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Eduardo Perozo

TitleProfessor
InstitutionUniversity of Chicago
DepartmentBiochemistry and Molecular Biology
AddressChicago IL 60637
Email
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    Collapse Research 
    Collapse research activities and funding
    R01DC019833     (PEROZO, EDUARDO A)Jul 1, 2021 - May 31, 2026
    NIH
    Structural basis of Outer Hair Cell Electromotility at High Resolution
    Role: Principal Investigator
    R01GM133191     (PEROZO, EDUARDO A)Sep 1, 2019 - Jul 31, 2023
    NIH
    Structural Basis of “Force from Lipids” Activation in Mechanosensitive Channels
    Role: Principal Investigator
    R01GM120561     (PEROZO, EDUARDO A)Jul 1, 2017 - Jun 30, 2021
    NIH
    Structural basis of Mg2+ homeostasis
    Role: Principal Investigator
    U54GM087519     (PEROZO, EDUARDO A)Aug 10, 2010 - Aug 31, 2019
    NIH
    Membrane Protein Structural Dynamics Consortium
    Role: Principal Investigator
    R01GM088406     (PEROZO, EDUARDO A)Sep 1, 2009 - Aug 31, 2014
    NIH
    Structural basis for transmembrane Mg2+ transport
    Role: Principal Investigator
    R24GM084757     (PEROZO, EDUARDO A)Mar 1, 2008 - Feb 28, 2010
    NIH
    Midwest Center for Membrane Protein Structural Dynamics
    Role: Principal Investigator
    R01GM063617     (PEROZO, EDUARDO A)Jul 1, 2001 - Jun 30, 2010
    NIH
    Structural Dynamics of Mechanosensitive Channels
    Role: Principal Investigator
    R01GM057846     (PEROZO, EDUARDO A)Aug 1, 1998 - Jan 31, 2020
    NIH
    High Resolution Structural Dynamics of K Channels
    Role: Principal Investigator
    R01GM054690     (PEROZO, EDUARDO A)Aug 1, 1996 - Jul 31, 2001
    NIH
    MOLECULAR ARCHITECTURE OF POTASSIUM CHANNELS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lin X, Haller P, Bavi N, Faruk N, Perozo E, Sosnick TR. Folding of Prestin's Anion-Binding Site and the Mechanism of Outer Hair Cell Electromotility. bioRxiv. 2023 Oct 01. PMID: 36909622; PMCID: PMC10002659.
      Citations:    
    2. Erramilli SK, Dominik PK, Deneka D, Tokarz P, Kim SS, Reddy BG, Skrobek BM, Dalmas O, Perozo E, Kossiakoff AA. Conformation-specific Synthetic Antibodies Discriminate Multiple Functional States of the Ion Channel CorA. J Mol Biol. 2023 09 01; 435(17):168192. PMID: 37394032; PMCID: PMC10529903.
      Citations:    Fields:    Translation:Cells
    3. Erramilli SK, Dominik PK, Deneka D, Tokarz P, Kim SS, Reddy BG, Skrobek BM, Dalmas O, Perozo E, Kossiakoff AA. Conformation-specific synthetic antibodies discriminate multiple functional states of the ion channel CorA. bioRxiv. 2023 May 07. PMID: 37205530; PMCID: PMC10187328.
      Citations:    
    4. Park YC, Reddy B, Bavi N, Perozo E, Faraldo-Gómez JD. State-specific morphological deformations of the lipid bilayer explain mechanosensitive gating of MscS ion channels. Elife. 2023 01 30; 12. PMID: 36715097; PMCID: PMC9925053.
      Citations: 4     Fields:    Translation:Cells
    5. Shen R, Meng Y, Perozo E, Roux B. Mechanism of voltage gating in the voltage-sensing phosphatase Ci-VSP. Proc Natl Acad Sci U S A. 2022 11; 119(44):e2206649119. PMID: 36279472; PMCID: PMC9636939.
      Citations: 3     Fields:    Translation:Cells
    6. Perozo E, Carrasquel-Ursulaez W, Segura I, Díaz-Franulic I, Echeverría F, Lorenzo-Ceballos Y, Espinoza N, Rojas M, Garate JA, Alvarez O, Gonzalez-Nilo FD, Latorre R. Mechanism of voltage sensing in Ca2+- and voltage-activated K+ (BK) channels. Proc Natl Acad Sci U S A. 2022 06 21; 119(25):e2204620119. PMID: 35704760; PMCID: PMC9231616.
      Citations: 4     Fields:    Translation:Cells
    7. Zhao R, Shen R, Dai H, Perozo E, Goldstein SAN. Molecular determinants of inhibition of the human proton channel hHv1 by the designer peptide C6 and a bivalent derivative. Proc Natl Acad Sci U S A. 2022 06 07; 119(23):e2120750119. PMID: 35648818; PMCID: PMC9191634.
      Citations: 3     Fields:    Translation:HumansCells
    8. Bavi N, Clark MD, Contreras GF, Shen R, Reddy BG, Milewski W, Perozo E. The conformational cycle of prestin underlies outer-hair cell electromotility. Nature. 2021 12; 600(7889):553-558. PMID: 34695838.
