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Alexander Pearson

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Hematology/Oncology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    The Pearson Lab integrates clinical expertise, mathematical modeling, high dimensional statistics, and basic tumor biology methods to investigate and propose new treatments for head and neck cancer.


    Collapse Biography 
    Collapse education and training
    Cornell University, Ithaca, NYBS05/2002Biometry and Statistics
    University of Rochester, Rochester, NYPhD03/2009Statistics
    University of Rochester, Rochester, NYMD05/2010Medicine
    University of Michigan, Ann Arbor, MIResidency06/2012Internal Medicine
    University of Michigan, Ann Arbor, MIFellowship06/2016Hematology/Oncology
    University of Michigan, Ann Arbor, MIPostdoctoral Fellowship06/2016Nor Lab (2013-2017)
    Collapse awards and honors
    2014 - 2015Chief Fellow in Hematology/Oncology, University of Michigan
    2015Mark Roth Award, University of Michigan

    Collapse ORNG Applications 
    Collapse Twitter

    Collapse Research 
    Collapse research activities and funding
    K08DE026500     (PEARSON, ALEXANDER THOMAS)Sep 1, 2016 - Aug 31, 2021
    NIH
    A reasoned approach to combination therapy development in head and neck cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Cipriani NA, Lusardi JJ, McElherne J, Pearson AT, Olivas AD, Fitzpatrick C, Lingen MW, Blair EA. Mucoepidermoid Carcinoma: A Comparison of Histologic Grading Systems and Relationship to MAML2 Rearrangement and Prognosis. Am J Surg Pathol. 2019 Jul; 43(7):885-897. PMID: 31021855.
      View in: PubMed
    2. Kather JN, Pearson AT, Halama N, Jäger D, Krause J, Loosen SH, Marx A, Boor P, Tacke F, Neumann UP, Grabsch HI, Yoshikawa T, Brenner H, Chang-Claude J, Hoffmeister M, Trautwein C, Luedde T. Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer. Nat Med. 2019 07; 25(7):1054-1056. PMID: 31160815.
      View in: PubMed
    3. Pearson AT, Sweis RF. Hyperprogression-Immunotherapy-Related Phenomenon vs Intrinsic Natural History of Cancer. JAMA Oncol. 2019 May 01; 5(5):743. PMID: 30896751.
      View in: PubMed
    4. Esvelt MA, Freeman ZT, Pearson AT, Harkema JR, Clines GT, Clines KL, Dyson MC, Hoenerhoff MJ. The Endothelin-A Receptor Antagonist Zibotentan Induces Damage to the Nasal Olfactory Epithelium Possibly Mediated in Part through Type 2 Innate Lymphoid Cells. Toxicol Pathol. 2019 02; 47(2):150-164. PMID: 30595110.
      View in: PubMed
    5. Wang WY, Pearson AT, Kutys ML, Choi CK, Wozniak MA, Baker BM, Chen CS. Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration. APL Bioeng. 2018 Dec; 2(4):046107. PMID: 31069329.
      View in: PubMed
    6. Andrews A, Warner K, Rodriguez-Ramirez C, Pearson AT, Nör F, Zhang Z, Kerk S, Kulkarni A, Helman JI, Brenner JC, Wicha MS, Wang S, Nör JE. Ablation of Cancer Stem Cells by Therapeutic Inhibition of the MDM2-p53 Interaction in Mucoepidermoid Carcinoma. Clin Cancer Res. 2019 03 01; 25(5):1588-1600. PMID: 30498096.
      View in: PubMed
    7. Coffman LG, Pearson AT, Frisbie LG, Freeman Z, Christie E, Bowtell DD, Buckanovich RJ. Ovarian Carcinoma-Associated Mesenchymal Stem Cells Arise from Tissue-Specific Normal Stroma. Stem Cells. 2019 02; 37(2):257-269. PMID: 30353617.
      View in: PubMed
    8. Warner KA, Oklejas AE, Pearson AT, Zhang Z, Wu W, Divi V, Rodriguez-Ramirez C, Castilho RM, Polverini PJ, Nör JE. UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line. Oral Oncol. 2018 12; 87:21-28. PMID: 30527239.
      View in: PubMed
    9. Nazari F, Pearson AT, Nör JE, Jackson TL. A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment. PLoS Comput Biol. 2018 01; 14(1):e1005920. PMID: 29351275.
      View in: PubMed
    10. Pearson AT, Ingram P, Bai S, O'Hayer P, Chung J, Yoon E, Jackson T, Buckanovich RJ. Sampling from single-cell observations to predict tumor cell growth in-vitro and in-vivo. Oncotarget. 2017 Dec 19; 8(67):111176-111189. PMID: 29340046.
