"Tryptophan Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
| Descriptor ID |
D014365
|
| MeSH Number(s) |
D08.811.682.690.708.870
|
| Concept/Terms |
Tryptophan Hydroxylase- Tryptophan Hydroxylase
- Hydroxylase, Tryptophan
- Tryptophan Monooxygenase
- Monooxygenase, Tryptophan
|
Below are MeSH descriptors whose meaning is more general than "Tryptophan Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Tryptophan Hydroxylase".
This graph shows the total number of publications written about "Tryptophan Hydroxylase" by people in this website by year, and whether "Tryptophan Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tryptophan Hydroxylase" by people in Profiles.
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Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology. 2018 04 01; 159(4):1609-1629.
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Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach. Eur Arch Psychiatry Clin Neurosci. 2018 Apr; 268(3):301-316.
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Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology. 2015 Feb; 156(2):444-52.
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Developmental basis for filamin-A-associated myxomatous mitral valve disease. Cardiovasc Res. 2012 Oct 01; 96(1):109-19.
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Control of breathing by raphe obscurus serotonergic neurons in mice. J Neurosci. 2011 Feb 09; 31(6):1981-90.
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Antidepressant response to chronic citalopram treatment in eight inbred mouse strains. Psychopharmacology (Berl). 2011 Feb; 213(2-3):509-20.
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Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study. Mol Psychiatry. 2010 Aug; 15(8):831-43.
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Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: new data from the Patch in Practice trial and pooled analyses. Drug Alcohol Depend. 2008 Nov 01; 98(1-2):77-85.
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Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression. Biol Psychiatry. 2007 Jul 01; 62(1):72-80.
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Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology. 2006 Dec; 31(12):2639-51.