      Citations: 18     Fields:    Translation:AnimalsCells
    9. Li J, Shen R, Rohaim A, Mendoza Uriarte R, Fajer M, Perozo E, Roux B. Computational study of non-conductive selectivity filter conformations and C-type inactivation in a voltage-dependent potassium channel. J Gen Physiol. 2021 09 06; 153(9). PMID: 34357375; PMCID: PMC8352720.
      Citations: 7     Fields:    Translation:Cells
    10. Zhao R, Dai H, Shen R, Perozo E, Goldstein SAN, Arias RJ, De Blas GA, Orta G, Pavarotti MA, Mayorga LS, Darszon A. Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils. Nat Commun. 2021 06 22; 12(1):3855. PMID: 34158477; PMCID: PMC8219737.
      Citations: 13     Fields:    Translation:HumansCells
    11. Li J, Shen R, Reddy B, Perozo E, Roux B. Mechanism of C-type inactivation in the hERG potassium channel. Sci Adv. 2021 01; 7(5). PMID: 33514547; PMCID: PMC7846155.
      Citations: 14     Fields:    
    12. Clark MD, Contreras GF, Shen R, Perozo E. Electromechanical coupling in the hyperpolarization-activated K+ channel KAT1. Nature. 2020 07; 583(7814):145-149. PMID: 32461693; PMCID: PMC7747229.
      Citations: 26     Fields:    Translation:AnimalsCells
    13. Reddy B, Bavi N, Lu A, Park Y, Perozo E. Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS. Elife. 2019 12 27; 8. PMID: 31880537; PMCID: PMC7299334.
      Citations: 45     Fields:    Translation:Cells
    14. Rangl M, Schmandt N, Perozo E, Scheuring S. Real time dynamics of Gating-Related conformational changes in CorA. Elife. 2019 11 27; 8. PMID: 31774394; PMCID: PMC6927688.
      Citations: 10     Fields:    Translation:AnimalsCells
    15. Li J, Zhang J, Tang W, Mizu RK, Kusumoto H, XiangWei W, Xu Y, Chen W, Amin JB, Hu C, Kannan V, Keller SR, Wilcox WR, Lemke JR, Myers SJ, Swanger SA, Wollmuth LP, Traynelis SF, Yuan H, Petrovski S. De novo GRIN variants in NMDA receptor M2 channel pore-forming loop are associated with neurological diseases. Hum Mutat. 2019 12; 40(12):2393-2413. PMID: 31429998; PMCID: PMC6874887.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    16. Zhao R, Kennedy K, Li Q, Dai H, Perozo E, Goldstein SAN, De Blas GA, Orta G, Pavarotti MA, Arias RJ, de la Vega-Beltrán JL, Mayorga LS, Darszon A. Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor. Proc Natl Acad Sci U S A. 2018 12 11; 115(50):E11847-E11856. PMID: 30478045; PMCID: PMC6294887.
      Citations: 30     Fields:    Translation:HumansCells
    17. Li J, Ostmeyer J, Cuello LG, Perozo E, Roux B. Rapid constriction of the selectivity filter underlies C-type inactivation in the KcsA potassium channel. J Gen Physiol. 2018 10 01; 150(10):1408-1420. PMID: 30072373; PMCID: PMC6168234.
      Citations: 43     Fields:    Translation:Cells
    18. Lau C, Hunter MJ, Stewart A, Perozo E, Vandenberg JI. Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy. J Physiol. 2018 04 01; 596(7):1107-1119. PMID: 29377132; PMCID: PMC5878226.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    19. Bavi N, Martinac AD, Cortes DM, Bavi O, Ridone P, Nomura T, Hill AP, Martinac B, Perozo E. Structural Dynamics of the MscL C-terminal Domain. Sci Rep. 2017 12 08; 7(1):17229. PMID: 29222414; PMCID: PMC5722894.
      Citations: 8     Fields:    Translation:Cells
    20. Cuello LG, Cortes DM, Perozo E. The gating cycle of a K+ channel at atomic resolution. Elife. 2017 11 22; 6. PMID: 29165243; PMCID: PMC5711375.
      Citations: 58     Fields:    Translation:Cells
    21. Li J, Ostmeyer J, Boulanger E, Rui H, Perozo E, Roux B. Chemical substitutions in the selectivity filter of potassium channels do not rule out constricted-like conformations for C-type inactivation. Proc Natl Acad Sci U S A. 2017 10 17; 114(42):11145-11150. PMID: 28973956; PMCID: PMC5651753.
      Citations: 22     Fields:    Translation:Cells
    22. Vandenberg JI, Perozo E, Allen TW. Towards a Structural View of Drug Binding to hERG K+ Channels. Trends Pharmacol Sci. 2017 10; 38(10):899-907. PMID: 28711156; PMCID: PMC6658208.
