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Wei Du

InstitutionUniversity of Chicago
DepartmentBen May Department of Cancer Research
AddressChicago IL 60637
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    Collapse Overview 
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    Rb Tumor Suppressor, Control of Cell Proliferation and Differentiation

    1) Novel approaches to target the loss of tumor suppressors in cancers

    The success of cancer therapies generally depend on their ability to target certain unique requirements of the cancer cells that are distinct from those of the normal cells. Current targeted cancer therapies at different stages of development mostly focus on inhibiting the deregulated oncogenic pathways kinases in cancers. In addition to deregulated oncogenic activation, cancer cells also often have inactivation of tumor suppressors. However such knowledge has yet to be exploited to develop targeted cancer therapies due to a lack of approaches to restore the lost tumor suppressor function in all the cancer cells and a lack of knowledge about the genes that are synthetic lethal with the lost tumor suppressors. While it is possible to carry out genome-wide RNAi screen to identify genes that are synthetic lethal with Rb using cell culture assays, such screen will depend largely on the particular culture conditions and may or may not reflect the in vivo situations.

    Rb is a tumor suppressor that is often lost in cancers. Because the Rb/E2F pathway is highly conserved between flies and mammalian systems, we hypothesize that genes that are synthetic lethal with loss of Rb will be conserved between the two systems as well. In a genetic screen for genes that can modulate the consequences of Rb loss, we found that mutation of gig, the Drosophila TSC2 homolog, show synergistically increased cell death with loss of Rb. Interestingly, knockdown of TSC2 in human cancer cells blocks cancer cell growth and induced cell death dependent on the Rb status, suggesting that TSC2 can potentially be used to specifically target Rb mutant cancers.

    Research in the lab include further characterization of the mechanisms of synergistic cell death induction, identification of genes/pathways/chemical inhibitors that can enhance the specific cell death induction by TSC2 knockdown, developing assays to screen for small molecule inhibitors of TSC2 function, and carry out additional genetic screen to identify additional potential targets.

    2) Molecular mechanisms that coordinate the control of cell proliferation and differentiation during normal development

    We use the Drosophila developing eye as a model system to elucidate mechanisms by which developmental mechanisms coordinate cell proliferation and differentiation. In third instar eye discs, the morphogenetic furrow (MF), which is marked by an indentation in the eye disc, moves from posterior of the eye disc to the anterior. Cells anterior to the MF are asynchronously proliferating, which become cell cycle arrest in G1 in the MF. Photoreceptor differentiation initiates in the MF and the first photoreceptor determined is R8. R8 photoreceptor differentiation is controlled by the Atonal (Ato), a bHLH protein initially expressed in the MF and then restricted to the future R8 cells. Therefore one project in the lab is to elucidate the regulation of Ato expression, which is regulated by retinal determination genes and developmental signaling pathways.

    Cells in the MF and the differentiating photoreceptor clusters are arrested in G1. immediately posterior to the MF, cells not in the photoreceptor clusters undergo a synchronous round of cell cycle called second mitotic wave (SMW). Notch and EGFR signaling plays critical roles in controlling photoreceptor differentiation or cell proliferation. We are investigating the molecular mechanisms by which these developmental signaling pathways coordinate cell proliferation and differentiation.
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    Collapse Biography 
    Collapse education and training
    Fudan University, Shanghai, ChinaB.S.Biochemistry
    Harvard University, Cambridge, MAPh.D.Biochemistry and Molecular Biology
    Harvard Medical School/MGH Cancer Center, Boston, MApostdocMolecular Oncology
    Collapse awards and honors
    1998 - 2000Sydney Kimmel Scholar
    2003 - 2008Leukemia & Lymphoma Society Scholar
    2006 - 2008Cancer Research Foundation Fletcher Scholar

    Collapse Research 
    Collapse research activities and funding
    R01GM120046     (DU, WEI)Sep 8, 2016 - Aug 31, 2021
    Regulation of EGFR Signaling in the Drosophila development
    Role: Principal Investigator

    R01CA149275     (DU, WEI)Apr 1, 2011 - Mar 31, 2016
    A novel approach to target Rb mutant cancers
    Role: Principal Investigator

    R01GM074197     (DU, WEI)Feb 1, 2006 - Jun 30, 2015
    Control of Cell Proliferation and Differentiation in the Developing Retina
    Role: Principal Investigator

