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One or more keywords matched the following properties of Rosner, Marsha
overview Cancer is the second leading cause of death but, unlike heart disease, it has been a difficult disease to effectively understand or treat. The reason relates to the complexity and heterogeneity of the disease. Most tumors have complicated origins and are driven by rare mutations. Furthermore, different tissues have distinct cancers, individual tissues have multiple cancer subtypes, and tumors are composed of cells that are both genetically and phenotypically diverse. Thus, every tumor is unique and dynamic. The cause of lethality in most solid tumors such as breast cancer is the metastatic dissemination of tumor cells throughout the body. Metastasis is characterized by many distinct properties that are driven by changing stresses in the tumor microenvironment. Underlying all of these events are subcellular signaling pathways within tumor and environmental cells that are ultimately responsible for driving cells to a tumorigenic state. The current focus of my laboratory is to understand fundamental signaling mechanisms leading to the generation of tumor cells and their progression to metastatic disease, particularly in triple-negative breast cancer that lacks targeted therapies. We use systems level approaches including activity-based proteomics, RNAseq, ChIPseq, and mass spectrometry as well as computational, molecular, biophysical, cellular and mouse model-based methodologies to identify and characterize key regulators of tumor growth and metastasis. As an additional tool, we have utilized a specific physiological suppressor of metastasis, Raf Kinase Inhibitory Protein (RKIP or PEBP1), and a downstream target of RKIP in cells, BACH1, to identify both molecular and cellular mediators of metastasis. Our recent studies have shown that regulators of metastasis control multiple processes within the tumor cell microenvironment including metabolism, redox state, extracellular matrix, and recruitment and programming of tumor-associated macrophages. These factors also direct extracellular vesicles (exosomes) secreted by tumor cells to reprogram other cells in the body toward a pro-metastatic phenotype. Correlating omic-generated data from these studies with clinical data from cancer patients led to the identification of novel signaling modules that we used to build gene signatures that predict the metastatic potential of a tumor. More recently, our studies have led us to potential therapeutic treatments based on the concept of targeting key regulators of tumorigenesis, mimicking the action of metastasis suppressors such as RKIP or reprogramming signaling networks in cells to sensitize tumors to therapeutic agents.
One or more keywords matched the following items that are connected to Rosner, Marsha
Item TypeName
Concept Protein-Tyrosine Kinases
Concept Protein Kinases
Concept Mitogen-Activated Protein Kinases
Concept MAP Kinase Kinase 1
Concept MAP Kinase Kinase 2
Concept src-Family Kinases
Concept Receptor Protein-Tyrosine Kinases
Concept MAP Kinase Kinase Kinases
Concept Cyclin-Dependent Kinase 4
Concept Protein Kinase C-delta
Concept Mitogen-Activated Protein Kinase 3
Concept Mitogen-Activated Protein Kinase 7
Concept Mitogen-Activated Protein Kinase Kinases
Concept Cyclin-Dependent Kinase Inhibitor p21
Concept Phosphotransferases
Concept Protein Kinase C
Concept Glycogen Synthase Kinase 3
Concept TOR Serine-Threonine Kinases
Concept MAP Kinase Kinase Kinase 1
Concept Cyclin-Dependent Kinases
Concept Mitogen-Activated Protein Kinase 1
Concept Calcium-Calmodulin-Dependent Protein Kinases
Concept Phosphatidylinositol 3-Kinases
Concept MAP Kinase Signaling System
Concept JNK Mitogen-Activated Protein Kinases
Concept Extracellular Signal-Regulated MAP Kinases
Concept raf Kinases
Concept Ribosomal Protein S6 Kinases, 70-kDa
Concept Cyclin-Dependent Kinase Inhibitor p27
Concept Protein Kinase C-alpha
Concept Cyclic AMP-Dependent Protein Kinases
Concept Protein Kinase Inhibitors
Concept MAP Kinase Kinase 5
Concept Cyclin-Dependent Kinase 2
Concept G-Protein-Coupled Receptor Kinase 2
Academic Article Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src.
Academic Article Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells.
Academic Article Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated protein kinase by the tumor promoter thapsigargin.
Academic Article Cloning and characterization of MST4, a novel Ste20-like kinase.
Academic Article Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel.
Academic Article Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth.
Academic Article A novel mitogen-activated protein kinase is responsive to Raf and mediates growth factor specificity.
Academic Article ERK7 is an autoactivated member of the MAPK family.
Academic Article ERK8, a new member of the mitogen-activated protein kinase family.
Academic Article ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway.
Academic Article Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.
Academic Article NMR assignment of rat Raf kinase inhibitor protein.
Academic Article A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle.
Academic Article Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism.
Academic Article A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
Academic Article Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands.
Academic Article Raf kinase inhibitory protein (RKIP): a physiological regulator and future therapeutic target.
Academic Article Identification of novel metastasis suppressor signaling pathways for breast cancer.
