 Amifostine
"Amifostine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
| Descriptor ID |
D004999
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| MeSH Number(s) |
D02.705.539.060 D02.886.309.060
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| Concept/Terms |
Amifostine- Amifostine
- S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid
- Ethiofos
- Gammaphos
- Aminopropylaminoethylthiophosphoric Acid
- Acid, Aminopropylaminoethylthiophosphoric
- APAETP
Ethyol- Ethyol
- US Bioscience Brand of Amifostine
- Lilly Brand of Amifostine
- Amifostine Lilly Brand
- Schering-Plough Brand of Amifostine
- Amifostine Schering-Plough Brand
- Schering Plough Brand of Amifostine
- Alza Brand of Amifostine
- Amifostine Alza Brand
- Essex Brand of Amifostine
- Amifostine Essex Brand
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Below are MeSH descriptors whose meaning is more general than "Amifostine".
Below are MeSH descriptors whose meaning is more specific than "Amifostine".
This graph shows the total number of publications written about "Amifostine" by people in this website by year, and whether "Amifostine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1985 | 1 | 0 | 1 | | 1986 | 1 | 0 | 1 | | 1987 | 1 | 0 | 1 | | 1988 | 0 | 1 | 1 | | 1991 | 1 | 1 | 2 | | 1992 | 4 | 0 | 4 | | 1995 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 2 | 0 | 2 | | 1999 | 1 | 0 | 1 | | 2000 | 1 | 2 | 3 | | 2002 | 5 | 1 | 6 | | 2003 | 1 | 0 | 1 | | 2004 | 1 | 2 | 3 | | 2007 | 1 | 1 | 2 | | 2008 | 4 | 0 | 4 | | 2009 | 1 | 0 | 1 | | 2010 | 2 | 0 | 2 | | 2011 | 1 | 1 | 2 | | 2014 | 1 | 1 | 2 |
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Below are the most recent publications written about "Amifostine" by people in Profiles.
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Miller RC, Murley JS, Grdina DJ. Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs. Radiat Res. 2014 May; 181(5):464-70.
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Ormsby RJ, Lawrence MD, Blyth BJ, Bexis K, Bezak E, Murley JS, Grdina DJ, Sykes PJ. Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent. Cell Biol Toxicol. 2014 Feb; 30(1):55-66.
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Fu P, Murley JS, Grdina DJ, Birukova AA, Birukov KG. Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury. Crit Care Med. 2011 Dec; 39(12):2711-21.
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Murley JS, Baker KL, Miller RC, Darga TE, Weichselbaum RR, Grdina DJ. SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine. Free Radic Biol Med. 2011 Nov 15; 51(10):1918-25.
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Phillips GL, Bernstein SH, Liesveld JL, Abboud CN, Becker MW, Constine LS, Ifthikharuddin JJ, Loughner JE, Milner LA, Vesole DH, Friedberg JW. A Phase I trial: dose escalation of melphalan in the "BEAM" regimen using amifostine cytoprotection. Biol Blood Marrow Transplant. 2011 Jul; 17(7):1033-42.
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Dziegielewski J, Goetz W, Murley JS, Grdina DJ, Morgan WF, Baulch JE. Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells. Radiat Res. 2010 Feb; 173(2):175-83.
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Grdina DJ, Murley JS, Kataoka Y, Baker KL, Kunnavakkam R, Coleman MC, Spitz DR. Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response. Int J Radiat Oncol Biol Phys. 2009 Mar 01; 73(3):886-96.
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Fu P, Birukova AA, Xing J, Sammani S, Murley JS, Garcia JG, Grdina DJ, Birukov KG. Amifostine reduces lung vascular permeability via suppression of inflammatory signalling. Eur Respir J. 2009 Mar; 33(3):612-24.
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Dziegielewski J, Baulch JE, Goetz W, Coleman MC, Spitz DR, Murley JS, Grdina DJ, Morgan WF. WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. Free Radic Biol Med. 2008 Dec 15; 45(12):1674-81.
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Paunesku D, Paunesku T, Wahl A, Kataoka Y, Murley J, Grdina DJ, Woloschak GE. Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine. Int J Radiat Biol. 2008 Aug; 84(8):623-34.
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