"alpha Karyopherins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
| Descriptor ID |
D028901
|
| MeSH Number(s) |
D12.776.157.530.750.500.100 D12.776.543.585.750.500.100 D12.776.660.502.100
|
| Concept/Terms |
alpha Karyopherins- alpha Karyopherins
- Karyopherins, alpha
- Karyopherin alpha
- Nuclear Localization Signal-Binding Protein
- NLS-Binding Protein
- NLSBP
- Nuclear Localization Sequence Receptor
- Importin-alpha
- NLS Receptor
- receptor, NLS
|
Below are MeSH descriptors whose meaning is more general than "alpha Karyopherins".
Below are MeSH descriptors whose meaning is more specific than "alpha Karyopherins".
This graph shows the total number of publications written about "alpha Karyopherins" by people in this website by year, and whether "alpha Karyopherins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "alpha Karyopherins" by people in Profiles.
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Germline predisposition to clonal hematopoiesis. Leuk Res. 2023 09; 132:107344.
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Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020 10; 586(7831):763-768.
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DnaJ-1 and karyopherin a3 suppress degeneration in a new Drosophila model of Spinocerebellar Ataxia Type 6. Hum Mol Genet. 2015 Aug 01; 24(15):4385-96.
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Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms and cerebellar malformation. Eur J Hum Genet. 2014 May; 22(5):587-93.
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Nuclear import of serum response factor in airway smooth muscle. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):453-8.
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Tiling of r7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion. Neuron. 2007 Dec 06; 56(5):793-806.