"4-Aminopyridine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the POTASSIUM CHANNEL BLOCKERS with secondary effect on calcium currents which is used mainly as a research tool and to characterize channel subtypes.
| Descriptor ID |
D015761
|
| MeSH Number(s) |
D02.092.080.060 D03.383.725.050.060
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "4-Aminopyridine".
Below are MeSH descriptors whose meaning is more specific than "4-Aminopyridine".
This graph shows the total number of publications written about "4-Aminopyridine" by people in this website by year, and whether "4-Aminopyridine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 2 | 3 |
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 1 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 3 | 3 |
| 2004 | 0 | 3 | 3 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "4-Aminopyridine" by people in Profiles.
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Clinical, Radiological and Pathological Features of a Large American Cohort of Spinocerebellar Ataxia (SCA27B). Ann Neurol. 2024 Dec; 96(6):1092-1103.
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Development of a PET radioligand for potassium channels to image CNS demyelination. Sci Rep. 2018 01 12; 8(1):607.
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Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation. PLoS One. 2015; 10(10):e0141349.
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Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel. Biophys J. 2014 Jan 07; 106(1):134-44.
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Exome sequencing detection of two untranslated GFPT1 mutations in a family with limb-girdle myasthenia. Clin Genet. 2014 Feb; 85(2):166-71.
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Properties of deactivation gating currents in Shaker channels. Biophys J. 2011 Mar 02; 100(5):L28-30.
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4-Aminopyridine toxicity mimics autoimmune-mediated limbic encephalitis. Neurology. 2009 Mar 24; 72(12):1100-1.
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Electrophysiological properties and gap junction coupling of striatal astrocytes. Neurochem Int. 2008 Jun; 52(7):1365-72.
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K+ channel blockade impairs remyelination in the cuprizone model. Glia. 2004 Nov 01; 48(2):156-65.
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Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. Circulation. 2004 Sep 14; 110(11):1372-9.