alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
| Descriptor ID |
D018350
|
| MeSH Number(s) |
D03.383.129.385.025
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid".
Below are MeSH descriptors whose meaning is more specific than "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid".
This graph shows the total number of publications written about "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" by people in this website by year, and whether "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 2000 | 0 | 3 | 3 |
| 2004 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" by people in Profiles.
-
A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors. Neuron. 2023 08 16; 111(16):2544-2556.e9.
-
AMPA workshop on challenges faced by investigators conducting Alzheimer's disease clinical trials. Alzheimers Dement. 2011 Jul; 7(4):e109-17.
-
Transient viral-mediated overexpression of alpha-calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell leads to long-lasting functional upregulation of alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors: dopamine type-1 receptor and protein kinase A dependence. Eur J Neurosci. 2010 Apr; 31(7):1243-51.
-
Synaptic SAP97 isoforms regulate AMPA receptor dynamics and access to presynaptic glutamate. J Neurosci. 2009 Apr 08; 29(14):4332-45.
-
Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats. Am J Physiol Regul Integr Comp Physiol. 2009 Feb; 296(2):R299-308.
-
Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate release of inhibitory amino acids in rat spinal cord dorsal horn. Neuroscience. 2006 May 12; 139(2):539-53.
-
Previous exposure to psychostimulants enhances the reinstatement of cocaine seeking by nucleus accumbens AMPA. Neuropsychopharmacology. 2004 Dec; 29(12):2149-59.
-
Peripheral inflamation-induced increase of AMPA-mediated currents and Ca2+ transients in the presence of cyclothiazide in the rat substantia gelatinosa neurons. Cell Calcium. 2004 May; 35(5):461-9.
-
Ethanol inhibits alpha-amino-3-hydyroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function in central nervous system neurons by stabilizing desensitization. J Pharmacol Exp Ther. 2003 Aug; 306(2):546-55.
-
AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability. J Neurosci. 2000 Oct 01; 20(19):7158-66.