"CRISPR-Cas Systems" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS.
| Descriptor ID |
D064113
|
| MeSH Number(s) |
G05.308.203.374.394
|
| Concept/Terms |
CRISPR-Cas Systems- CRISPR-Cas Systems
- CRISPR Cas Systems
- CRISPR-Cas System
- System, CRISPR-Cas
- Systems, CRISPR-Cas
|
Below are MeSH descriptors whose meaning is more general than "CRISPR-Cas Systems".
Below are MeSH descriptors whose meaning is more specific than "CRISPR-Cas Systems".
This graph shows the total number of publications written about "CRISPR-Cas Systems" by people in this website by year, and whether "CRISPR-Cas Systems" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 1 | 2 |
| 2015 | 2 | 3 | 5 |
| 2016 | 2 | 5 | 7 |
| 2017 | 5 | 6 | 11 |
| 2018 | 5 | 4 | 9 |
| 2019 | 0 | 4 | 4 |
| 2020 | 2 | 6 | 8 |
| 2021 | 2 | 5 | 7 |
| 2022 | 2 | 3 | 5 |
| 2023 | 4 | 4 | 8 |
| 2024 | 1 | 2 | 3 |
To return to the timeline,
click here.
Below are the most recent publications written about "CRISPR-Cas Systems" by people in Profiles.
-
Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease. Cell Genom. 2024 Nov 13; 4(11):100671.
-
Scaled and efficient derivation of loss-of-function alleles in risk genes for neurodevelopmental and psychiatric disorders in human iPSCs. Stem Cell Reports. 2024 Oct 08; 19(10):1489-1504.
-
Cas9-assisted biological containment of a genetically engineered human commensal bacterium and genetic elements. Nat Commun. 2024 Mar 07; 15(1):2096.
-
Base-editing mutagenesis maps alleles to tune human T cell functions. Nature. 2024 Jan; 625(7996):805-812.
-
A new Bayesian factor analysis method improves detection of genes and biological processes affected by perturbations in single-cell CRISPR screening. Nat Methods. 2023 Nov; 20(11):1693-1703.
-
CRISPR-Cas9 Editing of the HBG1 and HBG2 Promoters to Treat Sickle Cell Disease. N Engl J Med. 2023 Aug 31; 389(9):820-832.
-
CRISPR screens decode cancer cell pathways that trigger ?d T cell detection. Nature. 2023 Sep; 621(7977):188-195.
-
An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity. Nat Chem Biol. 2023 Nov; 19(11):1384-1393.
-
Creation of an albino squid line by CRISPR-Cas9 and its application for in vivo functional imaging of neural activity. Curr Biol. 2023 07 10; 33(13):2774-2783.e5.
-
Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy. Nature. 2023 03; 615(7953):697-704.