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Ivan Moskowitz

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    The Moskowitz laboratory is devoted to the genetic, genomic and molecular study of gene regulatory networks. A single overarching theme governs work in the Moskowitz laboratory: that understanding essential gene regulatory networks will unveil the molecular logic governing biological processes, and that understanding network disruption will inform the molecular basis underlying disease. We have recently pioneered approaches to identify non-coding RNAs as markers and modulators of enhancer function (Yang and Nadadur et al, 2017). The Moskowitz laboratory has focused on two areas of cardiac biology: (1) cardiac conduction with respect to cardiac arrhythmias and (2) cardiac development with respect to Congenital Heart Disease (CHD). In cardiac development, we investigate the genetic, genomic and developmental landscape of cardiac morphogenesis. We have identified an essential role for Hedgehog signaling in the cardiac development and congenital heart disease and contributed to a paradigm shift in the understanding of cardiac septation (e.g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017). We have recently identified a surprising and novel role for Hedgehog signaling in maintaining cardiac progenitor status and preventing premature differentiation (Rowton et al., 2018). In cardiac rhythm, we investigate the molecular mechanisms underlying the genetic basis of cardiac arrhythmias. We have defined the first molecular networks and linking GWAS loci in cardiac conduction (Arnolds et al, 2012), the first molecular network in Atrial Fibrillation, the most common arrhythmia world-wide (Nadadur et al., 2016) and the functional genomic mechanisms underlying genetic associations (Van den Boogaard et al., 2014).

    Collapse Biography 
    Collapse education and training
    Harvard Medical School, Boston, MAFellowship06/2006Genetics
    Children's Hospital, Boston, MAFellowship06/2001Congenital Heart Disease
    Brigham and Women’s Hospital, Boston, MA Residency06/2000Pathology
    University of Wisconsin, School of Medicine, Madison, WIM.D./Ph.D.06/1998Biochemistry
    Marine Biological Laboratory, Woods Hole, MA06/1994Embryology
    Wesleyan University, Middletown, CTB.A.06/1988Biochemistry/Molecular Biology
    Collapse awards and honors
    2015Fellow of the American Heart Association, American Heart Association
    2014American Society of Clinical Investigation, American Society of Clinical Investigation
    2013Established Investigator Award, American Heart Association
    2006Louis N. and Arnold M. Katz Basic Research Prize, American Heart Association

    Collapse Research 
    Collapse research activities and funding
    Pending     (MOSKOWITZ, IVAN PAUL)Jul 1, 2024 - Jun 30, 2029
    Cardiovascular Sciences Training Grant
    Role: Principal Investigator

    Pending     (MOSKOWITZ, IVAN PAUL)Apr 1, 2023 - Mar 31, 2028
    A Heterochronic Model for Birth Defects in Down Syndrome
    Role: Principal Investigator

    R01HD111938     (MOSKOWITZ, IVAN PAUL)Apr 1, 2023 - Mar 31, 2026
    A heterochronic model for birth defects in Down Syndrome
    Role: Principal Investigator

    Pending     (MOSKOWITZ, IVAN PAUL)Mar 1, 2023 - Feb 28, 2026
    Additional Ventures
    Hedgehog Signaling-Dependent Heterochronic Control of Differentiation Timing in Cardiac Development and the Pathogenesis of Single Ventricle
    Role: Principal Investigator

    R01HL147571     (MOSKOWITZ, IVAN PAUL)Dec 26, 2022 - May 31, 2023
    Evaluation of Hedgehog Signaling-Dependent Heart Development in a Mouse Model of Down Syndrome
    Role: Principal Investigator

    R01HL163523     (MOSKOWITZ, IVAN PAUL)Apr 1, 2022 - Mar 31, 2026
    Discovery and interrogation of Genetic Regulatory Variation Impacting Atrial Fibrillation Risk
    Role: Principal Investigator

    R21HD100921     (MOSKOWITZ, IVAN PAUL)Sep 1, 2020 - Aug 31, 2022
    Gene Expression Networks for Human Cardiac Differentiation in Down Syndrome
    Role: Principal Investigator

    R01HL149961     (MOSKOWITZ, IVAN PAUL)Jul 1, 2020 - Apr 30, 2024
    Washington University
    High-Throughput Identification of Causal Variants Underlying Cardiac Arrhythmia-Related GWAS Hits
    Role: Co-Principal Investigator

    R01HL148719     (MOSKOWITZ, IVAN PAUL)Aug 17, 2019 - Jul 31, 2023
    Gene Regulatory Non-Coding RNAs in the Human Heart
    Role: Principal Ivestigator

    R01HL148719     (MOSKOWITZ, IVAN PAUL ;RUTHENBURG, ALEXANDER JACKSON)Aug 17, 2019 - Jul 31, 2023
    Gene Regulatory Non-Coding RNAs in the Human Heart
    Role: Principal Investigator

