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Le Shen

TitleResearch Associate Professor
InstitutionUniversity of Chicago
DepartmentSurgery-General Surgery
AddressChicago IL 60637
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    Collapse Biography 
    Collapse education and training
    Peking University Health Science Center, Beijing, ChinaM.B. (M.D. equivalent)07/1998Basic Medicine
    The University of Chicago, ChicagoPh.D.12/2005Pathology
    The University of Chicago, ChicagoPost-doc03/2011Intestinal Pathophysiology

    Collapse Research 
    Collapse research activities and funding
    R21DE032833     (IZUMCHENKO, EVGENY (EUGENE) G)Aug 1, 2023 - Jul 31, 2025
    NIH
    PDCD10 as a novel driver for head and neck squamous cell carcinoma development
    Role: Co-Principal Investigator
    K01DK092381     (SHEN, LE)Jul 1, 2012 - Jun 30, 2017
    NIH
    Contribution of occludin to intestinal homeostasis and disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Olivas AD, Ngai PCM, Schahrer E, Olortegui KS, Cursio JF, Akiyama S, Chang EB, Shen L, Umanskiy K, Rubin DT, Zemmour D, Weber CR, Olivas AD, Ngai PCM, Schahrer E, Olortegui KS, Cursio JF, Akiyama S, Chang EB, Shen L, Umanskiy K, Rubin DT, Zemmour D, Weber CR. Histopathologic Evaluation and Single-Cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients with Inflammatory Bowel Disease. bioRxiv. 2025 Jan 28. PMID: 39974918; PMCID: PMC11838289.
      Citations:    
    2. Mishra V, Singh A, Korzinkin M, Cheng X, Wing C, Sarkisova V, Koppayi AL, Pogorelskaya A, Glushchenko O, Sundaresan M, Thodima V, Carter J, Ito K, Scherle P, Trzcinska A, Ozerov I, Vokes EE, Cole G, Pun FW, Shen L, Miao Y, Pearson AT, Lingen MW, Ruggeri B, Rosenberg AJ, Zhavoronkov A, Agrawal N, Izumchenko E. PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands. J Exp Clin Cancer Res. 2025 Jan 11; 44(1):11. PMID: 39794830; PMCID: PMC11724466.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Ambrosino CM, Shen LL, Mahjoub H, Memon W, Zhang SX, Breazzano MP. Povidone-iodine in vitro antiseptic efficacy as a function of exposure duration, concentration, preparation, and length of storage. Graefes Arch Clin Exp Ophthalmol. 2024 Dec; 262(12):4005-4012. PMID: 38969776.
      Citations:    Fields:    Translation:HumansCells
    4. Cyberski TF, Singh A, Korzinkin M, Mishra V, Pun F, Shen L, Wing C, Cheng X, Baird B, Miao Y, Elkabets M, Kochanny S, Guo W, Dyer E, Pearson AT, Juloori A, Lingen M, Cole G, Zhavoronkov A, Agrawal N, Izumchenko E, Rosenberg AJ. Acquired resistance to immunotherapy and chemoradiation in MYC amplified head and neck cancer. NPJ Precis Oncol. 2024 May 23; 8(1):114. PMID: 38783041; PMCID: PMC11116544.
      Citations: 5     
    5. Song S, Mohsin E, Zhang R, Kuznetsov A, Shen L, Grossman RL, Weber CR, Khan AA. ATAT: Automated Tissue Alignment and Traversal in Spatial Transcriptomics with Self-Supervised Learning. bioRxiv. 2023 Dec 10. PMID: 38106010; PMCID: PMC10723486.
      Citations:    
    6. Zhang D, Kinloch AJ, Srinath A, Shenkar R, Girard R, Lightle R, Moore T, Koskimäki J, Mohsin A, Carrión-Penagos J, Romanos S, Shen L, Clark MR, Shi C, Awad IA. Corrigendum to "Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu" [J. Autoimmun. 113 (2020) 102469]. J Autoimmun. 2023 Nov; 140:103116. PMID: 37748978; PMCID: PMC10959760.
