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Naoum Issa

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentNeurology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Naoum Issa, MD, PhD is a neurologist specializing in the treatment of epilepsy. He works closely with patients to control their seizures and is passionate about offering advanced options for epilepsy that is resistant to anti-seizure medications.

    Dr. Issa is the director of epilepsy research at the University of Chicago. His research focuses on detecting and diagnosing neurologic disorders using painless, electrophysiological techniques. He and his co-workers are developing ways to identify seizure footprints in deep brain structures without having to implant electrodes. Through collaborations with neuromuscular specialists, he is applying some of the same techniques used for seizure diagnosis to detect other neurological disorders like ALS.

    Dr. Issa has published over 40 scientific papers and book chapters, is an associate editor for epilepsy at BMC-Neurology, and is a reviewer for multiple neurology and neuroscience journals. His work has appeared in journals such as Neurology, Journal of Neuroscience, Nature Protocols, and Neuron.

    Dr. Issa directs the preclinical neurology education at the Pritzker School of Medicine and has been recognized for excellence in teaching with the L.D.H. Wood Preclerkship Teaching Award, the Arnold P. Gold Foundation Humanism and Excellence in Teaching Award, and he was a faculty honoree of the Alpha Omega Alpha Honor Medical Society for clinical teaching.


    Collapse Biography 
    Collapse education and training
    University of Chicago, Chicago06/2016Epilepsy (CNP) Fellowship
    University of Chicago, Chicago06/2015Neurology Residency
    University of Chicago, NorthShore06/2012Internship (Medicine)
    University of California, San Francisco07/2001Postdoctoral Fellowship, Physiology
    University of Texas -- Southwestern, DallasMD05/1997Medicine
    University of Texas -- Southwestern, DallasPhD05/1997Neuroscience
    Southern Methodist University, DallasBS, BA05/1989Chemistry, Biology
    Collapse awards and honors
    2019L.D.H. Wood Preclerkship Teaching Award – Pritzker School of Medicine, University of Chicago
    2018Faculty Honoree; Alpha Omega Alpha – Beta Chapter, Class of 2019, University of Chicago
    2015 - 2016American Epilepsy Association EpiPORT Fellowship, American Epilepsy Society
    2015Arnold P. Gold Foundation Humanism and Excellence in Teaching Award, University of Chicago
    2003 - 2005Alfred P. Sloan Research Fellow, University of Chicago

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Rose S, Issa NP, Wu S, Liu X, Tao JX. Reader response: Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP). Neurology. 2019 Dec 03; 93(23):1020-1021. PMID: 31792108.
      View in: PubMed
    2. Tao JX, Issa NP, Wu S, Rose S, Collins J, Warnke PC. Interstitial Stereotactic Laser Anterior Corpus Callosotomy: A Report of 2 Cases with Operative Technique and Effectiveness. Neurosurgery. 2019 Sep 01; 85(3):E569-E574. PMID: 29982584.
      View in: PubMed
    3. Liu X, Wu S, Daif A, Sun T, Chauhan V, Issa NP, Rose S, Tao JX. Clinical implications of scalp ictal EEG pattern in patients with temporal lobe epilepsy. Clin Neurophysiol. 2019 Sep; 130(9):1604-1610. PMID: 31319289.
      View in: PubMed
    4. Lee S, Issa NP, Rose S, Tao JX, Warnke PC, Towle VL, van Drongelen W, Wu S. DC shifts, high frequency oscillations, ripples and fast ripples in relation to the seizure onset zone. Seizure. 2019 May 03. PMID: 31101405.
      View in: PubMed
    5. Plass J, Ahn E, Towle VL, Stacey WC, Wasade VS, Tao J, Wu S, Issa NP, Brang D. Joint Encoding of Auditory Timing and Location in Visual Cortex. J Cogn Neurosci. 2019 Jul; 31(7):1002-1017. PMID: 30912728.