      Citations: 27     Fields:    Translation:HumansCells
    23. Kratochvil HT, Maj M, Matulef K, Annen AW, Ostmeyer J, Perozo E, Valiyaveetil FI, Zanni MT, Roux B. Probing the Effects of Gating on the Ion Occupancy of the K+ Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy. J Am Chem Soc. 2017 07 05; 139(26):8837-8845. PMID: 28472884; PMCID: PMC5544906.
      Citations: 16     Fields:    Translation:Cells
    24. Laguerre A, Henrich E, Hoffmann B, Abdul-Manan N, Connolly PJ, Perozo E, Moore JM, Bernhard F, Löhr F, Dötsch V. From Nanodiscs to Isotropic Bicelles: A Procedure for Solution Nuclear Magnetic Resonance Studies of Detergent-Sensitive Integral Membrane Proteins. Structure. 2016 Oct 04; 24(10):1830-1841. PMID: 27618661; PMCID: PMC5064851.
      Citations: 15     Fields:    
    25. Kratochvil HT, Carr JK, Matulef K, Annen AW, Li H, Maj M, Ostmeyer J, Serrano AL, Raghuraman H, Moran SD, Skinner JL, Perozo E, Valiyaveetil FI, Zanni MT, Roux B. Instantaneous ion configurations in the K+ ion channel selectivity filter revealed by 2D IR spectroscopy. Science. 2016 09 02; 353(6303):1040-1044. PMID: 27701114; PMCID: PMC5544905.
      Citations: 65     Fields:    Translation:Cells
    26. Bavi N, Cox CD, Perozo E, Martinac B. Toward a structural blueprint for bilayer-mediated channel mechanosensitivity. Channels (Austin). 2017 03 04; 11(2):91-93. PMID: 27533603; PMCID: PMC5398584.
      Citations: 14     Fields:    
    27. Bavi N, Cortes DM, Cox CD, Rohde PR, Liu W, Deitmer JW, Bavi O, Strop P, Hill AP, Rees D, Corry B, Perozo E, Martinac B. The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels. Nat Commun. 2016 06 22; 7:11984. PMID: 27329693; PMCID: PMC4917966.
      Citations: 47     Fields:    Translation:Cells
    28. Medovoy D, Perozo E, Roux B. Multi-ion free energy landscapes underscore the microscopic mechanism of ion selectivity in the KcsA channel. Biochim Biophys Acta. 2016 Jul; 1858(7 Pt B):1722-32. PMID: 26896693; PMCID: PMC4939264.
      Citations: 15     Fields:    Translation:Cells
    29. Matthies D, Dalmas O, Borgnia MJ, Dominik PK, Merk A, Rao P, Reddy BG, Islam S, Bartesaghi A, Perozo E, Subramaniam S. Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating. Cell. 2016 Feb 11; 164(4):747-56. PMID: 26871634; PMCID: PMC4752722.
      Citations: 56     Fields:    Translation:Cells
    30. Dominik PK, Borowska MT, Dalmas O, Kim SS, Perozo E, Keenan RJ, Kossiakoff AA. Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs. Structure. 2016 Feb 02; 24(2):300-9. PMID: 26749445; PMCID: PMC4740257.
      Citations: 33     Fields:    Translation:Cells
    31. Li Q, Shen R, Treger JS, Wanderling SS, Milewski W, Siwowska K, Bezanilla F, Perozo E. Resting state of the human proton channel dimer in a lipid bilayer. Proc Natl Acad Sci U S A. 2015 Nov 03; 112(44):E5926-35. PMID: 26443860; PMCID: PMC4640771.
      Citations: 39     Fields:    Translation:HumansCells
    32. van der Cruijsen EA, Koers EJ, Hulse RE, Weingarth M, Perozo E, Baldus M, Sauvée C, Ouari O, Tordo P. Biomolecular DNP-Supported NMR Spectroscopy using Site-Directed Spin Labeling. Chemistry. 2015 Sep 07; 21(37):12971-7. PMID: 26315337.
      Citations: 25     Fields:    
    33. McGreevy R, Singharoy A, Li Q, Zhang J, Xu D, Perozo E, Schulten K. xMDFF: molecular dynamics flexible fitting of low-resolution X-ray structures. Acta Crystallogr D Biol Crystallogr. 2014 Sep; 70(Pt 9):2344-55. PMID: 25195748; PMCID: PMC4157446.
      Citations: 26     Fields:    Translation:Cells
    34. Hulse RE, Sachleben JR, Wen PC, Moradi M, Tajkhorshid E, Perozo E. Conformational dynamics at the inner gate of KcsA during activation. Biochemistry. 2014 Apr 29; 53(16):2557-9. PMID: 24621378; PMCID: PMC4010282.
      Citations: 9     Fields:    Translation:Cells
    35. Dalmas O, Sompornpisut P, Bezanilla F, Perozo E. Molecular mechanism of Mg2+-dependent gating in CorA. Nat Commun. 2014 Apr 02; 5:3590. PMID: 24694723; PMCID: PMC4066822.
      Citations: 24     Fields:    Translation:Cells
    36. Randich AM, Cuello LG, Wanderling SS, Perozo E. Biochemical and structural analysis of the hyperpolarization-activated K(+) channel MVP. Biochemistry. 2014 Mar 18; 53(10):1627-36. PMID: 24490868; PMCID: PMC3985891.
