Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.

Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):326-31.

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subject areas

Allosteric Regulation
Amino Acid Substitution
Base Sequence
DNA
HeLa Cells
Humans
Molecular Sequence Data
Protein Binding
Protein Structure, Tertiary
Receptors, Glucocorticoid
Receptors, Mineralocorticoid
Response Elements
Sequence Homology, Amino Acid
Substrate Specificity
Transcription Factors

authors with profiles

Joseph Thornton