    R01CA080871     (DU, WEI)Aug 1, 1999 - Aug 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhang T, Hsu FN, Xie XJ, Li X, Liu M, Gao X, Pei X, Liao Y, Du W, Ji JY. Reversal of hyperactive Wnt signaling-dependent adipocyte defects by peptide boronic acids. Proc Natl Acad Sci U S A. 2017 09 05; 114(36):E7469-E7478. PMID: 28827348; PMCID: PMC5594642.
      Citations: 7     Fields:    Translation:AnimalsCells
    2. Zhang T, Sheng Z, Du W. Loss of histone deacetylase HDAC1 induces cell death in Drosophila epithelial cells through JNK and Hippo signaling. Mech Dev. 2016 08; 141:4-13. PMID: 27378074; PMCID: PMC4995152.
      Citations: 5     Fields:    Translation:AnimalsCells
    3. Sheng Z, Yu L, Zhang T, Pei X, Li X, Zhang Z, Du W. ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling. J Cell Sci. 2016 05 15; 129(10):2075-84. PMID: 27056762; PMCID: PMC4878992.
      Citations: 7     Fields:    Translation:AnimalsCells
    4. Wang CZ, Anderson S, DU W, He TC, Yuan CS. Red ginseng and cancer treatment. Chin J Nat Med. 2016 Jan; 14(1):7-16. PMID: 26850342.
      Citations: 61     Fields:    Translation:HumansAnimals
    5. Zhang T, Du W. Groucho restricts rhomboid expression and couples EGFR activation with R8 selection during Drosophila photoreceptor differentiation. Dev Biol. 2015 Nov 15; 407(2):246-55. PMID: 26417727; PMCID: PMC4663172.
      Citations: 8     Fields:    Translation:AnimalsCells
    6. Yu C, Wen XD, Zhang Z, Zhang CF, Wu X, He X, Liao Y, Wu N, Wang CZ, Du W, He TC, Yuan CS. American ginseng significantly reduced the progression of high-fat-diet-enhanced colon carcinogenesis in Apc (Min/+) mice. J Ginseng Res. 2015 Jul; 39(3):230-7. PMID: 26199554; PMCID: PMC4506368.
      Citations: 9     
    7. Zhang Z, Li Z, Wu X, Zhang CF, Calway T, He TC, Du W, Chen J, Wang CZ, Yuan CS. TRAIL pathway is associated with inhibition of colon cancer by protopanaxadiol. J Pharmacol Sci. 2015 Jan; 127(1):83-91. PMID: 25704023; PMCID: PMC5053100.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    8. Tanaka-Matakatsu M, Miller J, Du W. The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation function. Protein Cell. 2015 Jan; 6(1):68-78. PMID: 25234589; PMCID: PMC4286722.
      Citations: 5     Fields:    Translation:AnimalsCells
    9. Zhang Z, Yu C, Zhang CF, Wu XH, Wen XD, Anderson S, Du W, Huang WH, Li SP, Wang CZ, Yuan CS. Chemopreventive effects of oplopantriol A, a novel compound isolated from Oplopanax horridus, on colorectal cancer. Nutrients. 2014 Jul 18; 6(7):2668-80. PMID: 25045937; PMCID: PMC4113763.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    10. Yu C, Wen XD, Zhang Z, Zhang CF, Wu XH, Martin A, Du W, He TC, Wang CZ, Yuan CS. American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice. J Ginseng Res. 2015 Jan; 39(1):14-21. PMID: 25535472; PMCID: PMC4268560.
      Citations: 19     
    11. Tanaka-Matakatsu M, Miller J, Borger D, Tang WJ, Du W. Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation. Dev Biol. 2014 Aug 15; 392(2):256-65. PMID: 24886829; PMCID: PMC4106475.
      Citations: 11     Fields:    Translation:AnimalsCells
    12. Zhang T, Liao Y, Hsu FN, Zhang R, Searle JS, Pei X, Li X, Ryoo HD, Ji JY, Du W. Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities. PLoS Genet. 2014 May; 10(5):e1004357. PMID: 24809668; PMCID: PMC4014429.
      Citations: 12     Fields:    Translation:AnimalsCells
    13. Jin HR, Liao Y, Li X, Zhang Z, Zhao J, Wang CZ, Huang WH, Li SP, Yuan CS, Du W. Anticancer compound Oplopantriol A kills cancer cells through inducing ER stress and BH3 proteins Bim and Noxa. Cell Death Dis. 2014 Apr 24; 5:e1190. PMID: 24763047; PMCID: PMC4001317.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    14. Chi W, Zhang L, Du W, Zhuang X. A nutritional conditional lethal mutant due to pyridoxine 5'-phosphate oxidase deficiency in Drosophila melanogaster. G3 (Bethesda). 2014 Apr 16; 4(6):1147-54. PMID: 24739647; PMCID: PMC4065258.
