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David A. Ehrmann

TitleClinical Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Endocrinology
AddressChicago IL 60637
Phone+1 (773) 702-9653
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Utzschneider KM, Ehrmann DA, Arslanian SA, Barengolts E, Buchanan TA, Caprio S, Edelstein SL, Hannon TS, Kahn SE, Kozedub A, Mather KJ, Nadeau KJ, Sam S, Tripputi M, Xiang AH, El Ghormli L, RISE Consortium. Weight loss and ß-cell responses following gastric banding or pharmacotherapy in adults with impaired glucose tolerance or type 2 diabetes: a randomized trial. Obesity (Silver Spring). 2022 08; 30(8):1579-1588. PMID: 35894078; PMCID: PMC10849844.
      Citations:    Fields:    Translation:Humans
    2. Doycheva I, Ehrmann DA. Nonalcoholic fatty liver disease and obstructive sleep apnea in women with polycystic ovary syndrome. Fertil Steril. 2022 05; 117(5):897-911. PMID: 35512974.
      Citations: 3     Fields:    Translation:Humans
    3. Lee CG, Heckman-Stoddard B, Dabelea D, Gadde KM, Ehrmann D, Ford L, Prorok P, Boyko EJ, Pi-Sunyer X, Wallia A, Knowler WC, Crandall JP, Temprosa M, Diabetes Prevention Program Research Group, Diabetes Prevention Program Research Group:. Effect of Metformin and Lifestyle Interventions on Mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study. Diabetes Care. 2021 12; 44(12):2775-2782. PMID: 34697033; PMCID: PMC8669534.
      Citations: 19     Fields:    Translation:Humans
    4. Kahn SE, Edelstein SL, Arslanian SA, Barengolts E, Caprio S, Ehrmann DA, Hannon TS, Marcovina S, Mather KJ, Nadeau KJ, Utzschneider KM, Xiang AH, Buchanan TA, RISE Consortium, Rise Consortium Investigators:. Effect of Medical and Surgical Interventions on a-Cell Function in Dysglycemic Youth and Adults in the RISE Study. Diabetes Care. 2021 09; 44(9):1948-1960. PMID: 34135015; PMCID: PMC8740921.
      Citations: 1     Fields:    Translation:Humans
    5. Kahn SE, Mather KJ, Arslanian SA, Barengolts E, Buchanan TA, Caprio S, Ehrmann DA, Hannon TS, Marcovina S, Nadeau KJ, Utzschneider KM, Xiang AH, Edelstein SL, RISE Consortium, Rise Consortium Investigators:. Hyperglucagonemia Does Not Explain the ß-Cell Hyperresponsiveness and Insulin Resistance in Dysglycemic Youth Compared With Adults: Lessons From the RISE Study. Diabetes Care. 2021 09; 44(9):1961-1969. PMID: 34131047; PMCID: PMC8740916.
      Citations: 7     Fields:    Translation:Humans
    6. Sam S, Edelstein SL, Arslanian SA, Barengolts E, Buchanan TA, Caprio S, Ehrmann DA, Hannon TS, Tjaden AH, Kahn SE, Mather KJ, Tripputi M, Utzschneider KM, Xiang AH, Nadeau KJ, RISE Consortium, RISE Consortium Investigators. Baseline Predictors of Glycemic Worsening in Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study. Diabetes Care. 2021 09; 44(9):1938-1947. PMID: 34131048; PMCID: PMC8740917.
      Citations: 10     Fields:    Translation:Humans
    7. Xiang AH, Martinez MP, Trigo E, Utzschneider KM, Cree-Green M, Arslanian SA, Ehrmann DA, Caprio S, Mohamed PHIH, Hwang DH, Katkhouda N, Nayak KS, Buchanan TA, RISE Consortium. Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and ß-Cell Function. Obesity (Silver Spring). 2021 07; 29(7):1155-1163. PMID: 34038037; PMCID: PMC8222142.
      Citations: 1     Fields:    Translation:Humans
    8. Mokhlesi B, Tjaden AH, Temple KA, Edelstein SL, Sam S, Nadeau KJ, Hannon TS, Manchanda S, Mather KJ, Kahn SE, Ehrmann DA, Van Cauter E, RISE Consortium. Obstructive Sleep Apnea, Glucose Tolerance, and ß-Cell Function in Adults With Prediabetes or Untreated Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study. Diabetes Care. 2021 04; 44(4):993-1001. PMID: 33547205; PMCID: PMC7985427.
      Citations: 9     Fields:    Translation:Humans
    9. Hannon TS, Edelstein SL, Arslanian SA, Caprio S, Zeitler PS, Buchanan TA, Ehrmann DA, Mather KJ, Tripputi M, Kahn SE, Nadeau KJ, RISE Consortium. Withdrawal of medications leads to worsening of OGTT parameters in youth with impaired glucose tolerance or recently-diagnosed type 2 diabetes. Pediatr Diabetes. 2020 12; 21(8):1437-1446. PMID: 32985775; PMCID: PMC7642167.
      Citations: 4     Fields:    Translation:Humans
    10. Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, Karaderi T, Barber TM, McCarthy MI, Franks S, Lindgren CM, Welt CK, Diamanti-Kandarakis E, Panidis D, Goodarzi MO, Azziz R, Zhang Y, James RG, Olivier M, Kissebah AH, Reproductive Medicine Network, Stener-Victorin E, Legro RS, Dunaif A. Publisher Correction: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun. 2020 04 28; 11(1):2158. PMID: 32345980; PMCID: PMC7188886.
