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Alexander Pearson

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Hematology and Oncology
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    The Pearson Lab integrates clinical expertise, mathematical modeling, high dimensional statistics, and basic tumor biology methods to investigate and propose new treatments for head and neck cancer.

    Collapse Biography 
    Collapse education and training
    Cornell University, Ithaca, NYBS05/2002Biometry and Statistics
    University of Rochester, Rochester, NYPhD03/2009Statistics
    University of Rochester, Rochester, NYMD05/2010Medicine
    University of Michigan, Ann Arbor, MIResidency06/2012Internal Medicine
    University of Michigan, Ann Arbor, MIFellowship06/2016Hematology/Oncology
    University of Michigan, Ann Arbor, MIPostdoctoral Fellowship06/2016Nor Lab (2013-2017)
    Collapse awards and honors
    2014 - 2015Chief Fellow in Hematology/Oncology, University of Michigan
    2015Mark Roth Award, University of Michigan

    Collapse Research 
    Collapse research activities and funding
    R56DE030958     (PEARSON, ALEXANDER THOMAS)Sep 2, 2021 - Sep 1, 2022
    NIH
    Deep learning for oral premalignancy evaluation
    Role: Principal Investigator
    K08DE026500     (PEARSON, ALEXANDER THOMAS)Sep 1, 2016 - Aug 31, 2021
    NIH
    A reasoned approach to combination therapy development in head and neck cancer
    Role: Principal Investigator

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. de Souza LL, Fonseca FP, Ara?jo ALD, Lopes MA, Vargas PA, Khurram SA, Kowalski LP, Dos Santos HT, Warnakulasuriya S, Dolezal J, Pearson AT, Santos-Silva AR. Machine learning for detection and classification of oral potentially malignant disorders: A conceptual review. J Oral Pathol Med. 2023 Mar; 52(3):197-205. PMID: 36792771.
      Citations:    Fields:    Translation:Humans
    2. Srisuwananukorn A, Salama ME, Pearson AT. Deep learning applications in visual data for benign and malignant hematological conditions: a systematic review and visual glossary. Haematologica. 2023 Jan 26. PMID: 36700396.
      Citations:    Fields:    
    3. Ara?jo ALD, da Silva VM, Kudo MS, de Souza ESC, Saldivia-Siracusa C, Giraldo-Rold?n D, Lopes MA, Vargas PA, Khurram SA, Pearson AT, Kowalski LP, de Carvalho ACPLF, Santos-Silva AR, Moraes MC. Machine learning concepts applied to oral pathology and oral medicine: A convolutional neural networks' approach. J Oral Pathol Med. 2023 Feb; 52(2):109-118. PMID: 36599081.
      Citations:    Fields:    Translation:Humans
    4. Goldberg M, Manzi A, Birdi A, Laporte B, Conway P, Cantin S, Mishra V, Singh A, Pearson AT, Goldberg ER, Goldberger S, Flaum B, Hasina R, London NR, Gallia GL, Bettegowda C, Young S, Sandulache V, Melville J, Shun J, O'Neill SE, Aydin E, Zhavoronkov A, Vidal A, Soto A, Alonso MJ, Rosenberg AJ, Lingen MW, D'Cruz A, Agrawal N, Izumchenko E. Author Correction: A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer. Nat Commun. 2022 Dec 21; 13(1):7865. PMID: 36543765.
      Citations:    Fields:    
    5. Ramesh S, Dolezal JM, Pearson AT. Applications of Deep Learning in Endocrine Neoplasms. Surg Pathol Clin. 2023 Mar; 16(1):167-176. PMID: 36739164.
      Citations:    Fields:    Translation:Humans
    6. Howard FM, Kather JN, Pearson AT. Multimodal deep learning: An improvement in prognostication or a reflection of batch effect? Cancer Cell. 2023 01 09; 41(1):5-6. PMID: 36368319.
      Citations: 2     Fields:    Translation:Humans
    7. Dolezal JM, Srisuwananukorn A, Karpeyev D, Ramesh S, Kochanny S, Cody B, Mansfield AS, Rakshit S, Bansal R, Bois MC, Bungum AO, Schulte JJ, Vokes EE, Garassino MC, Husain AN, Pearson AT. Uncertainty-informed deep learning models enable high-confidence predictions for digital histopathology. Nat Commun. 2022 Nov 02; 13(1):6572. PMID: 36323656; PMCID: PMC9630455.
