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Samuel L. Volchenboum

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentPediatrics-Hematology/Oncology
AddressChicago IL 60637
Email
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    Samuel Volchenboum is a physician who treats pediatric cancers and blood disorders, with a specialization in treating children with neuroblastoma and other pediatric solid tumors. His research explores the use of computation to define diseases in greater detail. His discoveries in genetics could lead to personalized and targeted therapies with better outcomes and fewer side effects in children as well as adults.

    As a researcher and physician, Volchenboum serves as an assistant professor in the Department of Pediatrics. His research methodologies include using proteomics to study pediatric solid tumors and building tools for high-throughput mass spectrometry data analysis.

    His lab has a number of outside collaborations, including an international multi-institutional effort to establish a database for neuroblastoma patient data. He also works with the Children’s Hospital of Philadelphia to study the effects of TrkA and TrkB signaling in neuroblastoma cell lines.

    Volchenboum is the of the BSD Center for Research Informatics. He also is the associate director of the Institute for Translational Medicine, Associate Chief Research Informatics Officer, and a fellow and faculty member of the Computation Institute.

    Volchenboum has been on the UChicago faculty since 2007, and in 2009 he was named a St. Baldrick's Foundation Scholar. Volchenboum received his PhD in molecular biology and MD from the Mayo Medical School. He completed his residency at Cincinnati Children’s Hospital Medical Center before going to Boston for his pediatric hematology/oncology fellowship at the Dana-Farber Cancer Institute and Boston Children’s Hospital. He also completed a fellowship in informatics and received his Master’s in biomedical informatics from the Massachusetts Institute of Technology.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hernandez W, Danahey K, Pei X, Yeo KJ, Leung E, Volchenboum SL, Ratain MJ, Meltzer DO, Stranger BE, Perera MA, O'Donnell PH. Pharmacogenomic genotypes define genetic ancestry in patients and enable population-specific genomic implementation. Pharmacogenomics J. 2019 Sep 11. PMID: 31506565.
      View in: PubMed
    2. Oliwa T, Maron SB, Chase LM, Lomnicki S, Catenacci DVT, Furner B, Volchenboum SL. Obtaining Knowledge in Pathology Reports Through a Natural Language Processing Approach With Classification, Named-Entity Recognition, and Relation-Extraction Heuristics. JCO Clin Cancer Inform. 2019 08; 3:1-8. PMID: 31365274.
      View in: PubMed
    3. Fukushima M, Austin C, Sato N, Maruyama T, Navarro E, Rocca M, Demotes J, Haendel M, Volchenboum SL, Cowperthwaite M, Silverstein JC, Webb C, Sim I, Chase M, Speakman J, Augustine E, Ford DE, Kush R. The Global academic research organization network: Data sharing to cure diseases and enable learning health systems. Learn Health Syst. 2019 Jan; 3(1):e10073. PMID: 31245596.
      View in: PubMed
    4. Cox SM, Lane A, Volchenboum SL. Use of Wearable, Mobile, and Sensor Technology in Cancer Clinical Trials. JCO Clin Cancer Inform. 2018 12; 2:1-11. PMID: 30652590.
      View in: PubMed
    5. Sokol EA, Engelmann R, Kang W, Pinto N, Starkey A, Lai H, Nadel H, Shulkin BL, Pu Y, Appelbaum D, Yanik GA, Cohn SL, Armato SG, Volchenboum S. Computer-assisted Curie scoring for metaiodobenzylguanidine (MIBG) scans in patients with neuroblastoma. Pediatr Blood Cancer. 2018 12; 65(12):e27417. PMID: 30198643.
      View in: PubMed
    6. Mayampurath A, Volchenboum SL, Sanchez-Pinto LN. Using photoplethysmography data to estimate heart rate variability and its association with organ dysfunction in pediatric oncology patients. NPJ Digit Med. 2018; 1:29. PMID: 31304311.