      Citations: 6     Fields:    Translation:Cells
    37. Dalmas O, Sandtner W, Medovoy D, Frezza L, Bezanilla F, Perozo E. A repulsion mechanism explains magnesium permeation and selectivity in CorA. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3002-7. PMID: 24516146; PMCID: PMC3939898.
      Citations: 15     Fields:    Translation:AnimalsCells
    38. Li Q, Wanderling S, Paduch M, Medovoy D, Singharoy A, McGreevy R, Villalba-Galea CA, Hulse RE, Schulten K, Kossiakoff A, Perozo E, Roux B. Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain. Nat Struct Mol Biol. 2014 Mar; 21(3):244-52. PMID: 24487958; PMCID: PMC4116111.
      Citations: 144     Fields:    Translation:HumansAnimalsCells
    39. Raghuraman H, Islam SM, Mukherjee S, Roux B, Perozo E. Dynamics transitions at the outer vestibule of the KcsA potassium channel during gating. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1831-6. PMID: 24429344; PMCID: PMC3918809.
      Citations: 28     Fields:    Translation:Cells
    40. Li Q, Wanderling S, Sompornpisut P, Perozo E. Structural basis of lipid-driven conformational transitions in the KvAP voltage-sensing domain. Nat Struct Mol Biol. 2014 Feb; 21(2):160-6. PMID: 24413055; PMCID: PMC3946318.
      Citations: 34     Fields:    Translation:Cells
    41. Ostmeyer J, Chakrapani S, Pan AC, Perozo E, Roux B. Recovery from slow inactivation in K+ channels is controlled by water molecules. Nature. 2013 Sep 05; 501(7465):121-4. PMID: 23892782; PMCID: PMC3799803.
      Citations: 83     Fields:    Translation:Cells
    42. van der Cruijsen EA, Nand D, Weingarth M, Prokofyev A, Cukkemane AA, Bonvin AM, Becker S, Hulse RE, Perozo E, Pongs O, Baldus M, Hornig S. Importance of lipid-pore loop interface for potassium channel structure and function. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):13008-13. PMID: 23882077; PMCID: PMC3740848.
      Citations: 28     Fields:    Translation:AnimalsCells
    43. White EA, Raghuraman H, Perozo E, Glotzer M. Binding of the CYK-4 subunit of the centralspindlin complex induces a large scale conformational change in the kinesin subunit. J Biol Chem. 2013 Jul 05; 288(27):19785-95. PMID: 23720745; PMCID: PMC3707682.
      Citations: 9     Fields:    Translation:AnimalsCells
    44. Vargas E, Yarov-Yarovoy V, Khalili-Araghi F, Catterall WA, Klein ML, Tarek M, Lindahl E, Schulten K, Perozo E, Bezanilla F, Roux B. An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. J Gen Physiol. 2012 Dec; 140(6):587-94. PMID: 23183694; PMCID: PMC3514734.
      Citations: 108     Fields:    Translation:Cells
    45. Li Q, Jogini V, Wanderling S, Cortes DM, Perozo E. Expression, purification, and reconstitution of the voltage-sensing domain from Ci-VSP. Biochemistry. 2012 Oct 16; 51(41):8132-42. PMID: 22989304; PMCID: PMC3845960.
      Citations: 8     Fields:    Translation:AnimalsCells
    46. Dalmas O, Hyde HC, Hulse RE, Perozo E. Symmetry-constrained analysis of pulsed double electron-electron resonance (DEER) spectroscopy reveals the dynamic nature of the KcsA activation gate. J Am Chem Soc. 2012 Oct 03; 134(39):16360-9. PMID: 22946877; PMCID: PMC3845908.
      Citations: 22     Fields:    Translation:Cells
    47. Raghuraman H, Cordero-Morales JF, Jogini V, Pan AC, Kollewe A, Perozo E, Roux B. Mechanism of Cd2+ coordination during slow inactivation in potassium channels. Structure. 2012 Aug 08; 20(8):1332-42. PMID: 22771214; PMCID: PMC3846092.
      Citations: 17     Fields:    Translation:Cells
    48. Torbeev VY, Raghuraman H, Hamelberg D, Tonelli M, Westler WM, Perozo E, Kent SB. Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):20982-7. PMID: 22158985; PMCID: PMC3248522.
      Citations: 45     Fields:    Translation:Cells
    49. Pan AC, Cuello LG, Perozo E, Roux B. Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations. J Gen Physiol. 2011 Dec; 138(6):571-80. PMID: 22124115; PMCID: PMC3226968.
      Citations: 42     Fields:    Translation:Cells
    50. Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M. Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway. J Biol Chem. 2011 Nov 11; 286(45):39091-9. PMID: 21908602; PMCID: PMC3234734.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    51. Uysal S, Cuello LG, Cortes DM, Koide S, Kossiakoff AA, Perozo E. Mechanism of activation gating in the full-length KcsA K+ channel. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11896-9. PMID: 21730186; PMCID: PMC3141920.
