"Dual Oxidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
NADPH oxidases that contain two additional EF HAND MOTIFS and an N-terminal PEROXIDASE domain. They are expressed by THYROCYTES and EPITHELIAL CELLS of the kidney, liver, trachea, lung, and glandular tissues such as the testis, pancreas, and prostate. They are critical for the activity of THYROID PEROXIDASE and play a role in the production of thyroid hormones; they may also have antimicrobial activity through the generation of REACTIVE OXYGEN SPECIES.
| Descriptor ID |
D000074623
|
| MeSH Number(s) |
D08.811.682.608.575.500 D12.776.331.894.500 D12.776.543.653.500
|
| Concept/Terms |
Dual Oxidases- Dual Oxidases
- Oxidases, Dual
- Duox Proteins
- Proteins, Duox
Dual Oxidase 2- Dual Oxidase 2
- Oxidase 2, Dual
- NADPH Thyroid Oxidase 2
- Thyroid Oxidase 2
- Oxidase 2, Thyroid
- DUOX2
|
Below are MeSH descriptors whose meaning is more general than "Dual Oxidases".
Below are MeSH descriptors whose meaning is more specific than "Dual Oxidases".
This graph shows the total number of publications written about "Dual Oxidases" by people in this website by year, and whether "Dual Oxidases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2020 | 0 | 2 | 2 |
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Below are the most recent publications written about "Dual Oxidases" by people in Profiles.
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Increased Prevalence of TG and TPO Mutations in Sudanese Children With Congenital Hypothyroidism. J Clin Endocrinol Metab. 2020 05 01; 105(5).
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Interactions between the gut microbiome and host gene regulation in cystic fibrosis. Genome Med. 2020 01 28; 12(1):12.
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Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families. Thyroid. 2019 02; 29(2):302-304.
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DUOX2 Gene Mutation Manifesting as Resistance to Thyrotropin Phenotype. Thyroid. 2017 01; 27(1):129-131.
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Overexpression of Interleukin-4 in the Thyroid of Transgenic Mice Upregulates the Expression of Duox1 and the Anion Transporter Pendrin. Thyroid. 2016 10; 26(10):1499-1512.
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Mice deficient in dual oxidase maturation factors are severely hypothyroid. Mol Endocrinol. 2012 Mar; 26(3):481-92.
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Genetic causes of congenital hypothyroidism due to dyshormonogenesis. Curr Opin Pediatr. 2011 Aug; 23(4):421-8.
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A single copy of the recently identified dual oxidase maturation factor (DUOXA) 1 gene produces only mild transient hypothyroidism in a patient with a novel biallelic DUOXA2 mutation and monoallelic DUOXA1 deletion. J Clin Endocrinol Metab. 2011 May; 96(5):E841-5.
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Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor. Mol Endocrinol. 2007 Jun; 21(6):1408-21.
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Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent. J Biol Chem. 2006 Jul 07; 281(27):18269-72.