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Alexander Pearson

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Hematology and Oncology
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    The Pearson Lab integrates clinical expertise, mathematical modeling, high dimensional statistics, and basic tumor biology methods to investigate and propose new treatments for head and neck cancer.

    Collapse Biography 
    Collapse education and training
    Cornell University, Ithaca, NYBS05/2002Biometry and Statistics
    University of Rochester, Rochester, NYPhD03/2009Statistics
    University of Rochester, Rochester, NYMD05/2010Medicine
    University of Michigan, Ann Arbor, MIResidency06/2012Internal Medicine
    University of Michigan, Ann Arbor, MIFellowship06/2016Hematology/Oncology
    University of Michigan, Ann Arbor, MIPostdoctoral Fellowship06/2016Nor Lab (2013-2017)
    Collapse awards and honors
    2014 - 2015Chief Fellow in Hematology/Oncology, University of Michigan
    2015Mark Roth Award, University of Michigan

    Collapse Research 
    Collapse research activities and funding
    UE5EB035490     (ARIBISALA, BENJAMIN SEGUN)Sep 20, 2023 - Aug 31, 2026
    NIH
    Data Science and Medical Image Analysis Training for Improved Health Care Delivery in Nigeria - DATICAN
    Role: Co-Principal Investigator
    R56DE030958     (PEARSON, ALEXANDER THOMAS)Sep 2, 2021 - Sep 1, 2022
    NIH
    Deep learning for oral premalignancy evaluation
    Role: Principal Investigator
    K08DE026500     (PEARSON, ALEXANDER THOMAS)Sep 1, 2016 - Aug 31, 2021
    NIH
    A reasoned approach to combination therapy development in head and neck cancer
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rabasco Meneghetti A, Ligero Hernández M, Kuehn JP, Löck S, Itzel Carrero Z, Perez-Lopez R, Bressem K, Brinker TK, Pearson AT, Truhn D, Nebelung S, Kather JN, Meneghetti AR, Hernández ML, Kuehn JP, Löck S, Carrero ZI, Perez-Lopez R, Bressem K, Brinker TK, Pearson AT, Truhn D, Nebelung S, Kather JN. End-to-end prediction of clinical outcomes in head and neck squamous cell carcinoma with foundation model-based multiple instance learning. medRxiv. 2025 Jan 25. PMID: 39974018; PMCID: PMC11839013.
      Citations:    
    2. Mishra V, Singh A, Korzinkin M, Cheng X, Wing C, Sarkisova V, Koppayi AL, Pogorelskaya A, Glushchenko O, Sundaresan M, Thodima V, Carter J, Ito K, Scherle P, Trzcinska A, Ozerov I, Vokes EE, Cole G, Pun FW, Shen L, Miao Y, Pearson AT, Lingen MW, Ruggeri B, Rosenberg AJ, Zhavoronkov A, Agrawal N, Izumchenko E. PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands. J Exp Clin Cancer Res. 2025 Jan 11; 44(1):11. PMID: 39794830; PMCID: PMC11724466.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Žigutyte L, Lenz T, Han T, Hewitt KJ, Reitsam NG, Foersch S, Carrero ZI, Unger M, Pearson AT, Truhn D, Kather JN, Žigutyte L, Lenz T, Han T, Hewitt KJ, Reitsam NG, Foersch S, Carrero ZI, Unger M, Pearson AT, Truhn D, Kather JN, Lenz T, Hewitt KJ, Reitsam NG, Carrero ZI, Unger M, Lenz T, Hewitt KJ, Reitsam NG, Carrero ZI, Unger M. Counterfactual Diffusion Models for Mechanistic Explainability of Artificial Intelligence Models in Pathology. bioRxiv. 2025 Jan 08. PMID: 39554184; PMCID: PMC11565818.
      Citations:    
    4. Howard FM, Hieromnimon HM, Ramesh S, Dolezal J, Kochanny S, Zhang Q, Feiger B, Peterson J, Fan C, Perou CM, Vickery J, Sullivan M, Cole K, Khramtsova G, Pearson AT. Generative adversarial networks accurately reconstruct pan-cancer histology from pathologic, genomic, and radiographic latent features. Sci Adv. 2024 Nov 15; 10(46):eadq0856. PMID: 39546597; PMCID: PMC11567005.
      Citations:    Fields:    Translation:Humans
    5. Ramesh S, Dyer E, Pomaville M, Doytcheva K, Dolezal J, Kochanny S, Terhaar R, Mehrhoff CJ, Patel K, Brewer J, Kusswurm B, Naranjo A, Shimada H, Cipriani NA, Husain AN, Pytel P, Sokol EA, Cohn SL, George RE, Pearson AT, Applebaum MA. Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology. NPJ Precis Oncol. 2024 Nov 08; 8(1):255. PMID: 39511421; PMCID: PMC11544094.
      Citations:    
    6. Choudhury D, Dolezal JM, Dyer E, Kochanny S, Ramesh S, Howard FM, Margalus JR, Schroeder A, Schulte J, Garassino MC, Kather JN, Pearson AT. Developing a low-cost, open-source, locally manufactured workstation and computational pipeline for automated histopathology evaluation using deep learning. EBioMedicine. 2024 Sep; 107:105276. PMID: 39197222; PMCID: PMC11399610.
      Citations:    Fields:    Translation:Humans
    7. Wang Y, Bergman DR, Trujillo E, Fernald AA, Li L, Pearson AT, Sweis RF, Jackson TL. Agent-Based Modeling of Virtual Tumors Reveals the Critical Influence of Microenvironmental Complexity on Immunotherapy Efficacy. Cancers (Basel). 2024 Aug 23; 16(17). PMID: 39272799; PMCID: PMC11394213.
      Citations:    
    8. Srisuwananukorn A, Krull JE, Ma Q, Zhang P, Pearson AT, Hoffman R. Applications of artificial intelligence to myeloproliferative neoplasms: a narrative review. Expert Rev Hematol. 2024 Oct; 17(10):669-677. PMID: 39114884.
      Citations:    Fields:    Translation:Humans
    9. Viet CT, Zhang M, Dharmaraj N, Li GY, Pearson AT, Manon VA, Grandhi A, Xu K, Aouizerat BE, Young S. Artificial Intelligence Applications in Oral Cancer and Oral Dysplasia. Tissue Eng Part A. 2024 Oct; 30(19-20):640-651. PMID: 39041628; PMCID: PMC11564848.
      Citations:    Fields:    Translation:Humans
    10. Frisbie L, Pressimone C, Dyer E, Baruwal R, Garcia G, St Croix C, Watkins S, Calderone M, Gorecki G, Javed Z, Atiya HI, Hempel N, Pearson A, Coffman LG. Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer. Cell Rep. 2024 08 27; 43(8):114551. PMID: 39067022; PMCID: PMC11420855.
      Citations: 2     Fields:    
    11. Rosenberg AJ, Agrawal N, Juloori A, Cursio J, Gooi Z, Blair E, Chin J, Ginat D, Pasternak-Wise O, Hasina R, Starus A, Jones FS, Izumchenko E, MacCracken E, Wolk R, Cipriani N, Lingen MW, Pearson AT, Seiwert TY, Haraf DJ, Vokes EE. Neoadjuvant Nivolumab Plus Chemotherapy Followed By Response-Adaptive Therapy for HPV+ Oropharyngeal Cancer: OPTIMA II Phase 2 Open-Label Nonrandomized Controlled Trial. JAMA Oncol. 2024 Jul 01; 10(7):923-931. PMID: 38842838; PMCID: PMC11157444.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    12. Ríos-Hoyo A, Shan NL, Li A, Pearson AT, Pusztai L, Howard FM. Evaluation of large language models as a diagnostic aid for complex medical cases. Front Med (Lausanne). 2024; 11:1380148. PMID: 38966538; PMCID: PMC11222590.
