"Geminin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Geminin inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex. It is absent during G1 phase of the CELL CYCLE and accumulates through S, G2,and M phases. It is degraded at the metaphase-anaphase transition by the ANAPHASE-PROMOTING COMPLEX-CYCLOSOME.
| Descriptor ID |
D064248
|
| MeSH Number(s) |
D12.776.167.265
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Geminin".
Below are MeSH descriptors whose meaning is more specific than "Geminin".
This graph shows the total number of publications written about "Geminin" by people in this website by year, and whether "Geminin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Geminin" by people in Profiles.
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Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavanoid apigenin in pancreatic cancer cell lines. Mol Carcinog. 2008 Nov; 47(11):835-44.