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Alexandre Chlenski

TitleResearch Associate Professor
InstitutionUniversity of Chicago
DepartmentPediatrics-Hematology and Oncology
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kaufman ME, Vayani OR, Moore K, Chlenksi A, Wu T, Lee SM, Desai AV, He C, Cohn SL, Applebaum MA, Kaufman ME, Vayani OR, Moore K, Chlenski A, Wu T, Lee SM, Desai AV, He C, Cohn SL, Applebaum MA. Characterizing Relationships between T-cell Inflammation and Outcomes in Patients with High-Risk Neuroblastoma According to Mesenchymal and Adrenergic Signatures. Cancer Res Commun. 2024 Aug 01; 4(8):2255-2266. PMID: 39099200; PMCID: PMC11350481.
      Citations:    Fields:    Translation:HumansCells
    2. Pomaville M, Chennakesavalu M, Wang P, Jiang Z, Sun HL, Ren P, Borchert R, Gupta V, Ye C, Ge R, Zhu Z, Brodnik M, Zhong Y, Moore K, Salwen H, George RE, Krajewska M, Chlenski A, Applebaum MA, He C, Cohn SL. Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation. Cell Rep. 2024 May 28; 43(5):114165. PMID: 38691450; PMCID: PMC11181463.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    3. Chennakesavalu M, Moore K, Chaves G, Veeravalli S, TerHaar R, Wu T, Lyu R, Chlenski A, He C, Piunti A, Applebaum MA. 5-Hydroxymethylcytosine Profiling of Cell-Free DNA Identifies Bivalent Genes That Are Prognostic of Survival in High-Risk Neuroblastoma. JCO Precis Oncol. 2024 Jan; 8:e2300297. PMID: 38295320; PMCID: PMC10843272.
      Citations: 5     Fields:    Translation:Humans
    4. Vayani OR, Kaufman ME, Moore K, Chennakesavalu M, TerHaar R, Chaves G, Chlenski A, He C, Cohn SL, Applebaum MA. Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma. Pediatr Blood Cancer. 2024 Jan; 71(1):e30735. PMID: 37859597; PMCID: PMC10842006.
      Citations: 1     Fields:    Translation:Humans
    5. Vayani OR, Kaufman ME, Moore K, Chennakesavalu M, TerHaar R, Chaves G, Chlenski A, He C, Cohn SL, Applebaum MA. Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma. bioRxiv. 2023 Sep 01. PMID: 37693610; PMCID: PMC10491182.
      Citations:    
    6. Kaufman ME, Vayani OR, Moore K, Chlenski A, Wu T, Chavez G, Lee SM, Desai AV, He C, Cohn SL, Applebaum MA. T-cell inflammation is prognostic of survival in patients with high-risk neuroblastoma enriched for an adrenergic signature. bioRxiv. 2023 Jun 28. PMID: 37425883; PMCID: PMC10326980.
      Citations:    
    7. Chennakesavalu M, Moore K, Chaves G, Veeravalli S, TerHaar R, Wu T, Lyu R, Chlenski A, He C, Piunti A, Applebaum MA. 5-hydroxymethylcytosine profiling of cell-free DNA identifies bivalent genes that are prognostic of survival in high-risk neuroblastoma. bioRxiv. 2023 Apr 30. PMID: 37163024; PMCID: PMC10168384.
      Citations:    
    8. Applebaum MA, Barr EK, Karpus J, West-Szymanski DC, Oliva M, Sokol EA, Zhang S, Zhang Z, Zhang W, Chlenski A, Salwen HR, Wilkinson E, Dobratic M, Grossman RL, Godley LA, Stranger BE, He C, Cohn SL. 5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma. Clin Cancer Res. 2020 03 15; 26(6):1309-1317. PMID: 31852832; PMCID: PMC7073281.
      Citations: 16     Fields:    Translation:HumansCells
    9. Applebaum MA, Barr EK, Karpus J, Nie J, Zhang Z, Armstrong AE, Uppal S, Sukhanova M, Zhang W, Chlenski A, Salwen HR, Wilkinson E, Dobratic M, Grossman R, Godley LA, Stranger BE, He C, Cohn SL. 5-Hydroxymethylcytosine Profiles Are Prognostic of Outcome in Neuroblastoma and Reveal Transcriptional Networks That Correlate With Tumor Phenotype. JCO Precis Oncol. 2019; 3. PMID: 31179414; PMCID: PMC6553657.