      Citations: 2     
    13. Dhungana A, Vannier A, Zhao F, Freeman JQ, Saha P, Sullivan M, Yao K, Flores EM, Olopade OI, Pearson AT, Huo D, Howard FM. Development and validation of a clinical breast cancer tool for accurate prediction of recurrence. NPJ Breast Cancer. 2024 Jun 15; 10(1):46. PMID: 38879577; PMCID: PMC11180107.
      Citations: 1     
    14. Viet CT, Asam KR, Yu G, Dyer EC, Kochanny S, Thomas CM, Callahan NF, Morlandt AB, Cheng AC, Patel AA, Roden DF, Young S, Melville J, Shum J, Walker PC, Nguyen KK, Kidd SN, Lee SC, Folk GS, Viet DT, Grandhi A, Deisch J, Ye Y, Momen-Heravi F, Pearson AT, Aouizerat BE. Artificial intelligence-based epigenomic, transcriptomic and histologic signatures of tobacco use in oral squamous cell carcinoma. NPJ Precis Oncol. 2024 Jun 08; 8(1):130. PMID: 38851780; PMCID: PMC11162452.
      Citations: 1     
    15. Applebaum M, Ramesh S, Dyer E, Pomaville M, Doytcheva K, Dolezal J, Kochanny S, Terhaar R, Mehrhoff C, Patel K, Brewer J, Kusswurm B, Naranjo A, Shimada H, Sokol E, Cohn S, George R, Pearson A. Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology. Res Sq. 2024 Jun 04. PMID: 38883758; PMCID: PMC11177984.
      Citations:    
    16. Ramesh S, Tomesh T, Riesenfeld SJ, Chong FT, Pearson AT. Quantum computing for oncology. Nat Cancer. 2024 Jun; 5(6):811-816. PMID: 38760645.
      Citations:    Fields:    Translation:Humans
    17. Cyberski TF, Singh A, Korzinkin M, Mishra V, Pun F, Shen L, Wing C, Cheng X, Baird B, Miao Y, Elkabets M, Kochanny S, Guo W, Dyer E, Pearson AT, Juloori A, Lingen M, Cole G, Zhavoronkov A, Agrawal N, Izumchenko E, Rosenberg AJ. Acquired resistance to immunotherapy and chemoradiation in MYC amplified head and neck cancer. NPJ Precis Oncol. 2024 May 23; 8(1):114. PMID: 38783041; PMCID: PMC11116544.
      Citations: 1     
    18. Howard FM, Li A, Riffon MF, Garrett-Mayer E, Pearson AT. Characterizing the Increase in Artificial Intelligence Content Detection in Oncology Scientific Abstracts From 2021 to 2023. JCO Clin Cancer Inform. 2024 May; 8:e2400077. PMID: 38822755; PMCID: PMC11371107.
      Citations:    Fields:    Translation:Humans
    19. Niehues JM, Müller-Franzes G, Schirris Y, Wagner SJ, Jendrusch M, Kloor M, Pearson AT, Muti HS, Hewitt KJ, Veldhuizen GP, Zigutyte L, Truhn D, Kather JN. Using histopathology latent diffusion models as privacy-preserving dataset augmenters improves downstream classification performance. Comput Biol Med. 2024 06; 175:108410. PMID: 38678938.
      Citations:    Fields:    Translation:Humans
    20. Dolezal JM, Kochanny S, Dyer E, Ramesh S, Srisuwananukorn A, Sacco M, Howard FM, Li A, Mohan P, Pearson AT. Slideflow: deep learning for digital histopathology with real-time whole-slide visualization. BMC Bioinformatics. 2024 Mar 27; 25(1):134. PMID: 38539070; PMCID: PMC10967068.
      Citations: 10     Fields:    
    21. Bergman DR, Wang Y, Trujillo E, Fernald AA, Li L, Pearson AT, Sweis RF, Jackson TL. Dysregulated FGFR3 signaling alters the immune landscape in bladder cancer and presents therapeutic possibilities in an agent-based model. Front Immunol. 2024; 15:1358019. PMID: 38515743; PMCID: PMC10954792.
      Citations: 2     Fields:    Translation:HumansCells
    22. Jagadeeshan S, Suryamohan K, Shin N, Mathukkada S, Boyko A, Melikhova D, Tsareva A, Yunusova L, Pravdivtseva E, Stupichev D, Shaposhnikov K, Peterson A, Bednyagin L, Shugaev-Mendosa E, Kessler L, Burrows F, Ho AL, Agrawal N, Pearson AT, Izumchenko E, Cole G, Elkabets M, Rosenberg AJ. Evolutionary dynamics of tipifarnib in HRAS mutated head and neck squamous cell carcinoma. Oral Oncol. 2024 Feb; 149:106688. PMID: 38219706; PMCID: PMC11309563.
      Citations: 1     Fields:    
    23. Vannier AGL, Dhungana A, Zhao F, Chen N, Shubeck S, Hahn OM, Nanda R, Jaskowiak NT, Fleming GF, Olopade OI, Pearson AT, Huo D, Howard FM. Validation of the RSClin risk calculator in the National Cancer Data Base. Cancer. 2024 Apr 15; 130(8):1210-1220. PMID: 38146744; PMCID: PMC10948297.
      Citations: 2     Fields:    Translation:Humans
    24. Wang Y, Bergman DR, Trujillo E, Pearson AT, Sweis RF, Jackson TL. Mathematical model predicts tumor control patterns induced by fast and slow cytotoxic T lymphocyte killing mechanisms. Sci Rep. 2023 12 18; 13(1):22541. PMID: 38110479; PMCID: PMC10728095.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    25. Wardley AM, Baird RD, Ring A, Kilburn LS, Pearson A, Moretti L, Afshari-Mehr A, Gurel B, Macpherson IR, Riisnaes R, Martin S, Roylance R, Johnson H, Ferreira A, Winter MC, Dunne K, Copson E, Hickish T, Burcombe R, Randle K, Serra V, Llop-Guevara A, Bliss JM, Turner NC. Olaparib and Ceralasertib (AZD6738) in Patients with Triple-Negative Advanced Breast Cancer: Results from Cohort E of the plasmaMATCH Trial (CRUK/15/010). Clin Cancer Res. 2023 12 01; 29(23):4751-4759. PMID: 37773077; PMCID: PMC10690092.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    26. Araújo ALD, Silva VMD, Moraes MC, de Amorim HA, Fonseca FP, Sant'Ana MSP, Mesquita RA, Mariz BALA, Pontes HAR, de Souza LL, Saldivia-Siracusa C, Khurram SA, Pearson AT, Martins MD, Lopes MA, Vargas PA, Kowalski LP, Santos-Silva AR. The use of deep learning state-of-the-art architectures for oral epithelial dysplasia grading: A comparative appraisal. J Oral Pathol Med. 2023 Nov; 52(10):980-987. PMID: 37712321.