      Citations: 2     Fields:    Translation:Humans
    8. Howard FM, He G, Peterson JR, Pfeiffer JR, Earnest T, Pearson AT, Abe H, Cole JA, Nanda R. Highly accurate response prediction in high-risk early breast cancer patients using a biophysical simulation platform. Breast Cancer Res Treat. 2022 Nov; 196(1):57-66. PMID: 36063220; PMCID: PMC9550684.
      Citations: 2     Fields:    Translation:Humans
    9. Luo T, Nash GT, Jiang X, Feng X, Mao J, Liu J, Juloori A, Pearson AT, Lin W. A 2D Nanoradiosensitizer Enhances Radiotherapy and Delivers STING Agonists to Potentiate Cancer Immunotherapy. Adv Mater. 2022 Sep; 34(39):e2110588. PMID: 35952624; PMCID: PMC9529854.
      Citations: 2     Fields:    Translation:Humans
    10. Goldberg M, Manzi A, Birdi A, Laporte B, Conway P, Cantin S, Mishra V, Singh A, Pearson AT, Goldberg ER, Goldberger S, Flaum B, Hasina R, London NR, Gallia GL, Bettegowda C, Young S, Sandulache V, Melville J, Shum J, O'Neill SE, Aydin E, Zhavoronkov A, Vidal A, Soto A, Alonso MJ, Rosenberg AJ, Lingen MW, D'Cruz A, Agrawal N, Izumchenko E. A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer. Nat Commun. 2022 08 17; 13(1):4829. PMID: 35977936; PMCID: PMC9385702.
      Citations: 3     Fields:    Translation:Animals
    11. Rosenberg AJ, Agrawal N, Pearson AT, Gooi Z, Blair E, Portugal L, Cursio JF, Juloori A, Chin J, Rouse K, Villaflor VM, Seiwert TY, Izumchenko E, Lingen MW, Haraf DJ, Vokes EE. Phase I study of nab-paclitaxel-based induction followed by nab-paclitaxel-based concurrent chemotherapy and re-irradiation in previously treated head and neck squamous cell carcinoma. Br J Cancer. 2022 11; 127(8):1497-1506. PMID: 35945244; PMCID: PMC9553920.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    12. Hara JH, Gutiontov SI, Uddin S, Rosenberg AJ, Pearson AT, Gooi Z, Blair EA, Agrawal N, Vokes EE, Ginat DT, Haraf DJ, Juloori A. Characterizing Lymph Node Burden With Elective Unilateral Neck Irradiation in Human Papillomavirus-Positive Tonsil Squamous Cell Carcinoma: Defining the Upper Limits. Cureus. 2022 Jul; 14(7):e27521. PMID: 36060366; PMCID: PMC9424785.
      Citations:    
    13. Howard FM, Pearson AT, Nanda R. Clinical trials of immunotherapy in triple-negative breast cancer. Breast Cancer Res Treat. 2022 Aug; 195(1):1-15. PMID: 35834065; PMCID: PMC9338129.
      Citations: 5     Fields:    Translation:Humans
    14. Hieromnimon HM, Pearson AT. Ovarian cancer through a multi-modal lens. Nat Cancer. 2022 06; 3(6):662-664. PMID: 35764744.
      Citations:    Fields:    Translation:Humans
    15. Bergman D, Sweis RF, Pearson AT, Nazari F, Jackson TL. A global method for fast simulations of molecular dynamics in multiscale agent-based models of biological tissues. iScience. 2022 Jun 17; 25(6):104387. PMID: 35637730; PMCID: PMC9142654.
      Citations: 3     
    16. Nair V, Auger S, Kochanny S, Howard FM, Ginat D, Pasternak-Wise O, Juloori A, Koshy M, Izumchenko E, Agrawal N, Rosenberg A, Vokes EE, Skandari MR, Pearson AT. Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma. JAMA Netw Open. 2022 04 01; 5(4):e227240. PMID: 35416988; PMCID: PMC9008506.
      Citations:    Fields:    Translation:HumansCells
    17. Ghaffari Laleh N, Loeffler CML, Grajek J, Stankov? K, Pearson AT, Muti HS, Trautwein C, Enderling H, Poleszczuk J, Kather JN. Classical mathematical models for prediction of response to chemotherapy and immunotherapy. PLoS Comput Biol. 2022 02; 18(2):e1009822. PMID: 35120124; PMCID: PMC8903251.