    R01HL147571     (MOSKOWITZ, IVAN PAUL)Jun 1, 2019 - May 31, 2023
    The Molecular Basis of Cardiac Differentiation Control
    Role: Principal Investigator

    R01HL126509     (CONLON, FRANK LEO)Apr 1, 2017 - Feb 28, 2021
    Gene Regulatory Networks for Cardiac Morphogenesis
    Role: Co-Principal Investigator

    R33HL123857     (NOBREGA, MARCELO A.)Aug 8, 2014 - Jun 30, 2020
    Functional Assays to Screen Genomic Hits
    Role: Co-Principal Investigator

    R21HL123857     (NOBREGA, MARCELO A.)Aug 8, 2014 - Jun 30, 2016
    Functional Assays to Screen Genomic Hits
    Role: Co-Principal Investigator

    R01HL124836     (MOSKOWITZ, IVAN PAUL)Aug 1, 2014 - Jul 31, 2019
    Etiology of Congenital Heart Disease in Down Syndrome
    Role: Principal Investigator

    R01HL114010     (MOSKOWITZ, IVAN PAUL)Apr 1, 2012 - Mar 31, 2017
    Transcriptional Control of Cardiac Conduction System Function by T-box Genes
    Role: Principal Investigator

    R01HL092153     (MOSKOWITZ, IVAN PAUL)Apr 1, 2008 - Jul 31, 2018
    Genetic and Molecular Analysis of Congenital Heart Disease
    Role: Principal Investigator