      Citations:    Fields:    Translation:Humans
    27. Srisuwananukorn A, Salama ME, Pearson AT. Deep learning applications in visual data for benign and malignant hematologic conditions: a systematic review and visual glossary. Haematologica. 2023 08 01; 108(8):1993-2010. PMID: 36700396; PMCID: PMC10388280.
      Citations: 1     Fields:    Translation:Humans
    28. Omoleye OJ, Woodard AE, Howard FM, Zhao F, Yoshimatsu TF, Zheng Y, Pearson AT, Levental M, Aribisala BS, Kulkarni K, Karczmar GS, Olopade OI, Abe H, Huo D. External Evaluation of a Mammography-based Deep Learning Model for Predicting Breast Cancer in an Ethnically Diverse Population. Radiol Artif Intell. 2023 Nov; 5(6):e220299. PMID: 38074785; PMCID: PMC10698602.
      Citations: 3     Fields:    
    29. Veldhuizen GP, Röcken C, Behrens HM, Cifci D, Muti HS, Yoshikawa T, Arai T, Oshima T, Tan P, Ebert MP, Pearson AT, Calderaro J, Grabsch HI, Kather JN. Deep learning-based subtyping of gastric cancer histology predicts clinical outcome: a multi-institutional retrospective study. Gastric Cancer. 2023 09; 26(5):708-720. PMID: 37269416; PMCID: PMC10361890.
      Citations: 3     Fields:    Translation:Humans
    30. Dolezal JM, Wolk R, Hieromnimon HM, Howard FM, Srisuwananukorn A, Karpeyev D, Ramesh S, Kochanny S, Kwon JW, Agni M, Simon RC, Desai C, Kherallah R, Nguyen TD, Schulte JJ, Cole K, Khramtsova G, Garassino MC, Husain AN, Li H, Grossman R, Cipriani NA, Pearson AT. Deep learning generates synthetic cancer histology for explainability and education. NPJ Precis Oncol. 2023 May 29; 7(1):49. PMID: 37248379; PMCID: PMC10227067.
      Citations: 11     
    31. Senthil Kumar K, Miskovic V, Blasiak A, Sundar R, Pedrocchi ALG, Pearson AT, Prelaj A, Ho D. Artificial Intelligence in Clinical Oncology: From Data to Digital Pathology and Treatment. Am Soc Clin Oncol Educ Book. 2023 May; 43:e390084. PMID: 37235822.
      Citations: 13     Fields:    Translation:Humans
    32. Gao CA, Howard FM, Markov NS, Dyer EC, Ramesh S, Luo Y, Pearson AT. Comparing scientific abstracts generated by ChatGPT to real abstracts with detectors and blinded human reviewers. NPJ Digit Med. 2023 Apr 26; 6(1):75. PMID: 37100871; PMCID: PMC10133283.
      Citations: 87     
    33. Howard FM, Dolezal J, Kochanny S, Khramtsova G, Vickery J, Srisuwananukorn A, Woodard A, Chen N, Nanda R, Perou CM, Olopade OI, Huo D, Pearson AT. Integration of clinical features and deep learning on pathology for the prediction of breast cancer recurrence assays and risk of recurrence. NPJ Breast Cancer. 2023 Apr 14; 9(1):25. PMID: 37059742; PMCID: PMC10104799.
      Citations: 15     
    34. Vayani OR, Asif H, Klein A, Hahn OM, Pearson AT, Arora VM, Olopade OI, Golden DW. Adapting a Medical School Cancer Research Education Program to the Virtual Environment: a Mixed-Methods Study. J Cancer Educ. 2023 10; 38(5):1501-1508. PMID: 37058222; PMCID: PMC10102672.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    35. Kochanny S, Pearson A, Khurram SA, Migliorati CA, Araújo ALD, Moraes MC, Pérez-de-Oliveira ME, Silva VMD, Saldivia-Siracusa C, Pedroso CM, Lopes MA, Vargas PA, Kowalski LP, Santos-Silva AR. Machine learning for the prediction of toxicities from head and neck cancer treatment: A systematic review with meta-analysis. Oral Oncol. 2023 05; 140:106386. PMID: 37023561.
      Citations: 1     Fields:    Translation:Humans
    36. Saldanha OL, Loeffler CML, Niehues JM, van Treeck M, Hewitt KJ, Cifci D, Veldhuizen GP, Ramesh S, Pearson AT, Kather JN, Seraphin TP. Self-supervised attention-based deep learning for pan-cancer mutation prediction from histopathology. NPJ Precis Oncol. 2023 Mar 28; 7(1):35. PMID: 36977919; PMCID: PMC10050159.
      Citations: 23     
    37. Khurram SA, Kowalski LP, Dos Santos HT, Warnakulasuriya S, Dolezal J, Pearson AT, de Souza LL, Fonseca FP, Araújo ALD, Lopes MA, Vargas PA, Santos-Silva AR. Machine learning for detection and classification of oral potentially malignant disorders: A conceptual review. J Oral Pathol Med. 2023 Mar; 52(3):197-205. PMID: 36792771.
      Citations: 2     Fields:    Translation:Humans
    38. Partin A, Brettin T, Zhu Y, Dolezal JM, Kochanny S, Pearson AT, Shukla M, Evrard YA, Doroshow JH, Stevens RL. Data augmentation and multimodal learning for predicting drug response in patient-derived xenografts from gene expressions and histology images. Front Med (Lausanne). 2023; 10:1058919. PMID: 36960342; PMCID: PMC10027779.
      Citations: 2     
    39. Prelaj A, Ganzinelli M, Trovo' F, Roisman LC, Pedrocchi ALG, Kosta S, Restelli M, Ambrosini E, Broggini M, Pravettoni G, Monzani D, Nuara A, Amat R, Spathas N, Willis M, Pearson A, Dolezal J, Mazzeo L, Sangaletti S, Correa AM, Aguaron A, Popa C, Raimondi G, Triulzi T, Steurer S, Lo Russo G, Linardou H, Peled N, Felip E, Garassino MC, Watermann I, Reck M. The EU-funded I3LUNG Project: Integrative Science, Intelligent Data Platform for Individualized LUNG Cancer Care With Immunotherapy. Clin Lung Cancer. 2023 06; 24(4):381-387. PMID: 36959048.
      Citations: 5     Fields:    Translation:Humans
    40. Khurram SA, Pearson AT, Araújo ALD, da Silva VM, Kudo MS, de Souza ESC, Saldivia-Siracusa C, Giraldo-Roldán D, Lopes MA, Vargas PA, Kowalski LP, de Carvalho ACPLF, Santos-Silva AR, Moraes MC. Machine learning concepts applied to oral pathology and oral medicine: A convolutional neural networks' approach. J Oral Pathol Med. 2023 Feb; 52(2):109-118. PMID: 36599081.
      Citations: 4     Fields:    Translation:Humans
    41. Goldberg M, Manzi A, Birdi A, Laporte B, Conway P, Cantin S, Mishra V, Singh A, Pearson AT, Goldberg ER, Goldberger S, Flaum B, Hasina R, London NR, Gallia GL, Bettegowda C, Young S, Sandulache V, Melville J, Shun J, O'Neill SE, Aydin E, Zhavoronkov A, Vidal A, Soto A, Alonso MJ, Rosenberg AJ, Lingen MW, D'Cruz A, Agrawal N, Izumchenko E. Author Correction: A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer. Nat Commun. 2022 Dec 21; 13(1):7865. PMID: 36543765; PMCID: PMC9772340.
