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Alfredo Garcia

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Emergency Medicine
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    My research is focused on understanding how local brain circuit physiology is impacted by changes in blood gas homeostasis. We study the hippocampus, a brain region important to learning and memory, and brainstem networks involved cardio-respiratory control.


    Collapse Biography 
    Collapse education and training
    The Ohio State University, Columbus, OhioB.Sc.06/1999Biological Science
    Wright State University, Dayton, OhioPh.D.05/2006Biomedical Science
    The University of Chicago, Chicago, IllinoisPostdoctoral Fellowship06/2009Neuroscience

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Dalgin G, Tryba AK, Cohen AP, Park SY, Philipson LH, Greeley SAW, Garcia AJ. Developmental defects and impaired network excitability in a cerebral organoid model of KCNJ11 p.V59M-related neonatal diabetes. Sci Rep. 2021 11 03; 11(1):21590. PMID: 34732776.
      View in: PubMed
    2. Ousta A, Piao L, Fang YH, Vera A, Nallamothu T, Garcia AJ, Sharp WW. Microglial Activation and Neurological Outcomes in a Murine Model of Cardiac Arrest. Neurocrit Care. 2021 Jul 15. PMID: 34268646.
      View in: PubMed
    3. Arias-Cavieres A, Fonteh A, Castro-Rivera CI, Garcia AJ. Intermittent Hypoxia causes targeted disruption to NMDA receptor dependent synaptic plasticity in area CA1 of the hippocampus. Exp Neurol. 2021 10; 344:113808. PMID: 34256046.
      View in: PubMed
    4. Wang W, Alzate-Correa D, Alves MJ, Jones M, Garcia AJ, Zhao J, Czeisler CM, Otero JJ. Machine learning-based data analytic approaches for evaluating post-natal mouse respiratory physiological evolution. Respir Physiol Neurobiol. 2021 01; 283:103558. PMID: 33010456.
      View in: PubMed
    5. Alzate-Correa D, Mei-Ling Liu J, Jones M, Silva TM, Alves MJ, Burke E, Zuñiga J, Kaya B, Zaza G, Aslan MT, Blackburn J, Shimada MY, Fernandes-Junior SA, Baer LA, Stanford KI, Kempton A, Smith S, Szujewski CC, Silbaugh A, Viemari JC, Takakura AC, Garcia AJ, Moreira TS, Czeisler CM, Otero JJ. Neonatal apneic phenotype in a murine congenital central hypoventilation syndrome model is induced through non-cell autonomous developmental mechanisms. Brain Pathol. 2021 01; 31(1):84-102. PMID: 32654284.
      View in: PubMed
    6. Arias-Cavieres A, Khuu MA, Nwakudu CU, Barnard JE, Dalgin G, Garcia AJ. A HIF1a-Dependent Pro-Oxidant State Disrupts Synaptic Plasticity and Impairs Spatial Memory in Response to Intermittent Hypoxia. eNeuro. 2020 May/Jun; 7(3). PMID: 32493757.
      View in: PubMed
    7. Garcia AJ, Szujewski CC. Finding inspiration in opioid-induced respiratory depression. J Physiol. 2020 01; 598(1):3. PMID: 31675443.
      View in: PubMed
    8. Garcia AJ, Viemari JC, Khuu MA. Respiratory rhythm generation, hypoxia, and oxidative stress-Implications for development. Respir Physiol Neurobiol. 2019 12; 270:103259. PMID: 31369874.
      View in: PubMed
    9. Khuu MA, Pagan CM, Nallamothu T, Hevner RF, Hodge RD, Ramirez JM, Garcia AJ. Intermittent Hypoxia Disrupts Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus. J Neurosci. 2019 02 13; 39(7):1320-1331. PMID: 30587544.
      View in: PubMed
    10. Garcia AJ, Dashevskiy T, Khuu MA, Ramirez JM. Chronic Intermittent Hypoxia Differentially Impacts Different States of Inspiratory Activity at the Level of the preBötzinger Complex. Front Physiol. 2017; 8:571. PMID: 28936176.
      View in: PubMed
    11. Harris KD, Dashevskiy T, Mendoza J, Garcia AJ, Ramirez JM, Shea-Brown E. Different roles for inhibition in the rhythm-generating respiratory network. J Neurophysiol. 2017 10 01; 118(4):2070-2088. PMID: 28615332.
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    12. Garcia AJ, Ramirez JM. Keeping carbon dioxide in check. Elife. 2017 05 17; 6. PMID: 28513432.
      View in: PubMed
    13. Anderson TM, Garcia AJ, Baertsch NA, Pollak J, Bloom JC, Wei AD, Rai KG, Ramirez JM. A novel excitatory network for the control of breathing. Nature. 2016 08 04; 536(7614):76-80. PMID: 27462817.
      View in: PubMed
    14. Garcia AJ, Zanella S, Dashevskiy T, Khan SA, Khuu MA, Prabhakar NR, Ramirez JM. Chronic Intermittent Hypoxia Alters Local Respiratory Circuit Function at the Level of the preBötzinger Complex. Front Neurosci. 2016; 10:4. PMID: 26869872.
      View in: PubMed
    15. Koch H, Caughie C, Elsen FP, Doi A, Garcia AJ, Zanella S, Ramirez JM. Prostaglandin E2 differentially modulates the central control of eupnoea, sighs and gasping in mice. J Physiol. 2015 01 01; 593(1):305-19. PMID: 25556802.
      View in: PubMed
    16. Ramirez JM, Anderson TM, Garcia AJ. The ins and outs of breathing. Elife. 2014 Jun 17; 3:e03375. PMID: 24940002.