      Citations: 11     Fields:    Translation:Humans
    18. Rosenberg AJ, Izumchenko E, Pearson A, Gooi Z, Blair E, Karrison T, Juloori A, Ginat D, Cipriani N, Lingen M, Sloane H, Edelstein DL, Keyser K, Fredebohm J, Holtrup F, Jones FS, Haraf D, Agrawal N, Vokes EE. Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and response-adaptive treatment. BMC Cancer. 2022 Jan 03; 22(1):17. PMID: 34980038; PMCID: PMC8722316.
      Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
    19. Pulianmackal AJ, Sun D, Yumoto K, Li Z, Chen YC, Patel MV, Wang Y, Yoon E, Pearson A, Yang Q, Taichman R, Cackowski FC, Buttitta LA. Monitoring Spontaneous Quiescence and Asynchronous Proliferation-Quiescence Decisions in Prostate Cancer Cells. Front Cell Dev Biol. 2021; 9:728663. PMID: 34957090; PMCID: PMC8703172.
      Citations:    
    20. Mishra V, Singh A, Chen X, Rosenberg AJ, Pearson AT, Zhavoronkov A, Savage PA, Lingen MW, Agrawal N, Izumchenko E. Application of liquid biopsy as multi-functional biomarkers in head and neck cancer. Br J Cancer. 2022 02; 126(3):361-370. PMID: 34876674; PMCID: PMC8810877.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    21. Herzog AE, Warner KA, Zhang Z, Bellile E, Bhagat MA, Castilho RM, Wolf GT, Polverini PJ, Pearson AT, N?r JE. The IL-6R and Bmi-1 axis controls self-renewal and chemoresistance of head and neck cancer stem cells. Cell Death Dis. 2021 10 23; 12(11):988. PMID: 34689150; PMCID: PMC8542035.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    22. Rosenberg AJ, Agrawal N, Pearson A, Gooi Z, Blair E, Cursio J, Juloori A, Ginat D, Howard A, Chin J, Kochanny S, Foster C, Cipriani N, Lingen M, Izumchenko E, Seiwert TY, Haraf D, Vokes EE. Risk and response adapted de-intensified treatment for HPV-associated oropharyngeal cancer: Optima paradigm expanded experience. Oral Oncol. 2021 11; 122:105566. PMID: 34662771; PMCID: PMC9295443.
      Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
    23. Ghantous Y, Omar M, Broner EC, Agrawal N, Pearson AT, Rosenberg AJ, Mishra V, Singh A, El-Naaj IA, Savage PA, Sidransky D, Marchionni L, Izumchenko E. A robust and interpretable gene signature for predicting the lymph node status of primary T1/T2 oral cavity squamous cell carcinoma. Int J Cancer. 2022 02 01; 150(3):450-460. PMID: 34569064; PMCID: PMC8760163.
      Citations: 2     Fields:    Translation:HumansCells
    24. Howard FM, Villamar D, He G, Pearson AT, Nanda R. The emerging role of immune checkpoint inhibitors for the treatment of breast cancer. Expert Opin Investig Drugs. 2022 Jun; 31(6):531-548. PMID: 34569400; PMCID: PMC8995399.
      Citations: 5     Fields:    Translation:Humans
    25. Muti HS, Heij LR, Keller G, Kohlruss M, Langer R, Dislich B, Cheong JH, Kim YW, Kim H, Kook MC, Cunningham D, Allum WH, Langley RE, Nankivell MG, Quirke P, Hayden JD, West NP, Irvine AJ, Yoshikawa T, Oshima T, Huss R, Grosser B, Roviello F, d'Ignazio A, Quaas A, Alakus H, Tan X, Pearson AT, Luedde T, Ebert MP, J?ger D, Trautwein C, Gaisa NT, Grabsch HI, Kather JN. Development and validation of deep learning classifiers to detect Epstein-Barr virus and microsatellite instability status in gastric cancer: a retrospective multicentre cohort study. Lancet Digit Health. 2021 10; 3(10):e654-e664. PMID: 34417147; PMCID: PMC8460994.
      Citations: 19     Fields:    Translation:Humans
    26. Pearson AT. Current and future uses of digital pathology in oncology. Clin Adv Hematol Oncol. 2021 Aug; 19(8):508-510. PMID: 34411070.