      View in: PubMed
    11. Kim HS, Chen YC, Nör F, Warner KA, Andrews A, Wagner VP, Zhang Z, Zhang Z, Martins MD, Pearson AT, Yoon E, Nör JE. Endothelial-derived interleukin-6 induces cancer stem cell motility by generating a chemotactic gradient towards blood vessels. Oncotarget. 2017 Nov 21; 8(59):100339-100352. PMID: 29245982.
      View in: PubMed
    12. Manohar PM, Sapir E, Bellile E, Swiecicki PL, Pearson AT, Prince ME, Shuman AG, Bradford CR, Chepeha DB, Wolf GT, Eisbruch A, Worden FP, Spector ME. Capecitabine after Surgical Salvage in Recurrent Squamous Cell Carcinoma of Head and Neck. Otolaryngol Head Neck Surg. 2017 12; 157(6):995-997. PMID: 28809131.
      View in: PubMed
    13. Kerk SA, Finkel KA, Pearson AT, Warner KA, Zhang Z, Nör F, Wagner VP, Vargas PA, Wicha MS, Hurt EM, Hollingsworth RE, Tice DA, Nör JE. 5T4-Targeted Therapy Ablates Cancer Stem Cells and Prevents Recurrence of Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2017 May 15; 23(10):2516-2527. PMID: 27780858.
      View in: PubMed
    14. Nör F, Warner KA, Zhang Z, Acasigua GA, Pearson AT, Kerk SA, Helman JI, Sant'Ana Filho M, Wang S, Nör JE. Therapeutic Inhibition of the MDM2-p53 Interaction Prevents Recurrence of Adenoid Cystic Carcinomas. Clin Cancer Res. 2017 Feb 15; 23(4):1036-1048. PMID: 27550999.
      View in: PubMed
    15. Swiecicki PL, Bellile E, Sacco AG, Pearson AT, Taylor JM, Jackson TL, Chepeha DB, Spector ME, Shuman A, Malloy K, Moyer J, McKean E, McLean S, Sukari A, Wolf GT, Eisbruch A, Prince M, Bradford C, Carey TE, Wang S, Nör JE, Worden FP. A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck cancer. Invest New Drugs. 2016 08; 34(4):481-9. PMID: 27225873.
      View in: PubMed
    16. Pearson AT, Jackson TL, Nör JE. Modeling head and neck cancer stem cell-mediated tumorigenesis. Cell Mol Life Sci. 2016 09; 73(17):3279-89. PMID: 27151511.
      View in: PubMed
    17. Warner KA, Nör F, Acasigua GA, Martins MD, Zhang Z, McLean SA, Spector ME, Chepeha DB, Helman J, Wick MJ, Moskaluk CA, Castilho RM, Pearson AT, Wang S, Nör JE. Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma. Clin Cancer Res. 2016 07 15; 22(14):3550-9. PMID: 26936915.
      View in: PubMed
    18. Pearson AT, Finkel KA, Warner KA, Nör F, Tice D, Martins MD, Jackson TL, Nör JE. Patient-derived xenograft (PDX) tumors increase growth rate with time. Oncotarget. 2016 Feb 16; 7(7):7993-8005. PMID: 26783960.
      View in: PubMed
    19. Kim HS, Pearson AT, Nör JE. Isolation and Characterization of Cancer Stem Cells from Primary Head and Neck Squamous Cell Carcinoma Tumors. Methods Mol Biol. 2016; 1395:241-9. PMID: 26910078.
      View in: PubMed
    20. Saxon D, Pearson AT, Wu P. Hyperlink-Embedded Journal Articles Improve Statistical Knowledge and Reader Satisfaction. J Grad Med Educ. 2015 Dec; 7(4):654-7. PMID: 26692981.
      View in: PubMed
    21. Adams A, Warner K, Pearson AT, Zhang Z, Kim HS, Mochizuki D, Basura G, Helman J, Mantesso A, Castilho RM, Wicha MS, Nör JE. ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas. Oncotarget. 2015 Sep 29; 6(29):26633-50. PMID: 26449187.
      View in: PubMed
    22. Mochizuki D, Adams A, Warner KA, Zhang Z, Pearson AT, Misawa K, McLean SA, Wolf GT, Nör JE. Anti-tumor effect of inhibition of IL-6 signaling in mucoepidermoid carcinoma. Oncotarget. 2015 Sep 08; 6(26):22822-35. PMID: 26287605.
      View in: PubMed
    23. Acasigua GA, Warner KA, Nör F, Helman J, Pearson AT, Fossati AC, Wang S, Nör JE. BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma. Oral Oncol. 2015 Sep; 51(9):839-47. PMID: 26121939.
      View in: PubMed
    24. Myers GJ, Thurston SW, Pearson AT, Davidson PW, Cox C, Shamlaye CF, Cernichiari E, Clarkson TW. Postnatal exposure to methyl mercury from fish consumption: a review and new data from the Seychelles Child Development Study. Neurotoxicology. 2009 May; 30(3):338-49. PMID: 19442817.
      View in: PubMed
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