| Item Type | Name |
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Concept
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Asparagine
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Concept
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Cyclic AMP
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Concept
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Acidosis
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Concept
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Benzocaine
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Concept
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Amino Acid Sequence
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Concept
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Amphetamine
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Concept
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Anti-Arrhythmia Agents
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Concept
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Anesthetics, Local
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Concept
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Base Sequence
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Concept
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Cations, Divalent
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Concept
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Aspartic Acid
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Concept
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Cardiology
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Concept
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Genes, Synthetic
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Concept
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Cardiotonic Agents
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Concept
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Golgi Apparatus
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Concept
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Cysteine
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Concept
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Cyclopentanes
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Concept
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Isoproterenol
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Concept
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Endoplasmic Reticulum
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Concept
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Long QT Syndrome
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Concept
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Ethyl Methanesulfonate
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Concept
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Manganese
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Concept
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DNA
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Concept
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Colforsin
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Concept
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Indicators and Reagents
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Concept
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Endocytosis
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Concept
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Atrial Natriuretic Factor
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Concept
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Insecticides
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Concept
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Isometric Contraction
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Concept
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Leucine
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Concept
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Magnesium
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Concept
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Insecticide Resistance
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Concept
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Molecular Sequence Data
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Concept
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Monte Carlo Method
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Concept
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Purkinje Fibers
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Concept
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Myocardial Contraction
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Concept
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HeLa Cells
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Concept
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Ion Channels
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Concept
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Oocytes
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Concept
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Mesylates
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Concept
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Microscopy, Electron
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|
Concept
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Oxazoles
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Concept
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Verapamil
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Concept
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Potassium Channels
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Concept
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RNA
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Concept
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Homeostasis
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Concept
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Humans
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Concept
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Calcium Channels
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Concept
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Sodium Channels
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Concept
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Glutamic Acid
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Concept
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Veratridine
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Concept
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Moricizine
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Concept
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Exercise
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Concept
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Ion Channel Gating
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Concept
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Mutagenesis, Site-Directed
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Concept
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Motor Activity
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Concept
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DNA, Complementary
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Concept
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Receptors, AMPA
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|
Concept
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Sodium Channel Blockers
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Concept
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Nucleus Accumbens
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Concept
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Calcium Channels, T-Type
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Concept
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Gap Junctions
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|
Concept
|
History, 21st Century
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Concept
|
Shaker Superfamily of Potassium Channels
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|
Concept
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Casein Kinase Idelta
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Concept
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Ryanodine Receptor Calcium Release Channel
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|
Concept
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Amino Acid Substitution
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Concept
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Purkinje Cells
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Concept
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Rats, Inbred Strains
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Concept
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Sarcoplasmic Reticulum
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|
Concept
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Sulfhydryl Reagents
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|
Concept
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HEK293 Cells
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Concept
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Temperature
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Concept
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Cardiac Electrophysiology
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|
Concept
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Delayed Rectifier Potassium Channels
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|
Concept
|
Blotting, Northern
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|
Concept
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Molecular Structure
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|
Concept
|
Mibefradil
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|
Concept
|
History, 20th Century
|
|
Concept
|
Calcium Channel Blockers
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|
Concept
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Cations
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Concept
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Diastole
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Concept
|
Epilepsy, Generalized
|
|
Concept
|
Fluorescent Dyes
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|
Concept
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Lysine
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Concept
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Neuroblastoma
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|
Concept
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Protons
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|
Concept
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Systole
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|
Concept
|
DNA Primers
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|
Concept
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Calcium Channels, L-Type
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Concept
|
Potassium Channels, Voltage-Gated
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|
Concept
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Shab Potassium Channels
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Academic Article
|
Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel.
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|
Academic Article
|
Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics.
|
|
Academic Article
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The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B.
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Academic Article
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Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms.
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Academic Article
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Optimization of a mammalian expression system for the measurement of sodium channel gating currents.
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|
Academic Article
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Nonequilibrium response spectroscopy of voltage-sensitive ion channel gating.
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|
Academic Article
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Role for Pro-13 in directing high-affinity binding of anthopleurin B to the voltage-sensitive sodium channel.
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Academic Article
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A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B.
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Academic Article
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Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8.
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Academic Article
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Modification of inactivation in cardiac sodium channels: ionic current studies with Anthopleurin-A toxin.
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|
Academic Article
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Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxin.
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Academic Article
|
Augmentation of recovery from inactivation by site-3 Na channel toxins. A single-channel and whole-cell study of persistent currents.
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Academic Article
|
Differences in the binding sites of two site-3 sodium channel toxins.
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|
Academic Article
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The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.
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|
Academic Article
|
Gating of skeletal and cardiac muscle sodium channels in mammalian cells.
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Academic Article
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The role of the putative inactivation lid in sodium channel gating current immobilization.
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|
Academic Article
|
Point mutations in domain III of a Drosophila neuronal Na channel confer resistance to allethrin.