      Citations:    Fields:    
    11. Day F, Karaderi T, Jones MR, Meun C, He C, Drong A, Kraft P, Lin N, Huang H, Broer L, Magi R, Saxena R, Laisk T, Urbanek M, Hayes MG, Thorleifsson G, Fernandez-Tajes J, Mahajan A, Mullin BH, Stuckey BGA, Spector TD, Wilson SG, Goodarzi MO, Davis L, Obermayer-Pietsch B, Anttila V, Neale BM, Jarvelin MR, Fauser B, Kowalska I, Visser JA, Andersen M, Ong K, Stener-Victorin E, Ehrmann D, Legro RS, Salumets A, McCarthy MI, Morin-Papunen L, Thorsteinsdottir U, Stefansson K, 23andMe Research Team, Styrkarsdottir U, Perry JRB, Dunaif A, Laven J, Franks S, Lindgren CM, Welt CK, Uitterlinden AG. Correction: Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria. PLoS Genet. 2019 Dec; 15(12):e1008517. PMID: 31805045; PMCID: PMC6894746.
      Citations: 9     Fields:    
    12. Mokhlesi B, Temple KA, Tjaden AH, Edelstein SL, Nadeau KJ, Hannon TS, Manchanda S, Sam S, Barengolts E, Utzschneider KM, Ehrmann DA, Van Cauter E, RISE Consortium. The association of sleep disturbances with glycemia and obesity in youth at risk for or with recently diagnosed type 2 diabetes. Pediatr Diabetes. 2019 12; 20(8):1056-1063. PMID: 31486162; PMCID: PMC7199716.
      Citations: 6     Fields:    Translation:Humans
    13. Sam S, Ehrmann DA. Pathogenesis and Consequences of Disordered Sleep in PCOS. Clin Med Insights Reprod Health. 2019; 13:1179558119871269. PMID: 31516314; PMCID: PMC6724486.
      Citations: 15     
    14. Temple KA, Tjaden AH, Atkinson KM, Barengolts E, Hannon TS, Mather KJ, Utzschneider KM, Edelstein SL, Ehrmann DA, Mokhlesi B, RISE Consortium. Association of Habitual Daily Physical Activity With Glucose Tolerance and ß-Cell Function in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes From the Restoring Insulin Secretion (RISE) Study. Diabetes Care. 2019 08; 42(8):1521-1529. PMID: 31177181; PMCID: PMC6647043.
      Citations: 6     Fields:    Translation:HumansCells
    15. Mokhlesi B, Temple KA, Tjaden AH, Edelstein SL, Utzschneider KM, Nadeau KJ, Hannon TS, Sam S, Barengolts E, Manchanda S, Ehrmann DA, Van Cauter E, RISE Consortium. Association of Self-Reported Sleep and Circadian Measures With Glycemia in Adults With Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes. Diabetes Care. 2019 07; 42(7):1326-1332. PMID: 31048411; PMCID: PMC6609965.
      Citations: 26     Fields:    Translation:Humans
    16. Day F, Karaderi T, Jones MR, Meun C, He C, Drong A, Kraft P, Lin N, Huang H, Broer L, Magi R, Saxena R, Laisk T, Urbanek M, Hayes MG, Thorleifsson G, Fernandez-Tajes J, Mahajan A, Mullin BH, Stuckey BGA, Spector TD, Wilson SG, Goodarzi MO, Davis L, Obermayer-Pietsch B, Anttila V, Neale BM, Jarvelin MR, Fauser B, Kowalska I, Visser JA, Andersen M, Ong K, Stener-Victorin E, Ehrmann D, Legro RS, Salumets A, McCarthy MI, Morin-Papunen L, Thorsteinsdottir U, Stefansson K, 23andMe Research Team, Styrkarsdottir U, Perry JRB, Dunaif A, Laven J, Franks S, Lindgren CM, Welt CK, Uitterlinden AG. Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria. PLoS Genet. 2018 12; 14(12):e1007813. PMID: 30566500; PMCID: PMC6300389.
      Citations: 178     Fields:    Translation:Humans
    17. Morselli LL, Temple KA, Leproult R, Ehrmann DA, Van Cauter E, Mokhlesi B. Determinants of Slow-Wave Activity in Overweight and Obese Adults: Roles of Sex, Obstructive Sleep Apnea and Testosterone Levels. Front Endocrinol (Lausanne). 2018; 9:377. PMID: 30050500; PMCID: PMC6052085.
      Citations: 6     Fields:    
    18. Temple KA, Leproult R, Morselli L, Ehrmann DA, Van Cauter E, Mokhlesi B. Sex Differences in the Impact of Obstructive Sleep Apnea on Glucose Metabolism. Front Endocrinol (Lausanne). 2018; 9:376. PMID: 30042734; PMCID: PMC6048262.
      Citations: 10     Fields:    
    19. Kim C, Aroda VR, Goldberg RB, Younes N, Edelstein SL, Carrion-Petersen ML, Ehrmann DA, Diabetes Prevention Program Outcomes Study Group. Response to Letter to the Editor: "Androgens, Irregular Menses, and Risk of Diabetes and Coronary Artery Calcification in the Diabetes Prevention Program". J Clin Endocrinol Metab. 2018 05 01; 103(5):2068. PMID: 29546419; PMCID: PMC7263787.
