"Phospholipase D" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme found mostly in plant tissue. It hydrolyzes glycerophosphatidates with the formation of a phosphatidic acid and a nitrogenous base such as choline. This enzyme also catalyzes transphosphatidylation reactions. EC 3.1.4.4.
| Descriptor ID |
D010739
|
| MeSH Number(s) |
D08.811.277.352.640.700.710
|
| Concept/Terms |
Phospholipase D- Phospholipase D
- Lecithinase D
- Phosphatidylcholine Phosphohydrolase
|
Below are MeSH descriptors whose meaning is more general than "Phospholipase D".
Below are MeSH descriptors whose meaning is more specific than "Phospholipase D".
This graph shows the total number of publications written about "Phospholipase D" by people in this website by year, and whether "Phospholipase D" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 2 | 1 | 3 |
| 2006 | 2 | 0 | 2 |
| 2008 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phospholipase D" by people in Profiles.
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Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation. J Biol Chem. 2020 05 29; 295(22):7669-7685.
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Role of phospholipase D in bleomycin-induced mitochondrial reactive oxygen species generation, mitochondrial DNA damage, and pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2019 08 01; 317(2):L175-L187.
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Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development. Pain. 2017 Nov; 158(11):2222-2232.
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Genome-Wide Association Studies of the Human Gut Microbiota. PLoS One. 2015; 10(11):e0140301.
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Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction. PLoS One. 2013; 8(5):e63007.
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Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells. Mol Pharmacol. 2008 Sep; 74(3):574-84.
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Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells. Biochem J. 2008 May 15; 412(1):153-62.
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Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1941-6.
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Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1936-40.
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1,25-dihydroxyvitamin D3 but not TPA activates PLD in Caco-2 cells via pp60(c-src) and RhoA. Am J Physiol. 1999 Apr; 276(4 Pt 1):G1005-15.