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An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron.
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An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron.
An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron. Sci Transl Med. 2016 07 13; 8(347):347ra94.
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PubMed
subject areas
Animals
Blotting, Western
Calcium Channels
Calcium Channels, N-Type
Fluorescent Antibody Technique
Genes
HEK293 Cells
Humans
Immunohistochemistry
Immunoprecipitation
Internal Ribosome Entry Sites
Mice
Mice, Inbred C57BL
MicroRNAs
Purkinje Cells
Real-Time Polymerase Chain Reaction
RNA, Small Interfering
Spinocerebellar Ataxias
authors with profiles
Xiaofei Du
Christopher M. Gomez