      View in: PubMed
    7. Rajkomar A, Oren E, Chen K, Dai AM, Hajaj N, Hardt M, Liu PJ, Liu X, Marcus J, Sun M, Sundberg P, Yee H, Zhang K, Zhang Y, Flores G, Duggan GE, Irvine J, Le Q, Litsch K, Mossin A, Tansuwan J. Scalable and accurate deep learning with electronic health records. NPJ Digit Med. 2018; 1:18. PMID: 31304302.
      View in: PubMed
    8. Kang W, Kadri S, Puranik R, Wurst MN, Patil SA, Mujacic I, Benhamed S, Niu N, Zhen CJ, Ameti B, Long BC, Galbo F, Montes D, Iracheta C, Gamboa VL, Lopez D, Yourshaw M, Lawrence CA, Aisner DL, Fitzpatrick C, McNerney ME, Wang YL, Andrade J, Volchenboum SL, Furtado LV, Ritterhouse LL, Segal JP. System for Informatics in the Molecular Pathology Laboratory: An Open-Source End-to-End Solution for Next-Generation Sequencing Clinical Data Management. J Mol Diagn. 2018 07; 20(4):522-532. PMID: 29698836.
      View in: PubMed
    9. Hungate EA, Applebaum MA, Skol AD, Vaksman Z, Diamond M, McDaniel L, Volchenboum SL, Stranger BE, Maris JM, Diskin SJ, Onel K, Cohn SL. Evaluation of Genetic Predisposition for MYCN-Amplified Neuroblastoma. J Natl Cancer Inst. 2017 10 01; 109(10). PMID: 29117357.
      View in: PubMed
    10. Danahey K, Borden BA, Furner B, Yukman P, Hussain S, Saner D, Volchenboum SL, Ratain MJ, O'Donnell PH. Simplifying the use of pharmacogenomics in clinical practice: Building the genomic prescribing system. J Biomed Inform. 2017 Nov; 75:110-121. PMID: 28963061.
      View in: PubMed
    11. O'Donnell PH, Wadhwa N, Danahey K, Borden BA, Lee SM, Hall JP, Klammer C, Hussain S, Siegler M, Sorrentino MJ, Davis AM, Sacro YA, Nanda R, Polonsky TS, Koyner JL, Burnet DL, Lipstreuer K, Rubin DT, Mulcahy C, Strek ME, Harper W, Cifu AS, Polite B, Patrick-Miller L, Yeo KT, Leung E, Volchenboum SL, Altman RB, Olopade OI, Stadler WM, Meltzer DO, Ratain MJ. Pharmacogenomics-Based Point-of-Care Clinical Decision Support Significantly Alters Drug Prescribing. Clin Pharmacol Ther. 2017 Nov; 102(5):859-869. PMID: 28398598.
      View in: PubMed
    12. Volchenboum SL, Cox SM, Heath A, Resnick A, Cohn SL, Grossman R. Data Commons to Support Pediatric Cancer Research. Am Soc Clin Oncol Educ Book. 2017; 37:746-752. PMID: 28561664.
      View in: PubMed
    13. Volchenboum SL, Mayampurath A, Göksu-Gürsoy G, Edelson DP, Howell MD, Churpek MM. Association Between In-Hospital Critical Illness Events and Outcomes in Patients on the Same Ward. JAMA. 2016 12 27; 316(24):2674-2675. PMID: 28027358.
      View in: PubMed
    14. Applebaum MA, Vaksman Z, Lee SM, Hungate EA, Henderson TO, London WB, Pinto N, Volchenboum SL, Park JR, Naranjo A, Hero B, Pearson AD, Stranger BE, Cohn SL, Diskin SJ. Neuroblastoma survivors are at increased risk for second malignancies: A report from the International Neuroblastoma Risk Group Project. Eur J Cancer. 2017 02; 72:177-185. PMID: 28033528.
      View in: PubMed
    15. Eckert MA, Pan S, Hernandez KM, Loth RM, Andrade J, Volchenboum SL, Faber P, Montag A, Lastra R, Peter ME, Yamada SD, Lengyel E. Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube. Cancer Discov. 2016 12; 6(12):1342-1351. PMID: 27856443.
