"Sequestosome-1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.
| Descriptor ID |
D000071456
|
| MeSH Number(s) |
D12.644.360.024.329 D12.776.094.750 D12.776.157.057.160 D12.776.476.024.422
|
| Concept/Terms |
Sequestosome-1 Protein- Sequestosome-1 Protein
- Sequestosome 1 Protein
- Ubiquitin-Binding Protein p62
- Ubiquitin Binding Protein p62
- Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda
- Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda
- EBI3-Associated Protein of 60 KDa
- EBI3 Associated Protein of 60 KDa
- EBIAP Protein
|
Below are MeSH descriptors whose meaning is more general than "Sequestosome-1 Protein".
Below are MeSH descriptors whose meaning is more specific than "Sequestosome-1 Protein".
This graph shows the total number of publications written about "Sequestosome-1 Protein" by people in this website by year, and whether "Sequestosome-1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sequestosome-1 Protein" by people in Profiles.
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Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis. Nat Commun. 2021 04 12; 12(1):2183.
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p62/Sequestosome 1 levels increase and phosphorylation is altered in Cx50D47A lenses, but deletion of p62/sequestosome 1 does not improve transparency. Mol Vis. 2020; 26:204-215.
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Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer. Molecules. 2017 Jan 24; 22(2).
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NF-?B Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance. J Biol Chem. 2017 02 24; 292(8):3379-3388.
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Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. PLoS Genet. 2015; 11(2):e1004987.
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Measuring autophagy in stressed cells. Methods Mol Biol. 2015; 1292:129-50.
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Regulation of cell proliferation and migration by p62 through stabilization of Twist1. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9241-6.
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p62/SQSTM1 accumulation in squamous cell carcinoma of head and neck predicts sensitivity to phosphatidylinositol 3-kinase pathway inhibitors. PLoS One. 2014; 9(3):e90171.
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A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy. Eur J Immunol. 2013 May; 43(5):1333-44.
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Autophagy controls p38 activation to promote cell survival under genotoxic stress. J Biol Chem. 2013 Jan 18; 288(3):1603-11.