      Citations: 41     Fields:    Translation:Cells
    52. Cordero-Morales JF, Jogini V, Chakrapani S, Perozo E. A multipoint hydrogen-bond network underlying KcsA C-type inactivation. Biophys J. 2011 May 18; 100(10):2387-93. PMID: 21575572; PMCID: PMC3093550.
      Citations: 66     Fields:    Translation:AnimalsCells
    53. Chakrapani S, Cordero-Morales JF, Jogini V, Pan AC, Cortes DM, Perozo E, Roux B. On the structural basis of modal gating behavior in K(+) channels. Nat Struct Mol Biol. 2011 Jan; 18(1):67-74. PMID: 21186363; PMCID: PMC3059741.
      Citations: 49     Fields:    Translation:Cells
    54. Hulse RE, Li Q, Perozo E. Up a hydrophobic creek with a short paddle. Cell. 2010 Aug 20; 142(4):515-6. PMID: 20723752.
      Citations: 1     Fields:    
    55. Dalmas O, Cuello LG, Jogini V, Cortes DM, Roux B, Perozo E. Structural dynamics of the magnesium-bound conformation of CorA in a lipid bilayer. Structure. 2010 Jul 14; 18(7):868-78. PMID: 20637423; PMCID: PMC2935691.
      Citations: 16     Fields:    Translation:Cells
    56. Cuello LG, Jogini V, Cortes DM, Perozo E. Structural mechanism of C-type inactivation in K(+) channels. Nature. 2010 Jul 08; 466(7303):203-8. PMID: 20613835; PMCID: PMC3033749.
      Citations: 287     Fields:    Translation:Cells
    57. Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, Dalmas O, Cordero-Morales JF, Chakrapani S, Perozo E, Roux B. Structural basis for the coupling between activation and inactivation gates in K(+) channels. Nature. 2010 Jul 08; 466(7303):272-5. PMID: 20613845; PMCID: PMC3033755.
      Citations: 192     Fields:    Translation:HumansCells
    58. Chakrapani S, Sompornpisut P, Intharathep P, Perozo E, Roux B. The activated state of a sodium channel voltage sensor in a membrane environment. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5435-40. PMID: 20207950; PMCID: PMC2851821.
      Citations: 33     Fields:    Translation:Cells
    59. Cuello LG, Jogini V, Cortes DM, Sompornpisut A, Purdy MD, Wiener MC, Perozo E. Design and characterization of a constitutively open KcsA. FEBS Lett. 2010 Mar 19; 584(6):1133-8. PMID: 20153331; PMCID: PMC2848999.
      Citations: 18     Fields:    Translation:Cells
    60. Cuello LG, Cortes DM, Jogini V, Sompornpisut A, Perozo E. A molecular mechanism for proton-dependent gating in KcsA. FEBS Lett. 2010 Mar 19; 584(6):1126-32. PMID: 20138880; PMCID: PMC2858269.
      Citations: 30     Fields:    Translation:Cells
    61. Takacs Z, Toups M, Kollewe A, Johnson E, Cuello LG, Driessens G, Biancalana M, Koide A, Ponte CG, Perozo E, Gajewski TF, Suarez-Kurtz G, Koide S, Goldstein SA. A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22211-6. PMID: 20007782; PMCID: PMC2799710.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    62. Perozo E, Vásquez V. Structural biology: A channel with a twist. Nature. 2009 Sep 03; 461(7260):47-9. PMID: 19727188.
      Citations:    Fields:    Translation:Cells
    63. Uysal S, Tereshko V, Esaki K, Fellouse FA, Sidhu SS, Koide S, Perozo E, Kossiakoff A, Vásquez V. Crystal structure of full-length KcsA in its closed conformation. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6644-9. PMID: 19346472; PMCID: PMC2672561.
      Citations: 133     Fields:    Translation:Cells
    64. Torbeev VY, Raghuraman H, Mandal K, Senapati S, Perozo E, Kent SB. Dynamics of "flap" structures in three HIV-1 protease/inhibitor complexes probed by total chemical synthesis and pulse-EPR spectroscopy. J Am Chem Soc. 2009 Jan 28; 131(3):884-5. PMID: 19117390.
      Citations: 19     Fields:    Translation:Cells
    65. Goetz BA, Perozo E, Locher KP. Distinct gate conformations of the ABC transporter BtuCD revealed by electron spin resonance spectroscopy and chemical cross-linking. FEBS Lett. 2009 Jan 22; 583(2):266-70. PMID: 19101549.
      Citations: 18     Fields:    Translation:Cells
    66. Sotomayor M, Cordero-Morales J, Schulten K, Perozo E, Vásquez V. A structural mechanism for MscS gating in lipid bilayers. Science. 2008 Aug 29; 321(5893):1210-4. PMID: 18755978; PMCID: PMC2897165.
      Citations: 93     Fields:    Translation:Cells
    67. Sompornpisut P, Perozo E, Roux B. Structural refinement of membrane proteins by restrained molecular dynamics and solvent accessibility data. Biophys J. 2008 Dec; 95(11):5349-61. PMID: 18676641; PMCID: PMC2586578.
