"Helix-Turn-Helix Motifs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)
| Descriptor ID |
D019077
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.360.360
|
| Concept/Terms |
Helix-Turn-Helix Motifs- Helix-Turn-Helix Motifs
- Helix Turn Helix Motifs
- Helix-Turn-Helix Motif
- Motif, Helix-Turn-Helix
- Motifs, Helix-Turn-Helix
- Motifs, Helix Turn Helix
- HTH Motifs
- HTH Motif
- Motif, HTH
- Motifs, HTH
|
Below are MeSH descriptors whose meaning is more general than "Helix-Turn-Helix Motifs".
Below are MeSH descriptors whose meaning is more specific than "Helix-Turn-Helix Motifs".
This graph shows the total number of publications written about "Helix-Turn-Helix Motifs" by people in this website by year, and whether "Helix-Turn-Helix Motifs" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Helix-Turn-Helix Motifs" by people in Profiles.
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Recognition of an a-helical hairpin in P22 large terminase by a synthetic antibody fragment. Acta Crystallogr D Struct Biol. 2020 Sep 01; 76(Pt 9):876-888.
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The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical. Structure. 2016 11 01; 24(11):1936-1946.
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Solution NMR structures reveal unique homodimer formation by a winged helix-turn-helix motif and provide first structures for protein domain family PF10771. J Struct Funct Genomics. 2012 Mar; 13(1):1-7.
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Crystal structure of YfiR, an unusual TetR/CamR-type putative transcriptional regulator from Bacillus subtilis. Proteins. 2006 Oct 01; 65(1):255-7.
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Cyanobacterial response regulator PatA contains a conserved N-terminal domain (PATAN) with an alpha-helical insertion. Bioinformatics. 2006 Jun 01; 22(11):1297-301.
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Heterocyst-specific expression of patB, a gene required for nitrogen fixation in Anabaena sp. strain PCC 7120. J Bacteriol. 2003 Apr; 185(7):2306-14.
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Crystal structure of the signal sequence binding subunit of the signal recognition particle. Cell. 1998 Jul 24; 94(2):181-91.
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Transformation by the Bmi-1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity. Mol Cell Biol. 1996 Oct; 16(10):5527-35.