      Citations:    Fields:    
    7. Srinath A, Xie B, Li Y, Sone JY, Romanos S, Chen C, Sharma A, Polster S, Dorrestein PC, Weldon KC, DeBiasse D, Moore T, Lightle R, Zhang D, Stadnik A, Piedad K, Hagan M, Shkoukani A, Bi D, Shen L, Shenkar R, Ji Y, Sidebottom A, Pamer E, Gilbert JA, Kahn ML, D'Souza M, Sulakhe D, Awad IA, Girard R, Koskimäki J, Carrión-Penagos J. Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma. Commun Med (Lond). 2023 Mar 03; 3(1):35. PMID: 36869161; PMCID: PMC9984539.
      Citations: 5     
    8. Matthews JM, Schuster B, Kashaf SS, Liu P, Ben-Yishay R, Ishay-Ronen D, Izumchenko E, Shen L, Weber CR, Bielski M, Kupfer SS, Bilgic M, Rzhetsky A, Tay S. OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics. PLoS Comput Biol. 2022 11; 18(11):e1010584. PMID: 36350878; PMCID: PMC9645660.
      Citations: 43     Fields:    
    9. Fuladi S, McGuinness S, Shen L, Weber CR, Khalili-Araghi F. Molecular mechanism of claudin-15 strand flexibility: A computational study. J Gen Physiol. 2022 12 05; 154(12). PMID: 36318156; PMCID: PMC9629798.
      Citations: 11     Fields:    Translation:Cells
    10. Romanos SG, Srinath A, Li Y, Xie B, Chen C, Li Y, Moore T, Bi D, Sone JY, Lightle R, Hobson N, Zhang D, Shen L, McCurdy S, Lai CC, Stadnik A, Piedad K, Shkoukani A, Snellings D, Shenkar R, Sulakhe D, Ji Y, Lopez-Ramirez MA, Kahn ML, Marchuk DA, Ginsberg MH, Girard R, Awad IA, Koskimäki J, Carrión-Penagos J. Circulating Plasma miRNA Homologs in Mice and Humans Reflect Familial Cerebral Cavernous Malformation Disease. Transl Stroke Res. 2023 08; 14(4):513-529. PMID: 35715588; PMCID: PMC9758276.
      Citations: 1     Fields:    Translation:HumansAnimals
    11. Wagstaff W, Mwamba RN, Grullon K, Armstrong M, Zhao P, Hendren-Santiago B, Qin KH, Li AJ, Hu DA, Youssef A, Reid RR, Luu HH, Shen L, He TC, Haydon RC. Melanoma: Molecular genetics, metastasis, targeted therapies, immunotherapies, and therapeutic resistance. Genes Dis. 2022 Nov; 9(6):1608-1623. PMID: 36157497; PMCID: PMC9485270.
      Citations: 26     
    12. He F, Ni N, Wang H, Zeng Z, Zhao P, Shi D, Xia Y, Chen C, Hu DA, Qin KH, Wagstaff W, Qin D, Hendren-Santiago B, Ho SH, Haydon RC, Luu HH, Reid RR, Shen L, Gan H, Fan J, He TC. OUHP: an optimized universal hairpin primer system for cost-effective and high-throughput RT-qPCR-based quantification of microRNA (miRNA) expression. Nucleic Acids Res. 2022 02 28; 50(4):e22. PMID: 34850128; PMCID: PMC8887422.
      Citations: 9     Fields:    
    13. Zhong J, Wang H, Yang K, Wang H, Duan C, Ni N, An L, Luo Y, Zhao P, Gou Y, Sheng S, Shi D, Chen C, Wagstaff W, Hendren-Santiago B, Haydon RC, Luu HH, Reid RR, Ho SH, Ameer GA, Shen L, He TC, Fan J. Reversibly immortalized keratinocytes (iKera) facilitate re-epithelization and skin wound healing: Potential applications in cell-based skin tissue engineering. Bioact Mater. 2022 Mar; 9:523-540. PMID: 34820586; PMCID: PMC8581279.