      Citations: 14     Fields:    
    10. Chlenski A, Park C, Dobratic M, Salwen HR, Budke B, Park JH, Miller R, Applebaum MA, Wilkinson E, Nakamura Y, Connell PP, Cohn SL. Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma. Mol Cancer Ther. 2019 03; 18(3):507-516. PMID: 30674566; PMCID: PMC6398941.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    11. Oshima G, Poli EC, Bolt MJ, Chlenski A, Forde M, Jutzy JMS, Biyani N, Posner MC, Pitroda SP, Weichselbaum RR, Khodarev NN. DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs. Cancer Res. 2019 02 01; 79(3):650-662. PMID: 30538122.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    12. Applebaum MA, Jha AR, Kao C, Hernandez KM, DeWane G, Salwen HR, Chlenski A, Dobratic M, Mariani CJ, Godley LA, Prabhakar N, White K, Stranger BE, Cohn SL. Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients. Oncotarget. 2016 Nov 22; 7(47):76816-76826. PMID: 27765905; PMCID: PMC5340231.
      Citations: 23     Fields:    Translation:HumansCells
    13. Chlenski A, Dobratic M, Salwen HR, Applebaum M, Guerrero LJ, Miller R, DeWane G, Solomaha E, Marks JD, Cohn SL. Secreted protein acidic and rich in cysteine (SPARC) induces lipotoxicity in neuroblastoma by regulating transport of albumin complexed with fatty acids. Oncotarget. 2016 Nov 22; 7(47):77696-77706. PMID: 27776337; PMCID: PMC5363614.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    14. Pinto N, Mayfield JR, Raca G, Applebaum MA, Chlenski A, Sukhanova M, Bagatell R, Irwin MS, Little A, Rawwas J, Gosiengfiao Y, Cohn SL, Delattre O, Janoueix-Lerosey I, Lapouble E, Schleiermacher G. Segmental Chromosomal Aberrations in Localized Neuroblastoma Can be Detected in Formalin-Fixed Paraffin-Embedded Tissue Samples and Are Associated With Recurrence. Pediatr Blood Cancer. 2016 Jun; 63(6):1019-23. PMID: 26864375; PMCID: PMC5109976.
      Citations: 10     Fields:    Translation:Humans
    15. Stricker TP, Morales La Madrid A, Chlenski A, Guerrero L, Salwen HR, Gosiengfiao Y, Perlman EJ, Furman W, Bahrami A, Shohet JM, Zage PE, Hicks MJ, Shimada H, Suganuma R, Park JR, So S, London WB, Pytel P, Maclean KH, Cohn SL. Validation of a prognostic multi-gene signature in high-risk neuroblastoma using the high throughput digital NanoString nCounter™ system. Mol Oncol. 2014 May; 8(3):669-78. PMID: 24560446; PMCID: PMC4004665.
      Citations: 20     Fields:    Translation:Humans
    16. Lu Z, Tian Y, Salwen HR, Chlenski A, Godley LA, Raj JU, Yang Q. Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells. Anticancer Drugs. 2013 Jun; 24(5):484-93. PMID: 23466651; PMCID: PMC3649845.
      Citations: 31     Fields:    Translation:HumansCells
    17. Gu S, Tian Y, Chlenski A, Salwen HR, Lu Z, Raj JU, Yang Q. Valproic acid shows a potent antitumor effect with alteration of DNA methylation in neuroblastoma. Anticancer Drugs. 2012 Nov; 23(10):1054-66. PMID: 22863973; PMCID: PMC3710400.
      Citations: 23     Fields:    Translation:HumansCells
    18. Ostler KR, Yang Q, Looney TJ, Zhang L, Vasanthakumar A, Tian Y, Kocherginsky M, Raimondi SL, DeMaio JG, Salwen HR, Gu S, Chlenski A, Naranjo A, Gill A, Peddinti R, Lahn BT, Cohn SL, Godley LA. Truncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma. Cancer Res. 2012 Sep 15; 72(18):4714-23. PMID: 22815530; PMCID: PMC3445765.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    19. Kakodkar NC, Peddinti RR, Tian Y, Guerrero LJ, Chlenski A, Yang Q, Salwen HR, Maitland ML, Cohn SL. Sorafenib inhibits neuroblastoma cell proliferation and signaling, blocks angiogenesis, and impairs tumor growth. Pediatr Blood Cancer. 2012 Oct; 59(4):642-7. PMID: 22147414.