      View in: PubMed
    16. Lyon SM, Mayampurath A, Rogers MR, Wolfgeher DJ, Fisher SM, Volchenboum SL, He TC, Reid RR. A method for whole protein isolation from human cranial bone. Anal Biochem. 2016 Dec 15; 515:33-39. PMID: 27677936.
      View in: PubMed
    17. Morgenstern DA, London WB, Stephens D, Volchenboum SL, Simon T, Nakagawara A, Shimada H, Schleiermacher G, Matthay KK, Cohn SL, Pearson AD, Irwin MS. Prognostic significance of pattern and burden of metastatic disease in patients with stage 4 neuroblastoma: A study from the International Neuroblastoma Risk Group database. Eur J Cancer. 2016 09; 65:1-10. PMID: 27434878.
      View in: PubMed
    18. Villablanca JG, Volchenboum SL, Cho H, Kang MH, Cohn SL, Anderson CP, Marachelian A, Groshen S, Tsao-Wei D, Matthay KK, Maris JM, Hasenauer CE, Czarnecki S, Lai H, Goodarzian F, Shimada H, Reynolds CP. A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma. Pediatr Blood Cancer. 2016 08; 63(8):1349-56. PMID: 27092812.
      View in: PubMed
    19. Bagatell R, McHugh K, Naranjo A, Van Ryn C, Kirby C, Brock P, Lyons KA, States LJ, Rojas Y, Miller A, Volchenboum SL, Simon T, Krug B, Sarnacki S, Valteau-Couanet D, von Schweinitz D, Kammer B, Granata C, Pio L, Park JR, Nuchtern J. Assessment of Primary Site Response in Children With High-Risk Neuroblastoma: An International Multicenter Study. J Clin Oncol. 2016 Mar 01; 34(7):740-6. PMID: 26755515.
      View in: PubMed
    20. Padula WV, Blackshaw L, Brindle CT, Volchenboum SL. An Approach to Acquiring, Normalizing, and Managing EHR Data From a Clinical Data Repository for Studying Pressure Ulcer Outcomes. J Wound Ostomy Continence Nurs. 2016 Jan-Feb; 43(1):39-45. PMID: 26727681.
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    21. Rosebeck S, Alonge MM, Kandarpa M, Mayampurath A, Volchenboum SL, Jasielec J, Dytfeld D, Maxwell SP, Kraftson SJ, McCauley D, Shacham S, Kauffman M, Jakubowiak AJ. Synergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10-Dependent Apoptosis by Carfilzomib and Selinexor. Mol Cancer Ther. 2016 Jan; 15(1):60-71. PMID: 26637366.
      View in: PubMed
    22. Pinto NR, Applebaum MA, Volchenboum SL, Matthay KK, London WB, Ambros PF, Nakagawara A, Berthold F, Schleiermacher G, Park JR, Valteau-Couanet D, Pearson AD, Cohn SL. Advances in Risk Classification and Treatment Strategies for Neuroblastoma. J Clin Oncol. 2015 Sep 20; 33(27):3008-17. PMID: 26304901.
      View in: PubMed
    23. Bao R, Hernandez K, Huang L, Kang W, Bartom E, Onel K, Volchenboum S, Andrade J. ExScalibur: A High-Performance Cloud-Enabled Suite for Whole Exome Germline and Somatic Mutation Identification. PLoS One. 2015; 10(8):e0135800. PMID: 26271043.
      View in: PubMed
    24. Pinto N, Volchenboum SL, Skol AD, Rhodes L, Doan A, Fein-Levy C, Lipton JM, Cunningham JM, Onel K. Establishing a translational genomics infrastructure in pediatric cancer: the GREAT KIDS experience. Per Med. 2015 Jun; 12(3):221-229. PMID: 29771652.
      View in: PubMed
    25. Volchenboum SL, Andrade J, Huang L, Barkauskas DA, Krailo M, Womer RB, Ranft A, Potratz J, Dirksen U, Triche TJ, Lawlor ER. Gene Expression Profiling of Ewing Sarcoma Tumors Reveals the Prognostic Importance of Tumor-Stromal Interactions: A Report from the Children's Oncology Group. J Pathol Clin Res. 2015 Apr; 1(2):83-94. PMID: 26052443.