      View in: PubMed
    6. Liu X, Issa NP, Rose S, Wu S, Sun T, Towle LV, Warnke PC, Tao JX. The first-hour-of-the-day sleep EEG reliably identifies interictal epileptiform discharges during long-term video-EEG monitoring. Seizure. 2018 Dec; 63:48-51. PMID: 30399461.
      View in: PubMed
    7. Del Brutto OH, Issa NP. Focal Seizures with Corresponding Neuroimaging and Electroencephalographic Findings in a Patient with Scolex Remnants within a Calcified Cysticercus. Am J Trop Med Hyg. 2018 10; 99(4):815-816. PMID: 30292247.
      View in: PubMed
    8. Issa NP, Lee S, Wu S, Rose S, Towle VL, Warnke PC, van Drongelen W, Tao JX. Reply to "which small sharp spikes are benign epileptiform transients of sleep?" Clin Neurophysiol. 2018 11; 129(11):2495-2496. PMID: 30268708.
      View in: PubMed
    9. Bruzzone MJ, Issa N, Rose S, Warnke P, Towle VL, Tao JX, Wu S. Insights Into the Therapeutic Effect of Responsive Neurostimulation Assessed With Scalp EEG Recording: A Case Report. J Clin Neurophysiol. 2018 Sep; 35(5):438-441. PMID: 29023305.
      View in: PubMed
    10. Issa NP, Sedler MJ, Del Brutto VJ, Darsan E, Milla L, Montes J, Zambrano M, Del Brutto OH. EEG Patterns in Patients With Calcified Neurocysticercosis With or Without Hippocampal Atrophy. J Clin Neurophysiol. 2018 Jul; 35(4):332-338. PMID: 29649013.
      View in: PubMed
    11. Issa NP, Wu S, Rose S, Towle VL, Warnke PC, Tao JX. Small sharp spikes as EEG markers of mesiotemporal lobe epilepsy. Clin Neurophysiol. 2018 09; 129(9):1796-1803. PMID: 30005212.
      View in: PubMed
    12. Daif A, Lukas RV, Issa NP, Javed A, VanHaerents S, Reder AT, Tao JX, Warnke P, Rose S, Towle VL, Wu S. Antiglutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy. Epilepsy Behav. 2018 03; 80:331-336. PMID: 29433947.
      View in: PubMed
    13. Tao JX, Wu S, Lacy M, Rose S, Issa NP, Yang CW, Dorociak KE, Bruzzone M, Kim J, Daif A, Choi J, Towle VL, Warnke PC. Stereotactic EEG-guided laser interstitial thermal therapy for mesial temporal lobe epilepsy. J Neurol Neurosurg Psychiatry. 2018 05; 89(5):542-548. PMID: 29183959.
      View in: PubMed
    14. Ali A, Wu S, Issa NP, Rose S, Towle VL, Warnke P, Tao JX. Association of sleep with sudden unexpected death in epilepsy. Epilepsy Behav. 2017 11; 76:1-6. PMID: 28917499.
      View in: PubMed
    15. Issa NP, Frank S, Roos RP, Soliven B, Towle VL, Rezania K. Intermuscular coherence in amyotrophic lateral sclerosis: A preliminary assessment. Muscle Nerve. 2017 06; 55(6):862-868. PMID: 27699797.
      View in: PubMed
    16. Tao JX, Issa N, Collins JW, Wu S, Rose S, Warnke P. Homonymous hemianopsia after MR-guided stereotactic laser amygdalohippocampectomy. Epilepsy Behav. 2017 01; 66:140-141. PMID: 27993511.
      View in: PubMed
    17. Serafini A, Issa NP, Rose S, Wu S, Warnke P, Tao JX. TIRDA Originating From Lateral Temporal Cortex in a Patient With mTLE Is Not Related to Hippocampal Activity. J Clin Neurophysiol. 2016 Dec; 33(6):e34-e38. PMID: 27753735.