      Citations:    Fields:    Translation:Humans
    20. Martin KA, Anderson RR, Chang RJ, Ehrmann DA, Lobo RA, Murad MH, Pugeat MM, Rosenfield RL. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018 04 01; 103(4):1233-1257. PMID: 29522147.
      Citations: 64     Fields:    Translation:Humans
    21. Kim C, Aroda VR, Goldberg RB, Younes N, Edelstein SL, Carrion-Petersen M, Ehrmann DA, Diabetes Prevention Program Outcomes Study Group. Androgens, Irregular Menses, and Risk of Diabetes and Coronary Artery Calcification in the Diabetes Prevention Program. J Clin Endocrinol Metab. 2018 02 01; 103(2):486-496. PMID: 29220533; PMCID: PMC5800828.
      Citations: 5     Fields:    Translation:Humans
    22. Sam S, Ehrmann DA. Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome. Diabetologia. 2017 09; 60(9):1656-1661. PMID: 28770330.
      Citations: 27     Fields:    Translation:Humans
    23. Billings LK, Jablonski KA, Warner AS, Cheng YC, McAteer JB, Tipton L, Shuldiner AR, Ehrmann DA, Manning AK, Dabelea D, Kahn SE, Pollin TI, Knowler WC, Altshuler D, Florez JC, Diabetes Prevention Program Research Group, Franks PW. Variation in Maturity-Onset Diabetes of the Young Genes Influence Response to Interventions for Diabetes Prevention. J Clin Endocrinol Metab. 2017 08 01; 102(8):2678-2689. PMID: 28453780; PMCID: PMC5546852.
      Citations: 8     Fields:    
    24. Hannon TS, Kahn SE, Utzschneider KM, Buchanan TA, Nadeau KJ, Zeitler PS, Ehrmann DA, Arslanian SA, Caprio S, Edelstein SL, Savage PJ, Mather KJ, RISE Consortium. Review of methods for measuring ß-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium. Diabetes Obes Metab. 2018 01; 20(1):14-24. PMID: 28493515; PMCID: PMC6095472.
      Citations: 41     Fields:    Translation:HumansCells
    25. Hermanns N, Ehrmann D, Schall S, Maier B, Haak T, Kulzer B. The effect of an education programme (MEDIAS 2 BSC) of non-intensive insulin treatment regimens for people with Type 2 diabetes: a randomized, multi-centre trial. Diabet Med. 2017 08; 34(8):1084-1091. PMID: 28257159.
      Citations: 9     Fields:    Translation:Humans
    26. Mokhlesi B, Sam S, Ehrmann DA. Obstructive sleep apnea and polycystic ovary syndrome: cause or association? Sleep Med. 2017 08; 36:170-171. PMID: 28238552.
      Citations:    Fields:    Translation:Humans
    27. Rosenfield RL, Ehrmann DA. The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited. Endocr Rev. 2016 10; 37(5):467-520. PMID: 27459230; PMCID: PMC5045492.
      Citations: 405     Fields:    Translation:HumansAnimals
    28. Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, Karaderi T, Barber TM, McCarthy MI, Franks S, Lindgren CM, Welt CK, Diamanti-Kandarakis E, Panidis D, Goodarzi MO, Azziz R, Zhang Y, James RG, Olivier M, Kissebah AH, Reproductive Medicine Network, Stener-Victorin E, Legro RS, Dunaif A. Corrigendum: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun. 2016 Feb 12; 7:10762. PMID: 26867975; PMCID: PMC4754347.
      Citations: 4     Fields:    
    29. Sam S, Ehrmann DA. Hormonal Evaluation of Hyperandrogenism in Women. JAMA. 2015 Dec 15; 314(23):2557-8. PMID: 26670974.
      Citations: 1     Fields:    Translation:Humans
    30. Christophi CA, Jablonski KA, Ehrmann DA, Kahn SE, Horton ES, Pollin TI, Mather KJ, Perreault L, Barrett-Connor E, Knowler WC, Florez JC, Diabetes Prevention Program Research Group, Hivert MF, Franks PW. Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants. Diabetes. 2016 Feb; 65(2):520-6. PMID: 26525880; PMCID: PMC4747453.
      Citations: 18     Fields:    Translation:Humans
    31. Schmitt A, Reimer A, Kulzer B, Haak T, Ehrmann D, Hermanns N. How to assess diabetes distress: comparison of the Problem Areas in Diabetes Scale (PAID) and the Diabetes Distress Scale (DDS). Diabet Med. 2016 06; 33(6):835-43. PMID: 26287511.
      Citations: 54     Fields:    Translation:Humans
    32. Ehrmann D, Kulzer B, Haak T, Hermanns N. Longitudinal relationship of diabetes-related distress and depressive symptoms: analysing incidence and persistence. Diabet Med. 2015 Oct; 32(10):1264-71. PMID: 26202341.
      Citations: 25     Fields:    Translation:Humans
    33. Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, Karaderi T, Barber TM, McCarthy MI, Franks S, Lindgren CM, Welt CK, Diamanti-Kandarakis E, Panidis D, Goodarzi MO, Azziz R, Zhang Y, James RG, Olivier M, Kissebah AH, Reproductive Medicine Network, Stener-Victorin E, Legro RS, Dunaif A. Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun. 2015 Aug 18; 6:7502. PMID: 26284813; PMCID: PMC4557132.
