"Allosteric Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.
| Descriptor ID |
D000494
|
| MeSH Number(s) |
G02.111.044
|
| Concept/Terms |
Allosteric Regulation- Allosteric Regulation
- Regulation, Allosteric
- Allosteric Regulations
- Regulations, Allosteric
|
Below are MeSH descriptors whose meaning is more general than "Allosteric Regulation".
Below are MeSH descriptors whose meaning is more specific than "Allosteric Regulation".
This graph shows the total number of publications written about "Allosteric Regulation" by people in this website by year, and whether "Allosteric Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 2 | 3 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2011 | 3 | 2 | 5 |
| 2013 | 0 | 3 | 3 |
| 2014 | 0 | 4 | 4 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 3 | 2 | 5 |
| 2018 | 0 | 6 | 6 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 4 | 4 |
| 2021 | 0 | 2 | 2 |
| 2022 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
| 2026 | 0 | 5 | 5 |
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Below are the most recent publications written about "Allosteric Regulation" by people in Profiles.
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Receptor allostery promotes context-specific Sonic Hedgehog signaling during embryonic development. Nat Commun. 2026 Jul 24; 17(1).
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Glycerol-driven TNAP activation in thermogenesis and mineralization. Nature. 2026 Jun; 654(8117):198-208.
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Human GlyRa2 pore dynamics in gating and inhibition. Structure. 2026 May 07; 34(5):798-813.e7.
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Structural basis for domain coupling in heteromeric glycine receptors revealed by an atypical allosteric agonist. Sci Adv. 2026 Feb 13; 12(7):eaeb2036.
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The BK channel-NS1619 agonist complex reveals molecular insights into allosteric activation gating. Proc Natl Acad Sci U S A. 2026 Feb 03; 123(5):e2507707123.
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Distal Mutations Rewire Allosteric Networks to Control Substrate Specificity in PTP1B. Biochemistry. 2025 12 16; 64(24):4661-4674.
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HDX-MS performed on BtuB in E. coli outer membranes delineates the luminal domain's allostery and unfolding upon B12 and TonB binding. Proc Natl Acad Sci U S A. 2022 05 17; 119(20):e2119436119.
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Catalytically impaired TrpA subunit of tryptophan synthase from Chlamydia trachomatis is an allosteric regulator of TrpB. Protein Sci. 2021 09; 30(9):1904-1918.
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Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis. Cell. 2021 06 10; 184(12):3163-3177.e21.
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Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase". Science. 2020 11 20; 370(6519).