      View in: PubMed
    18. Kak M, Issa NP, Roos RP, Sweitzer BJ, Gottlieb O, Guralnick A, White SR, Semrad CE, Soliven B, Baroody J, Rezania K. Gastrostomy tube placement is safe in advanced amyotrophic lateral sclerosis. Neurol Res. 2017 Jan; 39(1):16-22. PMID: 27876446.
      View in: PubMed
    19. Del Brutto OH, Issa NP, Salgado P, Del Brutto VJ, Zambrano M, Lama J, García HH. The Association Between Neurocysticercosis and Hippocampal Atrophy is Related to Age. Am J Trop Med Hyg. 2017 Jan 11; 96(1):243-248. PMID: 28077750.
      View in: PubMed
    20. Wang S, Graf S, Xu J, Issa NP, Ali A, Rose S, Wu S, Jacobsen J, Warnke P, Tao JX. The incidence of peri-ictal prone position in patients with generalized convulsive seizures. Epilepsy Behav. 2016 08; 61:158-161. PMID: 27351726.
      View in: PubMed
    21. Thakral S, Issa NP, Barboi AC, Lee JM. Prominent dysautonomia in a patient with POEMS syndrome. Clin Auton Res. 2016 06; 26(3):223-8. PMID: 27165541.
      View in: PubMed
    22. Wu S, Issa NP, Rose SL, Ali A, Tao JX. Impact of periictal nurse interventions on postictal generalized EEG suppression in generalized convulsive seizures. Epilepsy Behav. 2016 05; 58:22-5. PMID: 26994879.
      View in: PubMed
    23. Issa NP, Fisher WG, Narayanan JT. QT interval prolongation in a patient with LQT2 on levetiracetam. Seizure. 2015 Jul; 29:134-6. PMID: 26076856.
      View in: PubMed
    24. Issa NP, Hentati A. VZV encephalitis that developed in an immunized patient during fingolimod therapy. Neurology. 2015 Jan 06; 84(1):99-100. PMID: 25416038.
      View in: PubMed
    25. Issa NP. Neurobiology of continuous spike-wave in slow-wave sleep and Landau-Kleffner syndromes. Pediatr Neurol. 2014 Sep; 51(3):287-96. PMID: 25160535.
      View in: PubMed
    26. Assimacopoulos S, Kao T, Issa NP, Grove EA. Fibroblast growth factor 8 organizes the neocortical area map and regulates sensory map topography. J Neurosci. 2012 May 23; 32(21):7191-201. PMID: 22623663.
      View in: PubMed
    27. Rosenberg A, Issa NP. The Y cell visual pathway implements a demodulating nonlinearity. Neuron. 2011 Jul 28; 71(2):348-61. PMID: 21791292.
      View in: PubMed
    28. Theyel BB, Llano DA, Issa NP, Mallik AK, Sherman SM. In vitro imaging using laser photostimulation with flavoprotein autofluorescence. Nat Protoc. 2011 Apr; 6(4):502-8. PMID: 21455186.
      View in: PubMed
    29. Rosenberg A, Husson TR, Issa NP. Subcortical representation of non-Fourier image features. J Neurosci. 2010 Feb 10; 30(6):1985-93. PMID: 20147527.
      View in: PubMed
    30. Llano DA, Theyel BB, Mallik AK, Sherman SM, Issa NP. Rapid and sensitive mapping of long-range connections in vitro using flavoprotein autofluorescence imaging combined with laser photostimulation. J Neurophysiol. 2009 Jun; 101(6):3325-40. PMID: 19321634.
      View in: PubMed
    31. Mallik AK, Husson TR, Zhang JX, Rosenberg A, Issa NP. The organization of spatial frequency maps measured by cortical flavoprotein autofluorescence. Vision Res. 2008 Jun; 48(14):1545-53. PMID: 18511098.
      View in: PubMed
    32. Grossman KJ, Mallik AK, Ross J, Kay LM, Issa NP. Glomerular activation patterns and the perception of odor mixtures. Eur J Neurosci. 2008 May; 27(10):2676-85. PMID: 18445053.