      Citations:    Fields:    Translation:Humans
    27. Howard FM, Dolezal J, Kochanny S, Schulte J, Chen H, Heij L, Huo D, Nanda R, Olopade OI, Kather JN, Cipriani N, Grossman RL, Pearson AT. The impact of site-specific digital histology signatures on deep learning model accuracy and bias. Nat Commun. 2021 07 20; 12(1):4423. PMID: 34285218; PMCID: PMC8292530.
      Citations: 27     Fields:    Translation:Humans
    28. Broner EC, Trujillo JA, Korzinkin M, Subbannayya T, Agrawal N, Ozerov IV, Zhavoronkov A, Rooper L, Kotlov N, Shen L, Pearson AT, Rosenberg AJ, Savage PA, Mishra V, Chatterjee A, Sidransky D, Izumchenko E. Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma. Front Oncol. 2021; 11:677051. PMID: 34336664; PMCID: PMC8323482.
      Citations: 7     
    29. Naumov V, Putin E, Pushkov S, Kozlova E, Romantsov K, Kalashnikov A, Galkin F, Tihonova N, Shneyderman A, Galkin E, Zinkevich A, Cope SM, Sethuraman R, Oprea TI, Pearson AT, Tay S, Agrawal N, Dubovenko A, Vanhaelen Q, Ozerov I, Aliper A, Izumchenko E, Zhavoronkov A. COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severity. PLoS Comput Biol. 2021 07; 17(7):e1009183. PMID: 34260589; PMCID: PMC8312936.
      Citations: 2     Fields:    Translation:HumansCells
    30. Kacew AJ, Strohbehn GW, Saulsberry L, Laiteerapong N, Cipriani NA, Kather JN, Pearson AT. Artificial Intelligence Can Cut Costs While Maintaining Accuracy in Colorectal Cancer Genotyping. Front Oncol. 2021; 11:630953. PMID: 34168975; PMCID: PMC8217761.
      Citations: 5     
    31. Okuneye K, Bergman D, Bloodworth JC, Pearson AT, Sweis RF, Jackson TL. A validated mathematical model of FGFR3-mediated tumor growth reveals pathways to harness the benefits of combination targeted therapy and immunotherapy in bladder cancer. Comput Syst Oncol. 2021 Jun; 1(2). PMID: 34984415; PMCID: PMC8722426.
      Citations: 3     
    32. Zhang MH, Hasse A, Carroll T, Pearson AT, Cipriani NA, Ginat DT. Differentiating low and high grade mucoepidermoid carcinoma of the salivary glands using CT radiomics. Gland Surg. 2021 May; 10(5):1646-1654. PMID: 34164309; PMCID: PMC8184388.
      Citations: 1     
    33. Pearson AT, Vokes EE. Is This the Dawn of Precision Oncology in Head and Neck Cancer? J Clin Oncol. 2021 06 10; 39(17):1839-1841. PMID: 33877869.
      Citations:    Fields:    Translation:Humans
    34. Krause J, Grabsch HI, Kloor M, Jendrusch M, Echle A, Buelow RD, Boor P, Luedde T, Brinker TJ, Trautwein C, Pearson AT, Quirke P, Jenniskens J, Offermans K, van den Brandt PA, Kather JN. Deep learning detects genetic alterations in cancer histology generated by adversarial networks. J Pathol. 2021 05; 254(1):70-79. PMID: 33565124.
      Citations: 13     Fields:    Translation:Humans
    35. Quandt J, Arnovitz S, Haghi L, Woehlk J, Mohsin A, Okoreeh M, Mathur PS, Emmanuel AO, Osman A, Krishnan M, Morin SB, Pearson AT, Sweis RF, Pekow J, Weber CR, Khazaie K, Gounari F. Wnt-?-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression. Nat Immunol. 2021 04; 22(4):471-484. PMID: 33664518; PMCID: PMC8262575.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    36. Burgin SJM, Spector ME, Pearson AT, Bellile E, Vainshtein JM, Rosko A, Mclean SA, Bradford CR, Wolf GT, Prince ME, Worden FP, Eisbruch A, Chepeha DB. Long-term neck and shoulder function among survivors of oropharyngeal squamous cell carcinoma treated with chemoradiation as assessed with the neck dissection impairment index. Head Neck. 2021 05; 43(5):1621-1628. PMID: 33580560.
      Citations: 1     Fields:    Translation:Humans
    37. Andrade NP, Warner KA, Zhang Z, Pearson AT, Mantesso A, Guimaraes DM, Altemani A, Mariano FV, Nunes FD, N?r JE. Survival of salivary gland cancer stem cells requires mTOR signaling. Cell Death Dis. 2021 01 21; 12(1):108. PMID: 33479203; PMCID: PMC7820616.