    K08HL078180     (MOSKOWITZ, IVAN PAUL)Sep 15, 2004 - Aug 31, 2009
    A Screen for Mouse Cardiovascular Morphogenesis Mutants
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Broman MT, Nadadur RD, Perez-Cervantes C, Burnicka-Turek O, Lazarevic S, Gams A, Laforest B, Steimle JD, Iddir S, Wang Z, Smith L, Mazurek SR, Olivey HE, Zhou P, Gadek M, Shen KM, Khan Z, Theisen JWM, Yang XH, Ikegami K, Efimov IR, Pu WT, Weber CR, McNally EM, Svensson EC, Moskowitz IP. A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024 Jan 08. PMID: 38189150.
      Citations:    Fields:    
    2. Sweat ME, Cao Y, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Arulsamy K, Lu F, Keating EM, Akerberg BN, Ma Q, Wakimoto H, Gorham JM, Hill LD, Kyoung Song M, Trembley MA, Wang P, Gianeselli M, Prondzynski M, Bortolin RH, Bezzerides VJ, Chen K, Seidman JG, Seidman CE, Moskowitz IP, Pu WT. Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network. Nat Cardiovasc Res. 2023 Oct; 2(10):881-898. PMID: 38344303; PMCID: PMC10854392.
    3. Yamaguchi N, Chang EW, Lin Z, Shekhar A, Bu L, Khodadadi-Jamayran A, Tsirigos A, Cen Y, Phoon CKL, Moskowitz IP, Park DS, Yamaguchi N, Chang EW, Lin Z, Bu L, Khodadadi-Jamayran A, Tsirigos A, Cen Y, Phoon CKL, Park DS. An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract. Circulation. 2023 Nov 21; 148(21):1705-1722. PMID: 37772400.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. En A, Bogireddi H, Thomas B, Stutzman A, Ikegami S, LaForest B, Almakki O, Pytel P, Moskowitz IP, Ikegami K. The cGAS-STING pathway is dispensable in a mouse model of LMNA-cardiomyopathy despite nuclear envelope rupture. bioRxiv. 2023 Aug 28. PMID: 37693381; PMCID: PMC10491116.
    5. Selewa A, Luo K, Wasney M, Smith L, Sun X, Tang C, Eckart H, Moskowitz IP, Basu A, He X, Pott S. Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation. Nat Commun. 2023 08 17; 14(1):4999. PMID: 37591828; PMCID: PMC10435551.
      Citations: 1     Fields:    Translation:HumansCells
    6. Steimle JD, Kim C, Rowton M, Nadadur RD, Wang Z, Stocker M, Hoffmann AD, Hanson E, Kweon J, Sinha T, Choi K, Black BL, Cunningham JM, Moskowitz IP, Ikegami K. ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment. Cell Rep. 2023 06 27; 42(6):112665. PMID: 37330911; PMCID: PMC10592526.
      Citations: 1     Fields:    Translation:Cells
    7. Sweat ME, Cao Y, Zhang X, Burnicka-Turek O, Perez-Cervantes C, Akerberg BN, Ma Q, Wakimoto H, Gorham JM, Song MK, Trembley MA, Wang P, Lu F, Gianeselli M, Prondzynski M, Bortolin RH, Seidman JG, Seidman CE, Moskowitz IP, Pu WT. Tbx5 maintains atrial identity by regulating an atrial enhancer network. bioRxiv. 2023 Apr 22. PMID: 37131696; PMCID: PMC10153240.
    8. McLaughlin MT, Sun MR, Beames TG, Steward AC, Theisen JWM, Chung HM, Everson JL, Moskowitz IP, Sheets MD, Lipinski RJ. Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis. Dev Dyn. 2023 04; 252(4):483-494. PMID: 36495293; PMCID: PMC10066825.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Bersell KR, Yang T, Mosley JD, Glazer AM, Hale AT, Kryshtal DO, Kim K, Steimle JD, Brown JD, Salem JE, Campbell CC, Hong CC, Wells QS, Johnson AN, Short L, Blair MA, Behr ER, Petropoulou E, Jamshidi Y, Benson MD, Keyes MJ, Ngo D, Vasan RS, Yang Q, Gerszten RE, Shaffer C, Parikh S, Sheng Q, Kannankeril PJ, Moskowitz IP, York JD, Wang TJ, Knollmann BC, Roden DM. Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization. Circulation. 2023 03 07; 147(10):824-840. PMID: 36524479; PMCID: PMC9992308.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    10. Rowton M, Perez-Cervantes C, Hur S, Jacobs-Li J, Lu E, Deng N, Guzzetta A, Hoffmann AD, Stocker M, Steimle JD, Lazarevic S, Oubaha S, Yang XH, Kim C, Yu S, Eckart H, Koska M, Hanson E, Chan SSK, Garry DJ, Kyba M, Basu A, Ikegami K, Pott S, Moskowitz IP. Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages. Dev Cell. 2022 09 26; 57(18):2181-2203.e9. PMID: 36108627; PMCID: PMC10506397.
      Citations:    Fields:    Translation:AnimalsCells
    11. Goldstein A, Wei M, Yang XH, Sun Y, Wang Z, Moskowitz IP, Cunningham JM. Detecting critical transition signals from single-cell transcriptomes to infer lineage-determining transcription factors. Nucleic Acids Res. 2022 09 09; 50(16):e91. PMID: 35640613; PMCID: PMC9458468.
      Citations: 2     Fields:    Translation:AnimalsCells
    12. Sinha T, Lammerts van Bueren K, Dickel DE, Zlatanova I, Thomas R, Lizama CO, Xu SM, Zovein AC, Ikegami K, Moskowitz IP, Pollard KS, Pennacchio LA, Black BL. Differential Etv2 threshold requirement for endothelial and erythropoietic development. Cell Rep. 2022 05 31; 39(9):110881. PMID: 35649376; PMCID: PMC9203129.
      Citations: 2     Fields:    
