Histocompatibility Antigens Class I
"Histocompatibility Antigens Class I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
| Descriptor ID |
D015395
|
| MeSH Number(s) |
D12.776.395.550.489 D12.776.543.550.439 D23.050.301.500.100 D23.050.705.552.100
|
| Concept/Terms |
Histocompatibility Antigens Class I- Histocompatibility Antigens Class I
- Class I Histocompatibility Antigens
- Class I Antigens
- Antigens, Class I
- I Antigens, Class
- Class I Major Histocompatibility Antigens
|
Below are MeSH descriptors whose meaning is more general than "Histocompatibility Antigens Class I".
Below are MeSH descriptors whose meaning is more specific than "Histocompatibility Antigens Class I".
This graph shows the total number of publications written about "Histocompatibility Antigens Class I" by people in this website by year, and whether "Histocompatibility Antigens Class I" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 2 | 4 |
| 1995 | 4 | 2 | 6 |
| 1996 | 4 | 1 | 5 |
| 1997 | 7 | 0 | 7 |
| 1998 | 3 | 3 | 6 |
| 1999 | 7 | 6 | 13 |
| 2000 | 2 | 1 | 3 |
| 2001 | 5 | 5 | 10 |
| 2002 | 6 | 2 | 8 |
| 2003 | 5 | 1 | 6 |
| 2004 | 4 | 0 | 4 |
| 2005 | 8 | 4 | 12 |
| 2006 | 3 | 0 | 3 |
| 2007 | 4 | 2 | 6 |
| 2008 | 4 | 3 | 7 |
| 2009 | 2 | 0 | 2 |
| 2010 | 2 | 2 | 4 |
| 2011 | 3 | 1 | 4 |
| 2012 | 4 | 3 | 7 |
| 2013 | 5 | 0 | 5 |
| 2014 | 2 | 5 | 7 |
| 2015 | 1 | 1 | 2 |
| 2016 | 5 | 0 | 5 |
| 2017 | 1 | 0 | 1 |
| 2018 | 2 | 1 | 3 |
| 2019 | 0 | 2 | 2 |
| 2020 | 2 | 2 | 4 |
| 2021 | 0 | 3 | 3 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 2 | 2 |
| 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Histocompatibility Antigens Class I" by people in Profiles.
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Multiple Isomers of Photolumazine V Bind MR1 and Differentially Activate MAIT Cells. J Immunol. 2024 Mar 15; 212(6):933-940.
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Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation. Commun Biol. 2024 Feb 24; 7(1):228.
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Targeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy. Proc Natl Acad Sci U S A. 2023 Dec 05; 120(49):e2314416120.
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Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection. J Clin Invest. 2023 11 01; 133(21).
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Deaza-modification of MR1 ligands modulates recognition by MR1-restricted T cells. Sci Rep. 2022 12 29; 12(1):22539.
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De novo human leukocyte antigen allosensitization patterns in patients bridged to heart transplantation using left ventricular assist devices. Transpl Immunol. 2022 06; 72:101567.
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Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection. Nat Commun. 2021 07 16; 12(1):4372.
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Safety, Tolerability, and Activity of ALXN1830 Targeting the Neonatal Fc Receptor in Chronic Pemphigus. J Invest Dermatol. 2021 12; 141(12):2858-2865.e4.
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Suppression of Rheumatoid Arthritis by Enhanced Lymph Node Trafficking of Engineered Interleukin-10 in Murine Models. Arthritis Rheumatol. 2021 05; 73(5):769-778.
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Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer. Nat Commun. 2020 11 04; 11(1):5583.