      Citations: 150     Fields:    Translation:Humans
    34. Rosenfield RL, Ehrmann DA, Littlejohn EE. Adolescent polycystic ovary syndrome due to functional ovarian hyperandrogenism persists into adulthood. J Clin Endocrinol Metab. 2015 Apr; 100(4):1537-43. PMID: 25675386; PMCID: PMC4399308.
      Citations: 5     Fields:    Translation:Humans
    35. Legro RS, Arslanian SA, Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, Welt CK, Endocrine Society. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2013 Dec; 98(12):4565-92. PMID: 24151290; PMCID: PMC5399492.
      Citations: 543     Fields:    Translation:Humans
    36. Domecq JP, Prutsky G, Mullan RJ, Sundaresh V, Wang AT, Erwin PJ, Welt C, Ehrmann D, Montori VM, Murad MH. Adverse effects of the common treatments for polycystic ovary syndrome: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2013 Dec; 98(12):4646-54. PMID: 24092830; PMCID: PMC5399491.
      Citations: 36     Fields:    Translation:Humans
    37. Reutrakul S, Zaidi N, Wroblewski K, Kay HH, Ismail M, Ehrmann DA, Van Cauter E. Interactions between pregnancy, obstructive sleep apnea, and gestational diabetes mellitus. J Clin Endocrinol Metab. 2013 Oct; 98(10):4195-202. PMID: 23966237; PMCID: PMC3790617.
      Citations: 34     Fields:    Translation:Humans
    38. Broussard JL, Ehrmann DA, Van Cauter E, Tasali E, Brady MJ. Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study. Ann Intern Med. 2012 Oct 16; 157(8):549-57. PMID: 23070488; PMCID: PMC4435718.
      Citations: 157     Fields:    Translation:HumansCells
    39. Welt CK, Styrkarsdottir U, Ehrmann DA, Thorleifsson G, Arason G, Gudmundsson JA, Ober C, Rosenfield RL, Saxena R, Thorsteinsdottir U, Crowley WF, Stefansson K. Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. J Clin Endocrinol Metab. 2012 Jul; 97(7):E1342-7. PMID: 22547425; PMCID: PMC3387396.
      Citations: 62     Fields:    Translation:Humans
    40. Rosenfield RL, Wroblewski K, Padmanabhan V, Littlejohn E, Mortensen M, Ehrmann DA. Antimüllerian hormone levels are independently related to ovarian hyperandrogenism and polycystic ovaries. Fertil Steril. 2012 Jul; 98(1):242-9. PMID: 22541936; PMCID: PMC3597099.
      Citations: 23     Fields:    Translation:Humans
    41. Ehrmann DA. Metabolic dysfunction in pcos: Relationship to obstructive sleep apnea. Steroids. 2012 Mar 10; 77(4):290-4. PMID: 22178788; PMCID: PMC3279609.
      Citations: 13     Fields:    Translation:Humans
    42. Reutrakul S, Zaidi N, Wroblewski K, Kay HH, Ismail M, Ehrmann DA, Van Cauter E. Sleep disturbances and their relationship to glucose tolerance in pregnancy. Diabetes Care. 2011 Nov; 34(11):2454-7. PMID: 21926292; PMCID: PMC3198297.
      Citations: 47     Fields:    Translation:Humans
    43. Rosenfield RL, Mortensen M, Wroblewski K, Littlejohn E, Ehrmann DA. Determination of the source of androgen excess in functionally atypical polycystic ovary syndrome by a short dexamethasone androgen-suppression test and a low-dose ACTH test. Hum Reprod. 2011 Nov; 26(11):3138-46. PMID: 21908468; PMCID: PMC3196876.
      Citations: 30     Fields:    Translation:Humans
    44. Tasali E, Chapotot F, Leproult R, Whitmore H, Ehrmann DA. Treatment of obstructive sleep apnea improves cardiometabolic function in young obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2011 Feb; 96(2):365-74. PMID: 21123449; PMCID: PMC3048326.
      Citations: 37     Fields:    Translation:Humans
    45. Van Cauter E, Ehrmann DA. Sleep and metabolism. Preface. Best Pract Res Clin Endocrinol Metab. 2010 Oct; 24(5):vii-viii. PMID: 21112018.
      Citations: 2     Fields:    Translation:HumansAnimals
    46. Nitsche K, Ehrmann DA. Obstructive sleep apnea and metabolic dysfunction in polycystic ovary syndrome. Best Pract Res Clin Endocrinol Metab. 2010 Oct; 24(5):717-30. PMID: 21112021; PMCID: PMC3030192.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    47. Zimmer CA, Ehrmann DA, Rosenfield RL. Potential diagnostic utility of intermittent administration of short-acting gonadotropin-releasing hormone agonist in gonadotropin deficiency. Fertil Steril. 2010 Dec; 94(7):2697-702. PMID: 20553679; PMCID: PMC2944005.
      Citations: 7     Fields:    Translation:Humans
    48. Kawai T, Ng MC, Hayes MG, Yoshiuchi I, Tsuchiya T, Robertson H, Cox NJ, Polonsky KS, Bell GI, Ehrmann DA. Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome. Diabetes Res Clin Pract. 2009 Dec; 86(3):186-92. PMID: 19782423; PMCID: PMC2794304.
      Citations: 7     Fields:    Translation:Humans
    49. Hirshfeld-Cytron J, Barnes RB, Ehrmann DA, Caruso A, Mortensen MM, Rosenfield RL. Characterization of functionally typical and atypical types of polycystic ovary syndrome. J Clin Endocrinol Metab. 2009 May; 94(5):1587-94. PMID: 19240152; PMCID: PMC2684483.