    13. Simonett SP, Shin S, Herring JA, Bacher R, Smith LA, Dong C, Rabaglia ME, Stapleton DS, Schueler KL, Choi J, Bernstein MN, Turkewitz DR, Perez-Cervantes C, Spaeth J, Stein R, Tessem JS, Kendziorski C, Moskowitz IP, Keller MP, Attie AD, Keles S. Identification of direct transcriptional targets of NFATC2 that promote ß cell proliferation. J Clin Invest. 2021 11 01; 131(21). PMID: 34491912; PMCID: PMC8553569.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    14. Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AM. Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. Elife. 2021 10 13; 10. PMID: 34643182; PMCID: PMC8555986.
      Citations: 6     Fields:    Translation:AnimalsCells
    15. Trevino CE, Holleman AM, Corbitt H, Maslen CL, Rosser TC, Cutler DJ, Johnston HR, Rambo-Martin BL, Oberoi J, Dooley KJ, Capone GT, Reeves RH, Cordell HJ, Keavney BD, Agopian AJ, Goldmuntz E, Gruber PJ, O'Brien JE, Bittel DC, Wadhwa L, Cua CL, Moskowitz IP, Mulle JG, Epstein MP, Sherman SL, Zwick ME. Author Correction: Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome. Sci Rep. 2021 Jul 20; 11(1):15164. PMID: 34285246; PMCID: PMC8292424.
      Citations:    Fields:    
    16. Rowton M, Guzzetta A, Rydeen AB, Moskowitz IP. Control of cardiomyocyte differentiation timing by intercellular signaling pathways. Semin Cell Dev Biol. 2021 10; 118:94-106. PMID: 34144893; PMCID: PMC8968240.
      Citations: 9     Fields:    Translation:HumansCells
    17. Trevino CE, Holleman AM, Corbitt H, Maslen CL, Rosser TC, Cutler DJ, Johnston HR, Rambo-Martin BL, Oberoi J, Dooley KJ, Capone GT, Reeves RH, Cordell HJ, Keavney BD, Agopian AJ, Goldmuntz E, Gruber PJ, O'Brien JE, Bittel DC, Wadhwa L, Cua CL, Moskowitz IP, Mulle JG, Epstein MP, Sherman SL, Zwick ME. Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome. Sci Rep. 2020 10 22; 10(1):18051. PMID: 33093519; PMCID: PMC7582922.
      Citations: 10     Fields:    Translation:Humans
    18. Lipovsky CE, Jimenez J, Guo Q, Li G, Yin T, Hicks SC, Bhatnagar S, Takahashi K, Zhang DM, Brumback BD, Goldsztejn U, Nadadur RD, Perez-Cervantez C, Moskowitz IP, Liu S, Zhang B, Rentschler SL. Chamber-specific transcriptional responses in atrial fibrillation. JCI Insight. 2020 09 17; 5(18). PMID: 32841220; PMCID: PMC7526559.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    19. Guzzetta A, Koska M, Rowton M, Sullivan KR, Jacobs-Li J, Kweon J, Hidalgo H, Eckart H, Hoffmann AD, Back R, Lozano S, Moon AM, Basu A, Bressan M, Pott S, Moskowitz IP. Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15712-15723. PMID: 32561646; PMCID: PMC7354932.
      Citations: 14     Fields:    Translation:AnimalsCells
    20. van Ouwerkerk AF, Hall AW, Kadow ZA, Lazarevic S, Reyat JS, Tucker NR, Nadadur RD, Bosada FM, Bianchi V, Ellinor PT, Fabritz L, Martin JF, de Laat W, Kirchhof P, Moskowitz IP, Christoffels VM. Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation. Circ Res. 2020 06 19; 127(1):34-50. PMID: 32717170; PMCID: PMC8315291.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    21. Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CR. ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Circ Res. 2020 07 03; 127(2):e28-e43. PMID: 32347164; PMCID: PMC7334106.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    22. Burnicka-Turek O, Broman MT, Steimle JD, Boukens BJ, Petrenko NB, Ikegami K, Nadadur RD, Qiao Y, Arnolds DE, Yang XH, Patel VV, Nobrega MA, Efimov IR, Moskowitz IP. Transcriptional Patterning of the Ventricular Cardiac Conduction System. Circ Res. 2020 07 17; 127(3):e94-e106. PMID: 32290757; PMCID: PMC8328577.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    23. Ikegami K, Secchia S, Almakki O, Lieb JD, Moskowitz IP. Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria. Dev Cell. 2020 03 23; 52(6):699-713.e11. PMID: 32208162; PMCID: PMC7201903.
      Citations: 40     Fields:    Translation:HumansCells
    24. Sun X, Wang Z, Hall JM, Perez-Cervantes C, Ruthenburg AJ, Moskowitz IP, Gribskov M, Yang XH. Chromatin-enriched RNAs mark active and repressive cis-regulation: An analysis of nuclear RNA-seq. PLoS Comput Biol. 2020 02; 16(2):e1007119. PMID: 32040509; PMCID: PMC7034927.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    25. Perez-Cervantes C, Smith LA, Nadadur RD, Hughes AEO, Wang S, Corbo JC, Cepko C, Lonfat N, Moskowitz IP. Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types. Development. 2020 02 05; 147(3). PMID: 31915147; PMCID: PMC7033740.
      Citations: 13     Fields:    Translation:AnimalsCells
    26. Perez-Cervantes C, Smith LA, Nadadur RD, Hughes AEO, Wang S, Corbo JC, Cepko C, Lonfat N, Moskowitz IP. Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types. Development. 2020 Jan 01. PMID: 34004872.
