DNA Damage
"DNA Damage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Descriptor ID |
D004249
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MeSH Number(s) |
G05.355.180
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Concept/Terms |
DNA Damage- DNA Damage
- DNA Damages
- Damage, DNA
- Damages, DNA
- DNA Injury
- DNA Injuries
- Injuries, DNA
- Injury, DNA
Genotoxic Stress- Genotoxic Stress
- Genotoxic Stresses
- Stresses, Genotoxic
- Stress, Genotoxic
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Below are MeSH descriptors whose meaning is more general than "DNA Damage".
Below are MeSH descriptors whose meaning is more specific than "DNA Damage".
This graph shows the total number of publications written about "DNA Damage" by people in this website by year, and whether "DNA Damage" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1985 | 0 | 1 | 1 | 1987 | 3 | 0 | 3 | 1988 | 3 | 1 | 4 | 1989 | 2 | 1 | 3 | 1990 | 2 | 1 | 3 | 1991 | 4 | 3 | 7 | 1992 | 2 | 1 | 3 | 1993 | 2 | 4 | 6 | 1994 | 0 | 1 | 1 | 1995 | 2 | 5 | 7 | 1996 | 4 | 4 | 8 | 1997 | 5 | 5 | 10 | 1998 | 2 | 2 | 4 | 1999 | 6 | 1 | 7 | 2000 | 4 | 3 | 7 | 2001 | 2 | 2 | 4 | 2002 | 3 | 4 | 7 | 2003 | 1 | 5 | 6 | 2004 | 4 | 9 | 13 | 2005 | 5 | 5 | 10 | 2006 | 7 | 8 | 15 | 2007 | 3 | 8 | 11 | 2008 | 3 | 4 | 7 | 2009 | 6 | 7 | 13 | 2010 | 4 | 3 | 7 | 2011 | 4 | 8 | 12 | 2012 | 3 | 8 | 11 | 2013 | 3 | 7 | 10 | 2014 | 3 | 7 | 10 | 2015 | 6 | 7 | 13 | 2016 | 3 | 8 | 11 | 2017 | 4 | 10 | 14 | 2018 | 3 | 3 | 6 | 2019 | 6 | 5 | 11 | 2020 | 2 | 3 | 5 | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Damage" by people in Profiles.
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Wang Y, Katanski CD, Watkins C, Pan JN, Dai Q, Jiang Z, Pan T. A high-throughput screening method for evolving a demethylase enzyme with improved and new functionalities. Nucleic Acids Res. 2021 03 18; 49(5):e30.
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Elkafas H, Ali M, Elmorsy E, Kamel R, Thompson WE, Badary O, Al-Hendy A, Yang Q. Vitamin D3 Ameliorates DNA Damage Caused by Developmental Exposure to Endocrine Disruptors in the Uterine Myometrial Stem Cells of Eker Rats. Cells. 2020 06 12; 9(6).
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Wang S, Gilbreath C, Kollipara RK, Sonavane R, Huo X, Yenerall P, Das A, Ma S, Raj GV, Kittler R. Mithramycin suppresses DNA damage repair via targeting androgen receptor in prostate cancer. Cancer Lett. 2020 09 28; 488:40-49.
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Kim SJ, Cheresh P, Jablonski RP, Rachek L, Yeldandi A, Piseaux-Aillon R, Ciesielski MJ, Ridge K, Gottardi C, Lam AP, Pardo A, Selman M, Natarajan V, Kamp DW. Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis. . 2020 05 01; 318(5):L1084-L1096.
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Betori RC, Liu Y, Mishra RK, Cohen SB, Kron SJ, Scheidt KA. Targeted Covalent Inhibition of Telomerase. ACS Chem Biol. 2020 03 20; 15(3):706-717.
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Abida W, Campbell D, Patnaik A, Shapiro JD, Sautois B, Vogelzang NJ, Voog EG, Bryce AH, McDermott R, Ricci F, Rowe J, Zhang J, Piulats JM, Fizazi K, Merseburger AS, Higano CS, Krieger LE, Ryan CJ, Feng FY, Simmons AD, Loehr A, Despain D, Dowson M, Green F, Watkins SP, Golsorkhi T, Chowdhury S. Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer: Analysis From the Phase II TRITON2 Study. Clin Cancer Res. 2020 06 01; 26(11):2487-2496.
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Knight JC, Torres JB, Goldin R, Mosley M, Dias GM, Bravo LC, Kersemans V, Allen PD, Mukherjee S, Smart S, Cornelissen B. Early Detection in a Mouse Model of Pancreatic Cancer by Imaging DNA Damage Response Signaling. J Nucl Med. 2020 07; 61(7):1006-1013.
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Bhargava V, Goldstein CD, Russell L, Xu L, Ahmed M, Li W, Casey A, Servage K, Kollipara R, Picciarelli Z, Kittler R, Yatsenko A, Carmell M, Orth K, Amatruda JF, Yanowitz JL, Buszczak M. GCNA Preserves Genome Integrity and Fertility Across Species. Dev Cell. 2020 01 06; 52(1):38-52.e10.
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Nik-Zainal S, Hall BA. Cellular survival over genomic perfection. Science. 2019 11 15; 366(6467):802-803.
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Shinohara M, Bishop DK, Shinohara A. Distinct Functions in Regulation of Meiotic Crossovers for DNA Damage Response Clamp Loader Rad24(Rad17) and Mec1(ATR) Kinase. Genetics. 2019 12; 213(4):1255-1269.
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