      Citations: 24     
    14. Broner EC, Trujillo JA, Korzinkin M, Subbannayya T, Agrawal N, Ozerov IV, Zhavoronkov A, Rooper L, Kotlov N, Shen L, Pearson AT, Rosenberg AJ, Savage PA, Mishra V, Chatterjee A, Sidransky D, Izumchenko E. Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma. Front Oncol. 2021; 11:677051. PMID: 34336664; PMCID: PMC8323482.
      Citations: 13     
    15. Huang L, Zhao L, Zhang J, He F, Wang H, Liu Q, Shi D, Ni N, Wagstaff W, Chen C, Reid RR, Haydon RC, Luu HH, Shen L, He TC, Tang L. Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways. Aging (Albany NY). 2021 07 07; 13(13):17407-17427. PMID: 34232919; PMCID: PMC8312413.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    16. Nguyen T, Zheng M, Knapp M, Sladojevic N, Zhang Q, Ai L, Harrison D, Chen A, Sitikov A, Shen L, Gonzalez FJ, Zhao Q, Fang Y, Liao JJK, Wu R. Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice With Type 2 Diabetes Mellitus. Front Cell Dev Biol. 2021; 9:691801. PMID: 34179020; PMCID: PMC8222825.
      Citations: 3     
    17. Zhao X, Huang B, Wang H, Ni N, He F, Liu Q, Shi D, Chen C, Zhao P, Wang X, Wagstaff W, Pakvasa M, Tucker AB, Lee MJ, Wolf JM, Reid RR, Hynes K, Strelzow J, Ho SH, Yu T, Yang J, Shen L, He TC, Zhang Y. A functional autophagy pathway is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs). Am J Transl Res. 2021; 13(5):4233-4250. PMID: 34150011; PMCID: PMC8205769.
      Citations: 9     
    18. Mao Y, Ni N, Huang L, Fan J, Wang H, He F, Liu Q, Shi D, Fu K, Pakvasa M, Wagstaff W, Tucker AB, Chen C, Reid RR, Haydon RC, Ho SH, Lee MJ, He TC, Yang J, Shen L, Cai L, Luu HH. Argonaute (AGO) proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells (MSCs). Genes Dis. 2021 Nov; 8(6):918-930. PMID: 34522718; PMCID: PMC8427325.
      Citations: 13     
    19. Zhao L, Huang L, Zhang J, Fan J, He F, Zhao X, Wang H, Liu Q, Shi D, Ni N, Wagstaff W, Pakvasa M, Fu K, Tucker AB, Chen C, Reid RR, Haydon RC, Luu HH, Shen L, Qi H, He TC. The inhibition of BRAF activity sensitizes chemoresistant human ovarian cancer cells to paclitaxel-induced cytotoxicity and tumor growth inhibition. Am J Transl Res. 2020; 12(12):8084-8098. PMID: 33437383; PMCID: PMC7791515.
      Citations: 8     
    20. Detter MR, Shenkar R, Benavides CR, Neilson CA, Moore T, Lightle R, Hobson N, Shen L, Cao Y, Girard R, Zhang D, Griffin E, Gallione CJ, Awad IA, Marchuk DA. Novel Murine Models of Cerebral Cavernous Malformations. Angiogenesis. 2020 11; 23(4):651-666. PMID: 32710309; PMCID: PMC7530029.
      Citations: 29     Fields:    Translation:Animals
    21. Hou Q, Dong Y, Yu Q, Wang B, Le S, Guo Y, Zhang B. Regulation of the Paneth cell niche by exogenous L-arginine couples the intestinal stem cell function. FASEB J. 2020 08; 34(8):10299-10315. PMID: 32725957.
      Citations: 11     Fields:    Translation:AnimalsCells
    22. Polster SP, Sharma A, Tanes C, Tang AT, Mericko P, Cao Y, Girard R, Zhang D, Stadnik A, Romanos SG, Shenkar R, Yan K, Lee C, Akers A, Morrison L, Robinson M, Zafar A, Bittinger K, Kim H, Gilbert JA, Kahn ML, Shen L, Awad IA, Carrión-Penagos J, Koskimäki J, Lyne SB. Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma. Nat Commun. 2020 05 27; 11(1):2659. PMID: 32461638; PMCID: PMC7253448.
