660100; PMCID: PMC317856.
      Citations: 5     Fields:    Translation:Cells
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