      Citations: 13     Fields:    Translation:Cells
    68. Chakrapani S, Cuello LG, Cortes DM, Perozo E. Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer. Structure. 2008 Mar; 16(3):398-409. PMID: 18334215; PMCID: PMC2703488.
      Citations: 66     Fields:    Translation:Cells
    69. Sotomayor M, Cortes DM, Schulten K, Perozo E, Vásquez V, Roux B. Three-dimensional architecture of membrane-embedded MscS in the closed conformation. J Mol Biol. 2008 Apr 18; 378(1):55-70. PMID: 18343404; PMCID: PMC2703500.
      Citations: 44     Fields:    Translation:Cells
    70. Chakrapani S, Cordero-Morales JF, Perozo E. A quantitative description of KcsA gating I: macroscopic currents. J Gen Physiol. 2007 Nov; 130(5):465-78. PMID: 17938230; PMCID: PMC2151670.
      Citations: 74     Fields:    Translation:Cells
    71. Chakrapani S, Cordero-Morales JF, Perozo E. A quantitative description of KcsA gating II: single-channel currents. J Gen Physiol. 2007 Nov; 130(5):479-96. PMID: 17938231; PMCID: PMC2151667.
      Citations: 58     Fields:    Translation:Cells
    72. Cordero-Morales JF, Jogini V, Lewis A, Cortes DM, Perozo E, Vásquez V, Roux B. Molecular driving forces determining potassium channel slow inactivation. Nat Struct Mol Biol. 2007 Nov; 14(11):1062-9. PMID: 17922012.
      Citations: 141     Fields:    Translation:AnimalsCells
    73. Hvorup RN, Goetz BA, Niederer M, Hollenstein K, Perozo E, Locher KP. Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF. Science. 2007 Sep 07; 317(5843):1387-90. PMID: 17673622.
      Citations: 109     Fields:    Translation:Cells
    74. Cortes DM, Furukawa H, Perozo E, Vásquez V. An optimized purification and reconstitution method for the MscS channel: strategies for spectroscopical analysis. Biochemistry. 2007 Jun 12; 46(23):6766-73. PMID: 17500538.
      Citations: 23     Fields:    Translation:Cells
    75. Chakrapani S, Perozo E. How to gate an ion channel: lessons from MthK. Nat Struct Mol Biol. 2007 Mar; 14(3):180-2. PMID: 17334406.
      Citations: 11     Fields:    Translation:Cells
    76. Sotomayor M, Perozo E, Schulten K, Vásquez V. Ion conduction through MscS as determined by electrophysiology and simulation. Biophys J. 2007 Feb 01; 92(3):886-902. PMID: 17114233; PMCID: PMC1779981.
      Citations: 68     Fields:    Translation:Cells
    77. Cordero-Morales JF, Cuello LG, Perozo E, Bezanilla F, Blunck R. Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction. J Gen Physiol. 2006 Nov; 128(5):569-81. PMID: 17043150; PMCID: PMC2151582.
      Citations: 58     Fields:    Translation:Cells
    78. Cordero-Morales JF, Cuello LG, Zhao Y, Jogini V, Cortes DM, Perozo E, Roux B. Molecular determinants of gating at the potassium-channel selectivity filter. Nat Struct Mol Biol. 2006 Apr; 13(4):311-8. PMID: 16532009.
      Citations: 266     Fields:    Translation:Cells
    79. Cordero-Morales JF, Cuello LG, Perozo E. Voltage-dependent gating at the KcsA selectivity filter. Nat Struct Mol Biol. 2006 Apr; 13(4):319-22. PMID: 16532008.
      Citations: 77     Fields:    Translation:Cells
    80. Perozo E. Gating prokaryotic mechanosensitive channels. Nat Rev Mol Cell Biol. 2006 Feb; 7(2):109-19. PMID: 16493417.
      Citations: 51     Fields:    Translation:Cells
    81. Sale K, Song L, Liu YS, Perozo E, Fajer P. Explicit treatment of spin labels in modeling of distance constraints from dipolar EPR and DEER. J Am Chem Soc. 2005 Jul 06; 127(26):9334-5. PMID: 15984837.
      Citations: 49     Fields:    Translation:Cells
    82. Ptak CP, Cuello LG, Perozo E. Electrostatic interaction of a K+ channel RCK domain with charged membrane surfaces. Biochemistry. 2005 Jan 11; 44(1):62-71. PMID: 15628846.
      Citations: 9     Fields:    Translation:Cells
    83. Cuello LG, Cortes DM, Perozo E. Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer. Science. 2004 Oct 15; 306(5695):491-5. PMID: 15486302.
      Citations: 102     Fields:    Translation:Cells
    84. Perozo E, Rees DC. Structure and mechanism in prokaryotic mechanosensitive channels. Curr Opin Struct Biol. 2003 Aug; 13(4):432-42. PMID: 12948773.
      Citations: 65     Fields:    Translation:Cells
    85. Bezanilla F, Perozo E. The voltage sensor and the gate in ion channels. Adv Protein Chem. 2003; 63:211-41. PMID: 12629972.
