Tumor Suppressor Protein p14ARF
"Tumor Suppressor Protein p14ARF" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gene product of the p16 tumor suppressor gene (GENES, P16). It antagonizes the function of MDM2 PROTEIN (which regulates P53 TUMOR SUPPRESSOR PROTEIN by targeting it for degradation). p14ARF is produced from the beta mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced alpha transcript, is CYCLIN-DEPENDENT KINASE INHIBITOR P16. Both p16 gene products have tumor suppressor functions.
| Descriptor ID |
D025803
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| MeSH Number(s) |
D12.776.167.600 D12.776.624.776.772
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tumor Suppressor Protein p14ARF".
Below are MeSH descriptors whose meaning is more specific than "Tumor Suppressor Protein p14ARF".
This graph shows the total number of publications written about "Tumor Suppressor Protein p14ARF" by people in this website by year, and whether "Tumor Suppressor Protein p14ARF" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tumor Suppressor Protein p14ARF" by people in Profiles.
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Osteosarcoma development and stem cell differentiation. Clin Orthop Relat Res. 2008 Sep; 466(9):2114-30.
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Simulation-based validation of the p53 transcriptional activity with hybrid functional petri net. In Silico Biol. 2006; 6(1-2):1-13.
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The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia. Nat Med. 2002 Jul; 8(7):743-50.
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Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Mol Cell. 2001 Dec; 8(6):1187-96.
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A G2/M growth arrest response to low-dose intermittent H2O2 in normal uroepithelial cells. Int J Oncol. 2000 Sep; 17(3):425-32.
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Preferential loss of expression of p16(INK4a) rather than p19(ARF) in breast cancer. Clin Cancer Res. 1996 Dec; 2(12):1993-8.