      Citations: 4     Fields:    Translation:HumansCells
    38. Reizine N, Vokes EE, Liu P, Truong TM, Nanda R, Fleming GF, Catenacci DVT, Pearson AT, Parsad S, Danahey K, van Wijk XMR, Yeo KJ, Ratain MJ, O'Donnell PH. Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial. Ther Adv Med Oncol. 2020; 12:1758835920974118. PMID: 33414846; PMCID: PMC7750903.
      Citations: 3     
    39. Dolezal JM, Trzcinska A, Liao CY, Kochanny S, Blair E, Agrawal N, Keutgen XM, Angelos P, Cipriani NA, Pearson AT. Deep learning prediction of BRAF-RAS gene expression signature identifies noninvasive follicular thyroid neoplasms with papillary-like nuclear features. Mod Pathol. 2021 05; 34(5):862-874. PMID: 33299111; PMCID: PMC8064913.
      Citations: 8     Fields:    Translation:HumansCells
    40. Echle A, Rindtorff NT, Brinker TJ, Luedde T, Pearson AT, Kather JN. Deep learning in cancer pathology: a new generation of clinical biomarkers. Br J Cancer. 2021 02; 124(4):686-696. PMID: 33204028; PMCID: PMC7884739.
      Citations: 68     Fields:    Translation:Humans
    41. Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT. Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer. JAMA Netw Open. 2020 11 02; 3(11):e2025881. PMID: 33211108; PMCID: PMC7677764.
      Citations: 18     Fields:    Translation:Humans
    42. Kather JN, Heij LR, Grabsch HI, Loeffler C, Echle A, Muti HS, Krause J, Niehues JM, Sommer KAJ, Bankhead P, Kooreman LFS, Schulte JJ, Cipriani NA, Buelow RD, Boor P, Ortiz-Br?chle N, Hanby AM, Speirs V, Kochanny S, Patnaik A, Srisuwananukorn A, Brenner H, Hoffmeister M, van den Brandt PA, J?ger D, Trautwein C, Pearson AT, Luedde T. Author Correction: Pan-cancer image-based detection of clinically actionable genetic alterations. Nat Cancer. 2020 Nov; 1(11):1129. PMID: 35122072.
      Citations:    Fields:    
    43. Kochanny SE, Pearson AT. Academics as leaders in the cancer artificial intelligence revolution. Cancer. 2021 03 01; 127(5):664-671. PMID: 33119903.
      Citations: 4     Fields:    Translation:Humans
    44. Kolbe AR, Bendall ML, Pearson AT, Paul D, Nixon DF, P?rez-Losada M, Crandall KA. Human Endogenous Retrovirus Expression Is Associated with Head and Neck Cancer and Differential Survival. Viruses. 2020 08 28; 12(9). PMID: 32872377; PMCID: PMC7552064.
      Citations: 11     Fields:    Translation:HumansCells
    45. Bryan DS, Stack M, Krysztofiak K, Cichon U, Thomas DG, Surcel A, Schiffhauer ES, Beckett MA, Khodarev NN, Xue L, Poli EC, Pearson AT, Posner MC, Robinson DN, Rock RS, Weichselbaum RR. 4-Hydroxyacetophenone modulates the actomyosin cytoskeleton to reduce metastasis. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22423-22429. PMID: 32848073; PMCID: PMC7486788.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    46. Kather JN, Heij LR, Grabsch HI, Loeffler C, Echle A, Muti HS, Krause J, Niehues JM, Sommer KAJ, Bankhead P, Kooreman LFS, Schulte JJ, Cipriani NA, Buelow RD, Boor P, Ortiz-Br?chle NN, Hanby AM, Speirs V, Kochanny S, Patnaik A, Srisuwananukorn A, Brenner H, Hoffmeister M, van den Brandt PA, J?ger D, Trautwein C, Pearson AT, Luedde T. Pan-cancer image-based detection of clinically actionable genetic alterations. Nat Cancer. 2020 08; 1(8):789-799. PMID: 33763651; PMCID: PMC7610412.