      Citations: 18     Fields:    Translation:Humans
    23. Zhang D, Kinloch AJ, Srinath A, Shenkar R, Girard R, Lightle R, Moore T, Mohsin A, Romanos S, Shen L, Clark MR, Shi C, Awad IA, Koskimäki J, Carrión-Penagos J. Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu. J Autoimmun. 2020 09; 113:102469. PMID: 32362501; PMCID: PMC7483292.
      Citations: 7     Fields:    Translation:HumansCells
    24. Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CR. ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Circ Res. 2020 07 03; 127(2):e28-e43. PMID: 32347164; PMCID: PMC7334106.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    25. Zou J, Li Y, Yu J, Dong L, Husain AN, Shen L, Weber CR. Idiopathic pulmonary fibrosis is associated with tight junction protein alterations. Biochim Biophys Acta Biomembr. 2020 05 01; 1862(5):183205. PMID: 32001212.
      Citations: 24     Fields:    Translation:HumansCells
    26. Fuladi S, Jannat RW, Shen L, Weber CR, Khalili-Araghi F. Computational Modeling of Claudin Structure and Function. Int J Mol Sci. 2020 Jan 23; 21(3). PMID: 31979311; PMCID: PMC7037046.
      Citations: 11     Fields:    Translation:AnimalsCells
    27. Wei S, Li Y, Polster SP, Weber CR, Awad IA, Shen L. Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation. Int J Mol Sci. 2020 Jan 20; 21(2). PMID: 31968585; PMCID: PMC7013531.
      Citations: 12     Fields:    Translation:HumansCells
    28. Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML, Schwaninger M, Rödel CJ. Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. Sci Transl Med. 2019 11 27; 11(520). PMID: 31776290; PMCID: PMC6937779.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    29. Zhang D, Li Y, Saadat L, Moore T, Lightle R, Polster SP, Zeineddine HA, Shi C, Shenkar R, Romanos S, Avner K, Srinath A, Shen L, Detter MR, Snellings D, Cao Y, Lopez-Ramirez MA, Fonseca G, Tang AT, Faber P, Andrade J, Ginsberg M, Kahn ML, Marchuk DA, Girard R, Awad IA, Koskimäki J, Carrión-Penagos J, Lyne SB. Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations. Acta Neuropathol Commun. 2019 08 19; 7(1):132. PMID: 31426861; PMCID: PMC6699077.
      Citations: 28     Fields:    Translation:AnimalsCells
    30. Kuo WT, Shen L, Zuo L, Shashikanth N, Ong MLDM, Wu L, Zha J, Edelblum KL, Wang Y, Wang Y, Nilsen SP, Turner JR. Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression. Gastroenterology. 2019 11; 157(5):1323-1337. PMID: 31401143; PMCID: PMC6815722.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    31. Dai W, Laforest B, Tyan L, Shen KM, Nadadur RD, Alvarado FJ, Mazurek SR, Lazarevic S, Gadek M, Wang Y, Li Y, Valdivia HH, Shen L, Broman MT, Moskowitz IP, Weber CR. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. Elife. 2019 03 21; 8. PMID: 30896405; PMCID: PMC6428569.
      Citations: 20     Fields:    Translation:AnimalsCells
    32. Wang Y, Li Y, Zou J, Polster SP, Lightle R, Moore T, Dimaano M, He TC, Weber CR, Awad IA, Shen L. The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation. FASEB J. 2019 02; 33(2):2132-2143. PMID: 30252535; PMCID: PMC6338648.
      Citations: 11     Fields:    Translation:HumansCells
    33. Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JR. The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. J Biol Chem. 2018 11 09; 293(45):17317-17335. PMID: 30242130; PMCID: PMC6231134.