      Citations: 4     Fields:    Translation:AnimalsCells
    15. Zhao J, Zhang Z, Liao Y, Du W. Mutation of the retinoblastoma tumor suppressor gene sensitizes cancers to mitotic inhibitor induced cell death. Am J Cancer Res. 2014; 4(1):42-52. PMID: 24482737; PMCID: PMC3902231.
      Citations: 7     
    16. Wen XD, Wang CZ, Yu C, Zhao L, Zhang Z, Matin A, Wang Y, Li P, Xiao SY, Du W, He TC, Yuan CS. Panax notoginseng attenuates experimental colitis in the azoxymethane/dextran sulfate sodium mouse model. Phytother Res. 2014 Jun; 28(6):892-8. PMID: 24142591; PMCID: PMC3994185.
      Citations: 16     Fields:    Translation:Animals
    17. Wang CZ, Zhang Z, Huang WH, Du GJ, Wen XD, Calway T, Yu C, Nass R, Zhao J, Du W, Li SP, Yuan CS. Identification of potential anticancer compounds from Oplopanax horridus. Phytomedicine. 2013 Aug 15; 20(11):999-1006. PMID: 23746754; PMCID: PMC3729876.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    18. Zhang Z, Wang CZ, Du GJ, Qi LW, Calway T, He TC, Du W, Yuan CS. Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells. Int J Oncol. 2013 Jul; 43(1):289-96. PMID: 23686257; PMCID: PMC3742162.
      Citations: 68     Fields:    Translation:HumansCells
    19. Gordon GM, Zhang T, Zhao J, Du W. Deregulated G1-S control and energy stress contribute to the synthetic-lethal interactions between inactivation of RB and TSC1 or TSC2. J Cell Sci. 2013 May 01; 126(Pt 9):2004-13. PMID: 23447678; PMCID: PMC3666254.
      Citations: 15     Fields:    Translation:AnimalsCells
    20. Zhang Z, Du GJ, Wang CZ, Wen XD, Calway T, Li Z, He TC, Du W, Bissonnette M, Musch MW, Chang EB, Yuan CS. Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions. Int J Mol Sci. 2013 Jan 31; 14(2):2980-95. PMID: 23434653; PMCID: PMC3588026.
      Citations: 36     Fields:    
    21. Wang CZ, Li B, Wen XD, Zhang Z, Yu C, Calway TD, He TC, Du W, Yuan CS. Paraptosis and NF-?B activation are associated with protopanaxadiol-induced cancer chemoprevention. BMC Complement Altern Med. 2013 Jan 03; 13:2. PMID: 23281928; PMCID: PMC3575249.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    22. Danos AM, Liao Y, Li X, Du W. Functional inactivation of Rb sensitizes cancer cells to TSC2 inactivation induced cell death. Cancer Lett. 2013 Jan 01; 328(1):36-43. PMID: 23022476; PMCID: PMC3494767.
      Citations: 4     Fields:    Translation:HumansCells
    23. Jin HR, Zhao J, Zhang Z, Liao Y, Wang CZ, Huang WH, Li SP, He TC, Yuan CS, Du W. The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress. Cell Death Dis. 2012 Aug 23; 3:e376. PMID: 22914324; PMCID: PMC3434669.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    24. Du GJ, Wang CZ, Qi LW, Zhang ZY, Calway T, He TC, Du W, Yuan CS. The synergistic apoptotic interaction of panaxadiol and epigallocatechin gallate in human colorectal cancer cells. Phytother Res. 2013 Feb; 27(2):272-7. PMID: 22566066; PMCID: PMC3416950.
      Citations: 16     Fields:    Translation:HumansCells
    25. Du GJ, Wang CZ, Zhang ZY, Wen XD, Somogyi J, Calway T, He TC, Du W, Yuan CS. Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells. J Pharm Pharmacol. 2012 May; 64(5):727-34. PMID: 22471369; PMCID: PMC3349342.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    26. Gordon GM, Du W. Conserved RB functions in development and tumor suppression. Protein Cell. 2011 Nov; 2(11):864-78. PMID: 22180086; PMCID: PMC3271014.
      Citations: 30     Fields:    Translation:HumansAnimals