      Citations: 15     Fields:    Translation:HumansCells
    50. Mortensen M, Ehrmann DA, Littlejohn E, Rosenfield RL. Asymptomatic volunteers with a polycystic ovary are a functionally distinct but heterogeneous population. J Clin Endocrinol Metab. 2009 May; 94(5):1579-86. PMID: 19240158; PMCID: PMC2684482.
      Citations: 26     Fields:    Translation:Humans
    51. Hultgren S, Goldstein JM, Delancey JO, Bandstra ES, Brady KT, Brown JS, Deng HW, Dunaif A, Ehrmann DA, Mayer EA, Sinha R, Tobet S, Levine JE. The vital role of ORWH. Science. 2009 Feb 20; 323(5917):1009-10. PMID: 19229019.
      Citations:    Fields:    Translation:Humans
    52. Tasali E, Van Cauter E, Hoffman L, Ehrmann DA. Impact of obstructive sleep apnea on insulin resistance and glucose tolerance in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2008 Oct; 93(10):3878-84. PMID: 18647805; PMCID: PMC2579653.
      Citations: 29     Fields:    Translation:Humans
    53. Tasali E, Van Cauter E, Ehrmann DA. Polycystic Ovary Syndrome and Obstructive Sleep Apnea. Sleep Med Clin. 2008 Mar; 3(1):37-46. PMID: 19255602; PMCID: PMC2390828.
      Citations: 27     Fields:    
    54. Hoffman LK, Ehrmann DA. Cardiometabolic features of polycystic ovary syndrome. Nat Clin Pract Endocrinol Metab. 2008 Apr; 4(4):215-22. PMID: 18250636.
      Citations: 26     Fields:    Translation:Humans
    55. Martin KA, Chang RJ, Ehrmann DA, Ibanez L, Lobo RA, Rosenfield RL, Shapiro J, Montori VM, Swiglo BA. Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2008 Apr; 93(4):1105-20. PMID: 18252793.
      Citations: 68     Fields:    Translation:Humans
    56. Tasali E, Leproult R, Ehrmann DA, Van Cauter E. Slow-wave sleep and the risk of type 2 diabetes in humans. Proc Natl Acad Sci U S A. 2008 Jan 22; 105(3):1044-9. PMID: 18172212; PMCID: PMC2242689.
      Citations: 364     Fields:    Translation:Humans
    57. Lachin JM, Christophi CA, Edelstein SL, Ehrmann DA, Hamman RF, Kahn SE, Knowler WC, Nathan DM, DDK Research Group. Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention program. Diabetes. 2007 Apr; 56(4):1153-9. PMID: 17395752; PMCID: PMC2533728.
      Citations: 41     Fields:    Translation:Humans
    58. Dronavalli S, Ehrmann DA. Pharmacologic therapy of polycystic ovary syndrome. Clin Obstet Gynecol. 2007 Mar; 50(1):244-54. PMID: 17304039.
      Citations: 11     Fields:    Translation:Humans
    59. Qin K, Ehrmann DA, Cox N, Refetoff S, Rosenfield RL. Identification of a functional polymorphism of the human type 5 17beta-hydroxysteroid dehydrogenase gene associated with polycystic ovary syndrome. J Clin Endocrinol Metab. 2006 Jan; 91(1):270-6. PMID: 16263811; PMCID: PMC1522092.
      Citations: 22     Fields:    Translation:Humans
    60. Ehrmann DA, Liljenquist DR, Kasza K, Azziz R, Legro RS, Ghazzi MN, PCOS/Troglitazone Study Group. Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2006 Jan; 91(1):48-53. PMID: 16249284.
      Citations: 174     Fields:    Translation:Humans
    61. Tasali E, Van Cauter E, Ehrmann DA. Relationships between sleep disordered breathing and glucose metabolism in polycystic ovary syndrome. J Clin Endocrinol Metab. 2006 Jan; 91(1):36-42. PMID: 16219719.
      Citations: 34     Fields:    Translation:HumansCTClinical Trials
    62. Knowler WC, Hamman RF, Edelstein SL, Barrett-Connor E, Ehrmann DA, Walker EA, Fowler SE, Nathan DM, Kahn SE, Diabetes Prevention Program Research Group. Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program. Diabetes. 2005 Apr; 54(4):1150-6. PMID: 15793255; PMCID: PMC1351025.
      Citations: 129     Fields:    Translation:HumansCTClinical Trials
    63. Ehrmann DA. Polycystic ovary syndrome. N Engl J Med. 2005 Mar 24; 352(12):1223-36. PMID: 15788499.
      Citations: 506     Fields:    Translation:Humans
    64. Ehrmann DA, Kasza K, Azziz R, Legro RS, Ghazzi MN, PCOS/Troglitazone Study Group. Effects of race and family history of type 2 diabetes on metabolic status of women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005 Jan; 90(1):66-71. PMID: 15507516.
      Citations: 46     Fields:    Translation:Humans
    65. Ehrmann DA. Genetic contributions to glucose intolerance in polycystic ovary syndrome. Reprod Biomed Online. 2004 Jul; 9(1):28-34. PMID: 15257813.
      Citations: 2     Fields:    Translation:Humans
    66. Alcoser SY, Hara M, Bell GI, Ehrmann DA. Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome. J Clin Endocrinol Metab. 2004 Jun; 89(6):2973-6. PMID: 15181086.
