 DNA Damage
"DNA Damage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
| Descriptor ID |
D004249
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| MeSH Number(s) |
G05.355.180
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| Concept/Terms |
DNA Damage- DNA Damage
- DNA Damages
- Damage, DNA
- Damages, DNA
- DNA Injury
- DNA Injuries
- Injuries, DNA
- Injury, DNA
Genotoxic Stress- Genotoxic Stress
- Genotoxic Stresses
- Stresses, Genotoxic
- Stress, Genotoxic
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Below are MeSH descriptors whose meaning is more general than "DNA Damage".
Below are MeSH descriptors whose meaning is more specific than "DNA Damage".
This graph shows the total number of publications written about "DNA Damage" by people in this website by year, and whether "DNA Damage" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1985 | 0 | 1 | 1 | | 1987 | 3 | 0 | 3 | | 1988 | 3 | 1 | 4 | | 1989 | 2 | 1 | 3 | | 1990 | 2 | 1 | 3 | | 1991 | 4 | 3 | 7 | | 1992 | 2 | 1 | 3 | | 1993 | 2 | 4 | 6 | | 1994 | 0 | 1 | 1 | | 1995 | 2 | 5 | 7 | | 1996 | 4 | 3 | 7 | | 1997 | 5 | 4 | 9 | | 1998 | 2 | 2 | 4 | | 1999 | 6 | 1 | 7 | | 2000 | 4 | 3 | 7 | | 2001 | 1 | 2 | 3 | | 2002 | 3 | 4 | 7 | | 2003 | 1 | 4 | 5 | | 2004 | 4 | 9 | 13 | | 2005 | 5 | 4 | 9 | | 2006 | 7 | 8 | 15 | | 2007 | 3 | 8 | 11 | | 2008 | 3 | 5 | 8 | | 2009 | 6 | 7 | 13 | | 2010 | 4 | 3 | 7 | | 2011 | 4 | 8 | 12 | | 2012 | 3 | 8 | 11 | | 2013 | 3 | 7 | 10 | | 2014 | 3 | 7 | 10 | | 2015 | 6 | 6 | 12 | | 2016 | 3 | 8 | 11 | | 2017 | 4 | 11 | 15 | | 2018 | 3 | 3 | 6 | | 2019 | 5 | 5 | 10 | | 2020 | 4 | 4 | 8 | | 2021 | 4 | 6 | 10 | | 2022 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "DNA Damage" by people in Profiles.
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Wang J, Liu K, Xiao T, Liu P, Prinz RA, Xu X. Uric acid accumulation in DNA-damaged tumor cells induces NKG2D ligand expression and antitumor immunity by activating TGF-ß-activated kinase 1. Oncoimmunology. 2022; 11(1):2016159.
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Lutze J, Warrington SE, Kron SJ. TdT-dUTP DSB End Labeling (TUDEL), for Specific, Direct In Situ Labeling of DNA Double Strand Breaks. Methods Mol Biol. 2022; 2394:299-317.
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Hine C, Wainwright DA, Lathia JD. Early DNA damage detection and cellular autophagy as drivers of stress-adaptive H2S production: A paradox resolved. Cell Chem Biol. 2021 12 16; 28(12):1665-1668.
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Lehrke MJ, Shapiro MJ, Rajcula MJ, Kennedy MM, McCue SA, Medina KL, Shapiro VS. The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice. Elife. 2021 11 11; 10.
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Jomova K, Hudecova L, Lauro P, Simunková M, Barbierikova Z, Malcek M, Alwasel SH, Alhazza IM, Rhodes CJ, Valko M. The effect of Luteolin on DNA damage mediated by a copper catalyzed Fenton reaction. J Inorg Biochem. 2022 01; 226:111635.
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Yang Z, Yang S, Cui YH, Wei J, Shah P, Park G, Cui X, He C, He YY. METTL14 facilitates global genome repair and suppresses skin tumorigenesis. Proc Natl Acad Sci U S A. 2021 08 31; 118(35).
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Falcinelli M, Thaker PH, Lutgendorf SK, Conzen SD, Flaherty RL, Flint MS. The Role of Psychologic Stress in Cancer Initiation: Clinical Relevance and Potential Molecular Mechanisms. Cancer Res. 2021 10 15; 81(20):5131-5140.
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Cheresh P, Kim SJ, Jablonski R, Watanabe S, Lu Z, Chi M, Helmin KA, Gius D, Budinger GRS, Kamp DW. SIRT3 Overexpression Ameliorates Asbestos-Induced Pulmonary Fibrosis, mt-DNA Damage, and Lung Fibrogenic Monocyte Recruitment. Int J Mol Sci. 2021 Jun 25; 22(13).
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Pillai VB, Samant S, Hund S, Gupta M, Gupta MP. The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy. Aging (Albany NY). 2021 05 02; 13(9):12334-12358.
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Nogami M, Ishikawa M, Doi A, Sano O, Sone T, Akiyama T, Aoki M, Nakanishi A, Ogi K, Yano M, Okano H. Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN. Neurobiol Dis. 2021 07; 155:105364.
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