 DNA-Directed DNA Polymerase
"DNA-Directed DNA Polymerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair. EC 2.7.7.7.
| Descriptor ID |
D004259
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| MeSH Number(s) |
D08.811.913.696.445.308.300
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| Concept/Terms |
DNA-Directed DNA Polymerase- DNA-Directed DNA Polymerase
- DNA Directed DNA Polymerase
- DNA Polymerase, DNA-Directed
- Polymerase, DNA-Directed DNA
- DNA Polymerases
- Polymerases, DNA
- DNA-Dependent DNA Polymerases
- DNA Dependent DNA Polymerases
- DNA Polymerases, DNA-Dependent
- Polymerases, DNA-Dependent DNA
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Below are MeSH descriptors whose meaning is more general than "DNA-Directed DNA Polymerase".
Below are MeSH descriptors whose meaning is more specific than "DNA-Directed DNA Polymerase".
This graph shows the total number of publications written about "DNA-Directed DNA Polymerase" by people in this website by year, and whether "DNA-Directed DNA Polymerase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1985 | 1 | 0 | 1 | | 1986 | 1 | 0 | 1 | | 1988 | 2 | 1 | 3 | | 1989 | 1 | 0 | 1 | | 1990 | 0 | 2 | 2 | | 1991 | 1 | 0 | 1 | | 1995 | 0 | 2 | 2 | | 1999 | 0 | 1 | 1 | | 2001 | 2 | 0 | 2 | | 2002 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 1 | 2 | 3 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA-Directed DNA Polymerase" by people in Profiles.
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Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BPC, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJ. CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature. 2017 06 01; 546(7656):168-172.
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Zhang J, Fei J, Leslie BJ, Han KY, Kuhlman TE, Ha T. Tandem Spinach Array for mRNA Imaging in Living Bacterial Cells. Sci Rep. 2015 Nov 27; 5:17295.
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Kanemaru Y, Suzuki T, Niimi N, Grúz P, Matsumoto K, Adachi N, Honma M, Nohmi T. Catalytic and non-catalytic roles of DNA polymerase ? in the protection of human cells against genotoxic stresses. Environ Mol Mutagen. 2015 Oct; 56(8):650-62.
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Sassa A, Suzuki T, Kanemaru Y, Niimi N, Fujimoto H, Katafuchi A, Grúz P, Yasui M, Gupta RC, Johnson F, Ohta T, Honma M, Adachi N, Nohmi T. In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase ?. DNA Repair (Amst). 2014 Mar; 15:21-8.
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Suzuki T, Ukai A, Honma M, Adachi N, Nohmi T. Restoration of mismatch repair functions in human cell line Nalm-6, which has high efficiency for gene targeting. PLoS One. 2013; 8(4):e61189.
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Wevers D, Metzger S, Babweteera F, Bieberbach M, Boesch C, Cameron K, Couacy-Hymann E, Cranfield M, Gray M, Harris LA, Head J, Jeffery K, Knauf S, Lankester F, Leendertz SA, Lonsdorf E, Mugisha L, Nitsche A, Reed P, Robbins M, Travis DA, Zommers Z, Leendertz FH, Ehlers B. Novel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissions. J Virol. 2011 Oct; 85(20):10774-84.
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Prichard MN, Quenelle DC, Hartline CB, Harden EA, Jefferson G, Frederick SL, Daily SL, Whitley RJ, Tiwari KN, Maddry JA, Secrist JA, Kern ER. Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides. Antimicrob Agents Chemother. 2009 Dec; 53(12):5251-8.
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Nojima K, Hochegger H, Saberi A, Fukushima T, Kikuchi K, Yoshimura M, Orelli BJ, Bishop DK, Hirano S, Ohzeki M, Ishiai M, Yamamoto K, Takata M, Arakawa H, Buerstedde JM, Yamazoe M, Kawamoto T, Araki K, Takahashi JA, Hashimoto N, Takeda S, Sonoda E. Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. Cancer Res. 2005 Dec 15; 65(24):11704-11.
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Nick McElhinny SA, Havener JM, Garcia-Diaz M, Juárez R, Bebenek K, Kee BL, Blanco L, Kunkel TA, Ramsden DA. A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Mol Cell. 2005 Aug 05; 19(3):357-66.
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Zheng NY, Wilson K, Jared M, Wilson PC. Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation. J Exp Med. 2005 May 02; 201(9):1467-78.
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