"Beclin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.
| Descriptor ID |
D000071186
|
| MeSH Number(s) |
D12.644.360.075.335 D12.776.094.500 D12.776.476.075.335
|
| Concept/Terms |
Beclin-1- Beclin-1
- Beclin 1
- Beclin-1 Protein
- Beclin 1 Protein
- GT197 Protein
- ATG-6 Protein
- ATG 6 Protein
- Coiled-coil Myosin-like Bcl2-interacting Protein
- Coiled coil Myosin like Bcl2 interacting Protein
- Beclin1
- ATG6 Protein
|
Below are MeSH descriptors whose meaning is more general than "Beclin-1".
Below are MeSH descriptors whose meaning is more specific than "Beclin-1".
This graph shows the total number of publications written about "Beclin-1" by people in this website by year, and whether "Beclin-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 3 | 3 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Beclin-1" by people in Profiles.
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Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing. Autophagy. 2021 09; 17(9):2128-2143.
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Autophagy and post-ischemic conditioning in retinal ischemia. Autophagy. 2021 06; 17(6):1479-1499.
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Autophagy regulation in the development and treatment of breast cancer. Acta Biochim Biophys Sin (Shanghai). 2016 Jan; 48(1):60-74.
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Intracellular HMGB1: defender of client proteins and cell fate. Oncotarget. 2015 Apr 20; 6(11):8432-3.
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Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest. 2015 Mar 02; 125(3):1098-110.
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Erythropoietin protects epithelial cells from excessive autophagy and apoptosis in experimental neonatal necrotizing enterocolitis. PLoS One. 2013; 8(7):e69620.
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Autophagy is decreased in mesenteric fat tissue but not in intestinal mucosae of patients with Crohn's disease. Cell Tissue Res. 2012 Dec; 350(3):549-52.
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Autophagy links inflammasomes to atherosclerotic progression. Cell Metab. 2012 Apr 04; 15(4):534-44.
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The CD40-autophagy pathway is needed for host protection despite IFN-G-dependent immunity and CD40 induces autophagy via control of P21 levels. PLoS One. 2010 Dec 31; 5(12):e14472.
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Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide. J Biol Chem. 2010 Sep 24; 285(39):29989-97.