    27. Laforest B, Dai W, Tyan L, Lazarevic S, Shen KM, Gadek M, Broman MT, Weber CR, Moskowitz IP. Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis. J Clin Invest. 2019 11 01; 129(11):4937-4950. PMID: 31609246; PMCID: PMC6819107.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    28. Liu J, Cheng H, Xiang M, Zhou L, Wu B, Moskowitz IP, Zhang K, Xie L. Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development. PLoS Genet. 2019 05; 15(5):e1007711. PMID: 31120883; PMCID: PMC6550424.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    29. Dai W, Laforest B, Tyan L, Shen KM, Nadadur RD, Alvarado FJ, Mazurek SR, Lazarevic S, Gadek M, Wang Y, Li Y, Valdivia HH, Shen L, Broman MT, Moskowitz IP, Weber CR. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. Elife. 2019 03 21; 8. PMID: 30896405; PMCID: PMC6428569.
      Citations: 16     Fields:    Translation:AnimalsCells
    30. Krause MD, Huang RT, Wu D, Shentu TP, Harrison DL, Whalen MB, Stolze LK, Di Rienzo A, Moskowitz IP, Civelek M, Romanoski CE, Fang Y. Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):E11349-E11358. PMID: 30429326; PMCID: PMC6275533.
      Citations: 39     Fields:    Translation:HumansCells
    31. Steimle JD, Rankin SA, Slagle CE, Bekeny J, Rydeen AB, Chan SS, Kweon J, Yang XH, Ikegami K, Nadadur RD, Rowton M, Hoffmann AD, Lazarevic S, Thomas W, Boyle Anderson EAT, Horb ME, Luna-Zurita L, Ho RK, Kyba M, Jensen B, Zorn AM, Conlon FL, Moskowitz IP. Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10615-E10624. PMID: 30352852; PMCID: PMC6233116.
      Citations: 29     Fields:    Translation:AnimalsCells
    32. Singh BN, Koyano-Nakagawa N, Gong W, Moskowitz IP, Weaver CV, Braunlin E, Das S, van Berlo JH, Garry MG, Garry DJ. A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human. Nat Commun. 2018 10 12; 9(1):4237. PMID: 30315164; PMCID: PMC6185975.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    33. Montefiori LE, Sobreira DR, Sakabe NJ, Aneas I, Joslin AC, Hansen GT, Bozek G, Moskowitz IP, McNally EM, Nóbrega MA. A promoter interaction map for cardiovascular disease genetics. Elife. 2018 07 10; 7. PMID: 29988018; PMCID: PMC6053306.
      Citations: 77     Fields:    Translation:HumansCells
    34. Musunuru K, Bernstein D, Cole FS, Khokha MK, Lee FS, Lin S, McDonald TV, Moskowitz IP, Quertermous T, Sankaran VG, Schwartz DA, Silverman EK, Zhou X, Hasan AAK, Luo XJ. Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research. Circ Genom Precis Med. 2018 04; 11(4):e002178. PMID: 29654098; PMCID: PMC5901889.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    35. Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Werner M, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, Moskowitz IP. Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm. Elife. 2017 12 27; 6. PMID: 29280435; PMCID: PMC5745077.
      Citations: 26     Fields:    Translation:AnimalsCells
    36. Werner MS, Sullivan MA, Shah RN, Nadadur RD, Grzybowski AT, Galat V, Moskowitz IP, Ruthenburg AJ. Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription. Nat Struct Mol Biol. 2017 Jul; 24(7):596-603. PMID: 28628087; PMCID: PMC5682930.
      Citations: 48     Fields:    Translation:HumansCells
    37. Zhou L, Liu J, Xiang M, Olson P, Guzzetta A, Zhang K, Moskowitz IP, Xie L. Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):E1422-E1431. PMID: 28167794; PMCID: PMC5338429.
      Citations: 27     Fields:    Translation:AnimalsCells
    38. Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Xie L, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP. Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation. PLoS Genet. 2016 Dec; 12(12):e1006533. PMID: 28033319; PMCID: PMC5199006.
      Citations:    Fields:    
    39. Steimle JD, Moskowitz IP. TBX5: A Key Regulator of Heart Development. Curr Top Dev Biol. 2017; 122:195-221. PMID: 28057264; PMCID: PMC5371404.
      Citations: 65     Fields:    Translation:HumansAnimals
    40. Nadadur RD, Broman MT, Boukens B, Mazurek SR, Yang X, van den Boogaard M, Bekeny J, Gadek M, Ward T, Zhang M, Qiao Y, Martin JF, Seidman CE, Seidman J, Christoffels V, Efimov IR, McNally EM, Weber CR, Moskowitz IP. Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm. Sci Transl Med. 2016 08 31; 8(354):354ra115. PMID: 27582060; PMCID: PMC5266594.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    41. Burnicka-Turek O, Steimle JD, Huang W, Felker L, Kamp A, Kweon J, Peterson M, Reeves RH, Maslen CL, Gruber PJ, Yang XH, Shendure J, Moskowitz IP. Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms. Hum Mol Genet. 2016 07 15; 25(14):3011-3028. PMID: 27340223; PMCID: PMC5181596.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    42. Priest JR, Osoegawa K, Mohammed N, Nanda V, Kundu R, Schultz K, Lammer EJ, Girirajan S, Scheetz T, Waggott D, Haddad F, Reddy S, Bernstein D, Burns T, Steimle JD, Yang XH, Moskowitz IP, Hurles M, Lifton RP, Nickerson D, Bamshad M, Eichler EE, Mital S, Sheffield V, Quertermous T, Gelb BD, Portman M, Ashley EA. De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects. PLoS Genet. 2016 Apr; 12(4):e1005963. PMID: 27058611; PMCID: PMC4825975.