      View in: PubMed
    33. Issa NP, Rosenberg A, Husson TR. Models and measurements of functional maps in V1. J Neurophysiol. 2008 Jun; 99(6):2745-54. PMID: 18400962.
      View in: PubMed
    34. Zhang JX, Rosenberg A, Mallik AK, Husson TR, Issa NP. The representation of complex images in spatial frequency domains of primary visual cortex. J Neurosci. 2007 Aug 29; 27(35):9310-8. PMID: 17728445.
      View in: PubMed
    35. Husson TR, Mallik AK, Zhang JX, Issa NP. Functional imaging of primary visual cortex using flavoprotein autofluorescence. J Neurosci. 2007 Aug 08; 27(32):8665-75. PMID: 17687044.
      View in: PubMed
    36. Baker TI, Issa NP. Cortical maps of separable tuning properties predict population responses to complex visual stimuli. J Neurophysiol. 2005 Jul; 94(1):775-87. PMID: 15758052.
      View in: PubMed
    37. Issa NP. Inhibitory circuits in sensory maps develop through excitation. Trends Neurosci. 2003 Sep; 26(9):456-8. PMID: 12948651.
      View in: PubMed
    38. Frank MG, Issa NP, Stryker MP. Sleep enhances plasticity in the developing visual cortex. Neuron. 2001 Apr; 30(1):275-87. PMID: 11343661.
      View in: PubMed
    39. Silver MA, Fagiolini M, Gillespie DC, Howe CL, Frank MG, Issa NP, Antonini A, Stryker MP. Infusion of nerve growth factor (NGF) into kitten visual cortex increases immunoreactivity for NGF, NGF receptors, and choline acetyltransferase in basal forebrain without affecting ocular dominance plasticity or column development. Neuroscience. 2001; 108(4):569-85. PMID: 11738495.
      View in: PubMed
    40. Issa NP, Trepel C, Stryker MP. Spatial frequency maps in cat visual cortex. J Neurosci. 2000 Nov 15; 20(22):8504-14. PMID: 11069958.
      View in: PubMed
    41. Issa NP, Trachtenberg JT, Chapman B, Zahs KR, Stryker MP. The critical period for ocular dominance plasticity in the Ferret's visual cortex. J Neurosci. 1999 Aug 15; 19(16):6965-78. PMID: 10436053.
      View in: PubMed
    42. Issa NP, Hudspeth AJ. The entry and clearance of Ca2+ at individual presynaptic active zones of hair cells from the bullfrog's sacculus. Proc Natl Acad Sci U S A. 1996 Sep 03; 93(18):9527-32. PMID: 8790364.
      View in: PubMed
    43. Issa NP, Hudspeth AJ. Characterization of fluo-3 labelling of dense bodies at the hair cell's presynaptic active zone. J Neurocytol. 1996 Apr; 25(4):257-66. PMID: 8793731.
      View in: PubMed
    44. Hudspeth AJ, Issa NP. Confocal-microscopic visualization of membrane addition during synaptic exocytosis at presynaptic active zones of hair cells. Cold Spring Harb Symp Quant Biol. 1996; 61:303-7. PMID: 9246459.
      View in: PubMed
    45. Issa NP, Hudspeth AJ. Clustering of Ca2+ channels and Ca(2+)-activated K+ channels at fluorescently labeled presynaptic active zones of hair cells. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7578-82. PMID: 8052623.
      View in: PubMed
    46. Benser ME, Issa NP, Hudspeth AJ. Hair-bundle stiffness dominates the elastic reactance to otolithic-membrane shear. Hear Res. 1993 Aug; 68(2):243-52. PMID: 8407610.
      View in: PubMed
    47. Ringland J, Issa N, Schell M. From U sequence to Farey sequence: A unification of one-parameter scenarios. Phys Rev A. 1990 Apr 15; 41(8):4223-4235. PMID: 9903615.
      View in: PubMed
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