    27. Sukhanova MJ, Steele LJ, Zhang T, Gordon GM, Du W. RBF and Rno promote photoreceptor differentiation onset through modulating EGFR signaling in the Drosophila developing eye. Dev Biol. 2011 Nov 15; 359(2):190-8. PMID: 21920355; PMCID: PMC3202672.
      Citations: 5     Fields:    Translation:AnimalsCells
    28. Gordon GM, Du W. Targeting Rb inactivation in cancers by synthetic lethality. Am J Cancer Res. 2011 Jun 30; 1(6):773-86. PMID: 21814623; PMCID: PMC3147291.
      Citations: 12     
    29. Li B, Zhao J, Wang CZ, Searle J, He TC, Yuan CS, Du W. Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Lett. 2011 Feb 28; 301(2):185-92. PMID: 21194832; PMCID: PMC3022099.
      Citations: 109     Fields:    Translation:HumansCells
    30. Li F, Duman-Scheel M, Yang D, Du W, Zhang J, Zhao C, Qin L, Xin S. Sonic hedgehog signaling induces vascular smooth muscle cell proliferation via induction of the G1 cyclin-retinoblastoma axis. Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9):1787-94. PMID: 20720195.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    31. Li B, Gordon GM, Du CH, Xu J, Du W. Specific killing of Rb mutant cancer cells by inactivating TSC2. Cancer Cell. 2010 May 18; 17(5):469-80. PMID: 20478529; PMCID: PMC2873973.
      Citations: 50     Fields:    Translation:HumansAnimals
    32. Li XL, Wang CZ, Sun S, Mehendale SR, Du W, He TC, Yuan CS. American ginseng berry enhances chemopreventive effect of 5-FU on human colorectal cancer cells. Oncol Rep. 2009 Oct; 22(4):943-52. PMID: 19724877.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    33. Steele L, Sukhanova MJ, Xu J, Gordon GM, Huang Y, Yu L, Du W. Retinoblastoma family protein promotes normal R8-photoreceptor differentiation in the absence of rhinoceros by inhibiting dE2F1 activity. Dev Biol. 2009 Nov 01; 335(1):228-36. PMID: 19744473; PMCID: PMC2763947.
      Citations: 10     Fields:    Translation:AnimalsCells
    34. Xie JT, Wang CZ, Zhang B, Mehendale SR, Li XL, Sun S, Han AH, Du W, He TC, Yuan CS. In vitro and in vivo anticancer effects of American ginseng berry: exploring representative compounds. Biol Pharm Bull. 2009 Sep; 32(9):1552-8. PMID: 19721231.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    35. Li B, Wang CZ, He TC, Yuan CS, Du W. Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells. Cancer Lett. 2010 Mar 01; 289(1):62-70. PMID: 19716228; PMCID: PMC2824022.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    36. Du W, Searle JS. The rb pathway and cancer therapeutics. Curr Drug Targets. 2009 Jul; 10(7):581-9. PMID: 19601762; PMCID: PMC3151466.
      Citations: 30     Fields:    Translation:HumansAnimals
    37. Wang CZ, Xie JT, Fishbein A, Aung HH, He H, Mehendale SR, He TC, Du W, Yuan CS. Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells. Phytother Res. 2009 Jan; 23(1):6-13. PMID: 19048608; PMCID: PMC2676878.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    38. Tanaka-Matakatsu M, Xu J, Cheng L, Du W. Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol. 2009 Feb 15; 326(2):347-56. PMID: 19100727; PMCID: PMC2634822.
      Citations: 46     Fields:    Translation:AnimalsCells
    39. Wang CZ, Aung HH, Zhang B, Sun S, Li XL, He H, Xie JT, He TC, Du W, Yuan CS. Chemopreventive effects of heat-processed Panax quinquefolius root on human breast cancer cells. Anticancer Res. 2008 Sep-Oct; 28(5A):2545-51. PMID: 19035277; PMCID: PMC2676904.
      Citations: 39     Fields:    Translation:HumansAnimals
    40. Deb DK, Tanaka-Matakatsu M, Jones L, Richardson HE, Du W. Wingless signaling directly regulates cyclin E expression in proliferating embryonic PNS precursor cells. Mech Dev. 2008 Sep-Oct; 125(9-10):857-64. PMID: 18606221; PMCID: PMC2614831.
      Citations: 4     Fields:    Translation:AnimalsCells