      Citations: 51     Fields:    Translation:AnimalsCells
    34. Zeineddine HA, Girard R, Saadat L, Shen L, Lightle R, Moore T, Cao Y, Hobson N, Shenkar R, Avner K, Chaudager K, Polster SP, Fam MD, Shi C, Lopez-Ramirez MA, Tang AT, Gallione C, Kahn ML, Ginsberg M, Marchuk DA, Awad IA, Koskimäki J. Phenotypic characterization of murine models of cerebral cavernous malformations. Lab Invest. 2019 03; 99(3):319-330. PMID: 29946133; PMCID: PMC6309944.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    35. Samanta P, Wang Y, Fuladi S, Zou J, Li Y, Shen L, Weber C, Khalili-Araghi F. Molecular determination of claudin-15 organization and channel selectivity. J Gen Physiol. 2018 07 02; 150(7):949-968. PMID: 29915162; PMCID: PMC6028499.
      Citations: 28     Fields:    Translation:AnimalsCells
    36. Tsai PY, Zhang B, He WQ, Zha JM, Odenwald MA, Singh G, Tamura A, Shen L, Sailer A, Yeruva S, Kuo WT, Fu YX, Tsukita S, Turner JR. IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance. Cell Host Microbe. 2017 Jun 14; 21(6):671-681.e4. PMID: 28618266; PMCID: PMC5541253.
      Citations: 122     Fields:    Translation:AnimalsCells
    37. Girard R, Zeineddine HA, Orsbon C, Tan H, Moore T, Hobson N, Shenkar R, Lightle R, Shi C, Fam MD, Cao Y, Shen L, Neander AI, Rorrer A, Gallione C, Tang AT, Kahn ML, Marchuk DA, Luo ZX, Awad IA. Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease. J Neurosci Methods. 2016 09 15; 271:14-24. PMID: 27345427; PMCID: PMC5003657.
      Citations: 19     Fields:    Translation:Animals
    38. Zhang Q, Huang L, Chang Q, Shi W, Shen L, Chen Q. Gravure-printed interdigital microsupercapacitors on a flexible polyimide substrate using crumpled graphene ink. Nanotechnology. 2016 Mar 11; 27(10):105401. PMID: 26861615.
      Citations: 2     Fields:    
    39. Mir H, Meena AS, Chaudhry KK, Shukla PK, Gangwar R, Manda B, Padala MK, Shen L, Turner JR, Dietrich P, Dragatsis I, Rao R. Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice. Biochim Biophys Acta. 2016 Apr; 1860(4):765-74. PMID: 26721332; PMCID: PMC4776745.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    40. Weber CR, Liang GH, Wang Y, Das S, Shen L, Yu AS, Nelson DJ, Turner JR. Claudin-2-dependent paracellular channels are dynamically gated. Elife. 2015 Nov 14; 4:e09906. PMID: 26568313; PMCID: PMC4755754.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    41. Pan J, Zhang L, Odenwald MA, Shen L, Turner JR, Bergelson JM. Expression of human decay-accelerating factor on intestinal epithelium of transgenic mice does not facilitate infection by the enteral route. J Virol. 2015 Apr; 89(8):4311-8. PMID: 25653430; PMCID: PMC4442383.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    42. Turner JR, Buschmann MM, Romero-Calvo I, Sailer A, Shen L. The role of molecular remodeling in differential regulation of tight junction permeability. Semin Cell Dev Biol. 2014 Dec; 36:204-12. PMID: 25263012; PMCID: PMC4253049.
      Citations: 104     Fields:    Translation:HumansCells
    43. Glotfelty LG, Zahs A, Iancu C, Shen L, Hecht GA. Microtubules are required for efficient epithelial tight junction homeostasis and restoration. Am J Physiol Cell Physiol. 2014 Aug 01; 307(3):C245-54. PMID: 24920678; PMCID: PMC4121580.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    44. Ma K, Malhotra P, Soni V, Hedroug O, Annaba F, Dudeja A, Shen L, Turner JR, Khramtsova EA, Saksena S, Dudeja PK, Gill RK, Alrefai WA. Overactivation of intestinal SREBP2 in mice increases serum cholesterol. PLoS One. 2014; 9(1):e84221. PMID: 24465397; PMCID: PMC3896331.
