HIV gag mRNA transfection of dendritic cells (DC) delivers encoded antigen to MHC class I and II molecules, causes DC maturation, and induces a potent human in vitro primary immune response.

HIV gag mRNA transfection of dendritic cells (DC) delivers encoded antigen to MHC class I and II molecules, causes DC maturation, and induces a potent human in vitro primary immune response. J Immunol. 2000 Oct 15; 165(8):4710-7.

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subject areas

Antigen Presentation
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Differentiation
Cells, Cultured
Cytotoxicity, Immunologic
Dendritic Cells
Gene Products, gag
Genes, Reporter
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
HIV
Humans
Immunologic Memory
RNA, Messenger
RNA, Viral
T-Lymphocyte Subsets
T-Lymphocytes, Cytotoxic
Transfection