    41. Dai H, Chen Y, Chen S, Mao Q, Kennedy D, Landback P, Eyre-Walker A, Du W, Long M. The evolution of courtship behaviors through the origination of a new gene in Drosophila. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7478-83. PMID: 18508971; PMCID: PMC2396706.
      Citations: 40     Fields:    Translation:AnimalsCells
    42. Luo X, Wang CZ, Chen J, Song WX, Luo J, Tang N, He BC, Kang Q, Wang Y, Du W, He TC, Yuan CS. Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells. Int J Oncol. 2008 May; 32(5):975-83. PMID: 18425323; PMCID: PMC2677725.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    43. Sukhanova MJ, Du W. Control of cell cycle entry and exiting from the second mitotic wave in the Drosophila developing eye. BMC Dev Biol. 2008 Jan 24; 8:7. PMID: 18218125; PMCID: PMC2267170.
      Citations: 9     Fields:    Translation:AnimalsCells
    44. Tanaka-Matakatsu M, Du W. Direct control of the proneural gene atonal by retinal determination factors during Drosophila eye development. Dev Biol. 2008 Jan 15; 313(2):787-801. PMID: 18083159; PMCID: PMC2231519.
      Citations: 30     Fields:    Translation:AnimalsCells
    45. Wang CZ, Xie JT, Zhang B, Ni M, Fishbein A, Aung HH, Mehendale SR, Du W, He TC, Yuan CS. Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells. Int J Oncol. 2007 Nov; 31(5):1149-56. PMID: 17912442; PMCID: PMC2676859.
      Citations: 26     Fields:    Translation:HumansCells
    46. Tanaka-Matakatsu M, Thomas BJ, Du W. Mutation of the Apc1 homologue shattered disrupts normal eye development by disrupting G1 cell cycle arrest and progression through mitosis. Dev Biol. 2007 Sep 15; 309(2):222-35. PMID: 17689521; PMCID: PMC2080841.
      Citations: 15     Fields:    Translation:AnimalsCells
    47. Sukhanova MJ, Deb DK, Gordon GM, Matakatsu MT, Du W. Proneural basic helix-loop-helix proteins and epidermal growth factor receptor signaling coordinately regulate cell type specification and cdk inhibitor expression during development. Mol Cell Biol. 2007 Apr; 27(8):2987-96. PMID: 17296729; PMCID: PMC1899942.
      Citations: 17     Fields:    Translation:AnimalsCells
    48. Pogoriler J, Millen K, Utset M, Du W. Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation. Development. 2006 Oct; 133(19):3929-37. PMID: 16943274; PMCID: PMC1868525.
      Citations: 47     Fields:    Translation:AnimalsCells
    49. Du W, Pogoriler J. Retinoblastoma family genes. Oncogene. 2006 Aug 28; 25(38):5190-200. PMID: 16936737; PMCID: PMC1899835.
      Citations: 67     Fields:    Translation:HumansAnimals
    50. Shafaee Z, Schmidt H, Du W, Posner M, Weichselbaum R. Cyclopamine increases the cytotoxic effects of paclitaxel and radiation but not cisplatin and gemcitabine in Hedgehog expressing pancreatic cancer cells. Cancer Chemother Pharmacol. 2006 Dec; 58(6):765-70. PMID: 16552573.
      Citations: 22     Fields:    Translation:HumansCells
    51. Lee S, Bao J, Zhou G, Shapiro J, Xu J, Shi RZ, Lu X, Clark T, Johnson D, Kim YC, Wing C, Tseng C, Sun M, Lin W, Wang J, Yang H, Wang J, Du W, Wu CI, Zhang X, Wang SM. Detecting novel low-abundant transcripts in Drosophila. RNA. 2005 Jun; 11(6):939-46. PMID: 15923377; PMCID: PMC1370778.
      Citations: 19     Fields:    Translation:AnimalsCells
    52. Pogoriler J, Du W. Chk1 activation and the nuclear/cytoplasmic ratio. Dev Cell. 2004 Aug; 7(2):147-8. PMID: 15296709.
      Citations: 1     Fields:    Translation:AnimalsCells
    53. Duman-Scheel M, Johnston LA, Du W. Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3857-62. PMID: 15001704; PMCID: PMC374334.
      Citations: 34     Fields:    Translation:Animals
    54. Du W. Endocycle and E2F-dependent transcriptional activation and repression. Cell Cycle. 2003 Nov-Dec; 2(6):515-6. PMID: 14504463.