      Citations: 99     Fields:    Translation:Humans
    47. Facompre ND, Rajagopalan P, Sahu V, Pearson AT, Montone KT, James CD, Gleber-Netto FO, Weinstein GS, Jalaly J, Lin A, Rustgi AK, Nakagawa H, Califano JA, Pickering CR, White EA, Windle BE, Morgan IM, Cohen RB, Gimotty PA, Basu D. Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models. Int J Cancer. 2020 12 01; 147(11):3236-3249. PMID: 32478869; PMCID: PMC7554059.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    48. Echle A, Grabsch HI, Quirke P, van den Brandt PA, West NP, Hutchins GGA, Heij LR, Tan X, Richman SD, Krause J, Alwers E, Jenniskens J, Offermans K, Gray R, Brenner H, Chang-Claude J, Trautwein C, Pearson AT, Boor P, Luedde T, Gaisa NT, Hoffmeister M, Kather JN. Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning. Gastroenterology. 2020 10; 159(4):1406-1416.e11. PMID: 32562722; PMCID: PMC7578071.
      Citations: 60     Fields:    Translation:Humans
    49. Howard FM, Pearson AT. Prognosis and Treatment of Non-Small Cell Lung Cancer in the Age of Deep Learning. JAMA Netw Open. 2020 06 01; 3(6):e206368. PMID: 32492160.
      Citations: 1     Fields:    Translation:Humans
    50. Freeman ZT, Nirschl TR, Hovelson DH, Johnston RJ, Engelhardt JJ, Selby MJ, Kochel CM, Lan RY, Zhai J, Ghasemzadeh A, Gupta A, Skaist AM, Wheelan SJ, Jiang H, Pearson AT, Snyder LA, Korman AJ, Tomlins SA, Yegnasubramanian S, Drake CG. A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target. J Clin Invest. 2020 03 02; 130(3):1405-1416. PMID: 32015231; PMCID: PMC7269585.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    51. Nazari F, Oklejas AE, N?r JE, Pearson AT, Jackson TL. In Silico Models Accurately Predict In Vivo Response for IL6 Blockade in Head and Neck Cancer. Cancer Res. 2020 04 01; 80(7):1451-1460. PMID: 32041834; PMCID: PMC7127935.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    52. Xavier JB, Young VB, Skufca J, Ginty F, Testerman T, Pearson AT, Macklin P, Mitchell A, Shmulevich I, Xie L, Caporaso JG, Crandall KA, Simone NL, Godoy-Vitorino F, Griffin TJ, Whiteson KL, Gustafson HH, Slade DJ, Schmidt TM, Walther-Antonio MRS, Korem T, Webb-Robertson BM, Styczynski MP, Johnson WE, Jobin C, Ridlon JM, Koh AY, Yu M, Kelly L, Wargo JA. The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View. Trends Cancer. 2020 03; 6(3):192-204. PMID: 32101723; PMCID: PMC7098063.
      Citations: 75     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    53. Agius R, Brieghel C, Andersen MA, Pearson AT, Ledergerber B, Cozzi-Lepri A, Louzoun Y, Andersen CL, Bergstedt J, von Stemann JH, J?rgensen M, Tang ME, Fontes M, Bahlo J, Herling CD, Hallek M, Lundgren J, MacPherson CR, Larsen J, Niemann CU. Machine learning can identify newly diagnosed patients with CLL at high risk of infection. Nat Commun. 2020 01 17; 11(1):363. PMID: 31953409; PMCID: PMC6969150.
      Citations: 20     Fields:    Translation:Humans
    54. Schubert AD, Channah Broner E, Agrawal N, London N, Pearson A, Gupta A, Wali N, Seiwert TY, Wheelan S, Lingen M, Macleod K, Allen H, Chatterjee A, Vassiliki S, Gaykalova D, Hoque MO, Sidransky D, Suresh K, Izumchenko E. Somatic mitochondrial mutation discovery using ultra-deep sequencing of the mitochondrial genome reveals spatial tumor heterogeneity in head and neck squamous cell carcinoma. Cancer Lett. 2020 02 28; 471:49-60. PMID: 31830557; PMCID: PMC6980748.
      Citations: 8     Fields:    Translation:Humans
    55. Cipriani NA, Lusardi JJ, McElherne J, Pearson AT, Olivas AD, Fitzpatrick C, Lingen MW, Blair EA. Mucoepidermoid Carcinoma: A Comparison of Histologic Grading Systems and Relationship to MAML2 Rearrangement and Prognosis. Am J Surg Pathol. 2019 07; 43(7):885-897. PMID: 31021855; PMCID: PMC6629427.
