"Smad7 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inhibitory smad protein that associates with TRANSFORMING GROWTH FACTOR BETA RECEPTORS and BONE MORPHOGENETIC PROTEIN RECEPTORS. It negatively regulates SIGNAL TRANSDUCTION PATHWAYS by inhibiting PHOSPHORYLATION of RECEPTOR-REGULATED SMAD PROTEINS.
| Descriptor ID |
D051906
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| MeSH Number(s) |
D12.644.360.024.334.200.700 D12.776.157.057.170.249.700 D12.776.476.024.428.249.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Smad7 Protein".
Below are MeSH descriptors whose meaning is more specific than "Smad7 Protein".
This graph shows the total number of publications written about "Smad7 Protein" by people in this website by year, and whether "Smad7 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
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Below are the most recent publications written about "Smad7 Protein" by people in Profiles.
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Shared and independent colorectal cancer risk alleles in TGFß-related genes in African and European Americans. Carcinogenesis. 2014 Sep; 35(9):2025-30.
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Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians. Int J Cancer. 2014 Aug 15; 135(4):948-55.
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Cbl-b mediates TGFß sensitivity by downregulating inhibitory SMAD7 in primary T cells. J Mol Cell Biol. 2013 Dec; 5(6):358-68.
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Smad7 inhibits autocrine expression of TGF-ß2 in intestinal epithelial cells in baboon necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15; 304(2):G167-80.
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Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase. Cancer Res. 2011 Feb 01; 71(3):955-63.
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Inhibition of transforming growth factor beta-enhanced serum response factor-dependent transcription by SMAD7. J Biol Chem. 2006 Jul 21; 281(29):20383-92.
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Prevention of chronic allograft nephropathy with vitamin D. Transpl Int. 2005 Oct; 18(10):1175-86.
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Smad and p38-MAPK signaling mediates apoptotic effects of transforming growth factor-beta1 in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L515-24.