E2F1 Transcription Factor
"E2F1 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An E2F transcription factor that interacts directly with RETINOBLASTOMA PROTEIN and CYCLIN A and activates GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F1 is involved in DNA REPAIR and APOPTOSIS.
| Descriptor ID |
D050687
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| MeSH Number(s) |
D12.644.360.024.328.049 D12.776.157.057.158.049 D12.776.476.024.420.049 D12.776.660.769.049 D12.776.930.211.500
|
| Concept/Terms |
E2F1 Transcription Factor- E2F1 Transcription Factor
- Transcription Factor, E2F1
- Transcription Factor E2F-1
- Transcription Factor E2F 1
- E2F Transcription Factor 1 Protein
- Retinoblastoma-Associated Protein 1
- Retinoblastoma Associated Protein 1
- Retinoblastoma Binding Protein 3
- E2F-1 Transcription Factor
- Transcription Factor, E2F-1
- Transcription Factor E2F1
|
Below are MeSH descriptors whose meaning is more general than "E2F1 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "E2F1 Transcription Factor".
This graph shows the total number of publications written about "E2F1 Transcription Factor" by people in this website by year, and whether "E2F1 Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "E2F1 Transcription Factor" by people in Profiles.
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Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer. PLoS One. 2014; 9(1):e85750.
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MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status. J Mol Med (Berl). 2011 Oct; 89(10):1037-50.
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The RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer? J Clin Invest. 2010 Dec; 120(12):4179-82.
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E2F1 and E2F2 have opposite effects on radiation-induced p53-independent apoptosis in Drosophila. Dev Biol. 2010 Oct 01; 346(1):80-9.
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Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer. 2010 Mar 13; 9:59.
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Retinoblastoma family protein promotes normal R8-photoreceptor differentiation in the absence of rhinoceros by inhibiting dE2F1 activity. Dev Biol. 2009 Nov 01; 335(1):228-36.
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Pathways of proliferation: new targets to inhibit the growth of vascular smooth muscle cells. Circ Res. 2008 Nov 07; 103(10):1047-9.
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Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition. Proc Natl Acad Sci U S A. 2007 Dec 04; 104(49):19488-93.
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Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis. Cancer Res. 2007 May 01; 67(9):4113-22.
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A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers. Nat Genet. 2005 Oct; 37(10):1104-7.