      Citations: 31     Fields:    Translation:Humans
    56. Kather JN, Pearson AT, Halama N, J?ger D, Krause J, Loosen SH, Marx A, Boor P, Tacke F, Neumann UP, Grabsch HI, Yoshikawa T, Brenner H, Chang-Claude J, Hoffmeister M, Trautwein C, Luedde T. Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer. Nat Med. 2019 07; 25(7):1054-1056. PMID: 31160815; PMCID: PMC7423299.
      Citations: 248     Fields:    Translation:Humans
    57. Pearson AT, Sweis RF. Hyperprogression-Immunotherapy-Related Phenomenon vs Intrinsic Natural History of Cancer. JAMA Oncol. 2019 05 01; 5(5):743. PMID: 30896751.
      Citations: 6     Fields:    Translation:Humans
    58. Esvelt MA, Freeman ZT, Pearson AT, Harkema JR, Clines GT, Clines KL, Dyson MC, Hoenerhoff MJ. The Endothelin-A Receptor Antagonist Zibotentan Induces Damage to the Nasal Olfactory Epithelium Possibly Mediated in Part through Type 2 Innate Lymphoid Cells. Toxicol Pathol. 2019 02; 47(2):150-164. PMID: 30595110; PMCID: PMC7357205.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    59. Wang WY, Pearson AT, Kutys ML, Choi CK, Wozniak MA, Baker BM, Chen CS. Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration. APL Bioeng. 2018 Dec; 2(4):046107. PMID: 31069329; PMCID: PMC6481732.
      Citations: 26     
    60. Andrews A, Warner K, Rodriguez-Ramirez C, Pearson AT, N?r F, Zhang Z, Kerk S, Kulkarni A, Helman JI, Brenner JC, Wicha MS, Wang S, N?r JE. Ablation of Cancer Stem Cells by Therapeutic Inhibition of the MDM2-p53 Interaction in Mucoepidermoid Carcinoma. Clin Cancer Res. 2019 03 01; 25(5):1588-1600. PMID: 30498096; PMCID: PMC6397688.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    61. Coffman LG, Pearson AT, Frisbie LG, Freeman Z, Christie E, Bowtell DD, Buckanovich RJ. Ovarian Carcinoma-Associated Mesenchymal Stem Cells Arise from Tissue-Specific Normal Stroma. Stem Cells. 2019 02; 37(2):257-269. PMID: 30353617; PMCID: PMC6392140.
      Citations: 31     Fields:    Translation:HumansCells
    62. Warner KA, Oklejas AE, Pearson AT, Zhang Z, Wu W, Divi V, Rodriguez-Ramirez C, Castilho RM, Polverini PJ, N?r JE. UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line. Oral Oncol. 2018 12; 87:21-28. PMID: 30527239; PMCID: PMC6294471.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    63. Nazari F, Pearson AT, N?r JE, Jackson TL. A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment. PLoS Comput Biol. 2018 01; 14(1):e1005920. PMID: 29351275; PMCID: PMC5792033.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    64. Pearson AT, Ingram P, Bai S, O'Hayer P, Chung J, Yoon E, Jackson T, Buckanovich RJ. Sampling from single-cell observations to predict tumor cell growth in-vitro and in-vivo. Oncotarget. 2017 Dec 19; 8(67):111176-111189. PMID: 29340046; PMCID: PMC5762314.
      Citations: 1     Fields:    
    65. Kim HS, Chen YC, N?r F, Warner KA, Andrews A, Wagner VP, Zhang Z, Zhang Z, Martins MD, Pearson AT, Yoon E, N?r JE. Endothelial-derived interleukin-6 induces cancer stem cell motility by generating a chemotactic gradient towards blood vessels. Oncotarget. 2017 Nov 21; 8(59):100339-100352. PMID: 29245982; PMCID: PMC5725024.
      Citations: 13     Fields:    
    66. Manohar PM, Sapir E, Bellile E, Swiecicki PL, Pearson AT, Prince ME, Shuman AG, Bradford CR, Chepeha DB, Wolf GT, Eisbruch A, Worden FP, Spector ME. Capecitabine after Surgical Salvage in Recurrent Squamous Cell Carcinoma of Head and Neck. Otolaryngol Head Neck Surg. 2017 12; 157(6):995-997. PMID: 28809131.
