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One or more keywords matched the following properties of Pincus, David
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overview David Pincus is an Assistant Professor in the Dept. of Molecular Genetics and Cell Biology. The Pincus lab is located in the Center for Physics of Evolving Systems on the 5th floor of GCIS. The Pincus Lab studies cellular adaptation at three levels: cell biological mechanisms of adaptation to environmental stress, global principles of adaptation and resource allocation in complex environments, and the intersection of physiological stress response factors and evolutionary adaptation. David is trained in approaches in biochemistry, biophysics, genetics, genomics, and molecular, cell, computational, systems and synthetic biology. The lab uses budding yeast and cultured human cells as experimental models. Key project areas: 1) Quantitative cell biology of the heat shock response 2) Single-cell transcriptomics in complex stress environments
One or more keywords matched the following items that are connected to Pincus, David
Item TypeName
Concept Fungal Proteins
Concept DNA-Binding Proteins
Concept Membrane Proteins
Concept Heat-Shock Proteins
Concept Protein Binding
Concept Protein Conformation
Concept Protein Processing, Post-Translational
Concept Proteins
Concept Repressor Proteins
Concept Protein Kinases
Concept Protein Biosynthesis
Concept Protein Engineering
Concept Protein Structure, Quaternary
Concept Mitogen-Activated Protein Kinases
Concept Protein Structure, Tertiary
Concept HSP70 Heat-Shock Proteins
Concept Protein Transport
Concept Receptors, G-Protein-Coupled
Concept Saccharomyces cerevisiae Proteins
Concept Recombinant Proteins
Concept Hedgehog Proteins
Concept Ribosomal Proteins
Concept Unfolded Protein Response
Concept HSP40 Heat-Shock Proteins
Concept Protein Multimerization
Concept Sequence Analysis, Protein
Concept HSP90 Heat-Shock Proteins
Concept Caenorhabditis elegans Proteins
Concept GTPase-Activating Proteins
Concept Mutant Proteins
Concept Protein Interaction Maps
Concept Carrier Proteins
Concept Cyclic AMP-Dependent Protein Kinases
Academic Article Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity.
Academic Article Engineering allosteric regulation in protein kinases.
Academic Article Genetic and epigenetic determinants establish a continuum of Hsf1 occupancy and activity across the yeast genome.
Academic Article Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response.
Academic Article Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation.
Academic Article BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response.
Academic Article Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.
Academic Article Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity.
Academic Article tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae.
Academic Article Formation of subnuclear foci is a unique spatial behavior of mating MAPKs during hyperosmotic stress.
Academic Article Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1.
Academic Article Size doesn't matter in the heat shock response.
Academic Article Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response.
Academic Article Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.
Academic Article Assigning quantitative function to post-translational modifications reveals multiple sites of phosphorylation that tune yeast pheromone signaling output.
Academic Article Serial Immunoprecipitation of 3xFLAG/V5-tagged Yeast Proteins to Identify Specific Interactions with Chaperone Proteins.
Academic Article Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range.
Academic Article Negative feedback that improves information transmission in yeast signalling.
Academic Article Reagents for investigating MAPK signalling in model yeast species.
Academic Article An evolution-based strategy for engineering allosteric regulation.
Academic Article Heat Shock Factor 1 Drives Intergenic Association of Its Target Gene Loci upon Heat Shock.
Academic Article Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness.
Academic Article Messenger RNA targeting to endoplasmic reticulum stress signalling sites.
Academic Article m6A modification of a 3' UTR site reduces RME1 mRNA levels to promote meiosis.
Academic Article Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses.
Academic Article Strategies for Engineering and Rewiring Kinase Regulation.
Academic Article Multi-kinase control of environmental stress responsive transcription.
Academic Article Regulation of Hsf1 and the Heat Shock Response.
Academic Article The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.
Academic Article Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides.
Academic Article Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.
Academic Article Subcellular localization of the J-protein Sis1 regulates the heat shock response.
Academic Article Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response.
Concept Protein Aggregation, Pathological
Concept Protein Aggregates
Grant Regulatory Dynamics of the Proteostasis Network
Grant Quantitative approaches to reveal the homeostatic control mechanisms of stress re
Academic Article Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response.
Academic Article Adaptive preservation of orphan ribosomal proteins in chaperone-dispersed condensates.
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  • Protein
  • Biochemistry