      Citations: 15     Fields:    Translation:Cells
    86. Bezanilla F, Perozo E, Bezanilla F, Perozo E. Structural biology. Force and voltage sensors in one structure. Science. 2002 Nov 22; 298(5598):1562-3. PMID: 12446894.
      Citations: 8     Fields:    Translation:Cells
    87. Perozo E, Kloda A, Cortes DM, Martinac B. Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating. Nat Struct Biol. 2002 Sep; 9(9):696-703. PMID: 12172537.
      Citations: 273     Fields:    Translation:Cells
    88. Perozo E, Cortes DM, Sompornpisut P, Kloda A, Martinac B, Perozo E, Cortes DM, Sompornpisut P, Kloda A, Martinac B. Open channel structure of MscL and the gating mechanism of mechanosensitive channels. Nature. 2002 Aug 29; 418(6901):942-8. PMID: 12198539.
      Citations: 236     Fields:    Translation:Cells
    89. Li J, Xu Q, Cortes DM, Perozo E, Laskey A, Karlin A, Li J, Xu Q, Cortes DM, Perozo E, Laskey A, Karlin A. Reactions of cysteines substituted in the amphipathic N-terminal tail of a bacterial potassium channel with hydrophilic and hydrophobic maleimides. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11605-10. PMID: 12189213; PMCID: PMC129316.
      Citations: 8     Fields:    
    90. Perozo E. New structural perspectives on K(+) channel gating. Structure. 2002 Aug; 10(8):1027-9. PMID: 12176380.
      Citations: 12     Fields:    Translation:Cells
    91. Perozo E, Cuello LG, Cortes DM, Liu YS, Sompornpisut P. EPR approaches to ion channel structure and function. Novartis Found Symp. 2002; 245:146-58; discussion 158-64, 165-8. PMID: 12027005.
      Citations: 17     Fields:    Translation:Cells
    92. Sompornpisut P, Liu YS, Perozo E. Calculation of rigid-body conformational changes using restraint-driven Cartesian transformations. Biophys J. 2001 Nov; 81(5):2530-46. PMID: 11606268; PMCID: PMC1301722.
      Citations: 9     Fields:    Translation:Cells
    93. Liu YS, Sompornpisut P, Perozo E, Liu YS, Sompornpisut P, Perozo E. Structure of the KcsA channel intracellular gate in the open state. Nat Struct Biol. 2001 Oct; 8(10):883-7. PMID: 11573095.
      Citations: 78     Fields:    Translation:Cells
    94. Perozo E, Kloda A, Cortes DM, Martinac B, Perozo E, Kloda A, Cortes DM, Martinac B. Site-directed spin-labeling analysis of reconstituted Mscl in the closed state. J Gen Physiol. 2001 Aug; 118(2):193-206. PMID: 11479346; PMCID: PMC2233830.
      Citations: 41     Fields:    Translation:Cells
    95. Cortes DM, Cuello LG, Perozo E. Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating. J Gen Physiol. 2001 Feb; 117(2):165-80. PMID: 11158168; PMCID: PMC2217246.
      Citations: 102     Fields:    Translation:Cells
    96. Perozo E. Structure and packing orientation of transmembrane segments in voltage-dependent channels. Lessons from perturbation analysis. J Gen Physiol. 2000 Jan; 115(1):29-32. PMID: 10613916; PMCID: PMC1887776.
      Citations: 2     Fields:    Translation:Animals
    97. Perozo E, Cortes DM, Cuello LG. Structural rearrangements underlying K+-channel activation gating. Science. 1999 Jul 02; 285(5424):73-8. PMID: 10390363.
      Citations: 192     Fields:    Translation:Cells
    98. Perozo E. Shedding light on voltage-dependent gating. J Gen Physiol. 1998 Oct; 112(4):373-6. PMID: 9758857; PMCID: PMC2229428.
      Citations:    Fields:    Translation:AnimalsCells
    99. Perozo E, Cortes DM, Cuello LG. Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopy. Nat Struct Biol. 1998 Jun; 5(6):459-69. PMID: 9628484.
      Citations: 119     Fields:    Translation:AnimalsCells
    100. Cuello LG, Romero JG, Cortes DM, Perozo E. pH-dependent gating in the Streptomyces lividans K+ channel. Biochemistry. 1998 Mar 10; 37(10):3229-36. PMID: 9536962.
      Citations: 82     Fields:    Translation:Cells
    101. Tatulian SA, Cortes DM, Perozo E. Structural dynamics of the Streptomyces lividans K+ channel (SKC1): secondary structure characterization from FTIR spectroscopy. FEBS Lett. 1998 Feb 20; 423(2):205-12. PMID: 9512358.
      Citations: 9     Fields:    Translation:Cells
    102. Cortes DM, Perozo E. Structural dynamics of the Streptomyces lividans K+ channel (SKC1): oligomeric stoichiometry and stability. Biochemistry. 1997 Aug 19; 36(33):10343-52. PMID: 9254634.