      Citations: 1     Fields:    
    42. Ramesh S, Dolezal JM, Pearson AT. Applications of Deep Learning in Endocrine Neoplasms. Surg Pathol Clin. 2023 Mar; 16(1):167-176. PMID: 36739164.
      Citations: 2     Fields:    Translation:Humans
    43. Howard FM, Kather JN, Pearson AT. Multimodal deep learning: An improvement in prognostication or a reflection of batch effect? Cancer Cell. 2023 01 09; 41(1):5-6. PMID: 36368319.
      Citations: 6     Fields:    Translation:Humans
    44. Dolezal JM, Srisuwananukorn A, Karpeyev D, Ramesh S, Kochanny S, Cody B, Mansfield AS, Rakshit S, Bansal R, Bois MC, Bungum AO, Schulte JJ, Vokes EE, Garassino MC, Husain AN, Pearson AT. Uncertainty-informed deep learning models enable high-confidence predictions for digital histopathology. Nat Commun. 2022 11 02; 13(1):6572. PMID: 36323656; PMCID: PMC9630455.
      Citations: 13     Fields:    Translation:Humans
    45. Howard FM, He G, Peterson JR, Pfeiffer JR, Earnest T, Pearson AT, Abe H, Cole JA, Nanda R. Highly accurate response prediction in high-risk early breast cancer patients using a biophysical simulation platform. Breast Cancer Res Treat. 2022 Nov; 196(1):57-66. PMID: 36063220; PMCID: PMC9550684.
      Citations: 6     Fields:    Translation:Humans
    46. Luo T, Nash GT, Jiang X, Feng X, Mao J, Liu J, Juloori A, Pearson AT, Lin W. A 2D Nanoradiosensitizer Enhances Radiotherapy and Delivers STING Agonists to Potentiate Cancer Immunotherapy. Adv Mater. 2022 Sep; 34(39):e2110588. PMID: 35952624; PMCID: PMC9529854.
      Citations: 9     Fields:    Translation:Humans
    47. Goldberg M, Manzi A, Birdi A, Laporte B, Conway P, Cantin S, Mishra V, Singh A, Pearson AT, Goldberg ER, Goldberger S, Flaum B, Hasina R, London NR, Gallia GL, Bettegowda C, Young S, Sandulache V, Melville J, Shum J, O'Neill SE, Aydin E, Zhavoronkov A, Vidal A, Soto A, Alonso MJ, Rosenberg AJ, Lingen MW, D'Cruz A, Agrawal N, Izumchenko E. A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer. Nat Commun. 2022 08 17; 13(1):4829. PMID: 35977936; PMCID: PMC9385702.
      Citations: 16     Fields:    Translation:Animals
    48. Rosenberg AJ, Agrawal N, Pearson AT, Gooi Z, Blair E, Portugal L, Cursio JF, Juloori A, Chin J, Rouse K, Villaflor VM, Seiwert TY, Izumchenko E, Lingen MW, Haraf DJ, Vokes EE. Phase I study of nab-paclitaxel-based induction followed by nab-paclitaxel-based concurrent chemotherapy and re-irradiation in previously treated head and neck squamous cell carcinoma. Br J Cancer. 2022 11; 127(8):1497-1506. PMID: 35945244; PMCID: PMC9553920.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    49. Ferrarotto R, Mishra V, Herz E, Yaacov A, Solomon O, Rauch R, Mondshine A, Motin M, Leibovich-Rivkin T, Davis M, Kaye J, Weber CR, Shen L, Pearson AT, Rosenberg AJ, Chen X, Singh A, Aster JC, Agrawal N, Izumchenko E. AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling. Cell Death Dis. 2022 08 05; 13(8):678. PMID: 35931701; PMCID: PMC9355983.
      Citations: 16     Fields:    Translation:HumansCells
    50. Hara JH, Gutiontov SI, Uddin S, Rosenberg AJ, Pearson AT, Gooi Z, Blair EA, Agrawal N, Vokes EE, Ginat DT, Haraf DJ, Juloori A. Characterizing Lymph Node Burden With Elective Unilateral Neck Irradiation in Human Papillomavirus-Positive Tonsil Squamous Cell Carcinoma: Defining the Upper Limits. Cureus. 2022 Jul; 14(7):e27521. PMID: 36060366; PMCID: PMC9424785.
      Citations:    
    51. Howard FM, Pearson AT, Nanda R. Clinical trials of immunotherapy in triple-negative breast cancer. Breast Cancer Res Treat. 2022 Aug; 195(1):1-15. PMID: 35834065; PMCID: PMC9338129.
      Citations: 21     Fields:    Translation:Humans
    52. Hieromnimon HM, Pearson AT. Ovarian cancer through a multi-modal lens. Nat Cancer. 2022 06; 3(6):662-664. PMID: 35764744.
      Citations:    Fields:    Translation:Humans
    53. Bergman D, Sweis RF, Pearson AT, Nazari F, Jackson TL. A global method for fast simulations of molecular dynamics in multiscale agent-based models of biological tissues. iScience. 2022 Jun 17; 25(6):104387. PMID: 35637730; PMCID: PMC9142654.
      Citations: 4     
    54. Nair V, Auger S, Kochanny S, Howard FM, Ginat D, Pasternak-Wise O, Juloori A, Koshy M, Izumchenko E, Agrawal N, Rosenberg A, Vokes EE, Skandari MR, Pearson AT. Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma. JAMA Netw Open. 2022 04 01; 5(4):e227240. PMID: 35416988; PMCID: PMC9008506.
      Citations: 3     Fields:    Translation:HumansCells
    55. Ghaffari Laleh N, Loeffler CML, Grajek J, Pearson AT, Muti HS, Trautwein C, Enderling H, Poleszczuk J, Kather JN, Stanková K. Classical mathematical models for prediction of response to chemotherapy and immunotherapy. PLoS Comput Biol. 2022 02; 18(2):e1009822. PMID: 35120124; PMCID: PMC8903251.
      Citations: 22     Fields:    Translation:Humans
    56. Rosenberg AJ, Izumchenko E, Pearson A, Gooi Z, Blair E, Karrison T, Juloori A, Ginat D, Cipriani N, Lingen M, Sloane H, Edelstein DL, Keyser K, Fredebohm J, Holtrup F, Jones FS, Haraf D, Agrawal N, Vokes EE. Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and response-adaptive treatment. BMC Cancer. 2022 Jan 03; 22(1):17. PMID: 34980038; PMCID: PMC8722316.
      Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
    57. Pulianmackal AJ, Sun D, Yumoto K, Li Z, Chen YC, Patel MV, Wang Y, Yoon E, Pearson A, Yang Q, Taichman R, Cackowski FC, Buttitta LA. Monitoring Spontaneous Quiescence and Asynchronous Proliferation-Quiescence Decisions in Prostate Cancer Cells. Front Cell Dev Biol. 2021; 9:728663. PMID: 34957090; PMCID: PMC8703172.
