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Discovery of 2,4-pyrimidinediamine derivatives as potent dual inhibitors of ALK and HDAC.
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Discovery of 2,4-pyrimidinediamine derivatives as potent dual inhibitors of ALK and HDAC.
Discovery of 2,4-pyrimidinediamine derivatives as potent dual inhibitors of ALK and HDAC. Eur J Med Chem. 2021 Nov 15; 224:113672.
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subject areas
Antineoplastic Agents
Apoptosis
Binding Sites
Cell Cycle Checkpoints
Cell Line, Tumor
Cell Movement
Cell Proliferation
Diamines
Drug Design
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
Histone Deacetylase Inhibitors
Histone Deacetylases
Humans
Molecular Dynamics Simulation
Protein Kinase Inhibitors
Pyrimidines
Structure-Activity Relationship
authors with profiles
Tao Pan