Histocompatibility Antigens Class II
"Histocompatibility Antigens Class II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Descriptor ID |
D000949
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MeSH Number(s) |
D12.776.395.550.509 D12.776.543.550.440 D23.050.301.500.400 D23.050.705.552.410
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Concept/Terms |
Histocompatibility Antigens Class II- Histocompatibility Antigens Class II
- Class II Antigens
- Antigens, Class II
- Class II Histocompatibility Antigens
- Ia-Like Antigens
- Antigens, Ia-Like
- Ia Like Antigens
- IA Antigen
- Antigen, IA
- I-A Antigen
- Antigen, I-A
- Antigens, Immune Response
- Immune Response Antigens
- Immune-Response-Associated Antigens
- Antigens, Immune-Response-Associated
- Immune Response Associated Antigens
- Class II Major Histocompatibility Antigens
- I-A-Antigen
- I A Antigen
- Class II Antigen
- Antigen, Class II
- Ia Antigens
- Antigens, Ia
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Below are MeSH descriptors whose meaning is more general than "Histocompatibility Antigens Class II".
Below are MeSH descriptors whose meaning is more specific than "Histocompatibility Antigens Class II".
This graph shows the total number of publications written about "Histocompatibility Antigens Class II" by people in this website by year, and whether "Histocompatibility Antigens Class II" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 2 | 1 | 3 |
1995 | 7 | 1 | 8 |
1996 | 3 | 2 | 5 |
1997 | 1 | 1 | 2 |
1998 | 1 | 3 | 4 |
1999 | 4 | 7 | 11 |
2000 | 0 | 1 | 1 |
2001 | 2 | 1 | 3 |
2002 | 1 | 1 | 2 |
2003 | 0 | 1 | 1 |
2004 | 0 | 2 | 2 |
2005 | 2 | 3 | 5 |
2006 | 0 | 1 | 1 |
2007 | 2 | 2 | 4 |
2008 | 1 | 2 | 3 |
2010 | 2 | 1 | 3 |
2011 | 0 | 1 | 1 |
2012 | 0 | 4 | 4 |
2013 | 2 | 3 | 5 |
2014 | 0 | 2 | 2 |
2015 | 1 | 1 | 2 |
2016 | 3 | 2 | 5 |
2017 | 1 | 3 | 4 |
2018 | 0 | 1 | 1 |
2019 | 0 | 3 | 3 |
2020 | 2 | 2 | 4 |
2021 | 2 | 4 | 6 |
2022 | 1 | 1 | 2 |
2023 | 2 | 2 | 4 |
2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Histocompatibility Antigens Class II" by people in Profiles.
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Deficiency in non-classical major histocompatibility class II-like molecule, H2-O confers protection against Staphylococcus aureus in mice. PLoS Pathog. 2024 Jun; 20(6):e1012306.
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MHC Tetramers Specifically Identify High- and Low-avidity Donor-specific B Cells in Transplantation Tolerance and Rejection. Transplantation. 2023 Dec 01; 107(12):2526-2532.
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TGF-ß Signaling Prevents MHC Class II-Expressing Lymphatic Endothelial Cells from Reactivating Human Allogenic Memory CD4+ T Cells. J Immunol. 2023 09 01; 211(5):782-790.
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MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses. Mucosal Immunol. 2024 Jun; 17(3):416-430.
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Donor programmed cell death 1 ligand 1 is required for organ transplant tolerance in major histocompatibility complex-mismatched mixed chimeras although programmed cell death 1 ligand 1 and major histocompatibility complex class II are not required for inducing chimerism. Am J Transplant. 2023 08; 23(8):1116-1129.
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De novo human leukocyte antigen allosensitization patterns in patients bridged to heart transplantation using left ventricular assist devices. Transpl Immunol. 2022 06; 72:101567.
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Positive and negative selection shape the human naive B cell repertoire. J Clin Invest. 2022 01 18; 132(2).
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Mouse Homologue of Human HLA-DO Does Not Preempt Autoimmunity but Controls Murine Gammaherpesvirus MHV68. J Immunol. 2021 12 15; 207(12):2944-2951.
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Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection. Nat Commun. 2021 07 16; 12(1):4372.
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MHC Class II Presentation Is Affected by Polymorphism in the H2-Ob Gene and Additional Loci. J Immunol. 2021 07 01; 207(1):5-14.