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Sindhu Rajan

TitleRESEARCH ASSOCIATE (ASSISTANT PROFESSOR)
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
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    K01DK075706     (RAJAN, SINDHU)Aug 1, 2007 - Jul 31, 2012
    NIH
    Towards understanding the role of sumoylation in ion channel regulation
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rajan S, Dickson LM, Mathew E, Orr CM, Ellenbroek JH, Philipson LH, Wicksteed B. Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic ß-cells via protein kinase A. Mol Metab. 2015 Apr; 4(4):265-76. PMID: 25830090; PMCID: PMC4354925.
      Citations: 33     Fields:    
    2. Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, Urano F, Kulkarni RN. Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic ß cells. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2319-28. PMID: 24843127; PMCID: PMC4050564.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    3. Morgan D, Musset B, Kulleperuma K, Smith SM, Rajan S, Cherny VV, DeCoursey TE, Pomès R. Peregrination of the selectivity filter delineates the pore of the human voltage-gated proton channel hHV1. J Gen Physiol. 2013 Dec; 142(6):625-40. PMID: 24218398; PMCID: PMC3840923.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    4. Eames SC, Kinkel MD, Rajan S, Prince VE, Philipson LH. Transgenic zebrafish model of the C43G human insulin gene mutation. J Diabetes Investig. 2013 Mar 18; 4(2):157-67. PMID: 24843647; PMCID: PMC4019270.
      Citations: 5     Fields:    
    5. Rajan S, Torres J, Thompson MS, Philipson LH. SUMO downregulates GLP-1-stimulated cAMP generation and insulin secretion. Am J Physiol Endocrinol Metab. 2012 Mar 15; 302(6):E714-23. PMID: 22234371; PMCID: PMC3311292.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    6. Musset B, Smith SM, Rajan S, Morgan D, Cherny VV, Decoursey TE. Aspartate?112 is the selectivity filter of the human voltage-gated proton channel. Nature. 2011 Oct 23; 480(7376):273-7. PMID: 22020278; PMCID: PMC3237871.
      Citations: 107     Fields:    
    7. Musset B, Smith SM, Rajan S, Cherny VV, Morgan D, DeCoursey TE. Oligomerization of the voltage-gated proton channel. Channels (Austin). 2010 Jul-Aug; 4(4):260-5. PMID: 20676047; PMCID: PMC3025757.
      Citations: 13     Fields:    
    8. Musset B, Smith SM, Rajan S, Cherny VV, Sujai S, Morgan D, DeCoursey TE. Zinc inhibition of monomeric and dimeric proton channels suggests cooperative gating. J Physiol. 2010 May 01; 588(Pt 9):1435-49. PMID: 20231140; PMCID: PMC2876801.
      Citations: 62     Fields:    
    9. Rajan S, Eames SC, Park SY, Labno C, Bell GI, Prince VE, Philipson LH. In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes. Am J Physiol Endocrinol Metab. 2010 Mar; 298(3):E403-10. PMID: 19952343; PMCID: PMC2838531.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    10. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. Pharmacol Rev. 2005 Dec; 57(4):527-40. PMID: 16382106.
      Citations: 109     Fields:    Translation:HumansAnimals
    11. Plant LD, Rajan S, Goldstein SA. K2P channels and their protein partners. Curr Opin Neurobiol. 2005 Jun; 15(3):326-33. PMID: 15922586.
      Citations: 13     Fields:    Translation:AnimalsCells
    12. Rajan S, Plant LD, Rabin ML, Butler MH, Goldstein SA. Sumoylation silences the plasma membrane leak K+ channel K2P1. Cell. 2005 Apr 08; 121(1):37-47. PMID: 15820677.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    13. Chen H, Kim LA, Rajan S, Xu S, Goldstein SA. Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex. Neuron. 2003 Sep 25; 40(1):15-23. PMID: 14527430.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    14. Sesti F, Rajan S, Gonzalez-Colaso R, Nikolaeva N, Goldstein SA. Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel. Nat Neurosci. 2003 Apr; 6(4):353-61. PMID: 12640457.
      Citations: 23     Fields:    Translation:AnimalsCells
    15. Rajan S, Wischmeyer E, Nehring R, Hanley PJ, Renigunta V, Musset B, Derst C, Karschin A, Preisig-Müller R, Schlichthörl G, Daut J. Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3. J Physiol. 2002 11 15; 545(1):13-26. PMID: 12433946; PMCID: PMC2290646.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    16. Goerge T, Heinen S, Rajan S, Derst C, Preisig-Müller R, Schlichthörl G, Brüggemann A, Veh RW, Daut J. Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7774-9. PMID: 12032359; PMCID: PMC124349.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    17. Kananura C, Sander T, Rajan S, Grzeschik KH, Derst C, Steinlein OK, Preisig-Müller R, Daut J. Tandem pore domain K(+)-channel TASK-3 (KCNK9) and idiopathic absence epilepsies. Am J Med Genet. 2002 Mar 08; 114(2):227-9. PMID: 11857586.
      Citations: 8     Fields:    Translation:Humans
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