"Connexin 26" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gap junction protein encoded by the Gap Junction Beta 2 or GJB2 gene. In the cochlea and epidermis, its hexamers form channels between cells that open to allow cell-to-cell diffusion of small molecules as well as recycling of potassium. Mutations in Connexin 26 are associated with congenital SENSORINEURAL HEARING LOSS.
| Descriptor ID |
D000072259
|
| MeSH Number(s) |
D12.776.543.585.250.100
|
| Concept/Terms |
Connexin 26- Connexin 26
- 26, Connexin
- beta2 Connexin
- Connexin, beta2
- Connexin beta-2
- Connexin beta 2
- beta-2, Connexin
- Connexin Cx26
- Cx26, Connexin
|
Below are MeSH descriptors whose meaning is more general than "Connexin 26".
Below are MeSH descriptors whose meaning is more specific than "Connexin 26".
This graph shows the total number of publications written about "Connexin 26" by people in this website by year, and whether "Connexin 26" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Connexin 26" by people in Profiles.
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Free energy and kinetics of cAMP permeation through connexin26 via applied voltage and milestoning. Biophys J. 2021 08 03; 120(15):2969-2983.
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Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase. Nat Commun. 2018 02 08; 9(1):578.
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Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function. Mol Biol Cell. 2012 Sep; 23(17):3299-311.
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Molecular dynamics simulations of the Cx26 hemichannel: insights into voltage-dependent loop-gating. Biophys J. 2012 Mar 21; 102(6):1341-51.
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Structural organization of intercellular channels II. Amino terminal domain of the connexins: sequence, functional roles, and structure. Biochim Biophys Acta. 2012 Aug; 1818(8):1823-30.
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Different domains are critical for oligomerization compatibility of different connexins. Biochem J. 2011 May 15; 436(1):35-43.
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A multicenter study of the frequency and distribution of GJB2 and GJB6 mutations in a large North American cohort. Genet Med. 2007 Jul; 9(7):413-26.
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N-terminal residues in Cx43 and Cx40 determine physiological properties of gap junction channels, but do not influence heteromeric assembly with each other or with Cx26. J Cell Sci. 2006 Jun 01; 119(Pt 11):2258-68.
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Müllerian anomalies, hearing loss, and connexin 26 mutations. Fertil Steril. 2006 Jun; 85(6):1824-5.
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Connexin43 with a cytoplasmic loop deletion inhibits the function of several connexins. Biochem Biophys Res Commun. 2005 Aug 12; 333(4):1185-93.