Academic Article Anthrax edema factor potency depends on mode of cell entry.
Academic Article Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context.
Academic Article Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells.
Academic Article Hydrogen peroxide stimulates mitogen-activated protein kinase in bovine tracheal myocytes: implications for human airway disease.
Academic Article Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration.
Academic Article The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis.
Academic Article Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin.
Academic Article A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer.
Academic Article Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis.
Academic Article Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor.
Academic Article Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor.
Academic Article Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters.
Academic Article Basic and acidic fibroblast growth factors modulate the epidermal growth factor receptor by a protein kinase C-independent pathway.
Academic Article Growth factors modify the epidermal growth factor receptor through multiple pathways.
Academic Article Characterization of rodent epidermal growth factor receptor transcripts using a mouse genomic probe.
Academic Article Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter.
Academic Article Characterization of protein kinase C from normal and transformed cultured murine fibroblasts.
Academic Article Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.
Academic Article Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase.
Academic Article Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells.
Academic Article Activation of mitogen-activated protein kinase by epidermal growth factor in hippocampal neurons and neuronal cell lines.
Academic Article Growth state-dependent regulation of protein kinase C in normal and transformed murine cells.
Academic Article Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium.
Academic Article Adenovirus and protein kinase C have distinct molecular requirements for regulating epidermal growth factor receptor trafficking.
Academic Article Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells.
Academic Article Mitogen-activated protein kinase regulates the epidermal growth factor receptor through activation of a tyrosine phosphatase.
Academic Article Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells.
Academic Article Different protein kinase C isoforms determine growth factor specificity in neuronal cells.
Academic Article Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.
Academic Article Role of threonine residues in regulation of the epidermal growth factor receptor by protein kinase C and mitogen-activated protein kinase.
Academic Article Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C.
Academic Article Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line.
Academic Article Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.
Academic Article CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders.
Academic Article Cytoplasmic/nuclear localization of tuberin in different cell lines.
Academic Article Tuberous sclerosis gene products in proliferation control.
Academic Article Role of cyclins in neuronal differentiation of immortalized hippocampal cells.
Academic Article mTOR phosphorylated at S2448 binds to raptor and rictor.
Academic Article Evidence for cell cycle-dependent, rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244.
Academic Article Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells.
Academic Article Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta.
Academic Article Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR.
Academic Article Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor.
Academic Article Nuclear/cytoplasmic localization of Akt activity in the cell cycle.
Academic Article Tuberin, p27 and mTOR in different cells.
Academic Article The TSC1 gene product, hamartin, negatively regulates cell proliferation.
Academic Article Characterization of a cysteine proteinase inhibitor induced during neuronal cell differentiation.
Academic Article Ras mediates cell survival by regulating tuberin.
Academic Article MAP kinase meets mitosis: a role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation.
Academic Article Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein.
Academic Article p70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6.
Academic Article Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7.
Academic Article Proliferation potential of human amniotic fluid stem cells differently responds to mercury and lead exposure.
Academic Article NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta.
Academic Article Akt regulates nuclear/cytoplasmic localization of tuberin.
Academic Article Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint.
Academic Article CDKs as therapeutic targets for the human genetic disease tuberous sclerosis?
Academic Article Embryoid body formation of human amniotic fluid stem cells depends on mTOR.
Academic Article MAP kinase regulation of the mitotic spindle checkpoint.
Academic Article RKIP regulates MAP kinase signaling in cells with defective B-Raf activity.
Academic Article RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy.
Academic Article Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.
Academic Article Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation.
Academic Article Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways.
Academic Article Tuberin activates the proapoptotic molecule BAD.
Academic Article Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236.
Academic Article An integrated view of cyclin E function and regulation.
Academic Article Raf kinase inhibitory protein (RKIP) as a metastasis suppressor: regulation of signaling networks in cancer.
Academic Article Interaction of tRNA with MEK2 in pancreatic cancer cells.
Academic Article Raf kinase inhibitor protein: lessons of a better way for ß-adrenergic receptor activation in the heart.
Academic Article Targeting Raf Kinase Inhibitory Protein Regulation and Function.
Academic Article Limited inhibition of multiple nodes in a driver network blocks metastasis.
Academic Article New strategies for targeting kinase networks in cancer.
Academic Article Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses.
Academic Article Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop.
Academic Article SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells.
Concept Protein Kinase C-theta
Concept Aurora Kinase B
Concept Aurora Kinases
Concept 3-Phosphoinositide-Dependent Protein Kinases
Grant Regulation of RKIP Function
Grant Tumor-stromal interactions as targets of tumor metastasis suppressors
Grant Signaling Pathways in Neuronal Cells
Grant Modulation of Head and Neck Cancer by Protein Kinase C
Grant Role of Raf Kinase Inhibitory Protein in Prostate Cancer
Grant Signaling Pathways in Neuronal Cells
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