      Citations: 53     Fields:    Translation:AnimalsCells
    103. Bogomolni RA, Stoeckenius W, Szundi I, Perozo E, Olson KD, Spudich JL. Removal of transducer HtrI allows electrogenic proton translocation by sensory rhodopsin I. Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21):10188-92. PMID: 7937859; PMCID: PMC44983.
      Citations: 37     Fields:    Translation:Cells
    104. Caputo C, Perozo E, Bezanilla F. Chemical modification of squid axon K+ channel -SH groups with the organic mercurial compound p-hydroxymercuriphenylsulfonic acid (PHMPS). Pflugers Arch. 1994 Oct; 428(3-4):315-22. PMID: 7816554.
      Citations: 1     Fields:    Translation:AnimalsCells
    105. Stefani E, Toro L, Perozo E, Bezanilla F. Gating of Shaker K+ channels: I. Ionic and gating currents. Biophys J. 1994 Apr; 66(4):996-1010. PMID: 8038403; PMCID: PMC1275807.
      Citations: 86     Fields:    Translation:AnimalsCells
    106. Bezanilla F, Perozo E, Stefani E. Gating of Shaker K+ channels: II. The components of gating currents and a model of channel activation. Biophys J. 1994 Apr; 66(4):1011-21. PMID: 8038375; PMCID: PMC1275808.
      Citations: 159     Fields:    Translation:AnimalsCells
    107. Santacruz-Toloza L, Perozo E, Papazian DM. Purification and reconstitution of functional Shaker K+ channels assayed with a light-driven voltage-control system. Biochemistry. 1994 Feb 15; 33(6):1295-9. PMID: 8312246.
      Citations: 2     Fields:    Translation:AnimalsCells
    108. Perozo E, Santacruz-Toloza L, Stefani E, Bezanilla F, Papazian DM. S4 mutations alter gating currents of Shaker K channels. Biophys J. 1994 Feb; 66(2 Pt 1):345-54. PMID: 8161688; PMCID: PMC1275701.
      Citations: 62     Fields:    Translation:AnimalsCells
    109. Perozo E, Hubbell WL. Voltage activation of reconstituted sodium channels: use of bacteriorhodopsin as a light-driven current source. Biochemistry. 1993 Oct 05; 32(39):10471-8. PMID: 8399193.
      Citations: 2     Fields:    Translation:Cells
    110. Perozo E, MacKinnon R, Bezanilla F, Stefani E. Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels. Neuron. 1993 Aug; 11(2):353-8. PMID: 8352943.
      Citations: 185     Fields:    Translation:AnimalsCells
    111. Perozo E, Papazian DM, Stefani E, Bezanilla F. Gating currents in Shaker K+ channels. Implications for activation and inactivation models. Biophys J. 1992 Apr; 62(1):160-8; discussion 169-71. PMID: 1600094; PMCID: PMC1260511.
      Citations: 50     Fields:    Translation:AnimalsCells
    112. Bezanilla F, Perozo E, Papazian DM, Stefani E. Molecular basis of gating charge immobilization in Shaker potassium channels. Science. 1991 Nov 01; 254(5032):679-83. PMID: 1948047.
      Citations: 101     Fields:    Translation:AnimalsCells
    113. Perozo E, Bezanilla F. Phosphorylation of K+ channels in the squid giant axon. A mechanistic analysis. J Bioenerg Biomembr. 1991 Aug; 23(4):599-613. PMID: 1917910.
      Citations: 7     Fields:    Translation:AnimalsCells
    114. Perozo E, Vandenberg CA, Jong DS, Bezanilla F. Single channel studies of the phosphorylation of K+ channels in the squid giant axon. I. Steady-state conditions. J Gen Physiol. 1991 Jul; 98(1):1-17. PMID: 1940846; PMCID: PMC2229041.
      Citations: 7     Fields:    Translation:AnimalsCells
    115. Perozo E, Jong DS, Bezanilla F. Single channel studies of the phosphorylation of K+ channels in the squid giant axon. II. Nonstationary conditions. J Gen Physiol. 1991 Jul; 98(1):19-34. PMID: 1940848; PMCID: PMC2229039.
      Citations: 16     Fields:    Translation:AnimalsCells
    116. Perozo E, Bezanilla F. Phosphorylation affects voltage gating of the delayed rectifier K+ channel by electrostatic interactions. Neuron. 1990 Nov; 5(5):685-90. PMID: 2223093.
      Citations: 41     Fields:    Translation:AnimalsCells
    117. Perozo E, Bezanilla F, Dipolo R. Modulation of K channels in dialyzed squid axons. ATP-mediated phosphorylation. J Gen Physiol. 1989 Jun; 93(6):1195-218. PMID: 2769224; PMCID: PMC2216247.
      Citations: 13     Fields:    Translation:AnimalsCells
    118. Urbina JA, Cohen BE, Perozo E, Cornivelli L. Spin-labeled amphotericin B: synthesis, characterization, biological and spectroscopic properties. Biochim Biophys Acta. 1987 Mar 12; 897(3):467-73. PMID: 3028486.
      Citations: 5     Fields:    Translation:Animals
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