      Citations: 1     Fields:    Translation:HumansCells
    67. Weiner CL, Primeau M, Ehrmann DA. Androgens and mood dysfunction in women: comparison of women with polycystic ovarian syndrome to healthy controls. Psychosom Med. 2004 May-Jun; 66(3):356-62. PMID: 15184695.
      Citations: 63     Fields:    Translation:Humans
    68. Van Scott MR, Hooker JL, Ehrmann D, Shibata Y, Kukoly C, Salleng K, Westergaard G, Sandrasagra A, Nyce J. Dust mite-induced asthma in cynomolgus monkeys. J Appl Physiol (1985). 2004 Apr; 96(4):1433-44. PMID: 14672959.
      Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    69. Ehrmann DA, Breda E, Corcoran MC, Cavaghan MK, Imperial J, Toffolo G, Cobelli C, Polonsky KS. Impaired beta-cell compensation to dexamethasone-induced hyperglycemia in women with polycystic ovary syndrome. Am J Physiol Endocrinol Metab. 2004 Aug; 287(2):E241-6. PMID: 14665448.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    70. Rosenfield RL, Barnes RB, Ehrmann DA, Toledano AY. The value of the low-dose dexamethasone suppression test in the differential diagnosis of hyperandrogenism in women. J Clin Endocrinol Metab. 2003 Dec; 88(12):6115; author reply 6115-6. PMID: 14671222.
      Citations: 3     Fields:    Translation:Humans
    71. Legro RS, Azziz R, Ehrmann D, Fereshetian AG, O'Keefe M, Ghazzi MN. Minimal response of circulating lipids in women with polycystic ovary syndrome to improvement in insulin sensitivity with troglitazone. J Clin Endocrinol Metab. 2003 Nov; 88(11):5137-44. PMID: 14602740.
      Citations: 12     Fields:    Translation:HumansCTClinical Trials
    72. Ehrmann DA, Rychlik D. Pharmacologic treatment of polycystic ovary syndrome. Semin Reprod Med. 2003 Aug; 21(3):277-83. PMID: 14593550.
      Citations: 1     Fields:    Translation:Humans
    73. Azziz R, Ehrmann DA, Legro RS, Fereshetian AG, O'Keefe M, Ghazzi MN, PCOS/Troglitazone Study Group. Troglitazone decreases adrenal androgen levels in women with polycystic ovary syndrome. Fertil Steril. 2003 Apr; 79(4):932-7. PMID: 12749433.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    74. Ehrmann DA, Tang X, Yoshiuchi I, Cox NJ, Bell GI. Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Sep; 87(9):4297-300. PMID: 12213887.
      Citations: 19     Fields:    Translation:HumansCells
    75. Ehrmann DA, Schwarz PE, Hara M, Tang X, Horikawa Y, Imperial J, Bell GI, Cox NJ. Relationship of calpain-10 genotype to phenotypic features of polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 Apr; 87(4):1669-73. PMID: 11932299.
      Citations: 20     Fields:    Translation:Humans
    76. Ehrmann DA, Breda E, Cavaghan MK, Bajramovic S, Imperial J, Toffolo G, Cobelli C, Polonsky KS. Insulin secretory responses to rising and falling glucose concentrations are delayed in subjects with impaired glucose tolerance. Diabetologia. 2002 Apr; 45(4):509-17. PMID: 12032626.
      Citations: 11     Fields:    Translation:Humans
    77. Hara M, Alcoser SY, Qaadir A, Beiswenger KK, Cox NJ, Ehrmann DA, Hara M, Alcoser SY, Qaadir A, Beiswenger KK, Cox NJ, Ehrmann DA. Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene. J Clin Endocrinol Metab. 2002 Feb; 87(2):772-5. PMID: 11836319.
      Citations: 20     Fields:    Translation:HumansCells
    78. Ehrmann DA. Insulin resistance and polycystic ovary syndrome. Curr Diab Rep. 2002 Feb; 2(1):71-6. PMID: 12643125.
      Citations: 4     Fields:    Translation:Humans
    79. Colilla S, Cox NJ, Ehrmann DA. Heritability of insulin secretion and insulin action in women with polycystic ovary syndrome and their first degree relatives. J Clin Endocrinol Metab. 2001 May; 86(5):2027-31. PMID: 11344202.
      Citations: 36     Fields:    Translation:Humans
    80. Azziz R, Ehrmann D, Legro RS, Whitcomb RW, Hanley R, Fereshetian AG, O'Keefe M, Ghazzi MN, PCOS/Troglitazone Study Group. Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial. J Clin Endocrinol Metab. 2001 Apr; 86(4):1626-32. PMID: 11297595.
      Citations: 104     Fields:    Translation:HumansCTClinical Trials
    81. Toffolo G, Breda E, Cavaghan MK, Ehrmann DA, Polonsky KS, Cobelli C. Quantitative indexes of beta-cell function during graded up&down glucose infusion from C-peptide minimal models. Am J Physiol Endocrinol Metab. 2001 Jan; 280(1):E2-10. PMID: 11120653.
      Citations: 31     Fields:    Translation:HumansCellsCTClinical Trials
    82. Cavaghan MK, Ehrmann DA, Polonsky KS. Interactions between insulin resistance and insulin secretion in the development of glucose intolerance. J Clin Invest. 2000 Aug; 106(3):329-33. PMID: 10930434; PMCID: PMC314336.
