E2F Transcription Factors
"E2F Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation.
| Descriptor ID |
D050684
|
| MeSH Number(s) |
D12.776.930.211
|
| Concept/Terms |
E2F Transcription Factors- E2F Transcription Factors
- Transcription Factors, E2F
- E2F Proteins
- Transcription Factor E2F
- E2F, Transcription Factor
|
Below are MeSH descriptors whose meaning is more general than "E2F Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "E2F Transcription Factors".
This graph shows the total number of publications written about "E2F Transcription Factors" by people in this website by year, and whether "E2F Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 3 | 3 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "E2F Transcription Factors" by people in Profiles.
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Rb family-independent activating E2F increases genome stability, promotes homologous recombination, and decreases non-homologous end joining. Mech Dev. 2020 06; 162:103607.
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An integrated view of cyclin E function and regulation. Cell Cycle. 2012 Jan 01; 11(1):57-64.
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RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo. Mol Biol Cell. 2011 Apr; 22(7):931-9.
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E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):704-9.
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Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol. 2009 Feb 15; 326(2):347-56.
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BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol. 2007 Sep; 27(17):6229-42.
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Cell cycle regulation. Fly (Austin). 2007 Mar-Apr; 1(2):125-31.
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Disruption of Rb/E2F pathway results in increased cyclooxygenase-2 expression and activity in prostate epithelial cells. Cancer Res. 2005 May 01; 65(9):3633-42.
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ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. Oncogene. 2004 Oct 07; 23(46):7601-10.
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Endocycle and E2F-dependent transcriptional activation and repression. Cell Cycle. 2003 Nov-Dec; 2(6):515-6.