      Citations: 55     Fields:    Translation:HumansAnimals
    43. Waldron L, Steimle JD, Greco TM, Gomez NC, Dorr KM, Kweon J, Temple B, Yang XH, Wilczewski CM, Davis IJ, Cristea IM, Moskowitz IP, Conlon FL. The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation. Dev Cell. 2016 Feb 08; 36(3):262-75. PMID: 26859351; PMCID: PMC4920128.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    44. Rowton M, Moskowitz IP. Many ways to break a heart. Elife. 2015 Aug 25; 4. PMID: 26305497; PMCID: PMC4548206.
      Citations:    Fields:    Translation:Animals
    45. Polk RC, Gergics P, Steimle JD, Li H, Moskowitz IP, Camper SA, Reeves RH. The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model. BMC Dev Biol. 2015 Jul 25; 15:30. PMID: 26208718; PMCID: PMC4514943.
      Citations: 8     Fields:    Translation:Animals
    46. Shamis Y, Cullen DE, Liu L, Yang G, Ng SF, Xiao L, Bell FT, Ray C, Takikawa S, Moskowitz IP, Cai CL, Yang X, Li X. Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):E2020-9. PMID: 25848000; PMCID: PMC4413352.
      Citations: 16     Fields:    Translation:AnimalsCells
    47. Quintero-Rivera F, Xi QJ, Keppler-Noreuil KM, Lee JH, Higgins AW, Anchan RM, Roberts AE, Seong IS, Fan X, Lage K, Lu LY, Tao J, Hu X, Berezney R, Gelb BD, Kamp A, Moskowitz IP, Lacro RV, Lu W, Morton CC, Gusella JF, Maas RL. MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus. Hum Mol Genet. 2015 Apr 15; 24(8):2375-89. PMID: 25574029; PMCID: PMC4380077.
      Citations: 50     Fields:    Translation:HumansAnimals
    48. Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP. Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation. PLoS Genet. 2014 Oct; 10(10):e1004604. PMID: 25356765; PMCID: PMC4214600.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    49. van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJ, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, Seidman C, Seidman JG, Christoffels VM, Nobrega MA, Barnett P, Moskowitz IP. A common genetic variant within SCN10A modulates cardiac SCN5A expression. J Clin Invest. 2014 Apr; 124(4):1844-52. PMID: 24642470; PMCID: PMC3973109.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    50. Xie L, Hoffmann AD, Burnicka-Turek O, Friedland-Little JM, Zhang K, Moskowitz IP. Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation. Dev Cell. 2012 Aug 14; 23(2):280-91. PMID: 22898775; PMCID: PMC3912192.
      Citations: 80     Fields:    Translation:Cells
    51. Arnolds DE, Liu F, Fahrenbach JP, Kim GH, Schillinger KJ, Smemo S, McNally EM, Nobrega MA, Patel VV, Moskowitz IP. TBX5 drives Scn5a expression to regulate cardiac conduction system function. J Clin Invest. 2012 Jul; 122(7):2509-18. PMID: 22728936; PMCID: PMC3386825.
      Citations: 75     Fields:    Translation:AnimalsCells
    52. Smemo S, Campos LC, Moskowitz IP, Pereira AC, Nobrega MA, Krieger JE. Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease. Hum Mol Genet. 2012 Jul 15; 21(14):3255-63. PMID: 22543974; PMCID: PMC3384386.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    53. Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J. Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction. J Mol Cell Cardiol. 2012 Mar; 52(3):638-49. PMID: 22155005; PMCID: PMC3294171.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    54. Arnolds DE, Moskowitz IP. Inducible recombination in the cardiac conduction system of minK: CreERT² BAC transgenic mice. Genesis. 2011 Nov; 49(11):878-84. PMID: 21504046.
      Citations: 14     Fields:    Translation:AnimalsCells
    55. Friedland-Little JM, Hoffmann AD, Ocbina PJ, Peterson MA, Bosman JD, Chen Y, Cheng SY, Anderson KV, Moskowitz IP. A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus. Hum Mol Genet. 2011 Oct 01; 20(19):3725-37. PMID: 21653639; PMCID: PMC3168284.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    56. Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J. Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects. PLoS One. 2011; 6(6):e20803. PMID: 21677783; PMCID: PMC3108998.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    57. Wang J, Chen L, Wen S, Zhu H, Yu W, Moskowitz IP, Shaw GM, Finnell RH, Schwartz RJ. Defective sumoylation pathway directs congenital heart disease. Birth Defects Res A Clin Mol Teratol. 2011 Jun; 91(6):468-76. PMID: 21563299; PMCID: PMC5031480.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    58. Ocbina PJ, Eggenschwiler JT, Moskowitz I, Anderson KV. Complex interactions between genes controlling trafficking in primary cilia. Nat Genet. 2011 Jun; 43(6):547-53. PMID: 21552265; PMCID: PMC3132150.
