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Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase.
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Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science. 2011 Nov 11; 334(6057):806-9.
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PubMed
subject areas
Acetylation
Animals
Carbamoyl-Phosphate Synthase (Ammonia)
Cattle
Crystallography, X-Ray
Histones
Humans
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Kinetics
Lysine
Male
Mice
Mice, Knockout
Mitochondria, Liver
NAD
Peptides
Protein Processing, Post-Translational
Sirtuins
Succinic Acid
authors with profiles
Hening Lin