      Citations: 15     Fields:    Translation:AnimalsCells
    20. Chlenski A, Guerrero LJ, Salwen HR, Yang Q, Tian Y, Morales La Madrid A, Mirzoeva S, Bouyer PG, Xu D, Walker M, Cohn SL. Secreted protein acidic and rich in cysteine is a matrix scavenger chaperone. PLoS One. 2011; 6(9):e23880. PMID: 21949685; PMCID: PMC3174944.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    21. Kakodkar NC, Peddinti R, Kletzel M, Tian Y, Guerrero LJ, Undevia SD, Geary D, Chlenski A, Yang Q, Salwen HR, Cohn SL. The quinoxaline anti-tumor agent (R+)XK469 inhibits neuroblastoma tumor growth. Pediatr Blood Cancer. 2011 Jan; 56(1):164-7. PMID: 20860039; PMCID: PMC4116189.
      Citations: 5     Fields:    Translation:HumansCells
    22. Yang Q, Tian Y, Ostler KR, Chlenski A, Guerrero LJ, Salwen HR, Godley LA, Cohn SL. Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines. BMC Cancer. 2010 Jun 14; 10:286. PMID: 20546602; PMCID: PMC2897803.
      Citations: 14     Fields:    Translation:HumansCells
    23. Chlenski A, Guerrero LJ, Peddinti R, Spitz JA, Leonhardt PT, Yang Q, Tian Y, Salwen HR, Cohn SL. Anti-angiogenic SPARC peptides inhibit progression of neuroblastoma tumors. Mol Cancer. 2010 Jun 04; 9:138. PMID: 20525313; PMCID: PMC2895596.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    24. Chlenski A, Cohn SL. Modulation of matrix remodeling by SPARC in neoplastic progression. Semin Cell Dev Biol. 2010 Feb; 21(1):55-65. PMID: 19958839.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    25. Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR. A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis. Blood. 2009 Nov 12; 114(20):4592-600. PMID: 19710505; PMCID: PMC2777131.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    26. Zeine R, Salwen HR, Peddinti R, Tian Y, Guerrero L, Yang Q, Chlenski A, Cohn SL. Presence of cancer-associated fibroblasts inversely correlates with Schwannian stroma in neuroblastoma tumors. Mod Pathol. 2009 Jul; 22(7):950-8. PMID: 19407854; PMCID: PMC3347894.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    27. Peddinti R, Zeine R, Luca D, Seshadri R, Chlenski A, Cole K, Pawel B, Salwen HR, Maris JM, Cohn SL. Prominent microvascular proliferation in clinically aggressive neuroblastoma. Clin Cancer Res. 2007 Jun 15; 13(12):3499-506. PMID: 17575212.
      Citations: 19     Fields:    Translation:Humans
    28. Yang Q, Kiernan CM, Tian Y, Salwen HR, Chlenski A, Brumback BA, London WB, Cohn SL. Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome. Clin Cancer Res. 2007 Jun 01; 13(11):3191-7. PMID: 17545522.
      Citations: 45     Fields:    Translation:HumansCells
    29. Yang Q, Tian Y, Liu S, Zeine R, Chlenski A, Salwen HR, Henkin J, Cohn SL. Thrombospondin-1 peptide ABT-510 combined with valproic acid is an effective antiangiogenesis strategy in neuroblastoma. Cancer Res. 2007 Feb 15; 67(4):1716-24. PMID: 17308113.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    30. Chlenski A, Guerrero LJ, Yang Q, Tian Y, Peddinti R, Salwen HR, Cohn SL. SPARC enhances tumor stroma formation and prevents fibroblast activation. Oncogene. 2007 Jul 05; 26(31):4513-22. PMID: 17260013.
      Citations: 26     Fields:    Translation:AnimalsCells
    31. Chlenski A, Liu S, Guerrero LJ, Yang Q, Tian Y, Salwen HR, Zage P, Cohn SL. SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular matrix. Int J Cancer. 2006 Jan 15; 118(2):310-6. PMID: 16052522.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    32. Liu S, Tian Y, Chlenski A, Yang Q, Salwen HR, Cohn SL. 'Cross-talk' between Schwannian stroma and neuroblasts promotes neuroblastoma tumor differentiation and inhibits angiogenesis. Cancer Lett. 2005 Oct 18; 228(1-2):125-31. PMID: 15935552.
