| Item Type | Name |
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Concept
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Rats, Inbred SHR
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Concept
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Rats, Zucker
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Concept
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Rats, Inbred WKY
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Concept
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Rats, Sprague-Dawley
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Concept
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Rats, Wistar
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Concept
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Rats, Inbred Strains
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Concept
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Rats
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Concept
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Rats, Mutant Strains
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Academic Article
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Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases.
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Academic Article
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A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells.
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Academic Article
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The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
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Academic Article
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Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.
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Academic Article
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Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.
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Academic Article
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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
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Academic Article
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A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
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Academic Article
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Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.
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Academic Article
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How is the insulin content regulated in nondiabetic hyperinsulinaemic, insulin resistant states? Study of spontaneously hypertensive rats.
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Academic Article
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Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.
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Academic Article
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Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism.
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Academic Article
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Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.
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Academic Article
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Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.
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Academic Article
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A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties.
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Academic Article
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Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.
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Academic Article
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Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
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Academic Article
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A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis.
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Academic Article
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Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats.
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Academic Article
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Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
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Academic Article
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Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
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Academic Article
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Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
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Academic Article
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Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.
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Academic Article
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Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
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Academic Article
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Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.
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Academic Article
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Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.
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Academic Article
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Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.
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Academic Article
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Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.
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Academic Article
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Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
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Academic Article
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Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.
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Academic Article
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A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.
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Academic Article
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Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell.
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Academic Article
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Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
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Academic Article
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Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump.
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Academic Article
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Proalbumin to albumin conversion by a proinsulin processing endopeptidase of insulin secretory granules.
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Academic Article
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[Biogenesis of the insulin secretion granule].
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Academic Article
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Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
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Academic Article
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Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.
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Academic Article
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The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.
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Academic Article
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Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.
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Academic Article
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The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptides.
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Academic Article
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Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets.
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Academic Article
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Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents.
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Academic Article
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Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
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Academic Article
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Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.
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Academic Article
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AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death.
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Academic Article
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Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.
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Academic Article
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Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet.
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Academic Article
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Degradation of islet amyloid polypeptide by neprilysin.
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Academic Article
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Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases.
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Academic Article
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High-performance liquid chromatography (HPLC): a rapid, flexible and sensitive method for separating islet proinsulin and insulin.
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Academic Article
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How does type 1 diabetes develop?: the notion of homicide or ß-cell suicide revisited.
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Academic Article
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Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets.
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Academic Article
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FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes.
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Academic Article
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A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor.
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Academic Article
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Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
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Academic Article
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Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans.
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Academic Article
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Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells.
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Academic Article
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The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide.
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Academic Article
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Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
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Academic Article
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Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.
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Academic Article
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IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
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Academic Article
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Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
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Academic Article
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Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve.
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Academic Article
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Translational control of glucose-induced islet amyloid polypeptide production in pancreatic islets.
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Academic Article
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Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
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Academic Article
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Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia.
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Academic Article
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Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
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Academic Article
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Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
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Academic Article
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Intracellular signalling. Key enzyme in leptin-induced anorexia.
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Academic Article
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A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake.
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Academic Article
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Characterization of the promoter for the rat and human link protein gene.
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Academic Article
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Developmental expression of the translocator protein 18 kDa (TSPO) in testicular germ cells.
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Academic Article
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Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
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Academic Article
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Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets.
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Academic Article
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Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.
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Academic Article
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Ca(2+)-regulated serine protease associated with the nuclear scaffold.
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Academic Article
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BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFß-TAK1-MAPK pathways in PAH.
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Academic Article
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Characterization of a glucocorticoid responsive element and identification of an AT-rich element that regulate the link protein gene.
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Academic Article
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Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits.
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Academic Article
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Leptin action in the forebrain regulates the hindbrain response to satiety signals.
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Academic Article
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Fluorometric assay of a calcium-dependent, paired-basic processing endopeptidase present in insulinoma granules.
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Academic Article
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Alternative splicing generates two different mRNA species for rat link protein.
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Academic Article
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Iron deficiency in pulmonary arterial hypertension: a potential therapeutic target.
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Academic Article
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ß-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats.
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Academic Article
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Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension.
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Academic Article
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Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production.
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Academic Article
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Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension.
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Academic Article
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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension.
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