      View in: PubMed
    26. Dytfeld D, Rosebeck S, Kandarpa M, Mayampurath A, Mellacheruvu D, Alonge MM, Ngoka L, Jasielec J, Richardson PG, Volchenboum S, Nesvizhskii AI, Sreekumar A, Jakubowiak AJ. Proteomic profiling of naïve multiple myeloma patient plasma cells identifies pathways associated with favourable response to bortezomib-based treatment regimens. Br J Haematol. 2015 Jul; 170(1):66-79. PMID: 25824111.
      View in: PubMed
    27. Hu Y, Mayampurath A, Khan S, Cohen JK, Mechref Y, Volchenboum SL. N-linked glycan profiling in neuroblastoma cell lines. J Proteome Res. 2015 May 01; 14(5):2074-81. PMID: 25730103.
      View in: PubMed
    28. Truman AW, Kristjansdottir K, Wolfgeher D, Ricco N, Mayampurath A, Volchenboum SL, Clotet J, Kron SJ. The quantitative changes in the yeast Hsp70 and Hsp90 interactomes upon DNA damage. Data Brief. 2015 Mar; 2:12-5. PMID: 26217697.
      View in: PubMed
    29. Truman AW, Kristjansdottir K, Wolfgeher D, Ricco N, Mayampurath A, Volchenboum SL, Clotet J, Kron SJ. Quantitative proteomics of the yeast Hsp70/Hsp90 interactomes during DNA damage reveal chaperone-dependent regulation of ribonucleotide reductase. J Proteomics. 2015 Jan 01; 112:285-300. PMID: 25452130.
      View in: PubMed
    30. Applebaum MA, Henderson TO, Lee SM, Pinto N, Volchenboum SL, Cohn SL. Second malignancies in patients with neuroblastoma: the effects of risk-based therapy. Pediatr Blood Cancer. 2015 Jan; 62(1):128-33. PMID: 25251613.
      View in: PubMed
    31. Kho AN, Hynes DM, Goel S, Solomonides AE, Price R, Hota B, Sims SA, Bahroos N, Angulo F, Trick WE, Tarlov E, Rachman FD, Hamilton A, Kaleba EO, Badlani S, Volchenboum SL, Silverstein JC, Tobin JN, Schwartz MA, Levine D, Wong JB, Kennedy RH, Krishnan JA, Meltzer DO, Collins JM, Mazany T. CAPriCORN: Chicago Area Patient-Centered Outcomes Research Network. J Am Med Inform Assoc. 2014 Jul-Aug; 21(4):607-11. PMID: 24821736.
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    32. Morgenstern DA, London WB, Stephens D, Volchenboum SL, Hero B, Di Cataldo A, Nakagawara A, Shimada H, Ambros PF, Matthay KK, Cohn SL, Pearson AD, Irwin MS. Metastatic neuroblastoma confined to distant lymph nodes (stage 4N) predicts outcome in patients with stage 4 disease: A study from the International Neuroblastoma Risk Group Database. J Clin Oncol. 2014 Apr 20; 32(12):1228-35. PMID: 24663047.
      View in: PubMed
    33. Wilson RA, Teng L, Bachmeyer KM, Bissonnette ML, Husain AN, Parham DM, Triche TJ, Wing MR, Gastier-Foster JM, Barr FG, Hawkins DS, Anderson JR, Skapek SX, Volchenboum SL. A novel algorithm for simplification of complex gene classifiers in cancer. Cancer Res. 2013 Sep 15; 73(18):5625-32. PMID: 23913937.
      View in: PubMed
    34. Mandal S, Baron BW, Mischeaux M, James K, Roig J, Landers J, Volchenboum SL, Cunningham JM, Reardon B, Musa G, Richa EM. Collection of peripheral blood stem cells from a 7 month-old girl weighing 7 kg with the use of combined heparin and citrate anticoagulation. J Clin Apher. 2013 Aug; 28(4):309-10. PMID: 23881772.