      Citations: 1     Fields:    Translation:Humans
    67. Kerk SA, Finkel KA, Pearson AT, Warner KA, Zhang Z, N?r F, Wagner VP, Vargas PA, Wicha MS, Hurt EM, Hollingsworth RE, Tice DA, N?r JE. 5T4-Targeted Therapy Ablates Cancer Stem Cells and Prevents Recurrence of Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2017 May 15; 23(10):2516-2527. PMID: 27780858; PMCID: PMC5405006.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    68. N?r F, Warner KA, Zhang Z, Acasigua GA, Pearson AT, Kerk SA, Helman JI, Sant'Ana Filho M, Wang S, N?r JE. Therapeutic Inhibition of the MDM2-p53 Interaction Prevents Recurrence of Adenoid Cystic Carcinomas. Clin Cancer Res. 2017 Feb 15; 23(4):1036-1048. PMID: 27550999; PMCID: PMC5315632.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    69. Swiecicki PL, Bellile E, Sacco AG, Pearson AT, Taylor JM, Jackson TL, Chepeha DB, Spector ME, Shuman A, Malloy K, Moyer J, McKean E, McLean S, Sukari A, Wolf GT, Eisbruch A, Prince M, Bradford C, Carey TE, Wang S, N?r JE, Worden FP. A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck cancer. Invest New Drugs. 2016 08; 34(4):481-9. PMID: 27225873; PMCID: PMC5036856.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    70. Pearson AT, Jackson TL, N?r JE. Modeling head and neck cancer stem cell-mediated tumorigenesis. Cell Mol Life Sci. 2016 09; 73(17):3279-89. PMID: 27151511; PMCID: PMC5312795.
      Citations: 4     Fields:    Translation:HumansCells
    71. Warner KA, N?r F, Acasigua GA, Martins MD, Zhang Z, McLean SA, Spector ME, Chepeha DB, Helman J, Wick MJ, Moskaluk CA, Castilho RM, Pearson AT, Wang S, N?r JE. Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma. Clin Cancer Res. 2016 07 15; 22(14):3550-9. PMID: 26936915; PMCID: PMC4947417.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    72. Pearson AT, Finkel KA, Warner KA, N?r F, Tice D, Martins MD, Jackson TL, N?r JE. Patient-derived xenograft (PDX) tumors increase growth rate with time. Oncotarget. 2016 Feb 16; 7(7):7993-8005. PMID: 26783960; PMCID: PMC4884970.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    73. Kim HS, Pearson AT, N?r JE. Isolation and Characterization of Cancer Stem Cells from Primary Head and Neck Squamous Cell Carcinoma Tumors. Methods Mol Biol. 2016; 1395:241-9. PMID: 26910078; PMCID: PMC5344035.
      Citations: 3     Fields:    Translation:HumansCells
    74. Saxon D, Pearson AT, Wu P. Hyperlink-Embedded Journal Articles Improve Statistical Knowledge and Reader Satisfaction. J Grad Med Educ. 2015 Dec; 7(4):654-7. PMID: 26692981; PMCID: PMC4675424.
      Citations: 1     Fields:    
    75. Adams A, Warner K, Pearson AT, Zhang Z, Kim HS, Mochizuki D, Basura G, Helman J, Mantesso A, Castilho RM, Wicha MS, N?r JE. ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas. Oncotarget. 2015 Sep 29; 6(29):26633-50. PMID: 26449187; PMCID: PMC4694941.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    76. Mochizuki D, Adams A, Warner KA, Zhang Z, Pearson AT, Misawa K, McLean SA, Wolf GT, N?r JE. Anti-tumor effect of inhibition of IL-6 signaling in mucoepidermoid carcinoma. Oncotarget. 2015 Sep 08; 6(26):22822-35. PMID: 26287605; PMCID: PMC4673202.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    77. Acasigua GA, Warner KA, N?r F, Helman J, Pearson AT, Fossati AC, Wang S, N?r JE. BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma. Oral Oncol. 2015 Sep; 51(9):839-47. PMID: 26121939; PMCID: PMC4532618.
      Citations: 5     Fields:    Translation:HumansAnimals
    78. Myers GJ, Thurston SW, Pearson AT, Davidson PW, Cox C, Shamlaye CF, Cernichiari E, Clarkson TW. Postnatal exposure to methyl mercury from fish consumption: a review and new data from the Seychelles Child Development Study. Neurotoxicology. 2009 May; 30(3):338-49. PMID: 19442817; PMCID: PMC2743883.
      Citations: 43     Fields:    Translation:HumansPHPublic Health
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