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|
Academic Article
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Heartthrobs.
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|
Academic Article
|
Lidocaine alters activation gating of cardiac Na channels.
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|
Academic Article
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Two components of use-dependent block of sodium current by lidocaine in voltage clamped cardiac Purkinje cells.
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|
Academic Article
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Atrionatriuretic peptide and calcium-conducting sodium channels.
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Academic Article
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Arg-14 loop of site 3 anemone toxins: effects of glycine replacement on toxin affinity.
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Academic Article
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Role of Asn-16 and Ser-19 in anthopleurin B binding. Implications for the electrostatic nature of Na(V) site 3.
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Academic Article
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Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation.
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Academic Article
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Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents.
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|
Academic Article
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Molecular action of lidocaine on the voltage sensors of sodium channels.
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|
Academic Article
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State-dependent mibefradil block of Na+ channels.
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|
Academic Article
|
Kinetic analysis of single sodium channels from canine cardiac Purkinje cells.
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|
Academic Article
|
Gating currents associated with Na channels in canine cardiac Purkinje cells.
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|
Academic Article
|
Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.
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|
Academic Article
|
Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.
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|
Academic Article
|
Sodium channels in cardiac Purkinje cells.
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|
Academic Article
|
Role of Domain IV/S4 outermost arginines in gating of T-type calcium channels.
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|
Academic Article
|
Isoform-dependent interaction of voltage-gated sodium channels with protons.
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|
Academic Article
|
Open sodium channel properties of single canine cardiac Purkinje cells.
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|
Academic Article
|
Site-3 toxins and cardiac sodium channels.
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|
Academic Article
|
Profiling the array of Ca(v)3.1 variants from the human T-type calcium channel gene CACNA1G: alternative structures, developmental expression, and biophysical variations.
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|
Academic Article
|
An inner pore residue (Asn406) in the Nav1.5 channel controls slow inactivation and enhances mibefradil block to T-type Ca2+ channel levels.
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|
Academic Article
|
Is there a second external lidocaine binding site on mammalian cardiac cells?
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|
Academic Article
|
Verapamil block of T-type calcium channels.
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|
Academic Article
|
Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation.
|
|
Academic Article
|
The relationship between single-channel and whole-cell conductance in the T-type Ca2+ channel CaV3.1.
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|
Academic Article
|
Use-dependent block of sodium current by ethmozin in voltage-clamped internally perfused canine cardiac Purkinje cells.
|
|
Academic Article
|
Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel.
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|
Academic Article
|
The sodium channel as a target for local anesthetic drugs.
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|
Academic Article
|
Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.
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|
Academic Article
|
A molecular model of the inner pore of the Ca channel in its open state.
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|
Academic Article
|
Sodium channel molecular conformations and antiarrhythmic drug affinity.
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|
Academic Article
|
A direct effect of forskolin on sodium channel bursting.
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Academic Article
|
In memoriam. Morton Arnsdorf: 1940-2010.
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Academic Article
|
Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells.
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|
Academic Article
|
Effects of physiological beating on the contractility of cat ventricular muscle.
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|
Academic Article
|
Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells.
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|
Academic Article
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Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discrimination.
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Academic Article
|
Time-dependent changes in kinetics of Na+ current in single canine cardiac Purkinje cells.
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Academic Article
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Modification of sodium channel inactivation by alpha-chymotrypsin in canine cardiac Purkinje cells.
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Academic Article
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Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5.
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Academic Article
|
A structural motif for the voltage-gated potassium channel pore.
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Academic Article
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Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells.
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|
Academic Article
|
Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATXII.
|
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Academic Article
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Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study.
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Academic Article
|
The outermost lysine in the S4 of domain III contributes little to the gating charge in sodium channels.
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|
Academic Article
|
Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels.
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Academic Article
|
Endocytosis and uptake of lucifer yellow by cultured atrial myocytes and isolated intact atria from adult rats. Regulation and subcellular localization.
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Academic Article
|
Outward stabilization of the voltage sensor in domain II but not domain I speeds inactivation of voltage-gated sodium channels.
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|
Academic Article
|
Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels.
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|
Concept
|
NAV1.2 Voltage-Gated Sodium Channel
|
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Concept
|
NAV1.5 Voltage-Gated Sodium Channel
|
|
Concept
|
Voltage-Gated Sodium Channel beta-3 Subunit
|
|
Concept
|
NAV1.3 Voltage-Gated Sodium Channel
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Concept
|
In Vitro Techniques
|
|
Grant
|
Cardiac Channels: Targets of Drugs that Affect Kinetics
|
|
Grant
|
STRUCTURAL BASES OF T-TYPE CALCIUM CHANNEL FUNCTION
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|
Grant
|
Structure-Function of the Cardiac Sodium Channel
|
|
Grant
|
Drug therapy targeted to the voltage-gated sodium channel
|