      Citations: 22     Fields:    Translation:Animals
    45. Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley EM, Breskin LA, Wu L, Anderson K, Turner JR, Weber CR. Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. Mol Biol Cell. 2013 Oct; 24(19):3056-68. PMID: 23924897; PMCID: PMC3784380.
      Citations: 100     Fields:    Translation:HumansCells
    46. Su L, Nalle SC, Shen L, Turner ES, Singh G, Breskin LA, Khramtsova EA, Khramtsova G, Tsai PY, Fu YX, Abraham C, Turner JR. TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology. 2013 Aug; 145(2):407-15. PMID: 23619146; PMCID: PMC3722284.
      Citations: 178     Fields:    Translation:AnimalsCells
    47. Davis JM, Hyjek E, Husain AN, Shen L, Jones J, Schuger LA. Lymphatic endothelial differentiation in pulmonary lymphangioleiomyomatosis cells. J Histochem Cytochem. 2013 Aug; 61(8):580-90. PMID: 23609227; PMCID: PMC3724387.
      Citations: 12     Fields:    Translation:Humans
    48. Bouyer PG, Tang X, Weber CR, Shen L, Turner JR, Matthews JB. Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15; 304(2):G142-56. PMID: 23139219; PMCID: PMC3543646.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    49. Shen L. Tight junctions on the move: molecular mechanisms for epithelial barrier regulation. Ann N Y Acad Sci. 2012 Jul; 1258:9-18. PMID: 22731710; PMCID: PMC3690943.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    50. Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR. Dynamic migration of ?d intraepithelial lymphocytes requires occludin. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):7097-102. PMID: 22511722; PMCID: PMC3345021.
      Citations: 100     Fields:    Translation:AnimalsCells
    51. Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JR. Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol. 2011 May 02; 193(3):565-82. PMID: 21536752; PMCID: PMC3087007.
      Citations: 127     Fields:    Translation:HumansCells
    52. Marchiando AM, Shen L, Graham WV, Edelblum KL, Duckworth CA, Guan Y, Montrose MH, Turner JR, Watson AJ. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology. 2011 Apr; 140(4):1208-1218.e1-2. PMID: 21237166; PMCID: PMC3066304.
      Citations: 146     Fields:    Translation:AnimalsCells
    53. Shen L, Weber CR, Raleigh DR, Yu D, Turner JR. Tight junction pore and leak pathways: a dynamic duo. Annu Rev Physiol. 2011; 73:283-309. PMID: 20936941; PMCID: PMC4655434.
      Citations: 415     Fields:    Translation:HumansAnimalsCells
    54. Yu D, Marchiando AM, Weber CR, Raleigh DR, Wang Y, Shen L, Turner JR. MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8237-41. PMID: 20404178; PMCID: PMC2889526.
      Citations: 135     Fields:    Translation:HumansAnimalsCells
    55. Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JR. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J Cell Biol. 2010 Apr 05; 189(1):111-26. PMID: 20351069; PMCID: PMC2854371.
      Citations: 269     Fields:    Translation:AnimalsCells
    56. Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J Biol Chem. 2010 Apr 16; 285(16):12037-46. PMID: 20177070; PMCID: PMC2852941.
      Citations: 166     Fields:    Translation:HumansAnimalsCells
    57. Raleigh DR, Marchiando AM, Zhang Y, Shen L, Sasaki H, Wang Y, Long M, Turner JR. Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Mol Biol Cell. 2010 Apr 01; 21(7):1200-13. PMID: 20164257; PMCID: PMC2847524.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    58. Shen L, Su L, Turner JR. Mechanisms and functional implications of intestinal barrier defects. Dig Dis. 2009; 27(4):443-9. PMID: 19897958; PMCID: PMC2814011.
      Citations: 61     Fields:    Translation:HumansCells
    59. Mykoniatis A, Shen L, Fedor-Chaiken M, Tang J, Tang X, Worrell RT, Delpire E, Turner JR, Matlin KS, Bouyer P, Matthews JB. Phorbol 12-myristate 13-acetate-induced endocytosis of the Na-K-2Cl cotransporter in MDCK cells is associated with a clathrin-dependent pathway. Am J Physiol Cell Physiol. 2010 Jan; 298(1):C85-97. PMID: 19864322; PMCID: PMC2806153.