      Citations: 3     
    58. Mishra V, Singh A, Chen X, Rosenberg AJ, Pearson AT, Zhavoronkov A, Savage PA, Lingen MW, Agrawal N, Izumchenko E. Application of liquid biopsy as multi-functional biomarkers in head and neck cancer. Br J Cancer. 2022 02; 126(3):361-370. PMID: 34876674; PMCID: PMC8810877.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    59. Herzog AE, Warner KA, Zhang Z, Bellile E, Bhagat MA, Castilho RM, Wolf GT, Polverini PJ, Pearson AT, Nör JE. The IL-6R and Bmi-1 axis controls self-renewal and chemoresistance of head and neck cancer stem cells. Cell Death Dis. 2021 10 23; 12(11):988. PMID: 34689150; PMCID: PMC8542035.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    60. Rosenberg AJ, Agrawal N, Pearson A, Gooi Z, Blair E, Cursio J, Juloori A, Ginat D, Howard A, Chin J, Kochanny S, Foster C, Cipriani N, Lingen M, Izumchenko E, Seiwert TY, Haraf D, Vokes EE. Risk and response adapted de-intensified treatment for HPV-associated oropharyngeal cancer: Optima paradigm expanded experience. Oral Oncol. 2021 11; 122:105566. PMID: 34662771; PMCID: PMC9295443.
      Citations: 10     Fields:    Translation:HumansCellsCTClinical Trials
    61. Ghantous Y, Omar M, Broner EC, Agrawal N, Pearson AT, Rosenberg AJ, Mishra V, Singh A, El-Naaj IA, Savage PA, Sidransky D, Marchionni L, Izumchenko E. A robust and interpretable gene signature for predicting the lymph node status of primary T1/T2 oral cavity squamous cell carcinoma. Int J Cancer. 2022 02 01; 150(3):450-460. PMID: 34569064; PMCID: PMC8760163.
      Citations: 3     Fields:    Translation:HumansCells
    62. Howard FM, Villamar D, He G, Pearson AT, Nanda R. The emerging role of immune checkpoint inhibitors for the treatment of breast cancer. Expert Opin Investig Drugs. 2022 Jun; 31(6):531-548. PMID: 34569400; PMCID: PMC8995399.
      Citations: 9     Fields:    Translation:Humans
    63. Muti HS, Heij LR, Keller G, Kohlruss M, Langer R, Dislich B, Cheong JH, Kim YW, Kim H, Kook MC, Cunningham D, Allum WH, Langley RE, Nankivell MG, Quirke P, Hayden JD, West NP, Irvine AJ, Yoshikawa T, Oshima T, Huss R, Grosser B, Roviello F, d'Ignazio A, Quaas A, Alakus H, Tan X, Pearson AT, Ebert MP, Trautwein C, Gaisa NT, Grabsch HI, Kather JN, Luedde T, Jäger D. Development and validation of deep learning classifiers to detect Epstein-Barr virus and microsatellite instability status in gastric cancer: a retrospective multicentre cohort study. Lancet Digit Health. 2021 10; 3(10):e654-e664. PMID: 34417147; PMCID: PMC8460994.
      Citations: 42     Fields:    Translation:Humans
    64. Pearson AT. Current and future uses of digital pathology in oncology. Clin Adv Hematol Oncol. 2021 Aug; 19(8):508-510. PMID: 34411070.
      Citations:    Fields:    Translation:Humans
    65. Howard FM, Dolezal J, Kochanny S, Schulte J, Chen H, Heij L, Huo D, Nanda R, Olopade OI, Kather JN, Cipriani N, Grossman RL, Pearson AT. The impact of site-specific digital histology signatures on deep learning model accuracy and bias. Nat Commun. 2021 07 20; 12(1):4423. PMID: 34285218; PMCID: PMC8292530.
      Citations: 83     Fields:    Translation:Humans
    66. Broner EC, Trujillo JA, Korzinkin M, Subbannayya T, Agrawal N, Ozerov IV, Zhavoronkov A, Rooper L, Kotlov N, Shen L, Pearson AT, Rosenberg AJ, Savage PA, Mishra V, Chatterjee A, Sidransky D, Izumchenko E. Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma. Front Oncol. 2021; 11:677051. PMID: 34336664; PMCID: PMC8323482.
      Citations: 11     
    67. Naumov V, Putin E, Pushkov S, Kozlova E, Romantsov K, Kalashnikov A, Galkin F, Tihonova N, Shneyderman A, Galkin E, Zinkevich A, Cope SM, Sethuraman R, Oprea TI, Pearson AT, Tay S, Agrawal N, Dubovenko A, Vanhaelen Q, Ozerov I, Aliper A, Izumchenko E, Zhavoronkov A. COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severity. PLoS Comput Biol. 2021 07; 17(7):e1009183. PMID: 34260589; PMCID: PMC8312936.
      Citations: 3     Fields:    Translation:HumansCells
    68. Kacew AJ, Strohbehn GW, Saulsberry L, Laiteerapong N, Cipriani NA, Pearson AT, Kather JN. Artificial Intelligence Can Cut Costs While Maintaining Accuracy in Colorectal Cancer Genotyping. Front Oncol. 2021; 11:630953. PMID: 34168975; PMCID: PMC8217761.
      Citations: 15     
    69. Okuneye K, Bergman D, Bloodworth JC, Pearson AT, Sweis RF, Jackson TL. A validated mathematical model of FGFR3-mediated tumor growth reveals pathways to harness the benefits of combination targeted therapy and immunotherapy in bladder cancer. Comput Syst Oncol. 2021 Jun; 1(2). PMID: 34984415; PMCID: PMC8722426.
      Citations: 8     
    70. Zhang MH, Hasse A, Carroll T, Pearson AT, Cipriani NA, Ginat DT. Differentiating low and high grade mucoepidermoid carcinoma of the salivary glands using CT radiomics. Gland Surg. 2021 May; 10(5):1646-1654. PMID: 34164309; PMCID: PMC8184388.
      Citations: 5     
    71. Pearson AT, Vokes EE. Is This the Dawn of Precision Oncology in Head and Neck Cancer? J Clin Oncol. 2021 06 10; 39(17):1839-1841. PMID: 33877869.
      Citations:    Fields:    Translation:Humans
    72. Krause J, Grabsch HI, Kloor M, Jendrusch M, Echle A, Buelow RD, Boor P, Luedde T, Brinker TJ, Trautwein C, Pearson AT, Quirke P, Jenniskens J, Offermans K, van den Brandt PA, Kather JN. Deep learning detects genetic alterations in cancer histology generated by adversarial networks. J Pathol. 2021 05; 254(1):70-79. PMID: 33565124.
      Citations: 23     Fields:    Translation:Humans
    73. Quandt J, Arnovitz S, Haghi L, Woehlk J, Mohsin A, Okoreeh M, Mathur PS, Emmanuel AO, Osman A, Krishnan M, Morin SB, Pearson AT, Sweis RF, Pekow J, Weber CR, Khazaie K, Gounari F. Wnt-ß-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression. Nat Immunol. 2021 04; 22(4):471-484. PMID: 33664518; PMCID: PMC8262575.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    74. Burgin SJM, Spector ME, Pearson AT, Bellile E, Vainshtein JM, Rosko A, Mclean SA, Bradford CR, Wolf GT, Prince ME, Worden FP, Eisbruch A, Chepeha DB. Long-term neck and shoulder function among survivors of oropharyngeal squamous cell carcinoma treated with chemoradiation as assessed with the neck dissection impairment index. Head Neck. 2021 05; 43(5):1621-1628. PMID: 33580560.
      Citations: 2     Fields:    Translation:Humans
    75. Andrade NP, Warner KA, Zhang Z, Pearson AT, Mantesso A, Altemani A, Mariano FV, Guimaraes DM, Nunes FD, Nör JE. Survival of salivary gland cancer stem cells requires mTOR signaling. Cell Death Dis. 2021 01 21; 12(1):108. PMID: 33479203; PMCID: PMC7820616.
