Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction.

Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction. Circulation. 2007 Apr 03; 115(13):1777-88.

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subject areas

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
Amides
Animals
Animals, Newborn
Calcium Channel Blockers
Calcium Channels, L-Type
Calcium Signaling
Ductus Arteriosus
Enzyme Activation
Enzyme Induction
Feedback, Physiological
Female
Fetal Heart
Gestational Age
Humans
Hydrogen Peroxide
Hypoplastic Left Heart Syndrome
Infant, Newborn
Intracellular Signaling Peptides and Proteins
Male
Mitochondria, Heart
Nifedipine
Organ Culture Techniques
Oxidation-Reduction
Oxygen
Partial Pressure
Phenylephrine
Pyridines
Rabbits
Reactive Oxygen Species
rhoA GTP-Binding Protein
rho-Associated Kinases
rhoB GTP-Binding Protein
Superoxides
Vasoconstriction

authors with profiles

Stephen Archer