      Citations: 113     Fields:    Translation:AnimalsCells
    59. Arnolds DE, Chu A, McNally EM, Nobrega MA, Moskowitz IP. The emerging genetic landscape underlying cardiac conduction system function. Birth Defects Res A Clin Mol Teratol. 2011 Jun; 91(6):578-85. PMID: 21538814; PMCID: PMC4839955.
      Citations: 11     Fields:    Translation:HumansAnimals
    60. Moskowitz IP, Wang J, Peterson MA, Pu WT, Mackinnon AC, Oxburgh L, Chu GC, Sarkar M, Berul C, Smoot L, Robertson EJ, Schwartz R, Seidman JG, Seidman CE. Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4006-11. PMID: 21330551; PMCID: PMC3053967.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    61. Shah MY, Vasanthakumar A, Barnes NY, Figueroa ME, Kamp A, Hendrick C, Ostler KR, Davis EM, Lin S, Anastasi J, Le Beau MM, Moskowitz IP, Melnick A, Pytel P, Godley LA. DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Res. 2010 Jul 15; 70(14):5840-50. PMID: 20587527; PMCID: PMC2905468.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    62. Kamp A, Peterson MA, Svenson KL, Bjork BC, Hentges KE, Rajapaksha TW, Moran J, Justice MJ, Seidman JG, Seidman CE, Moskowitz IP, Beier DR. Genome-wide identification of mouse congenital heart disease loci. Hum Mol Genet. 2010 Aug 15; 19(16):3105-13. PMID: 20511334; PMCID: PMC2908466.
      Citations: 14     Fields:    Translation:HumansAnimals
    63. Dellefave LM, Pytel P, Mewborn S, Mora B, Guris DL, Fedson S, Waggoner D, Moskowitz I, McNally EM. Sarcomere mutations in cardiomyopathy with left ventricular hypertrabeculation. Circ Cardiovasc Genet. 2009 Oct; 2(5):442-9. PMID: 20031619.
      Citations: 38     Fields:    Translation:HumansCellsCTClinical Trials
    64. Hoffmann AD, Peterson MA, Friedland-Little JM, Anderson SA, Moskowitz IP. sonic hedgehog is required in pulmonary endoderm for atrial septation. Development. 2009 May; 136(10):1761-70. PMID: 19369393; PMCID: PMC2673765.
      Citations: 71     Fields:    Translation:AnimalsCells
    65. Boles MK, Wilkinson BM, Maxwell A, Lai L, Mills AA, Nishijima I, Salinger AP, Moskowitz I, Hirschi KK, Liu B, Bradley A, Justice MJ. A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines. BMC Genet. 2009 Mar 06; 10:12. PMID: 19267930; PMCID: PMC2670824.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    66. King JC, Moskowitz IP, Burgon PG, Ahmad F, Stone JR, Seidman JG, Lees JA. E2F3 plays an essential role in cardiac development and function. Cell Cycle. 2008 Dec; 7(23):3775-80. PMID: 19029823; PMCID: PMC2723769.
      Citations: 15     Fields:    Translation:Animals
    67. Pytel P, Husain A, Moskowitz I, Raman J, MacLeod H, Anderson AS, Burke M, McNally EM. Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy. Cardiovasc Pathol. 2010 Mar-Apr; 19(2):e33-6. PMID: 19026577; PMCID: PMC2840612.
      Citations: 3     Fields:    Translation:Humans
    68. Ahmad F, Banerjee SK, Lage ML, Huang XN, Smith SH, Saba S, Rager J, Conner DA, Janczewski AM, Tobita K, Tinney JP, Moskowitz IP, Perez-Atayde AR, Keller BB, Mathier MA, Shroff SG, Seidman CE, Seidman JG. The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy. PLoS One. 2008 Jul 09; 3(7):e2642. PMID: 18612386; PMCID: PMC2441440.
      Citations: 35     Fields:    Translation:Animals
    69. Moskowitz IP, Kim JB, Moore ML, Wolf CM, Peterson MA, Shendure J, Nobrega MA, Yokota Y, Berul C, Izumo S, Seidman JG, Seidman CE. A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell. 2007 Jun 29; 129(7):1365-76. PMID: 17604724.
      Citations: 134     Fields:    Translation:AnimalsCells
    70. Viswanathan S, Burch JB, Fishman GI, Moskowitz IP, Benson DW. Characterization of sinoatrial node in four conduction system marker mice. J Mol Cell Cardiol. 2007 May; 42(5):946-53. PMID: 17459410; PMCID: PMC1936434.
      Citations: 6     Fields:    Translation:Animals
    71. Stroud DM, Darrow BJ, Kim SD, Zhang J, Jongbloed MR, Rentschler S, Moskowitz IP, Seidman J, Fishman GI. Complex genomic rearrangement in CCS-LacZ transgenic mice. Genesis. 2007 Feb; 45(2):76-82. PMID: 17269130; PMCID: PMC3635834.
      Citations: 8     Fields:    Translation:Animals
    72. Feng Y, Chen MH, Moskowitz IP, Mendonza AM, Vidali L, Nakamura F, Kwiatkowski DJ, Walsh CA. Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19836-41. PMID: 17172441; PMCID: PMC1702530.
      Citations: 159     Fields:    Translation:AnimalsCells