      Citations: 6     Fields:    Translation:HumansCells
    76. Reizine N, Vokes EE, Liu P, Truong TM, Nanda R, Fleming GF, Catenacci DVT, Pearson AT, Parsad S, Danahey K, van Wijk XMR, Yeo KJ, Ratain MJ, O'Donnell PH. Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial. Ther Adv Med Oncol. 2020; 12:1758835920974118. PMID: 33414846; PMCID: PMC7750903.
      Citations: 4     
    77. Dolezal JM, Trzcinska A, Liao CY, Kochanny S, Blair E, Agrawal N, Keutgen XM, Angelos P, Cipriani NA, Pearson AT. Deep learning prediction of BRAF-RAS gene expression signature identifies noninvasive follicular thyroid neoplasms with papillary-like nuclear features. Mod Pathol. 2021 05; 34(5):862-874. PMID: 33299111; PMCID: PMC8064913.
      Citations: 22     Fields:    Translation:HumansCells
    78. Echle A, Rindtorff NT, Brinker TJ, Pearson AT, Kather JN, Luedde T. Deep learning in cancer pathology: a new generation of clinical biomarkers. Br J Cancer. 2021 02; 124(4):686-696. PMID: 33204028; PMCID: PMC7884739.
      Citations: 166     Fields:    Translation:Humans
    79. Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT. Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer. JAMA Netw Open. 2020 11 02; 3(11):e2025881. PMID: 33211108; PMCID: PMC7677764.
      Citations: 59     Fields:    Translation:Humans
    80. Kather JN, Heij LR, Grabsch HI, Loeffler C, Echle A, Muti HS, Krause J, Niehues JM, Sommer KAJ, Bankhead P, Kooreman LFS, Schulte JJ, Cipriani NA, Buelow RD, Boor P, Hanby AM, Speirs V, Kochanny S, Patnaik A, Srisuwananukorn A, Brenner H, Hoffmeister M, van den Brandt PA, Trautwein C, Pearson AT, Luedde T, Ortiz-Brüchle N, Jäger D. Author Correction: Pan-cancer image-based detection of clinically actionable genetic alterations. Nat Cancer. 2020 Nov; 1(11):1129. PMID: 35122072.
      Citations: 2     Fields:    
    81. Kochanny SE, Pearson AT. Academics as leaders in the cancer artificial intelligence revolution. Cancer. 2021 03 01; 127(5):664-671. PMID: 33119903.
      Citations: 7     Fields:    Translation:Humans
    82. Kolbe AR, Bendall ML, Pearson AT, Paul D, Nixon DF, Crandall KA, Pérez-Losada M. Human Endogenous Retrovirus Expression Is Associated with Head and Neck Cancer and Differential Survival. Viruses. 2020 08 28; 12(9). PMID: 32872377; PMCID: PMC7552064.
      Citations: 15     Fields:    Translation:HumansCells
    83. Bryan DS, Stack M, Krysztofiak K, Cichon U, Thomas DG, Surcel A, Schiffhauer ES, Beckett MA, Khodarev NN, Xue L, Poli EC, Pearson AT, Posner MC, Robinson DN, Rock RS, Weichselbaum RR. 4-Hydroxyacetophenone modulates the actomyosin cytoskeleton to reduce metastasis. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22423-22429. PMID: 32848073; PMCID: PMC7486788.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    84. Kather JN, Heij LR, Grabsch HI, Loeffler C, Echle A, Muti HS, Krause J, Niehues JM, Sommer KAJ, Bankhead P, Kooreman LFS, Schulte JJ, Cipriani NA, Buelow RD, Boor P, Hanby AM, Speirs V, Kochanny S, Patnaik A, Srisuwananukorn A, Brenner H, Hoffmeister M, van den Brandt PA, Trautwein C, Pearson AT, Luedde T, Ortiz-Brüchle NN, Jäger D. Pan-cancer image-based detection of clinically actionable genetic alterations. Nat Cancer. 2020 08; 1(8):789-799. PMID: 33763651; PMCID: PMC7610412.
      Citations: 207     Fields:    Translation:Humans
    85. Facompre ND, Rajagopalan P, Sahu V, Pearson AT, Montone KT, James CD, Gleber-Netto FO, Weinstein GS, Jalaly J, Lin A, Rustgi AK, Nakagawa H, Califano JA, Pickering CR, White EA, Windle BE, Morgan IM, Cohen RB, Gimotty PA, Basu D. Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models. Int J Cancer. 2020 12 01; 147(11):3236-3249. PMID: 32478869; PMCID: PMC7554059.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    86. Echle A, Grabsch HI, Quirke P, van den Brandt PA, West NP, Hutchins GGA, Richman SD, Krause J, Alwers E, Jenniskens J, Offermans K, Gray R, Brenner H, Chang-Claude J, Trautwein C, Pearson AT, Boor P, Luedde T, Gaisa NT, Hoffmeister M, Kather JN, Heij LR, Tan X. Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning. Gastroenterology. 2020 10; 159(4):1406-1416.e11. PMID: 32562722; PMCID: PMC7578071.
      Citations: 112     Fields:    Translation:Humans
    87. Howard FM, Pearson AT. Prognosis and Treatment of Non-Small Cell Lung Cancer in the Age of Deep Learning. JAMA Netw Open. 2020 06 01; 3(6):e206368. PMID: 32492160.
      Citations: 3     Fields:    Translation:Humans
    88. Chopra N, Tovey H, Pearson A, Cutts R, Toms C, Proszek P, Hubank M, Dowsett M, Dodson A, Daley F, Kriplani D, Gevensleben H, Davies HR, Degasperi A, Roylance R, Chan S, Tutt A, Skene A, Evans A, Bliss JM, Nik-Zainal S, Turner NC. Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer. Nat Commun. 2020 05 29; 11(1):2662. PMID: 32471999; PMCID: PMC7260192.
      Citations: 111     Fields:    Translation:HumansCellsCTClinical Trials
    89. Freeman ZT, Nirschl TR, Hovelson DH, Johnston RJ, Engelhardt JJ, Selby MJ, Kochel CM, Lan RY, Zhai J, Ghasemzadeh A, Gupta A, Skaist AM, Wheelan SJ, Jiang H, Pearson AT, Snyder LA, Korman AJ, Tomlins SA, Yegnasubramanian S, Drake CG. A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target. J Clin Invest. 2020 03 02; 130(3):1405-1416. PMID: 32015231; PMCID: PMC7269585.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    90. Nazari F, Oklejas AE, Pearson AT, Jackson TL, Nör JE. In Silico Models Accurately Predict In Vivo Response for IL6 Blockade in Head and Neck Cancer. Cancer Res. 2020 04 01; 80(7):1451-1460. PMID: 32041834; PMCID: PMC7127935.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    91. Xavier JB, Young VB, Skufca J, Ginty F, Testerman T, Pearson AT, Macklin P, Mitchell A, Shmulevich I, Xie L, Caporaso JG, Crandall KA, Simone NL, Godoy-Vitorino F, Griffin TJ, Whiteson KL, Gustafson HH, Slade DJ, Schmidt TM, Walther-Antonio MRS, Korem T, Webb-Robertson BM, Styczynski MP, Johnson WE, Jobin C, Ridlon JM, Koh AY, Yu M, Kelly L, Wargo JA. The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View. Trends Cancer. 2020 03; 6(3):192-204. PMID: 32101723; PMCID: PMC7098063.