      View in: PubMed
    35. Wang W, Zhong Q, Teng L, Bhatnagar N, Sharma B, Zhang X, Luther W, Haynes LP, Burgoyne RD, Vidal M, Volchenboum S, Hill DE, George RE. Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma. Oncogene. 2014 Jun 19; 33(25):3316-24. PMID: 23873030.
      View in: PubMed
    36. Kirby C, Ambros PF, Billiter D, London WB, Mendonca E, Monclair T, Pearson AD, Cohn SL, Volchenboum SL. Development of an open-source, flexible framework for complex inter-institutional disparate data sharing and collaboration. AMIA Jt Summits Transl Sci Proc. 2013; 2013:103. PMID: 24303312.
      View in: PubMed
    37. Morales La Madrid A, Volchenboum S, Gastier-Foster JM, Pyatt R, Liu D, Pytel P, Lavarino C, Rodriguez E, Cohn SL. Locoregional MYCN-amplified neuroblastoma. Pediatr Blood Cancer. 2012 Oct; 59(4):736-8. PMID: 22213566.
      View in: PubMed
    38. Lu Z, Cheng Z, Zhao Y, Volchenboum SL. Bioinformatic analysis and post-translational modification crosstalk prediction of lysine acetylation. PLoS One. 2011; 6(12):e28228. PMID: 22164248.
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    39. McNerney ME, Baron BW, Volchenboum SL, Papari M, Keith M, Williams K, Richa E. Development of warm auto- and allo-antibodies in a 3-year old boy with sickle cell haemoglobinopathy following his first transfusion of a single unit of red blood cells. Blood Transfus. 2010 Apr; 8(2):126-8. PMID: 20383307.
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    40. Volchenboum SL, Cohn SL. Are molecular neuroblastoma classifiers ready for prime time? Lancet Oncol. 2009 Jul; 10(7):641-2. PMID: 19573794.
      View in: PubMed
    41. Volchenboum SL, Li C, Li S, Attiyeh EF, Reynolds CP, Maris JM, Look AT, George RE. Comparison of primary neuroblastoma tumors and derivative early-passage cell lines using genome-wide single nucleotide polymorphism array analysis. Cancer Res. 2009 May 15; 69(10):4143-9. PMID: 19435921.
      View in: PubMed
    42. Volchenboum SL, Kristjansdottir K, Wolfgeher D, Kron SJ. Rapid validation of Mascot search results via stable isotope labeling, pair picking, and deconvolution of fragmentation patterns. Mol Cell Proteomics. 2009 Aug; 8(8):2011-22. PMID: 19435713.
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    43. Volchenboum SL, Cohn SL. Progress in defining and treating high-risk neuroblastoma: lessons from the bench and bedside. J Clin Oncol. 2009 Mar 01; 27(7):1003-4. PMID: 19171702.
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    44. Hartford C, Volchenboum SL, Cohn SL. 3 + 3 not equal to (Rolling) 6. J Clin Oncol. 2008 Jan 10; 26(2):170-1. PMID: 18182656.
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    45. Volchenboum SL, Mohsen AW, Kim JJ, Vockley J. Arginine 387 of human isovaleryl-CoA dehydrogenase plays a crucial role in substrate/product binding. Mol Genet Metab. 2001 Sep-Oct; 74(1-2):226-37. PMID: 11592819.
      View in: PubMed
    46. Volchenboum SL, Vockley J. Mitochondrial import and processing of wild type and type III mutant isovaleryl-CoA dehydrogenase. J Biol Chem. 2000 Mar 17; 275(11):7958-63. PMID: 10713113.
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    47. Mohsen AW, Anderson BD, Volchenboum SL, Battaile KP, Tiffany K, Roberts D, Kim JJ, Vockley J. Characterization of molecular defects in isovaleryl-CoA dehydrogenase in patients with isovaleric acidemia. Biochemistry. 1998 Jul 14; 37(28):10325-35. PMID: 9665741.
      View in: PubMed
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