      View in: PubMed
    17. Zanella S, Doi A, Garcia AJ, Elsen F, Kirsch S, Wei AD, Ramirez JM. When norepinephrine becomes a driver of breathing irregularities: how intermittent hypoxia fundamentally alters the modulatory response of the respiratory network. J Neurosci. 2014 Jan 01; 34(1):36-50. PMID: 24381266.
      View in: PubMed
    18. Viemari JC, Garcia AJ, Doi A, Elsen G, Ramirez JM. ß-Noradrenergic receptor activation specifically modulates the generation of sighs in vivo and in vitro. Front Neural Circuits. 2013; 7:179. PMID: 24273495.
      View in: PubMed
    19. Ramirez JM, Garcia AJ, Anderson TM, Koschnitzky JE, Peng YJ, Kumar GK, Prabhakar NR. Central and peripheral factors contributing to obstructive sleep apneas. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):344-53. PMID: 23770311.
      View in: PubMed
    20. Garcia AJ, Koschnitzky JE, Ramirez JM. The physiological determinants of sudden infant death syndrome. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):288-300. PMID: 23735486.
      View in: PubMed
    21. Garcia AJ, Rotem-Kohavi N, Doi A, Ramirez JM. Post-hypoxic recovery of respiratory rhythm generation is gender dependent. PLoS One. 2013; 8(4):e60695. PMID: 23593283.
      View in: PubMed
    22. Garcia AJ, Koschnitzky JE, Dashevskiy T, Ramirez JM. Cardiorespiratory coupling in health and disease. Auton Neurosci. 2013 Apr; 175(1-2):26-37. PMID: 23497744.
      View in: PubMed
    23. Hodge RD, Garcia AJ, Elsen GE, Nelson BR, Mussar KE, Reiner SL, Ramirez JM, Hevner RF. Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus. J Neurosci. 2013 Feb 27; 33(9):4165-80. PMID: 23447624.
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    24. Koch H, Zanella S, Elsen GE, Smith L, Doi A, Garcia AJ, Wei AD, Xun R, Kirsch S, Gomez CM, Hevner RF, Ramirez JM. Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels. J Neurosci. 2013 Feb 20; 33(8):3633-45. PMID: 23426690.
      View in: PubMed
    25. Madisen L, Mao T, Koch H, Zhuo JM, Berenyi A, Fujisawa S, Hsu YW, Garcia AJ, Gu X, Zanella S, Kidney J, Gu H, Mao Y, Hooks BM, Boyden ES, Buzsáki G, Ramirez JM, Jones AR, Svoboda K, Han X, Turner EE, Zeng H. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci. 2012 Mar 25; 15(5):793-802. PMID: 22446880.
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    26. Koch H, Garcia AJ, Ramirez JM. Network reconfiguration and neuronal plasticity in rhythm-generating networks. Integr Comp Biol. 2011 Dec; 51(6):856-68. PMID: 21856733.
      View in: PubMed
    27. Garcia AJ, Khan SA, Kumar GK, Prabhakar NR, Ramirez JM. Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus. J Neurophysiol. 2011 Dec; 106(6):3045-55. PMID: 21849609.
      View in: PubMed
    28. Viemari JC, Garcia AJ, Doi A, Ramirez JM. Activation of alpha-2 noradrenergic receptors is critical for the generation of fictive eupnea and fictive gasping inspiratory activities in mammals in vitro. Eur J Neurosci. 2011 Jun; 33(12):2228-37. PMID: 21615559.
      View in: PubMed
    29. Ramirez JM, Koch H, Garcia AJ, Doi A, Zanella S. The role of spiking and bursting pacemakers in the neuronal control of breathing. J Biol Phys. 2011 Jun; 37(3):241-61. PMID: 22654176.
      View in: PubMed
    30. Garcia AJ, Zanella S, Koch H, Doi A, Ramirez JM. Chapter 3--networks within networks: the neuronal control of breathing. Prog Brain Res. 2011; 188:31-50. PMID: 21333801.
      View in: PubMed
    31. Hill AA, Garcia AJ, Zanella S, Upadhyaya R, Ramirez JM. Graded reductions in oxygenation evoke graded reconfiguration of the isolated respiratory network. J Neurophysiol. 2011 Feb; 105(2):625-39. PMID: 21084689.
      View in: PubMed
    32. Garcia AJ, Putnam RW, Dean JB. Hyperbaric hyperoxia and normobaric reoxygenation increase excitability and activate oxygen-induced potentiation in CA1 hippocampal neurons. J Appl Physiol (1985). 2010 Sep; 109(3):804-19. PMID: 20558753.
      View in: PubMed
    33. Garcia AJ, Putnam RW, Dean JB. Hyperoxic stimulation of synchronous orthodromic activity and induction of neural plasticity does not require changes in excitatory synaptic transmission. J Appl Physiol (1985). 2010 Sep; 109(3):820-9. PMID: 20558752.
      View in: PubMed
    34. Ramirez JM, Garcia A. Point: Medullary pacemaker neurons are essential for both eupnea and gasping in mammals. J Appl Physiol (1985). 2007 Aug; 103(2):717-8; discussion 722. PMID: 17272416.
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    35. Dean JB, Mulkey DK, Garcia AJ, Putnam RW, Henderson RA. Neuronal sensitivity to hyperoxia, hypercapnia, and inert gases at hyperbaric pressures. J Appl Physiol (1985). 2003 Sep; 95(3):883-909. PMID: 12909594.
      View in: PubMed
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