      Citations: 101     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    92. Agius R, Brieghel C, Andersen MA, Pearson AT, Ledergerber B, Cozzi-Lepri A, Louzoun Y, Andersen CL, Bergstedt J, von Stemann JH, Tang ME, Fontes M, Bahlo J, Herling CD, Hallek M, Lundgren J, MacPherson CR, Larsen J, Niemann CU, Jørgensen M. Machine learning can identify newly diagnosed patients with CLL at high risk of infection. Nat Commun. 2020 01 17; 11(1):363. PMID: 31953409; PMCID: PMC6969150.
      Citations: 35     Fields:    Translation:Humans
    93. Schubert AD, Channah Broner E, Agrawal N, London N, Pearson A, Gupta A, Wali N, Seiwert TY, Wheelan S, Lingen M, Macleod K, Allen H, Chatterjee A, Vassiliki S, Gaykalova D, Hoque MO, Sidransky D, Suresh K, Izumchenko E. Somatic mitochondrial mutation discovery using ultra-deep sequencing of the mitochondrial genome reveals spatial tumor heterogeneity in head and neck squamous cell carcinoma. Cancer Lett. 2020 02 28; 471:49-60. PMID: 31830557; PMCID: PMC6980748.
      Citations: 9     Fields:    Translation:Humans
    94. Hui R, Pearson A, Cortes J, Campbell C, Poirot C, Azim HA, Fumagalli D, Daly F, Arahmani A, Bedard PL, Xuereb L, Scheepers ED, Goulioti T, Loibl S, Loi S, Pierrat MJ, Turner NC, Andre F, Curigliano G, Lambertini M, Perez-Garcia J, Aftimos P, Vicente M. Lucitanib for the Treatment of HR+/HER2- Metastatic Breast Cancer: Results from the Multicohort Phase II FINESSE Study. Clin Cancer Res. 2020 01 15; 26(2):354-363. PMID: 31619444.
      Citations: 27     Fields:    Translation:HumansCTClinical Trials
    95. Pearson A, Proszek P, Pascual J, Fribbens C, Shamsher MK, Kingston B, O'Leary B, Herrera-Abreu MT, Cutts RJ, Garcia-Murillas I, Bye H, Walker BA, Gonzalez De Castro D, Yuan L, Jamal S, Hubank M, Lopez-Knowles E, Schuster EF, Dowsett M, Osin P, Nerurkar A, Parton M, Okines AFC, Johnston SRD, Ring A, Turner NC. Inactivating NF1 Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance. Clin Cancer Res. 2020 02 01; 26(3):608-622. PMID: 31591187.
      Citations: 52     Fields:    Translation:HumansCells
    96. Cipriani NA, Lusardi JJ, McElherne J, Pearson AT, Olivas AD, Fitzpatrick C, Lingen MW, Blair EA. Mucoepidermoid Carcinoma: A Comparison of Histologic Grading Systems and Relationship to MAML2 Rearrangement and Prognosis. Am J Surg Pathol. 2019 07; 43(7):885-897. PMID: 31021855; PMCID: PMC6629427.
      Citations: 41     Fields:    Translation:Humans
    97. Kather JN, Pearson AT, Halama N, Krause J, Loosen SH, Marx A, Boor P, Neumann UP, Grabsch HI, Yoshikawa T, Brenner H, Chang-Claude J, Hoffmeister M, Trautwein C, Luedde T, Jäger D, Tacke F. Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer. Nat Med. 2019 07; 25(7):1054-1056. PMID: 31160815; PMCID: PMC7423299.
      Citations: 420     Fields:    Translation:Humans
    98. Pearson AT, Sweis RF. Hyperprogression-Immunotherapy-Related Phenomenon vs Intrinsic Natural History of Cancer. JAMA Oncol. 2019 05 01; 5(5):743. PMID: 30896751.
      Citations: 6     Fields:    Translation:Humans
    99. Dillon MT, Bergerhoff KF, Pedersen M, Whittock H, Crespo-Rodriguez E, Patin EC, Pearson A, Smith HG, Paget JTE, Patel RR, Foo S, Bozhanova G, Ragulan C, Fontana E, Desai K, Wilkins AC, Sadanandam A, Melcher A, McLaughlin M, Harrington KJ. ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment. Clin Cancer Res. 2019 06 01; 25(11):3392-3403. PMID: 30770349; PMCID: PMC6551222.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    100. Esvelt MA, Freeman ZT, Pearson AT, Harkema JR, Clines GT, Clines KL, Dyson MC, Hoenerhoff MJ. The Endothelin-A Receptor Antagonist Zibotentan Induces Damage to the Nasal Olfactory Epithelium Possibly Mediated in Part through Type 2 Innate Lymphoid Cells. Toxicol Pathol. 2019 02; 47(2):150-164. PMID: 30595110; PMCID: PMC7357205.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    101. Wang WY, Pearson AT, Kutys ML, Choi CK, Wozniak MA, Baker BM, Chen CS. Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration. APL Bioeng. 2018 Dec; 2(4):046107. PMID: 31069329; PMCID: PMC6481732.
      Citations: 46     
    102. Lopez-Knowles E, Pearson A, Schuster G, Gellert P, Ribas R, Yeo B, Cutts R, Buus R, Garcia-Murillas I, Haynes B, Martin LA, Smith I, Turner N, Dowsett M. Molecular characterisation of aromatase inhibitor-resistant advanced breast cancer: the phenotypic effect of ESR1 mutations. Br J Cancer. 2019 01; 120(2):247-255. PMID: 30563991; PMCID: PMC6342946.
      Citations: 10     Fields:    Translation:Humans
    103. Andrews A, Warner K, Rodriguez-Ramirez C, Pearson AT, Zhang Z, Kerk S, Kulkarni A, Helman JI, Brenner JC, Wicha MS, Wang S, Nör F, Nör JE. Ablation of Cancer Stem Cells by Therapeutic Inhibition of the MDM2-p53 Interaction in Mucoepidermoid Carcinoma. Clin Cancer Res. 2019 03 01; 25(5):1588-1600. PMID: 30498096; PMCID: PMC6397688.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    104. Coffman LG, Pearson AT, Frisbie LG, Freeman Z, Christie E, Bowtell DD, Buckanovich RJ. Ovarian Carcinoma-Associated Mesenchymal Stem Cells Arise from Tissue-Specific Normal Stroma. Stem Cells. 2019 02; 37(2):257-269. PMID: 30353617; PMCID: PMC6392140.
      Citations: 42     Fields:    Translation:HumansCells
    105. Warner KA, Oklejas AE, Pearson AT, Zhang Z, Wu W, Divi V, Rodriguez-Ramirez C, Castilho RM, Polverini PJ, Nör JE. UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line. Oral Oncol. 2018 12; 87:21-28. PMID: 30527239; PMCID: PMC6294471.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    106. Nazari F, Pearson AT, Jackson TL, Nör JE. A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment. PLoS Comput Biol. 2018 01; 14(1):e1005920. PMID: 29351275; PMCID: PMC5792033.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    107. Pearson AT, Ingram P, Bai S, O'Hayer P, Chung J, Yoon E, Jackson T, Buckanovich RJ. Sampling from single-cell observations to predict tumor cell growth in-vitro and in-vivo. Oncotarget. 2017 Dec 19; 8(67):111176-111189. PMID: 29340046; PMCID: PMC5762314.