      Citations: 84     Fields:    Translation:HumansAnimals
    83. Ehrmann DA. Glucose intolerance in the polycystic ovary syndrome: role of the pancreatic beta-cell. J Pediatr Endocrinol Metab. 2000; 13 Suppl 5:1299-301. PMID: 11117674.
      Citations: 2     Fields:    Translation:Humans
    84. Rosenfield RL, Ghai K, Ehrmann DA, Barnes RB. Diagnosis of the polycystic ovary syndrome in adolescence: comparison of adolescent and adult hyperandrogenism. J Pediatr Endocrinol Metab. 2000; 13 Suppl 5:1285-9. PMID: 11117671.
      Citations: 17     Fields:    Translation:Humans
    85. Eaves IA, Bennett ST, Forster P, Ferber KM, Ehrmann D, Wilson AJ, Bhattacharyya S, Ziegler AG, Brinkmann B, Todd JA. Transmission ratio distortion at the INS-IGF2 VNTR. Nat Genet. 1999 Aug; 22(4):324-5. PMID: 10431232.
      Citations: 21     Fields:    Translation:HumansCells
    86. Cohen DP, Stein EM, Li Z, Matulis CK, Ehrmann DA, Layman LC. Molecular analysis of the gonadotropin-releasing hormone receptor in patients with polycystic ovary syndrome. Fertil Steril. 1999 Aug; 72(2):360-3. PMID: 10439012.
      Citations: 3     Fields:    Translation:Humans
    87. Urbanek M, Legro RS, Driscoll DA, Azziz R, Ehrmann DA, Norman RJ, Strauss JF, Spielman RS, Dunaif A. Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8573-8. PMID: 10411917; PMCID: PMC17558.
      Citations: 94     Fields:    Translation:Humans
    88. Ehrmann DA. Insulin-lowering therapeutic modalities for polycystic ovary syndrome. Endocrinol Metab Clin North Am. 1999 Jun; 28(2):423-38, viii. PMID: 10352927.
      Citations: 3     Fields:    Translation:Humans
    89. Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care. 1999 Jan; 22(1):141-6. PMID: 10333916.
      Citations: 256     Fields:    Translation:Humans
    90. Ehrmann DA. Attenuation of hyperinsulinemia in polycystic ovary syndrome: what are the options? J Endocrinol Invest. 1998 Oct; 21(9):632-5. PMID: 9856419.
      Citations:    Fields:    Translation:Humans
    91. Cavaghan MK, Ehrmann DA, Byrne MM, Polonsky KS. Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance. J Clin Invest. 1997 Aug 01; 100(3):530-7. PMID: 9239399; PMCID: PMC508219.
      Citations: 31     Fields:    Translation:HumansAnimalsCTClinical Trials
    92. Ehrmann DA, Schneider DJ, Sobel BE, Cavaghan MK, Imperial J, Rosenfield RL, Polonsky KS. Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 1997 Jul; 82(7):2108-16. PMID: 9215280.
      Citations: 54     Fields:    Translation:Humans
    93. Ehrmann DA. Relation of functional ovarian hyperandrogenism to non-insulin dependent diabetes mellitus. Baillieres Clin Obstet Gynaecol. 1997 Jun; 11(2):335-47. PMID: 9536214.
      Citations: 3     Fields:    Translation:Humans
    94. Barnes RB, Ehrmann DA. Long-term suppression of testosterone after treatment with a gonadotropin-releasing hormone agonist in a woman with a presumed testosterone secreting ovarian tumor. J Clin Endocrinol Metab. 1997 Jun; 82(6):1746-8. PMID: 9177374.
      Citations: 4     Fields:    Translation:Humans
    95. Ehrmann DA, Cavaghan MK, Imperial J, Sturis J, Rosenfield RL, Polonsky KS. Effects of metformin on insulin secretion, insulin action, and ovarian steroidogenesis in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 1997 Feb; 82(2):524-30. PMID: 9024248.
      Citations: 40     Fields:    Translation:HumansCTClinical Trials
    96. Rosenfield RL, Perovic N, Ehrmann DA, Barnes RB. Acute hormonal responses to the gonadotropin releasing hormone agonist leuprolide: dose-response studies and comparison to nafarelin--a clinical research center study. J Clin Endocrinol Metab. 1996 Sep; 81(9):3408-11. PMID: 8784105.
      Citations: 13     Fields:    Translation:HumansCTClinical Trials
    97. Raffel LJ, Robbins DC, Norris JM, Boerwinkle E, DeFronzo RA, Elbein SC, Fujimoto W, Hanis CL, Kahn SE, Permutt MA, Chiu KC, Cruz J, Ehrmann DA, Robertson RP, Rotter JI, Buse J. The GENNID Study. A resource for mapping the genes that cause NIDDM. Diabetes Care. 1996 Aug; 19(8):864-72. PMID: 8842605.
      Citations: 18     Fields:    Translation:Humans
    98. Ehrmann DA, Sturis J, Byrne MM, Karrison T, Rosenfield RL, Polonsky KS. Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J Clin Invest. 1995 Jul; 96(1):520-7. PMID: 7615824; PMCID: PMC185226.
      Citations: 85     Fields:    Translation:Humans
    99. Ehrmann DA, Barnes RB, Rosenfield RL. Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocr Rev. 1995 Jun; 16(3):322-53. PMID: 7671850.