      Citations:    Fields:    Translation:AnimalsCells
    55. Weng L, Zhu C, Xu J, Du W. Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J. 2003 Aug 01; 22(15):3865-75. PMID: 12881421; PMCID: PMC169046.
      Citations: 40     Fields:    Translation:Animals
    56. Xu J, Du W. Drosophila chk2 plays an important role in a mitotic checkpoint in syncytial embryos. FEBS Lett. 2003 Jun 19; 545(2-3):209-12. PMID: 12804777.
      Citations: 10     Fields:    Translation:AnimalsCells
    57. Duman-Scheel M, Weng L, Xin S, Du W. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature. 2002 May 16; 417(6886):299-304. PMID: 12015606.
      Citations: 148     Fields:    Translation:AnimalsCells
    58. Xin S, Weng L, Xu J, Du W. The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth. Development. 2002 Mar; 129(6):1345-56. PMID: 11880344.
      Citations: 27     Fields:    Translation:AnimalsCells
    59. Xu J, Xin S, Du W. Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis. FEBS Lett. 2001 Nov 23; 508(3):394-8. PMID: 11728459.
      Citations: 41     Fields:    Translation:Animals
    60. Bosco G, Du W, Orr-Weaver TL. DNA replication control through interaction of E2F-RB and the origin recognition complex. Nat Cell Biol. 2001 Mar; 3(3):289-95. PMID: 11231579.
      Citations: 98     Fields:    Translation:AnimalsCells
    61. Meyer CA, Jacobs HW, Datar SA, Du W, Edgar BA, Lehner CF. Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J. 2000 Sep 01; 19(17):4533-42. PMID: 10970847; PMCID: PMC302073.
      Citations: 68     Fields:    Translation:AnimalsCells
    62. Du W. Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain. Development. 2000 Jan; 127(2):367-79. PMID: 10603353.
      Citations: 36     Fields:    Translation:AnimalsCells
    63. Du W, Dyson N. The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J. 1999 Feb 15; 18(4):916-25. PMID: 10022834; PMCID: PMC1171184.
      Citations: 59     Fields:    Translation:Animals
    64. Du W, Xie JE, Dyson N. Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J. 1996 Jul 15; 15(14):3684-92. PMID: 8670872; PMCID: PMC452020.
      Citations: 51     Fields:    Translation:AnimalsCells
    65. Brook A, Xie JE, Du W, Dyson N. Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells. EMBO J. 1996 Jul 15; 15(14):3676-83. PMID: 8670871; PMCID: PMC452016.
      Citations: 30     Fields:    Translation:Animals
    66. Du W, Vidal M, Xie JE, Dyson N. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 1996 May 15; 10(10):1206-18. PMID: 8675008.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    67. Du W, Maniatis T. The high mobility group protein HMG I(Y) can stimulate or inhibit DNA binding of distinct transcription factor ATF-2 isoforms. Proc Natl Acad Sci U S A. 1994 Nov 22; 91(24):11318-22. PMID: 7972056; PMCID: PMC45222.
      Citations: 28     Fields:    Translation:AnimalsCells
    68. Du W, Thanos D, Maniatis T. Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell. 1993 Sep 10; 74(5):887-98. PMID: 8374955.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    69. Thanos D, Du W, Maniatis T. The high mobility group protein HMG I(Y) is an essential structural component of a virus-inducible enhancer complex. Cold Spring Harb Symp Quant Biol. 1993; 58:73-81. PMID: 7956090.
      Citations: 26     Fields:    Translation:HumansCells
    70. Du W, Maniatis T. An ATF/CREB binding site is required for virus induction of the human interferon beta gene [corrected]. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2150-4. PMID: 1532252; PMCID: PMC48614.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
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