      Citations: 1     Fields:    
    108. Kim HS, Chen YC, Warner KA, Andrews A, Wagner VP, Zhang Z, Zhang Z, Martins MD, Pearson AT, Yoon E, Nör F, Nör JE. Endothelial-derived interleukin-6 induces cancer stem cell motility by generating a chemotactic gradient towards blood vessels. Oncotarget. 2017 Nov 21; 8(59):100339-100352. PMID: 29245982; PMCID: PMC5725024.
      Citations: 19     Fields:    
    109. Manohar PM, Sapir E, Bellile E, Swiecicki PL, Pearson AT, Prince ME, Shuman AG, Bradford CR, Chepeha DB, Wolf GT, Eisbruch A, Worden FP, Spector ME. Capecitabine after Surgical Salvage in Recurrent Squamous Cell Carcinoma of Head and Neck. Otolaryngol Head Neck Surg. 2017 12; 157(6):995-997. PMID: 28809131.
      Citations: 1     Fields:    Translation:Humans
    110. Asghar US, Barr AR, Cutts R, Beaney M, Babina I, Sampath D, Giltnane J, Lacap JA, Crocker L, Young A, Pearson A, Herrera-Abreu MT, Bakal C, Turner NC. Single-Cell Dynamics Determines Response to CDK4/6 Inhibition in Triple-Negative Breast Cancer. Clin Cancer Res. 2017 Sep 15; 23(18):5561-5572. PMID: 28606920; PMCID: PMC6175044.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
    111. Bai S, Ingram P, Chen YC, Deng N, Pearson A, Niknafs YS, O'Hayer P, Wang Y, Zhang ZY, Boscolo E, Bischoff J, Yoon E, Buckanovich RJ. EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells. Cancer Res. 2016 11 01; 76(21):6396-6409. PMID: 27803106; PMCID: PMC5120866.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    112. Kerk SA, Finkel KA, Pearson AT, Warner KA, Zhang Z, Wagner VP, Vargas PA, Wicha MS, Hurt EM, Hollingsworth RE, Tice DA, Nör F, Nör JE. 5T4-Targeted Therapy Ablates Cancer Stem Cells and Prevents Recurrence of Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2017 May 15; 23(10):2516-2527. PMID: 27780858; PMCID: PMC5405006.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    113. Warner KA, Zhang Z, Acasigua GA, Pearson AT, Kerk SA, Helman JI, Sant'Ana Filho M, Wang S, Nör F, Nör JE. Therapeutic Inhibition of the MDM2-p53 Interaction Prevents Recurrence of Adenoid Cystic Carcinomas. Clin Cancer Res. 2017 Feb 15; 23(4):1036-1048. PMID: 27550999; PMCID: PMC5315632.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    114. Swiecicki PL, Bellile E, Sacco AG, Pearson AT, Taylor JM, Jackson TL, Chepeha DB, Spector ME, Shuman A, Malloy K, Moyer J, McKean E, McLean S, Sukari A, Wolf GT, Eisbruch A, Prince M, Bradford C, Carey TE, Wang S, Worden FP, Nör JE. A phase II trial of the BCL-2 homolog domain 3 mimetic AT-101 in combination with docetaxel for recurrent, locally advanced, or metastatic head and neck cancer. Invest New Drugs. 2016 08; 34(4):481-9. PMID: 27225873; PMCID: PMC5036856.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    115. Pearson AT, Jackson TL, Nör JE. Modeling head and neck cancer stem cell-mediated tumorigenesis. Cell Mol Life Sci. 2016 09; 73(17):3279-89. PMID: 27151511; PMCID: PMC5312795.
      Citations: 4     Fields:    Translation:HumansCells
    116. Herrera-Abreu MT, Palafox M, Asghar U, Cutts RJ, Garcia-Murillas I, Pearson A, Guzman M, Rodriguez O, Grueso J, Bellet M, Elliott R, Pancholi S, Dowsett M, Martin LA, Turner NC, Serra V, Rivas MA, Cortés J, Baselga J. Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor-Positive Breast Cancer. Cancer Res. 2016 04 15; 76(8):2301-13. PMID: 27020857; PMCID: PMC5426059.
      Citations: 351     Fields:    Translation:HumansAnimalsCells
    117. Warner KA, Acasigua GA, Martins MD, Zhang Z, McLean SA, Spector ME, Chepeha DB, Helman J, Wick MJ, Moskaluk CA, Castilho RM, Pearson AT, Wang S, Nör F, Nör JE. Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma. Clin Cancer Res. 2016 07 15; 22(14):3550-9. PMID: 26936915; PMCID: PMC4947417.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    118. Pearson AT, Finkel KA, Warner KA, Tice D, Martins MD, Jackson TL, Nör F, Nör JE. Patient-derived xenograft (PDX) tumors increase growth rate with time. Oncotarget. 2016 Feb 16; 7(7):7993-8005. PMID: 26783960; PMCID: PMC4884970.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    119. Kim HS, Pearson AT, Nör JE. Isolation and Characterization of Cancer Stem Cells from Primary Head and Neck Squamous Cell Carcinoma Tumors. Methods Mol Biol. 2016; 1395:241-9. PMID: 26910078; PMCID: PMC5344035.
      Citations: 5     Fields:    Translation:HumansCells
    120. Saxon D, Pearson AT, Wu P. Hyperlink-Embedded Journal Articles Improve Statistical Knowledge and Reader Satisfaction. J Grad Med Educ. 2015 Dec; 7(4):654-7. PMID: 26692981; PMCID: PMC4675424.
      Citations: 1     Fields:    
    121. Adams A, Warner K, Pearson AT, Zhang Z, Kim HS, Mochizuki D, Basura G, Helman J, Mantesso A, Wicha MS, Castilho RM, Nör JE. ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas. Oncotarget. 2015 Sep 29; 6(29):26633-50. PMID: 26449187; PMCID: PMC4694941.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    122. Mochizuki D, Adams A, Warner KA, Zhang Z, Pearson AT, Misawa K, McLean SA, Wolf GT, Nör JE. Anti-tumor effect of inhibition of IL-6 signaling in mucoepidermoid carcinoma. Oncotarget. 2015 Sep 08; 6(26):22822-35. PMID: 26287605; PMCID: PMC4673202.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    123. Acasigua GA, Warner KA, Helman J, Pearson AT, Fossati AC, Wang S, Nör F, Nör JE. BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma. Oral Oncol. 2015 Sep; 51(9):839-47. PMID: 26121939; PMCID: PMC4532618.
      Citations: 7     Fields:    Translation:HumansAnimals
    124. Sharpe R, Pearson A, Herrera-Abreu MT, Johnson D, Mackay A, Welti JC, Natrajan R, Reynolds AR, Reis-Filho JS, Ashworth A, Turner NC. FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo. Clin Cancer Res. 2011 Aug 15; 17(16):5275-86. PMID: 21712446; PMCID: PMC3432447.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    125. Myers GJ, Thurston SW, Pearson AT, Davidson PW, Cox C, Shamlaye CF, Cernichiari E, Clarkson TW. Postnatal exposure to methyl mercury from fish consumption: a review and new data from the Seychelles Child Development Study. Neurotoxicology. 2009 May; 30(3):338-49. PMID: 19442817; PMCID: PMC2743883.
      Citations: 47     Fields:    Translation:HumansPHPublic Health
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