      Citations: 101     Fields:    Translation:Humans
    100. Rosenfield RL, Barnes RB, Ehrmann DA. Studies of the nature of 17-hydroxyprogesterone hyperresonsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism. J Clin Endocrinol Metab. 1994 Dec; 79(6):1686-92. PMID: 7989476.
      Citations: 26     Fields:    Translation:Humans
    101. Barnes RB, Rosenfield RL, Ehrmann DA, Cara JF, Cuttler L, Levitsky LL, Rosenthal IM. Ovarian hyperandrogynism as a result of congenital adrenal virilizing disorders: evidence for perinatal masculinization of neuroendocrine function in women. J Clin Endocrinol Metab. 1994 Nov; 79(5):1328-33. PMID: 7962325.
      Citations: 91     Fields:    Translation:HumansCTClinical Trials
    102. Rosenfield RL, Ehrmann DA, Barnes RB, Sheikh Z. Gonadotropin-releasing hormone agonist as a probe for the pathogenesis and diagnosis of ovarian hyperandrogenism. Ann N Y Acad Sci. 1993 May 28; 687:162-81. PMID: 8323171.
      Citations: 1     Fields:    Translation:HumansAnimals
    103. O'Meara NM, Blackman JD, Ehrmann DA, Barnes RB, Jaspan JB, Rosenfield RL, Polonsky KS. Defects in beta-cell function in functional ovarian hyperandrogenism. J Clin Endocrinol Metab. 1993 May; 76(5):1241-7. PMID: 8496316.
      Citations: 56     Fields:    Translation:Humans
    104. Barnes RB, Ehrmann DA, Brigell DF, Rosenfield RL. Ovarian steroidogenic responses to gonadotropin-releasing hormone agonist testing with nafarelin in hirsute women with adrenal responses to adrenocorticotropin suggestive of 3 beta-hydroxy-delta 5-steroid dehydrogenase deficiency. J Clin Endocrinol Metab. 1993 Feb; 76(2):450-5. PMID: 8381802.
      Citations: 7     Fields:    Translation:Humans
    105. Cuttler L, Rosenfield RL, Ehrmann DA, Kreiter M, Burstein S, Cara JF, Levitsky LL. Maturation of gonadotropin and sex steroid responses to gonadotropin-releasing hormone agonist in males. J Clin Endocrinol Metab. 1993 Feb; 76(2):362-6. PMID: 8432780.
      Citations: 2     Fields:    Translation:Humans
    106. Ehrmann DA, Rosenfield RL, Barnes RB, Brigell DF, Sheikh Z. Detection of functional ovarian hyperandrogenism in women with androgen excess. N Engl J Med. 1992 Jul 16; 327(3):157-62. PMID: 1319000.
      Citations: 46     Fields:    Translation:Humans
    107. Ehrmann DA, Rosenfield RL. Gonadotropin-releasing hormone agonist testing of pituitary-gonadal function. Trends Endocrinol Metab. 1991 May-Jun; 2(3):86-91. PMID: 18411171.
      Citations:    Fields:    
    108. Ehrmann DA, Rosenfield RL. Hirsutism--beyond the steroidogenic block. N Engl J Med. 1990 Sep 27; 323(13):909-11. PMID: 2168517.
      Citations: 1     Fields:    Translation:Humans
    109. Ehrmann DA, Rosenfield RL. Clinical review 10: An endocrinologic approach to the patient with hirsutism. J Clin Endocrinol Metab. 1990 Jul; 71(1):1-4. PMID: 2196276.
      Citations: 9     Fields:    Translation:Humans
    110. Rosenfield RL, Burstein S, Cuttler L, Cara JF, Levitsky LL, Barnes RB, Ehrmann D. Use of nafarelin for testing pituitary-ovarian function. J Reprod Med. 1989 Dec; 34(12 Suppl):1044-50. PMID: 2533621.
      Citations: 2     Fields:    Translation:Humans
    111. Ehrmann DA, Rosenfield RL, Cuttler L, Burstein S, Cara JF, Levitsky LL. A new test of combined pituitary-testicular function using the gonadotropin-releasing hormone agonist nafarelin in the differentiation of gonadotropin deficiency from delayed puberty: pilot studies. J Clin Endocrinol Metab. 1989 Nov; 69(5):963-7. PMID: 2529266.
      Citations: 4     Fields:    Translation:Humans
    112. Barnes RB, Rosenfield RL, Burstein S, Ehrmann DA. Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome. N Engl J Med. 1989 Mar 02; 320(9):559-65. PMID: 2521688.
      Citations: 44     Fields:    Translation:Humans
    113. Ehrmann DA, Sarne DH. Serum thyrotropin and the assessment of thyroid status. Ann Intern Med. 1989 Feb 01; 110(3):179-81. PMID: 2643378.
      Citations: 1     Fields:    Translation:Humans
    114. Ehrmann DA, Weinberg M, Sarne DH. Limitations to the use of a sensitive assay for serum thyrotropin in the assessment of thyroid status. Arch Intern Med. 1989 Feb; 149(2):369-72. PMID: 2916881.
      Citations: 3     Fields:    Translation:Humans
    115. Fig LM, Gross MD, Shapiro B, Ehrmann DA, Freitas JE, Schteingart DE, Glazer GM, Francis IR. Adrenal localization in the adrenocorticotropic hormone-independent Cushing syndrome. Ann Intern Med. 1988 Oct 01; 109(7):547-53. PMID: 3421563.
      Citations: 8     Fields:    Translation:Humans
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