      Citations: 13     Fields:    Translation:HumansCells
    33. Liu S, Tian Y, Chlenski A, Yang Q, Zage P, Salwen HR, Crawford SE, Cohn SL. Cross-talk between Schwann cells and neuroblasts influences the biology of neuroblastoma xenografts. Am J Pathol. 2005 Mar; 166(3):891-900. PMID: 15743800; PMCID: PMC1602341.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    34. Yang Q, Zage P, Kagan D, Tian Y, Seshadri R, Salwen HR, Liu S, Chlenski A, Cohn SL. Association of epigenetic inactivation of RASSF1A with poor outcome in human neuroblastoma. Clin Cancer Res. 2004 Dec 15; 10(24):8493-500. PMID: 15623630.
      Citations: 32     Fields:    Translation:HumansCells
    35. Chlenski A, Liu S, Baker LJ, Yang Q, Tian Y, Salwen HR, Cohn SL. Neuroblastoma angiogenesis is inhibited with a folded synthetic molecule corresponding to the epidermal growth factor-like module of the follistatin domain of SPARC. Cancer Res. 2004 Oct 15; 64(20):7420-5. PMID: 15492265.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    36. Yang Q, Liu S, Tian Y, Hasan C, Kersey D, Salwen HR, Chlenski A, Perlman EJ, Cohn SL. Methylation-associated silencing of the heat shock protein 47 gene in human neuroblastoma. Cancer Res. 2004 Jul 01; 64(13):4531-8. PMID: 15231663.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    37. Yang QW, Liu S, Tian Y, Salwen HR, Chlenski A, Weinstein J, Cohn SL. Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma. Cancer Res. 2003 Oct 01; 63(19):6299-310. PMID: 14559817.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    38. Chlenski A, Liu S, Cohn SL. The regulation of angiogenesis in neuroblastoma. Cancer Lett. 2003 Jul 18; 197(1-2):47-52. PMID: 12880959.
      Citations: 12     Fields:    Translation:Humans
    39. Chlenski A, Liu S, Crawford SE, Volpert OV, DeVries GH, Evangelista A, Yang Q, Salwen HR, Farrer R, Bray J, Cohn SL. SPARC is a key Schwannian-derived inhibitor controlling neuroblastoma tumor angiogenesis. Cancer Res. 2002 Dec 15; 62(24):7357-63. PMID: 12499280.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    40. Nakashiro KI, Hayashi Y, Kita A, Tamatani T, Chlenski A, Usuda N, Hattori K, Reddy JK, Oyasu R. Role of peroxisome proliferator-activated receptor gamma and its ligands in non-neoplastic and neoplastic human urothelial cells. Am J Pathol. 2001 Aug; 159(2):591-7. PMID: 11485917; PMCID: PMC1850548.
      Citations: 30     Fields:    Translation:HumansCells
    41. Chlenski A, Nakashiro K, Ketels KV, Korovaitseva GI, Oyasu R. Androgen receptor expression in androgen-independent prostate cancer cell lines. Prostate. 2001 Apr; 47(1):66-75. PMID: 11304731.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    42. Chlenski A, Ketels KV, Korovaitseva GI, Talamonti MS, Oyasu R, Scarpelli DG. Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues. Biochim Biophys Acta. 2000 Oct 02; 1493(3):319-24. PMID: 11018256.
      Citations: 31     Fields:    Translation:Cells
    43. Watterson DM, Schavocky JP, Guo L, Weiss C, Chlenski A, Shirinsky VP, Van Eldik LJ, Haiech J. Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing, and polymorphic marker. J Cell Biochem. 1999 Dec 01; 75(3):481-91. PMID: 10536370.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    44. Chlenski A, Ketels KV, Engeriser JL, Talamonti MS, Tsao MS, Koutnikova H, Oyasu R, Scarpelli DG. zo-2 gene alternative promoters in normal and neoplastic human pancreatic duct cells. Int J Cancer. 1999 Oct 29; 83(3):349-58. PMID: 10495427.
      Citations: 7     Fields:    Translation:HumansCells
    45. Chlenski A, Ketels KV, Tsao MS, Talamonti MS, Anderson MR, Oyasu R, Scarpelli DG. Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma. Int J Cancer. 1999 Jul 02; 82(1):137-44. PMID: 10360833.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
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