"Helix-Loop-Helix Motifs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.
| Descriptor ID |
D018257
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.360
|
| Concept/Terms |
Helix-Loop-Helix Motifs- Helix-Loop-Helix Motifs
- Helix Loop Helix Motifs
- Motif, Helix-Loop-Helix
- Helix-Loop-Helix Domains
- Helix Loop Helix Domains
- Helix-Loop-Helix Motif
- Helix Loop Helix Motif
- Helix-Loop-Helix Domain
- Helix Loop Helix Domain
- HLH Motifs
- HLH Motif
- Motif, HLH
- Motifs, HLH
- Motifs, Helix-Loop-Helix
- Motifs, Helix Loop Helix
|
Below are MeSH descriptors whose meaning is more general than "Helix-Loop-Helix Motifs".
Below are MeSH descriptors whose meaning is more specific than "Helix-Loop-Helix Motifs".
This graph shows the total number of publications written about "Helix-Loop-Helix Motifs" by people in this website by year, and whether "Helix-Loop-Helix Motifs" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 0 | 2 |
| 1995 | 1 | 0 | 1 |
| 1998 | 1 | 1 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 2 | 2 | 4 |
| 2001 | 1 | 0 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Helix-Loop-Helix Motifs" by people in Profiles.
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Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains. Nat Biotechnol. 2023 04; 41(4):541-551.
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EsxB, a secreted protein from Bacillus anthracis forms two distinct helical bundles. Protein Sci. 2015 Sep; 24(9):1389-400.
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Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophys J. 2010 May 19; 98(10):2189-98.
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Extrinsic and intrinsic regulation of early natural killer cell development. Immunol Res. 2008; 40(3):193-207.
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Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells. J Orthop Res. 2007 May; 25(5):665-77.
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Helix-loop-helix proteins in lymphocyte lineage determination. Curr Top Microbiol Immunol. 2005; 290:15-27.
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Association of epigenetic inactivation of RASSF1A with poor outcome in human neuroblastoma. Clin Cancer Res. 2004 Dec 15; 10(24):8493-500.
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Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A. J Exp Med. 2004 Jun 21; 199(12):1689-700.
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Herpes simplex virus 1 alpha regulatory protein ICP0 functionally interacts with cellular transcription factor BMAL1. Proc Natl Acad Sci U S A. 2001 Feb 13; 98(4):1877-82.
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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems. Genes Dev. 2000 Nov 15; 14(22):2839-54.