"Mad2 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mad2 is a component of the spindle-assembly checkpoint apparatus. It binds to and inhibits the Cdc20 activator subunit of the anaphase-promoting complex, preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Mad2 is required for proper microtubule capture at KINETOCHORES.
| Descriptor ID |
D064246
|
| MeSH Number(s) |
D12.776.167.313 D12.776.660.526
|
| Concept/Terms |
Mad2 Proteins- Mad2 Proteins
- Mad2 Mitotic Arrest Deficient-like 1 Proteins
|
Below are MeSH descriptors whose meaning is more general than "Mad2 Proteins".
Below are MeSH descriptors whose meaning is more specific than "Mad2 Proteins".
This graph shows the total number of publications written about "Mad2 Proteins" by people in this website by year, and whether "Mad2 Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Mad2 Proteins" by people in Profiles.
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Structure of an intermediate conformer of the spindle checkpoint protein Mad2. Proc Natl Acad Sci U S A. 2015 Sep 08; 112(36):11252-7.
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The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint. J Cell Biol. 2008 Oct 20; 183(2):267-77.