      Citations: 12     Fields:    Translation:AnimalsCells
    60. Graham WV, Marchiando AM, Shen L, Turner JR. No static at all. Ann N Y Acad Sci. 2009 May; 1165:314-22. PMID: 19538322; PMCID: PMC2768559.
      Citations: 2     Fields:    
    61. Shen L. Functional morphology of the gastrointestinal tract. Curr Top Microbiol Immunol. 2009; 337:1-35. PMID: 19812978.
      Citations: 17     Fields:    Translation:HumansAnimals
    62. Shen L, Turner JR. Intercellular junctions: actin the PARt. Curr Biol. 2008 Nov 11; 18(21):R1014-7. PMID: 19000799.
      Citations: 3     Fields:    Translation:AnimalsCells
    63. Su L, Shen L, Clayburgh DR, Nalle SC, Sullivan EA, Meddings JB, Abraham C, Turner JR. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis. Gastroenterology. 2009 Feb; 136(2):551-63. PMID: 19027740; PMCID: PMC2712351.
      Citations: 206     Fields:    
    64. Gill RK, Shen L, Turner JR, Saksena S, Alrefai WA, Pant N, Esmaili A, Dwivedi A, Ramaswamy K, Dudeja PK. Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008 Oct; 295(4):G700-8. PMID: 18669621; PMCID: PMC2575920.
      Citations: 2     Fields:    Translation:HumansCells
    65. Shen L, Weber CR, Turner JR. The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. J Cell Biol. 2008 May 19; 181(4):683-95. PMID: 18474622; PMCID: PMC2386107.
      Citations: 175     Fields:    Translation:HumansAnimalsCells
    66. Schwarz BT, Wang F, Shen L, Clayburgh DR, Su L, Wang Y, Fu YX, Turner JR. LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology. 2007 Jun; 132(7):2383-94. PMID: 17570213; PMCID: PMC2709832.
      Citations: 90     Fields:    
    67. Shen L, Black ED, Witkowski ED, Lencer WI, Guerriero V, Schneeberger EE, Turner JR. Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J Cell Sci. 2006 May 15; 119(Pt 10):2095-106. PMID: 16638813.
      Citations: 185     Fields:    Translation:HumansCells
    68. Shen L, Turner JR. Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed. Am J Physiol Gastrointest Liver Physiol. 2006 Apr; 290(4):G577-82. PMID: 16537969.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    69. Wu L, Estrada O, Zaborina O, Bains M, Shen L, Kohler JE, Patel N, Musch MW, Chang EB, Fu YX, Jacobs MA, Nishimura MI, Hancock RE, Turner JR, Alverdy JC. Recognition of host immune activation by Pseudomonas aeruginosa. Science. 2005 Jul 29; 309(5735):774-7. PMID: 16051797.
      Citations: 142     Fields:    Translation:HumansAnimalsCells
    70. Shen L, Turner JR. Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. Mol Biol Cell. 2005 Sep; 16(9):3919-36. PMID: 15958494; PMCID: PMC1196308.
      Citations: 149     Fields:    Translation:AnimalsCells
    71. Russo JM, Florian P, Shen L, Graham WV, Tretiakova MS, Gitter AH, Mrsny RJ, Turner JR. Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure. Gastroenterology. 2005 Apr; 128(4):987-1001. PMID: 15825080; PMCID: PMC1237051.
      Citations: 60     Fields:    Translation:HumansCells
    72. Clayburgh DR, Shen L, Turner JR. A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest. 2004 Mar; 84(3):282-91. PMID: 14767487.
      Citations: 166     Fields:    Translation:HumansAnimalsCells
    73. Algeciras-Schimnich A, Shen L, Barnhart BC, Murmann AE, Burkhardt JK, Peter ME. Molecular ordering of the initial signaling events of CD95. Mol Cell Biol. 2002 Jan; 22(1):207-20. PMID: 11739735; PMCID: PMC134211.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
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