    73. Aru GM, Juraszek A, Moskowitz I, Van Praagh R. Tetralogy of Fallot with congenital aortic valvar stenosis: the tetralogy-truncus interrelationship. Pediatr Cardiol. 2006 May-Jun; 27(3):354-9. PMID: 16565907.
      Citations: 4     Fields:    Translation:Humans
    74. Wolf CM, Moskowitz IP, Arno S, Branco DM, Semsarian C, Bernstein SA, Peterson M, Maida M, Morley GE, Fishman G, Berul CI, Seidman CE, Seidman JG. Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18123-8. PMID: 16332958; PMCID: PMC1307513.
      Citations: 41     Fields:    Translation:AnimalsCells
    75. Kontani K, Moskowitz IP, Rothman JH. Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex. Dev Cell. 2005 May; 8(5):787-94. PMID: 15866168.
      Citations: 23     Fields:    Translation:Animals
    76. Moskowitz IP, Pizard A, Patel VV, Bruneau BG, Kim JB, Kupershmidt S, Roden D, Berul CI, Seidman CE, Seidman JG. The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development. 2004 Aug; 131(16):4107-16. PMID: 15289437.
      Citations: 91     Fields:    Translation:Animals
    77. Wakimoto H, Kasahara H, Maguire CT, Moskowitz IP, Izumo S, Berul CI. Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice. Genesis. 2003 Nov; 37(3):144-50. PMID: 14595838.
      Citations: 4     Fields:    Translation:AnimalsCells
    78. Patel VV, Arad M, Moskowitz IP, Maguire CT, Branco D, Seidman JG, Seidman CE, Berul CI. Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome. J Am Coll Cardiol. 2003 Sep 03; 42(5):942-51. PMID: 12957447.
      Citations: 21     Fields:    Translation:Animals
    79. Arad M, Moskowitz IP, Patel VV, Ahmad F, Perez-Atayde AR, Sawyer DB, Walter M, Li GH, Burgon PG, Maguire CT, Stapleton D, Schmitt JP, Guo XX, Pizard A, Kupershmidt S, Roden DM, Berul CI, Seidman CE, Seidman JG. Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Circulation. 2003 Jun 10; 107(22):2850-6. PMID: 12782567.
      Citations: 97     Fields:    Translation:HumansAnimals
    80. Laufs H, Nigrovic PA, Schneider LC, Oettgen H, Del NP, Moskowitz IP, Blume E, Perez-Atayde AR. Giant cell myocarditis in a 12-year-old girl with common variable immunodeficiency. Mayo Clin Proc. 2002 Jan; 77(1):92-6. PMID: 11795251.
      Citations: 9     Fields:    Translation:HumansCells
    81. Berul CI, McConnell BK, Wakimoto H, Moskowitz IP, Maguire CT, Semsarian C, Vargas MM, Gehrmann J, Seidman CE, Seidman JG. Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene. Circulation. 2001 Nov 27; 104(22):2734-9. PMID: 11723028.
      Citations: 18     Fields:    Translation:Animals
    82. McConnell BK, Fatkin D, Semsarian C, Jones KA, Georgakopoulos D, Maguire CT, Healey MJ, Mudd JO, Moskowitz IP, Conner DA, Giewat M, Wakimoto H, Berul CI, Schoen FJ, Kass DA, Seidman CE, Seidman JG. Comparison of two murine models of familial hypertrophic cardiomyopathy. Circ Res. 2001 Mar 02; 88(4):383-9. PMID: 11230104.
      Citations: 48     Fields:    Translation:AnimalsCells
    83. Moskowitz IP, Gaynon PS, Shahidi NT, Cripe TP. Low-dose cyclosporin A therapy in children with refractory immune thrombocytopenic purpura. J Pediatr Hematol Oncol. 1999 Jan-Feb; 21(1):77-9. PMID: 10029820.
      Citations: 2     Fields:    Translation:Humans
    84. Moskowitz IP, Rothman JH. lin-12 and glp-1 are required zygotically for early embryonic cellular interactions and are regulated by maternal GLP-1 signaling in Caenorhabditis elegans. Development. 1996 Dec; 122(12):4105-17. PMID: 9012530.
      Citations: 25     Fields:    Translation:AnimalsCells
    85. Gendreau SB, Moskowitz IP, Terns RM, Rothman JH. The potential to differentiate epidermis is unequally distributed in the AB lineage during early embryonic development in C. elegans. Dev Biol. 1994 Dec; 166(2):770-81. PMID: 7813794.
      Citations: 7     Fields:    Translation:Animals
    86. Moskowitz IP, Gendreau SB, Rothman JH. Combinatorial specification of blastomere identity by glp-1-dependent cellular interactions in the nematode Caenorhabditis elegans. Development. 1994 Nov; 120(11):3325-38. PMID: 7720570.
      Citations: 16     Fields:    Translation:AnimalsCells
    87. Heichman KA, Moskowitz IP, Johnson RC. Configuration of DNA strands and mechanism of strand exchange in the Hin invertasome as revealed by analysis of recombinant knots. Genes Dev. 1991 Sep; 5(9):1622-34. PMID: 1885004.
      Citations: 29     Fields:    Translation:Cells
    88. Moskowitz IP, Heichman KA, Johnson RC. Alignment of recombination sites in Hin-mediated site-specific DNA recombination. Genes Dev. 1991 Sep; 5(9):1635-45. PMID: 1885005.
      Citations: 14     Fields:    Translation:Cells
    89. FOX MJ, MOSKOWITZ I. Hysteria in poliomyelitis. Wis Med J. 1953 Jun; 52(6):313-6. PMID: 13078619.
      Citations:    Fields:    Translation:Humans
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